showing 36 of ~574560 from 574555 documents
Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation
2022
Funding Information: Amande Pauls was supported by a personal grant from the University of Helsinki . Olesia Korsun was supported by the Päivikki and Sakari Sohlberg Foundation , the Orion Research Foundation , the Finnish Parkinson Foundation and the Finnish Brain Foundation . Mia Liljeström was supported by the Swedish Cultural Foundation in Finland , the Päivikki and Sakari Sohlberg Foundation , and the Finnish Cultural Foundation . Eero Pekkonen was supported by Finnish Government research funding ( TYH- fund ). Hanna Renvall was supported by the Academy of Finland (grant number 321460 ) and Paulo Foundation. Publisher Copyright: © 2022 Exaggerated subthalamic beta oscillatory activity …
Study of Intumescent Coatings Growth for Fire Retardant Systems in Naval Applications: Experimental Test and Mathematical Model
2022
Onboard ships, fire is one of the most dangerous events that can occur. For both military and commercial ships, fire risks are the most worrying; for this reason they have an important impact on the design of the vessel. The intumescent coatings react when heated or in contact with a living flame, and a multi-layered insulating structure grows up, protecting the underlying structure. In this concern, the aim of the paper is to evaluate the intumescent capacity of different composite coatings coupling synergistically modeling and experimental tests. In particular, the experiments have been carried out on a new paint formulation, developed by Colorificio Atria S.r.l., in which the active comp…
Fouling characterisation in PVDF membrane contactors for dissolved methane recovery from anaerobic effluents: effect of surface organofluorosilanisat…
2022
Abstract Characterisation of the fouling attached to PVDF membranes treating an anaerobic effluent for dissolved CH4 recovery was carried out. A commercial flat-sheet PVDF membrane and a PVDF functionalised by grafting of organofluorosilanes (mPVDF) that increased its hydrophobicity were subjected to a continuous flux of an anaerobic reactor effluent in long-term operation tests (> 800 h). The fouling cakes were studied by the membrane autopsy after these tests, combining a staining technique, FTIR, and FESEM-EDX, and the fouling extraction with water and NaOH solutions. Both organic and inorganic fouling were observed, and the main foulants were proteins, polysaccharides, and different …
The association of cooking fuels with depression and anxiety symptoms among adults aged ≥65 years from low- and middle-income countries
2022
Background: We aimed to investigate associations of unclean cooking fuels with depression and anxiety symptoms in a large sample of adults aged ≥65 years from six low- and middle-income countries (LMICs). Methods: Cross-sectional, community-based, nationally representative data from the WHO Study on global AGEing and adult health (SAGE) were analyzed. Unclean cooking fuel referred to kerosene/paraffin, coal/charcoal, wood, agriculture/crop, animal dung, and shrubs/grass. Depression referred to DSM-IV depression based on past 12-month symptoms or receiving depression treatment in the last 12 months. Anxiety symptoms referred to severe/extreme problems with worry or anxiety in the past 30 day…
Determinants, even instantons and Bridgeland stability
2022
We provide a systematic way of calculating a quiver region associated to a given exceptional collection, which as an application is used to prove that $\mu$-stable sheaves represented by two-step complexes are Bridgeland stable. In the later sections, we focus on the case of even rank $2$ instantons over $\mathbb{P}^3$ and $Q_3$ to prove that the instanton sheaves, instanton bundles and perverse instantons are Bridgeland stable and provide a description of the moduli space near their only actual wall.
NewSQL Database Management System Compiler Errors : Effectiveness and Usefulness
2022
Modern database management is often faced with a high number of concurrent end-users, and the need for database distribution to ensure fault tolerance and high throughput. To flexibly address these challenges, many modern database management systems (DBMS) provide highly automated and effortless, i.e., highly usable database distribution, deployment, and maintenance. However, the usability considerations are yet to extend from the aforementioned DBMS features to query language compilers. In this study, based on participant answers (N = 157), we compare the error message qualities of four modern DBMSs (CockroachDB, SingleStore, NuoDB, and VoltDB) using one objective and three subjective metr…
Association between orthodontic treatment and the occurrence of temporomandibular disorders: A systematic review and meta-analysis
2022
Temporomandibular disorders (TMD) are related to a series of clinical manifestations that appear in the form of pain. Currently, there is controversy about the appearance of TMDs after orthodontic treatment. Therefore, the objective of the present study was to determine the association between orthodontic treatment and the occurrence of Temporomandibular Disorders (TMD).A bibliographic search was carried out until April 2022, in the following electronic databases: Pubmed/Medline, Scopus, Scielo, Google Scholar and Web of Science. We included studies that were case-control and cohort studies, dealing with the association between orthodontic treatment and TMD, in English and Spanish, and with…
Partnership of schools and civil society organisations to support education of students of varied linguistic backgrounds—The situation in the Czech R…
2022
This article reports on research examining the intensity and forms of partnership between civil society organisations (particularly non-profit non-governmental organisations with a focus on students with a different mother tongue) and schools in three European geographical areas, answering three research questions: (1) What services do non-profits offer for teachers? (2) How do non-profits see the current cooperation? (3) Do teachers know about the existence of non-profits in this area and are they interested in such cooperation? A mixed methods research approach was used. A questionnaire was used for eliciting responses from 34 non-profit organisations (nine in Czech Republic, nineteen in …
Microvascular density and tumor budding in oral squamous cell carcinoma
2022
Oral squamous cell carcinoma (OSCC) is the most prevalent malignant head and neck tumor, excluding the nonmelanoma skin cancer. Despite recent advances in the diagnosis and treatment, the disease's mortality rate is nonetheless high. The presence of isolated neoplastic cells or small clusters of up to four cells at the tumor?s invasive front, named tumor budding, is associated with a worse prognosis in OSCC. Angiogenesis has also been recognized as a determining factor in the progression of malignancies and in the development of metastases. Several studies have investigated the assessment of microvascular density (MVD) as a potential prognostic factor in OSCC. This study aimed to evaluate, …
Temari Balls, Spheres, SphereHarmonic: From Japanese Folkcraft to Music
2022
Temari balls are traditional Japanese toys and artworks. The variety of their geometries and tessellations can be investigated formally and computationally with the means of combinatorics. As a further step, we also propose a musical application of the core idea of Temari balls. In fact, inspired by the classical idea of music of spheres and by the CubeHarmonic, a musical application of the Rubik’s cube, we present the concept of a new musical instrument, the SphereHarmonic. The mathematical (and musical) description of Temari balls lies in the wide background of interactions between art and combinatorics. Concerning the methods, we present the tools of permutations and tessellations we ado…
Third Case of Visceral Leishmaniasis in COVID-19: Mini Review Article.
2022
Background: In the currently ongoing coronavirus pandemic, coinfections with unrelated life-threatening febrile conditions may pose a particular challenge to clinicians. Leishmaniasis is a zoonosis that may present general symptoms, including fever, malaise, and arthralgia, rendering it indistinguishable from COVID-19. Methods: In this paper, we aim to draw attention to this issue and analyze the clinical characteristics of the coinfection SARS-CoV-2/Leishmania through a systematic review of the literature. We were motivated by the observation of the first case of visceral leishmaniasis and COVID-19 in a paediatric patient. Conclusion: Our case is a reminder for healthcare providers to cons…
Novel mutations of the ABCA12, KRT1 and ST14 genes in three unrelated newborns showing congenital ichthyosis.
2022
Abstract Background Congenital ichthyosis (CI) is a heterogeneous group of genetic disorders characterized by generalized dry skin, scaling and hyperkeratosis, often associated to erythroderma. They are rare diseases, with overall incidence of 6.7 in 100,000. Clinical manifestations are due to mutations in genes mostly involved in skin barrier formation. Based on clinical presentation, CI is distinguished in non-syndromic and syndromic forms. To date, mutations of more than 50 genes have been associated to different types of CI. Cases presentation We report on three Italian unrelated newborns showing clinical signs compatible with different forms of CI of variable severity, namely Harlequin…
Interleukin-6 Is a Promising Marker of COVID-19 in Children: A Case Series of 2 Brothers with Severe COVID-19 Pneumonia.
2022
BACKGROUND To date, Coronavirus disease 2019 (COVID-19) remains a global health concern, with fatalities mostly in older age groups with underlying medical conditions, while children are less likely to manifest severe symptoms. CASE REPORT We describe the clinical cases of 2 brothers admitted to our Children's Hospital for persistent fever and cough during the COVID-19 pandemic. Case 1. A 1.5-year-old boy had fever, expiratory dyspnea, desaturation, oxygen saturation 94-96% with O2, and bilateral hissing and crackling rales. His interleukin-6 level in the acute phase of the disease was 100.41 and at the resolution it was 46.2 pg/ml. Treatment with amoxicillin plus clavulanic acid, methylpre…
A Review on Multi-GNSS for Earth Observation and Emerging Applications
2022
Global Navigation Satellite System (GNSS) has drawn the attention of scientists and users all over the world for its wide-ranging Earth observations and applications. Since the end of May 2022, more than 130 satellites are available for fully global operational satellite navigation systems, such as BeiDou Navigation Satellite System (BDS), Galileo, GLONASS and GPS, which have been widely used in positioning, navigation, and timing (PNT), e.g., precise orbit determination and location-based services. Recently, the refracted, reflected, and scattered signals from GNSS can remotely sense the Earth’s surface and atmosphere with potential applications in environmental remote sensing. In this pap…
Single-Center-Single-Blinded Clinical Trial to Evaluate the Efficacy of a Nutraceutical Containing Boswellia Serrata, Bromelain, Zinc, Magnesium, Hon…
2022
Some nutraceuticals have been studied as supportive treatment for fighting upper respiratory tract infection and middle ear disease. Our study aims at evaluating the effect of a specific oral supplementation in the treatment of pediatric otits media. The subjects were randomly assigned by the physician (single-blinded study) to one of three groups: Control Group (CG), Treatment Group 1 (TG1), or Treatment Group 2 (TG2). Both TG were treated with Flogostop Duo (for 20 days—TG1 or 30 days—TG2) in combination with the standard treatment, while CG underwent standard treatment only. The standard treatment was nasal aerosol with Fluticasone and Mucolytic, and nasal washing with hypertonic solutio…
Towards explainable interactive multiobjective optimization : R-XIMO
2022
AbstractIn interactive multiobjective optimization methods, the preferences of a decision maker are incorporated in a solution process to find solutions of interest for problems with multiple conflicting objectives. Since multiple solutions exist for these problems with various trade-offs, preferences are crucial to identify the best solution(s). However, it is not necessarily clear to the decision maker how the preferences lead to particular solutions and, by introducing explanations to interactive multiobjective optimization methods, we promote a novel paradigm of explainable interactive multiobjective optimization. As a proof of concept, we introduce a new method, R-XIMO, which provides …
Association between use of novel glucose-lowering drugs and COVID-19 hospitalization and death in patients with type 2 diabetes: a nationwide registr…
2022
Abstract Aims Type 2 diabetes (T2DM) in patients with coronavirus disease-19 (COVID-19) is associated with a worse prognosis. We separately investigated the associations between the use of sodium-glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and dipeptidyl peptidase-4 inhibitors (DPP-4i), and the risk of COVID-19 hospitalization and death. Methods and results Patients with T2DM registered in the Swedish National Patient Registry and alive on 1 February 2020 were included. ‘Incident severe COVID-19’ was defined as the first hospitalization and/or death from COVID-19. A modified Poisson regression approach was applied to a 1:1 propensity sc…
The Cuneiform Brick
2022
The study presents some results of an experimental research on brick wall cladding, proposing methodological approaches for the creation of new geometric-compositional configurations. Citing innovative case studies of historical and contemporary architecture, the research has allowed to determine a different geometric shape of the brick, which takes its cue from the traditional wedge-shaped brick in majolica brick, widespread in Sicily since the sixteenth century for the realization of cusps and domes. Through the definition of procedural parametric algorithms for the analysis and geometric-spatial control, it is described the path that led to the digital prototype of a modular component of…
The Stigmatization of Drug Addiction in South-East Turkey the Case of Drug Abuse Prevention Programme for Youth Project in Turkey
2022
Cannabis use undergoes a dynamic redefinition under selected legal frameworks globally. Many prevention programs face a dilemma between delivering abstinence objectives and pursuing more nuanced, harm reductionist aims. However, drug use in South-East Turkey is strongly stigmatized and is absent from the official life of the community, so neither of these discussions takes place. The authors participated in the development of a Drug Abuse Prevention programme for Youth and this article is grounded in qualitative data from Turkey. A follow-up study was conducted among the youth participants of a pilot phase of the program (n = 20), developed by an international group of professionals in the …
Massive quarks in NLO dipole factorization for DIS : Transverse photon
2022
We calculate the light cone wave functions for the QCD Fock components in a transverse virtual photon necessary for applications at next-to-leading order in the QCD coupling, including quark masses. We present a detailed calculation of both the one loop wave function for the quark-antiquark Fock component and the tree level wave function for the quark-antiquark-gluon Fock component. The quark masses are renormalized in the pole mass scheme, satisfying constraints from the requirement of Lorentz invariance. In particular the quark Pauli form factor at NLO is recovered from the on-shell limit of the quark-antiquark Fock component. We use our result to calculate the next-to-leading order corre…
A Path Model for Subjective Well-Being during the Second Wave of the COVID-19 Pandemic: A Comparative Study among Polish and Ukrainian University Stu…
2022
Background: Previous studies showed several associations between physical and mental health dimensions and well-being. This study aims to examine a complex path model explaining the life satisfaction of university students from Poland and Ukraine during the second wave of the COVID-19 pandemic. Methods: The cross-sectional web-based study was performed in November 2020 using Google Forms. The conventional sample of 3230 university students from Poland (n = 1581) and Ukraine (n = 1649), aged 18–59 (M = 21.40, SD = 3.46), with 59% women, participated in the study. We used standardized questionnaires to measure life satisfaction (SWLS), self-reported physical health (GSRH), perceived stress (P…
European Cross-Border Insolvency Law
2022
The first edition of this textbook was published in 2016, but since then the legal and factual scenario of European cross-border insolvency law has changed dramatically. In particular, three main events have occurred. First, the prescriptions of Regulation (EU) 2015/848 (Recast) have become applicable; second, the UK has left the European Union, without this completely reducing the meaning of the regulation for the UK though; and third, the European Union has enacted Directive (EU) 2019/1023 on preventive restructuring and insolvency. Moreover, since 2016, the Court of Justice of the European Union (CJEU) has delivered significant new judgments, albeit regarding the Regulation (EU) 1346/200…
The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the…
2022
The purpose of this study was to quantify the effect of moderate and severe orthodontic forces on Calcitonin gene-related peptide (CGRP) expression in the healthy human periodontal ligament (PDL) and its possible relationship with the human dental pulp.Ninety human periodontal ligament samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons. Prior to extraction, teeth were divided in 3 groups of 30 samples each: I) Untreated teeth control group; II) Moderate force group: A 56 g force was applied to the premolars for 24 hours; and III) Severe force group: A 224 g force was applied to the premolars for 7 days. All periodontal ligament samples were p…
The Use of Social Media in Children and Adolescents: Scoping Review on the Potential Risks.
2022
In recent years, social media has become part of our lives, even among children. From the beginning of COVID-19 pandemic period, media device and Internet access rapidly increased. Adolescents connected Internet alone, consulting social media, mostly Instagram, TikTok, and YouTube. During “lockdown”, the Internet usage allowed communication with peers and the continuity activities such as school teaching. However, we have to keep in mind that media usage may be related to some adverse consequences especially in the most vulnerable people, such as the young. Aim of the review is to focus on risks correlated to social media use by children and adolescents, identifying spies of ris…
1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary…
2022
In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). …
Massive Quarks at One Loop in the Dipole Picture of Deep Inelastic Scattering
2022
We calculate the light cone wave functions for a virtual photon to split into quark-antiquark states, including for the first time quark masses at one loop accuracy. These wave functions can be used to calculate cross sections for several precision probes of perturbative gluon saturation at the Electron-Ion Collider. Using these wave functions we derive, for the first time, the dipole picture DIS cross sections at one loop for longitudinal and transverse virtual photons including quark masses. The quark masses are renormalized in the pole mass scheme, satisfying constraints from the requirement of Lorentz invariance of the quark Dirac and Pauli form factors.
Appropriate management of growth hormone deficiency during the age of transition: an Italian Delphi consensus statement
2022
Growth hormone deficiency (GHD) describes the impairment of growth hormone (GH) secretion by the pituitary somatotroph cells. GHD may be congenital, with causes, including genetic alterations and structural brain malformations, or acquired, including midline tumours, cranial irradiation, traumatic brain injury, central nervous system infections and inflammatory conditions. GHD in children is characterised by short stature, delayed bone maturation and abnormalities in substrate metabolism, body composition, physical and psychosocial functioning, all of which improve with recombinant human GH (rhGH) therapy. The diagnosis of GHD is based on clinical signs and symptoms, biochemistry and imagin…
Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias
2022
In order to determine the site of origin (SOO) in outflow tract ventricular arrhythmias (OTVAs) before an ablation procedure, several algorithms based on manual identification of electrocardiogram (ECG) features, have been developed. However, the reported accuracy decreases when tested with different datasets. Machine learning algorithms can automatize the process and improve generalization, but their performance is hampered by the lack of large enough OTVA databases. We propose the use of detailed electrophysiological simulations of OTVAs to train a machine learning classification model to predict the ventricular origin of the SOO of ectopic beats. We generated a synthetic database of 12-l…
Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources
2022
In regenerative medicine and tissue engineering, the possibility to: (I) customize the shape and size of scaffolds, (II) develop highly mimicked tissues with a precise digital control, (III) manufacture complex structures and (IV) reduce the wastes related to the production process, are the main advantages of additive manufacturing technologies such as three-dimensional (3D) bioprinting. Specifically, this technique, which uses suitable hydrogel-based bioinks, enriched with cells and/or growth factors, has received significant consideration, especially in cartilage tissue engineering (CTE). In this field of interest, it may allow mimicking the complex native zonal hyaline cartilage organiza…
Application of the London Atlas Software App 2nd edition for the radiographic assessment of dental development
2022
Assessing the dental development of children and adolescents is an important part of treatment planning. The radiographic visualization of dental developmental stages prior to age estimation is currently feasible by means of digital software apps. Testing the existing software tools is necessary to safeguard application in practice. This study applied the London Atlas Software App 2nd edition™ for dental age estimation in Brazilian children.The software was applied to 1.104 digital panoramic radiographs of females (n = 509) and males (n = 595) with ages between 6 and 15.99 years (mean = 10.88 ± 2.84 years). The sample included at least 100 individuals similarly distributed based on sex with…
Multiscale partial information decomposition of dynamic processes with short and long-range correlations: theory and application to cardiovascular co…
2022
Abstract Objective. In this work, an analytical framework for the multiscale analysis of multivariate Gaussian processes is presented, whereby the computation of Partial Information Decomposition measures is achieved accounting for the simultaneous presence of short-term dynamics and long-range correlations. Approach. We consider physiological time series mapping the activity of the cardiac, vascular and respiratory systems in the field of Network Physiology. In this context, the multiscale representation of transfer entropy within the network of interactions among Systolic arterial pressure (S), respiration (R) and heart period (H), as well as the decomposition into unique, redundant and s…
Prosocial priming and bystander effect in an online context.
2022
The present study tested the effect of priming the concept of prosociality on the bystander effect in an online environment. Participants were sent an e-mail requesting a plea for help and randomly assigned to one of four conditions in a 2 (Bystander: 0 vs. 14) × 2 (Priming: present vs. absent) design. The results demonstrated support for the study hypothesis. As expected, the virtual presence of many others significantly reduced e-mail responsiveness except when the request for help is preceded by prosocial priming. Implications of these findings for the literature on the bystander effect and priming are discussed.
Körperkoordinations test für Kinder: A short form is not fully satisfactory
2022
Assessment of motor competence (MC) is crucial to finding deficiencies in children's motor development. Because of the need to ensure validity, reliability, and feasibility, the selection of contemporary testing batteries is a difficult task. Many papers report the validity of the KTK test in describing MC in school aged children. KTK consists of 4 four separate items: walking back, jumping sideways, moving sideways, and hopping for height. Some authors suggested the use of a short version of KTK that includes 3 items excluding one subtest: hopping for height. This study aimed to evaluate the effectiveness of short versions of Körperkoordinationstest für Kinder (KTK). A sample of 2,231 part…
Human Monkeypox: A Comprehensive Narrative Review and Analysis of the Public Health Implications.
2022
Recently, numerous cases of monkeypox were reported from several non-endemic countries in Europe, North America, and Oceania, suggesting an unusual and alarming public health issue, particularly considering that the disease is not directly related to human or animal travels. Attention is currently being drawn to this phenomenon since more than 70% of the global population is no longer vaccinated against smallpox. Indeed, the smallpox vaccination also confers some indirect degree of protection against other poxviruses, including monkeypox. We performed a narrative review to describe the existing literature with regard to monkeypox using the MEDLINE, EMBASE, and Scopus databases. This review …
Big data analytics and internationalisation in Italian firms
2022
The chapter focuses on the role of big data in developing firms’ international e-commerce. We explore the effect of three different types of big data approaches on the probability of firms entering international markets via web sales. Specifically, we consider the following approaches: (a) use of big data managed by internal firm staff; (b) use of big data managed by specialised consulting firms; and (c) use of big data jointly managed by internal firm staff and specialised consultant firms. Applying qualitative data models on a large sample of Italian firms (about 18,900 firms), we find that the use of big data managed by internal staff or by specialised consulting firms is positively asso…
The Utility of Ground Bryophytes in the Assessment of Soil Condition in Heavy Metal-Polluted Grasslands
2022
Bryophytes are commonly used in biomonitoring heavy metal pollution, whereas the bioindicative value of bryophyte communities is a less known issue. The aim of the present study is to recognize the utility of the bryophyte community’s structure in the assessment of soil condition in heavy metal-polluted, dry grasslands. The study plots are examined with respect to bryophytes; vascular plants; concentrations of Zn, Pb, Cd, and As in the soil; total nitrogen and organic carbon content in the soil; and soil pH. The results show that both bryophyte species richness and composition greatly depend on soil chemical characteristics, including heavy-metal pollution levels and soil pH. Three groups o…