Supersymmetry and Noncommutative Geometry

1996

The purpose of this article is to apply the concept of the spectral triple, the starting point for the analysis of noncommutative spaces in the sense of A.~Connes, to the case where the algebra $\cA$ contains both bosonic and fermionic degrees of freedom. The operator $\cD$ of the spectral triple under consideration is the square root of the Dirac operator und thus the forms of the generalized differential algebra constructed out of the spectral triple are in a representation of the Lorentz group with integer spin if the form degree is even and they are in a representation with half-integer spin if the form degree is odd. However, we find that the 2-forms, obtained by squaring the connectio…

Molecular characterization of cyclic and obligate parthenogens in the aphid Rhopalosiphum padi (L.)

1996

Holocyclic clones of the aphid Rhopalosiphum padi (L.) reproduce by cyclic parthenogenesis, whereas anholocyclic individuals are obligate parthenogens. Mitochondrial DNA (mtDNA) and random amplified polymorphic DNA markers in R . padi as well as plasmid DNA markers of its bacterial endosymbiont, Buchnera aphidicola , were examined to determine the extent of genetic divergence between clones with these differing breeding systems. These analyses revealed that cyclically parthenogenetic lineages possessed differing mtDNA and plasmid haplotypes than most obligately asexual clones. The extent of sequence divergence between these maternally inherited molecules suggests a relatively ancient origin…

How To Find Charm in Nuclear Collisions at RHIC and LHC

1996

Measurements of dilepton production from charm decay and Drell-Yan processes respectively probe the gluon and sea quark distributions in hadronic collisions. In nucleus-nucleus collisions, these hard scattering processes constitute a `background' to thermal contributions from the hot matter produced by the collision. To determine the magnitude and behavior of this background, we calculate the hard scattering contribution to dilepton production in nuclear collisions at RHIC and LHC at next to leading order in perturbative QCD. Invariant mass, rapidity and transverse momentum distributions are presented. We compare these results to optimistic hydrodynamic estimates of the thermal dilepton pro…

Chemoselective Removal of Protecting Groups from O-Glycosyl Amino Acid and Peptide (Methoxyethoxy)ethyl Esters Using Lipases and Papain

1996

The selective C-terminal deprotection of O-glycopeptide (methoxyethoxy)ethyl esters is achieved under mild conditions (pH 6.6, 37 degrees C) by enzymatic hydrolysis using papain or lipase M from Mucor javanicus to give building blocks useful for chain-extending glycopeptide synthesis. On the other hand, the selective removal of acetyl protecting groups from the saccharide portion of glycopeptides is accomplished by alternative enzymatic hydrolysis with lipase WG from wheat germ to furnish model substrates for enzymatic glycosyl transfer reactions in order to extend the carbohydrate side chain of these conjugates.

Book Review: Classics in Total Synthesis. Targets, Strategies, Methods. By K. C. Nicolaou and E. J. Sorensen

1996

Theoretical Study of the Electronic Spectrum of Imidazole

1996

The complete active space (CAS) self-consistent field (SCF) method and multireference second-order perturbation theory (CASPT2) have been used to study the electronic spectrum of imidazole and the imidazolium ion. The calculations comprise a large number of, both singlet and triplet, valence and Rydberg excited states. A newly developed continuum model has been used to compute solvatochromic shifts. In the gas phase the first and second π → π* excited singlet valence states of imidazole are computed at 6.72 and 7.15 eV, and they shift to 6.32 and 6.53 eV upon solvation. The gas-phase values are somewhat too large (≈0.3 eV) due to an erroneous valence−Rydberg mixing in the CASSCF wave functi…

Two-loop Anomalous Dimensions of Heavy Baryon Currents in Heavy Quark Effective Theory

1996

We present results on the two-loop anomalous dimensions of the heavy baryon HQET currents $J=(q^TC\Gamma\tau q)\Gamma'Q$ with arbitrary Dirac matrices $\Gamma$ and $\Gamma'$. From our general result we obtain the two-loop anomalous dimensions for currents with quantum numbers of the ground state heavy baryons $\Lambda_Q$, $\Sigma_Q$ and $\Sigma_Q^*$. As a by-product of our calculation and as an additional check we rederive the known two-loop anomalous dimensions of mesonic scalar, pseudoscalar, vector, axial vector and tensor currents $(J=\bar q\Gamma q)$ in massless QCD as well as in HQET.

Analysis of metabolic pathways by the growth of cells in the presence of organic solvents

1996

A new approach to the analysis of metabolic pathways involving poorly water-soluble intermediates is proposed. It relies upon the ability of the hydrophobic intermediates formed by a sequence of intracellular reactions to cross the membrane(s) and partition between aqueous and organic phases, when cells are incubated in the presence of a nonpolar and nontoxic organic solvent. As a result of this thermodynamically driven efflux of the formed intermediates from the cell, they accumulate in the organic medium in sufficient quantities for GC-MS analysis and identification. This enables direct determination of the sequence of chemical reactions involved with no requirement for the isolation of e…

FINITE ELEMENT RESOLUTION OF CONVECTION-DIFFUSION EQUATIONS WITH INTERIOR AND BOUNDARY LAYERS

1996

We present a new algorithm for the resolution of both interior and boundary layers present in the convection-diffusion equation in laminar regimes, based on the formulation of a family of polynomial-exponential elements. We have carried out an adaptation of the standard variational methods (finite element method and spectral element method), obtaining an algorithm which supplies non-oscillatory and accurate solutions. The algorithm consists of generating a coupled grid of polynomial standard elements and polynomial-exponential elements. The latter are able to represent the high gradients of the solution, while the standard elements represent the solution in the areas of smooth variation.

2'-O-methyl-5-formylcytidine (f5Cm), a new modified nucleotide at the 'wobble' of two cytoplasmic tRNAs Leu (NAA) from bovine liver.

1996

The nucleotide analysis of a cytoplasmic tRNA(Leu) isolated from bovine liver revealed the presence of an unknown modified nucleotide N. The corresponding N nucleoside was isolated by different enzymatic and chromatographic protocols from a partially purified preparation of this tRNA(Leu). Its chemical characterization was determined from its chromatographic properties, UV-absorption spectroscopy and mass spectrometric measurements, as well as from those of the borohydride reduced N nucleoside and its etheno-trimethylsilyl derivative. The structure of N was established as 2'-O-methyl-5-formylcytidine (f5CM), and its reduced derivative as 2'-O-methyl-5-hydroxy-methylcytidine (om5Cm). By sequ…

Biotin-Labelled and Photoactivatable Aldosterone and Progesterone Derivatives as Ligands for Affinity Chromatography, Fluorescence Immunoassays and P…

1996

New derivatives of progesterone and aldosterone were synthesized and functionally tested with commercially available antibodies. The covalent labelling of antibodies specific for aldosterone and progesterone was detected by SDS/PAGE analysis and subsequent autoradiography after using 3-(O-carboxymethyl)-oximino-(3-[125I]iodo-4-azidosalicylamidobu tylamine) derivatives of aldosterone and progesterone, respectively, as photoactivatable radioligands. Labelling was not observed in the presence of an excess of the unlabelled steroid. Aldosterone was labelled with biotin and used as a tracer in a time-resolved fluorescence immunoassay. The nonradioactive tracer is highly selective for its antibod…

A new lattice action for studying topological charge

1996

We propose a new lattice action for non-abelian gauge theories, which will reduce short-range lattice artifacts in the computation of the topological susceptibility. The standard Wilson action is replaced by the Wilson action of a gauge covariant interpolation of the original fields to a finer lattice. If the latter is fine enough, the action of all configurations with non-zero topological charge will satisfy the continuum bound. As a simpler example we consider the $O(3)$ $\sigma$-model in two dimensions, where a numerical analysis of discretized continuum instantons indicates that a finer lattice with half the lattice spacing of the original is enough to satisfy the continuum bound.

The parkes Southern pulsar Survey -- I. Observing and data analysis systems and initial results

1996

'Australia Telescope National Facility, CSIRO, PO Box 76, Epping NSW 2121, Australia Wuffield Radio Astronomy Laboratories, University of Manchester, lodrell Bank, Macclesfield, Cheshire SKII 9DL 3Istituto di Radioastronomia del CNR, Via Gobetti 101, 40129 Bologna, Italy 4Istituto di Fisica dell'Universita, Via Archirafi 36, 90123 Palermo, Italy 'Research Centre for Theoretical Astrophysics, University of Sydney, NSW 2006, Australia 6Mount Stromlo and Siding Spring Observatories, Australian National University, Private Bag, Weston ACT 2611, Australia

Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptidesin vivo: Implications for tumor vaccines with melanoma-associated…

1996

Peptide epitopes derived from differentiation antigens of the melanocyte lineage have been identified in human melanomas and normal cultured melanocytes as targets for MHC-restricted cytotoxic T lymphocytes (CTL). Characterization of multiple CTL-defined antigenic determinants and the presence of corresponding precursor CTL open perspectives for the development of antigen-based vaccines. In the present study, we determined the CTL reactivity against melanoma-associated peptides derived from Melan A/MART-1, tyrosinase and gp100/Pmel17 in 10 HLA-A2+ melanoma patients and 10 healthy individuals. Then, we examined the immunological effects and toxicity of intradermal inoculation of synthetic me…

Automatic SCSB analysis of motor and autonomic nervous functions compared with sleep stages

1996

All-night recordings of respiration, ballistocardiogram, and body movements were obtained using the static charge-sensitive bed (SCSB) and automatically analysed data were compared with sleep stages. The mean sum of eight SCSB variability parameters was lowest in slow wave sleep (SWS), higher during stage 2 (S2), and highest in REM sleep. The sum scores of the parameters with the highest correlations with the EEG data were classified into quiet (QS), intermediate (IS) and active (AS) states. SCSB signals during wakefulness, stage 1 and REM sleep were mostly scored as AS, whereas in S2 and especially in SWS they were scored as QS or IS. The SCSB is an easy and inexpensive tool for conducting…

Systematic screening for mutations in the human serotonin 1F receptor gene in patients with bipolar affective disorder and schizophrenia

1996

Using single strand conformational analysis we screened the complete coding sequence of the serotonin 1F (5-HT{sub 1F}) receptor gene for the presence of DNA sequence variation in a sample of 137 unrelated individuals including 45 schizophrenic patients, 46 bipolar patients, as well as 46 healthy controls. We detected only three rare sequence variants which are characterized by single base pair substitutions, namely a silent T{r_arrow}A transversion in the third position of codon 261 (encoding isoleucine), a silent C{r_arrow}T transition in the third position of codon 176 (encoding histidine), and a C{r_arrow}T transition in position -78 upstream from the start codon. The lack of significan…

A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.

1996

Enhanced platelet thromboxane synthesis and reduced macrophage-dependent fibrinolytic activity related to oxidative stress in oral contraceptive-trea…

1996

Abstract In previous studies conducted in rats and in women, we have shown that oral contraceptive (OC) administration induced a platelet hyperaggregation simultaneously with an increased platelet lipid biosynthesis which might be related to lipid peroxidation. In the present study, we specifically studied the arachidonic acid and the fibrinolytic pathways in relation to the fatty acid composition in female rats treated for 6 weeks with OC (ethinyl estradiol plus lynestrenol). We found that platelets of treated animals were not only hyper-responsive to thrombin and ADP, but also to sodium arachidonate. In addition, the results of the thrombin-induced release of labeled arachidonic acid pre-…

LEP sensitivities to spontaneous R-parity violating signals

1996

We illustrate the sensitivities of LEP experiments to leptonic signals associated to models where supersymmetry (SUSY) is realized with spontaneous breaking of R-parity. We focus on missing transverse momentum plus acoplanar muon events arising from lightest neutralino single production $\chi \nu$ as well as pair production $\chi \chi$, followed by $\chi$ decays, where $\chi$ denotes the lightest neutralino. We show that the integrated luminosity achieved at LEP already starts probing the basic parameters of the theory. We discuss the significance of these constraints for the simplest spontaneous R-parity breaking models and their relevance for future searches of SUSY particles.

Classics in Total Synthesis. Targets, Strategies, Methods. VonK. C. Nicolaou und E. J. Sorensen. VCH, Weinheim, 1996. 798 S., geb./ Broschur 128.00 D…

1996

Pâté de campagne et fabrication traditionnelle: Effet de l' information sur l'attente et l'appréciation

1996

National audience

Silicon detectors for forward tracking in ATLAS

1996

Abstract A 12 cm long silicon microstrip detector module with a fan geometry has been designed and constructed. The performance of the detector has been studied in a test beam at CERN. Results are presented on the hit efficiency and the position resolution as a function of position along the strips. With a hit efficiency of 99.5% and a spatial resolution of typically 35 μm the performance of these detectors exceeds that of other candidate technologies for the precision forward tracker of the ATLAS inner detector.

Hot electron effects in metallic single electron components

1996

Thermalisation of single electron devices is of considerable current interest because of its fundamental and practical consequences. We present experimental evidence of the effect of electrode volume and its shape on thermal equilibration of small metallic islands for single electron tunnelling. Heat transport between the conduction electrons and the lattice in a metal is commonly accepted to obey the ∝Te5-T0/5 law at low electron and lattice temperatures,Te andT0, respectively. We have investigated the power law and found that it obeys the ∝T5 law only for the smallest islands, and in the majority of the cases considered, it rather follows a law ∝Tp, wherep<5. The thermal coupling can be i…

Latvia in search of a social policy model

1996

Synthesis of bis(diphenylphosphinocyclopentadienyl) yttrium chloride complexes and heterodimetallic derivatives. X-ray structure of bis[(μ-chloro)bis…

1996

Abstract Reaction of lithium diphenylphosphinocyclopentadienide with YCl 3 or YCl 3 (THF) 3 and working lead to the formation of three yttrocene phosphines: the lithium metal adduct isolated as (Ph 2 PC 5 H 4 ) 2 Y(μ-Cl) 2 Li(THF) 2 · 0.5 LiCl ( 1 ), the chloride-bridged dimeric species {(Ph 2 PC 5 H 4 ) 2 Y(μ-Cl)} 2 ( 2 ), and the coordinated monometal species [(Ph 2 PC 5 H 4 ) 2 YCl(THF)] ( 3 ). The X-ray structure of 2 is remarkable in that the crystal exhibits two independent chloride-bridged dimers that differ in the arrangement ( syn, anti ) of the diphenylphosphino groups. Chelation of phosphorus atoms to a molydenum carbonyl moiety is also reported.

13C NMR Spectral Identification of Four Cyclolithocholates (3α-Hydroxy-5β-cholan-24-oate Macrolides)

1996

Cloning and characterization of the genes encoding the malolactic enzyme and the malate permease of Leuconostoc oenos

1996

Using degenerated primers from conserved regions of the protein sequences of malic enzymes, we amplified a 324-bp DNA fragment by PCR from Leuconostoc oenos and used this fragment as a probe for screening a Leuconostoc oenos genomic bank. Of the 2,990 clones in the genomic bank examined, 7 with overlapping fragments were isolated by performing colony hybridization experiments. Sequencing 3,453 bp from overlapping fragments revealed two open reading frames that were 1,623 and 942 nucleotides long and were followed by a putative terminator structure. The first deduced protein (molecular weight, 59,118) is very similar (level of similarity, 66%) to the malolactic enzyme of Lactococcus lactis; …

Fístula traqueoesofágica congénita en un varón de 15 años

1996

Se presenta el caso de un varon de 15 anos de edad con una fistula traqueoesofagica presumiblemente congenita (tipo H) y antecedentes de bronquitis de repeticion, bronconeumonia y tos frecuente tras la ingestion de liquidos. A raiz de un episodio de esputos hemoptoicos en la fibrobroncoscopia se hallo un orificio traqueal de la pars membranacea que comunicaba con la luz esofagica. Las radiografias simples de torax y abdomen mostraban aireacion esofagica y distension abdominal, respectivamente. El esofagograma reflejaba el paso de contraste al arbol traqueobronquial sin determinar otras lesiones concurrentes. Fue la resonancia magnetica cervical y toracica la que preciso la localizacion, mor…

Breast Cancer Incidence in Palermo City (Italy)

1996

Pseudo-force method for a stochastic analysis of nonlinear systems

1996

Nonlinear systems, driven by external white noise input processes and handled by means of pseudo-force theory, are transformed through simple coordinate transformation to quasi-linear systems. By means of Itô stochastic differential calculus for parametric processes, a finite hierarchy for the moment equations of these systems can be exactly obtained. Applications of this procedure to the first-order differential equation with cubic nonlinearity and to the Duffing oscillator show the versatility of the proposed method. The accuracy of the proposed procedure improves by making use of the classical equivalent linearization technique.

Geographic variation of the Greater white-toothed shrew (Crocidura russula Hermann, 1780 Mammalia, Soricidae)

1996

A multivariate morphometric study of the Greater white-toothed shrew (C. russula) throughout its Palearctic range was carried out to search for patterns of geographic variation within the species boundary. Burnaby's and multiple group principal component analysis allowed the adjustment of raw data with respect to within-sample allometric variation. Multivariate 'size-free' results show a stepped cline with the phenotypical trait reduction and shape change from the eastern to the western Maghreb. Pleistocene fossil mandibles proved to have low phenetic distances with eastern populations (Tunisia, east Algeria) and it is argued that their character set is the primitive condition. The ancestra…

Development of a coronary aneurysm 6 months after stent implantation assessed by intracoronary ultrasound.

1996

Alterations of regional cerebral blood flow and oxygen saturation in a rat sinus-vein thrombosis model.

1996

Background and Purpose The pathophysiology of sinus-vein thrombosis (SVT) in patients and experimental animals is still poorly understood. This study was designed to examine and further elucidate the pathophysiological sequence of events, especially the relationship between local and regional blood flow and hemoglobin oxygen saturation (HbSO 2 ) detected at identical locations. The use of both parameters as outcome indicators should be compared. Methods SVT was induced by ligation of the superior sagittal sinus (SSS) and slow injection of kaolin-cephalin suspension into the SSS in rats. Regional cerebral blood flow (rCBF) was assessed by laser-Doppler flowmetry together with regional HbSO …

Photosynthesis and Transpiration in Damaged and Undamaged Spruce Trees

1996

Abstract The investigations presented here focus on the CO2/H2O gas exchange in damaged and undamaged spruce trees while using open-air measurements as well as measurements under defined conditions in the laboratory. The studies were performed at two different sites in the Hunsrück and the Westerwald mountains. In the laboratory the CO2/H2O gas exchange was measured on detached branches under controlled conditions in the course of two years. CO2 saturation curves were also generated. In addition CO2 compensation points were deter­ mined employing a closed system. In the natural habitat diurnal course measurements of photosynthesis and transpiration as well as light-saturation curves for pho…

Synthesis, Reactivity and Theoretical Study of B3H8−and Related Derivatives

1996

Abstract Octahydrotriborate salts, B3H8 −, have been prepared by the reaction of NaBH4 with Lewis acids such as BX3·BDMA (BDMA = benzyldimethylamine, × = Cl,Br) or C2H5I in diglyme. The presence of BH3·BDMA as a by-product in the former reaction provides new insight into the reaction mechanism of B11H14 − formation. In acetonitrile-water solutions of HCl or CH3CO2H, the B3H8 − anion reacted to give B3H7CH3CN or B3H7CH3CO2 − characterized by 11B NMR spectroscopy. Their kinetic hydrolysis study was consistent with NMR analysis. Reaction of Bu4NB3H8 and CuCl2 at 0°C produced pure B3H6Cl2 −. An AM1 theoretical study of the substituted derivatives B3H7L (L = Cl−, CH3CN, CH3CO2 −, OH−) and B3H6L2…

Continent diversion with the Mainz pouch.

1996

From 1983 until July 1994, 561 patients in 2 urology departments (Mainz and Wuppertal) underwent a Mainz pouch 1 procedure. The Mainz pouch 1 was used for bladder augmentation in 60 patients, for orthotopic bladder substitution in 61 patients, and for continent cutaneous urinary diversion in 440 patients. In the group of continent cutaneous urinary diversion, the continence mechanism applied was an ileal intussusception nipple in 270 patients, an appendix stoma in 146 patients, a submucosal seromuscular bowel-flap tube in 14 patients, and a submucosal full-thickness bowel-flap tube in 10 patients. Indications for urinary diversion were bladder cancer in 339 patients, anatomical or functiona…