The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors

2022

Salivary gland tumors represent a serious medical problem and new tools for differential diagnosis and patient monitoring are needed. Here, we present data and discuss the potential of molecular chaperones as biomarkers and therapeutic targets, focusing on Hsp10 and Hsp90. The salivary glands are key physiological elements but, unfortunately, the information and the means available for the management of their pathologies, including cancer, are scarce. Progress in the study of carcinogenesis has occurred on various fronts lately, one of which has been the identification of the chaperone system (CS) as a physiological system with presence in all cells and tissues (including the salivary gland…

The barriers dentists face to communicate cancer diagnosis:self-assessment based on SPIKES protocol

2022

This study aimed to characterize the barriers faced by Brazilian dentists to deliver bad news (DBN) about oral and oropharyngeal cancer diagnoses to patients by using a questionnaire based on the guidelines of the SPIKES protocol. This was an observational cross-sectional study. The questionnaire contained 27 questions based on the SPIKES protocol, which were answered in the SurveyMonkey platform. A total of 186/249 dentists answered the questionnaire. The main specialties reported were 36.02% oral medicine, 21.5% oral pathology, and 9.13% oral and maxillofacial surgery. A total of 44.6% expressed concern about the patient?s emotional reactions, and 46.24% of respondents had never participa…

The SARS-CoV-2 Antibodies, Their Diagnostic Utility, and Their Potential for Vaccine Development.

2022

Antibodies (Abs) are important immune mediators and powerful diagnostic markers in a wide range of infectious diseases. Understanding the humoral immunity or the development of effective antibodies against SARS-CoV-2 is a prerequisite for limiting disease burden in the community and aids in the development of new diagnostic, therapeutic, and vaccination options. Accordingly, the role of antiviral antibodies in the resistance to and diagnosis of SARS-CoV-2 infection was explored. Antibody testing showed the potential in adding important diagnostic value to the routine diagnosis and clinical management of COVID-19. They could also play a critical role in COVID-19 surveillance, allowing for a …

Reassigning the shapes of the 0+ states in the 186Pb nucleus

2022

Across the physics disciplines, the 186Pb nucleus is the only known system, where the two first excited states, together with the ground state, form a triplet of zero-spin states assigned with prolate, oblate and spherical shapes. Here we report on a precision measurement where the properties of collective transitions in 186Pb were determined in a simultaneous in-beam γ-ray and electron spectroscopy experiment employing the recoil-decay tagging technique. The feeding of the 0+2 state and the interband 2+2→2+1 transition have been observed. We also present direct measurement of the energies of the electric monopole transitions from the excited 0+ states to the 0+ ground state. In contrast to…

Ten simple rules for a successful EU Marie Skłodowska-Curie Actions Postdoctoral (MSCA) fellowship application.

2022

Stress Levels in Handball Coaching-Case Study: Preliminary Analysis of the Differences between Training and Match.

2022

Stress plays a significant role in competitions and in the training of sports participants, and coaches are no exception. To better cope with stressful situations, close monitoring of coaches’ stress levels before, during, and after training and competitions is recommended. According to studies, the use of cortisol (C) and alpha-amylase (AA) as biomarkers for monitoring acute stress is recommended. Therefore, the aim of our study was to compare HR, salivary C and AA, and STAI scores before, during, and after handball matches and training sessions. The study examined one professional handball coach, aged 37, in stress markers (salivary cortisol (C) and alpha-amylase (AA) concentrations…

Fully nonperturbative charm-quark tuning using machine learning

2022

We present a relativistic heavy-quark action tuning for the charm sector on ensembles generated by the CLS consortium. We tune a particular 5-parameter action in an entirely non-perturbative and -- up to the chosen experimental input -- model-independent way using machine learning and the continuum experimental charmonium ground-state masses with various quantum numbers. In the end we are reasonably successful; obtaining a set of simulation parameters that we then verify produces the expected spectrum. In the future, we will use this action for finite-volume calculations of hadron-hadron scattering.

Changes in health-related quality of life in adolescents and the impact of gender and selected variables: a two-year longitudinal study

2022

Abstract Background Increased knowledge about factors that can impact changes in adolescents’ health-related quality of life (HRQOL) is needed. The present study aimed to investigate possible HRQOL changes in adolescents at 14 and 16 years, and assess the impact of sociodemographic factors, gender, pain, self-esteem, self-efficacy, loneliness, and stress on HRQOL changes over time. Further, to assess HRQOL stratified by gender. Methods A longitudinal study involving 211 adolescents was conducted. Sociodemographic variables, pain, self-esteem, self-efficacy, loneliness, and stress were all assessed with well-validated instruments. KIDSCREEN-27 was used to measure HRQOL. Data were analyzed us…

Exploring the effectiveness of the Digital Green Certificate Law as Public Health instrument to increase anti-COVID-19 vaccination in a sample of wor…

2022

Counteracting vaccine hesitancy should be considered an absolute priority for Public Health Authorities. A correct health communication represents one of the best ways to increase adhesion to vaccination among hesitant population. In order to increase vaccination coverage rates against COVID-19, the Italian government has issued a legislative decree with a mandatory “Digital Green Certificate” (DGC) to access workplaces for some categories considered at risk. Methods. We conducted a cross-sectional study with the aim to highlight the factors associated with the anti-COVID-19 vaccine acceptance and to estimate the influence of the introduction by law of the Digital Green Certificate (DGC) on…

Is a Catalyst Always Needed? The Case of the Knoevenagel Reaction with Malononitrile

2022

The aim of this Perspective is to start a discussion about the real usefulness of more or less sophisticated catalytic systems for the Knoevenagel reaction with malononitrile, a reaction that can take place under mild conditions without the need of a catalyst. From a sustainable viewpoint the questions are: Is it useful to increase the rate of a reaction that already occurs under mild conditions? Is it useful to spend resources and time in designing, characterizing and realizing complex catalytic systems for such reaction? Does it make sense to carry out the reaction under conditions such as to have a slower reaction rate and therefore to find a catalyst that is able to increase it?

Godhetsdiskursen om sang i barnehage og skole

2022

A Mathematical Model for Equitable In-country COVID-19 Vaccine Allocation

2022

Given the scarcity of COVID-19 vaccines, equitable (fair) allocation of limited vaccines across the main administrative units of a country (e.g. municipalities) has been an important concern for public health authorities worldwide. In this study, we address the equitable allocation of the COVID-19 vaccines inside countries by developing a novel, evidence-based mathematical model that accounts for multiple priority groups (e.g. elderly, healthcare workers), multiple vaccine types, and regional characteristics (e.g. storage capacities, infection risk levels). Our research contributes to the literature by developing and validating a model that proposes equitable vaccine allocation alternatives…

The Histone Deacetylase Inhibitor ITF2357 (Givinostat) Targets Oncogenic BRAF in Melanoma Cells and Promotes a Switch from Pro-Survival Autophagy to …

2022

Histone deacetylase inhibitors (HDACI) are epigenetic compounds that have been widely considered very promising antitumor agents. Here, we focus on the effects of the pan-HDAC inhibitor ITF2357 (Givinostat) in comparison with SAHA (Vorinostat) in melanoma cells bearing BRAF V600E oncogenic mutation. Our results indicate both ITF2357 and SAHA dose-dependently reduce the viability of BRAF-mutated SK-MEL-28 and A375 melanoma cells. The comparison of IC50 values revealed that ITF2357 was much more effective than SAHA. Interestingly, both inhibitors markedly decreased oncogenic BRAF protein expression levels, ITF2357 being the most effective compound. Moreover, the BRAF decrease induced by ITF23…

The Spanish Version of the State Self-Compassion Scale–Long Form (SSCS–L): A Study of Its Validity and Reliability in a Sample of Nursing Students

2022

Background: In nurses, self-compassion mitigates the effects of stress, burnout and compassion fatigue, and enhances empathy, compassion and well-being and quality of life. The Self-Compassion Scale is the most-used instrument. The aim of this study is to validate the Spanish version of the new developed State Self-Compassion Scale–Long (SSCS–L). Methods: Students of the first year of the Nursing Degree were surveyed online. Together with the SSCS–L, their levels of positive and negative affect was reported. Analyses included descriptive statistics, competitive confirmatory factor analysis, evidence on criterion-related validity and estimates of reliability. Results: The b…

6ZHW

2022

Towards a validated definition of the clinical transition to secondary progressive multiple sclerosis: A study from the Italian MS Register.

2022

Background: Definitions for reliable identification of transition from relapsing-remitting multiple sclerosis (MS) to secondary progressive (SP)MS in clinical cohorts are not available. Objectives: To compare diagnostic performances of two different data-driven SPMS definitions. Methods: Data-driven SPMS definitions based on a version of Lorscheider’s algorithm (DDA) and on the EXPAND trial inclusion criteria were compared, using the neurologist’s definition (ND) as gold standard, in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Akaike information criterion (AIC) and area under the curve (AUC). Results: A cohort of 10,240 MS patients wi…

The ethnobotany, phytochemistry, and biological properties of genus Phagnalon (Asteraceae): a review

2022

The genus Phagnalon Cass., included within the Asteraceae family, has a wide distribution, expanding from Macaronesia in the West to the Himalayas in the East, from S. France and N. Italy to Ethiopia and Arabian Peninsula. Various species of Phagnalon have been used in the popular medicine of several countries as medicinal herbs and food. This literature review, the first one of the Phagnalon genus, includes publications with the word ‘Phagnalon’, and considers the extracts and the single metabolites identified, characterized, and tested to evaluate their biological potential. The extracts and the secondary metabolites, have a varied application spectrum at a biological level, with antimicr…

Grade 8 students appropriating Sankey diagrams: The first cycle in an educational design research

2022

Many students do not experience usefulness in mathematics. To address this problem, we offered them a mathematical tool, Sankey diagrams, which is a flow chart appearing in news media to visualize social, industrial or environmental processes. We carried out an Educational Design Research (EDR) to develop and evaluate lesson materials about contextualized Sankey diagrams. We tested these materials with a class of grade 8 students and evaluated these on the feasibility of students’ appropriation of the diagrams. In the lesson, we observed how students were able to read the Sankey diagrams, liked the societal processes visualized, yet did not fully grasp their mathematical properties. However…

Maritime Crossroads : The Knowledge Pursuits of María de Betancourt (Tenerife, 1758-1824) and Joana de Vigo (Menorca, 1779-1855)

2022

This article explores the biographies of two gentlewomen, María de Betancourt (1758–1824) and Joana de Vigo (1779–1855), who lived respectively in Tenerife and Menorca, two crucial nodes in the scientific, commercial and military global networks of the late eighteenth century. Some of their scientific and literary contributions are mapped, paying particular attention to how they became active in contemporaneous learned networks. It is argued that the peculiar, intellectually rich microcosms of the islands shaped these women's lives in ways that enabled them to enter learned circles, either real or imaginary, and from a very modest site to contribute to the global circulation of ideas, goods…

Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects:a systematic review

2022

Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage. We performed a syst…

Role of Natural Cross Linkers in Resin–Dentin Bond Durability: A Systematic Review and Meta-Analysis

2022

Background: The role of endogenous Matrix Metallo Proteinases in resin dentin bond deterioration over time has been well documented. The present study aimed to systematically review the literature; in vitro and ex vivo studies that assessed the outcomes of natural cross-linkers for immediate and long-term tensile bond strength were included. Methods: The manuscript search was carried out in six electronic databases—PubMed/MEDLINE, LILACS, SciELO, Cochrane, Web of Science and DOAJ, without publication year limits. Only manuscripts in English (including the translated articles) were selected, and the last search was performed in December 2020. The Preferred Reporting Items for Systematic Revi…

How to assist the students while learning from text? Effects of inserting adjunct questions on text processing

2022

AbstractThis study analyzes the effect of text-inserted questions and post-text-reading questions, i.e., questions timing, on students’ processing and learning when studying challenging texts. Seventy-six freshmen read two science texts and answered ten adjunct questions with the text available, being tested on learning 5 days afterwards. Questions were presented either after reading the whole text or inserted in the text after reading the relevant information. Online processing data were recorded while reading and searching the texts, and measures of processing strategies (i.e., paraphrases, elaborations) while answering the questions were collected. Compared to students in the post-readin…

Assessment of the Mass and Surface Area of the Scots Pine (Pinus sylvestris L.) Needles

2022

The assessment of the surface area of all leaves from a tree crown is regarded as one of the key parameters in scaling ecophysiological processes, such as growth, carbon budget, and water management. The purpose of this study was to investigate the variation of the mass and surface area of Scots pine needles, obtained from trees growing in the same habitat conditions but at different stock densities, therefore occupying different biosocial positions. The mass of needles and the leaf area index (LAI) were determined for an even-aged 33-year-old Scots pine stand located at a fresh mixed coniferous forest site in southwest Poland (50°32′ N; 17°42′ E). The needles, collected…

Immunohistochemical Expression of Vitamin D Receptor in Uterine Fibroids

2022

One of the many factors involved in the development of uterine fibroids is vitamin D deficiency. One aspect of this deficiency is decreased serum concentration of calcidiol-25(OH)D, a metabolite of D3 vitamin. The active form of vitamin D3, which arises after numerous enzymatic reactions, is calcitriol-1,25(OH)2D3; this compound is transported to various body tissues. Vitamin D possesses extra-genomic effects due to its influence on various signaling pathways, i.e., through activating tyrosine kinases and by genomic effects via binding to a specific nuclear receptor, vitamin D receptor (VDR). The vitamin D/VDR complex regulates the expression of genes and is involved in the pathogenesis of …

À propos de Damon Galgut

2022

Ce court article s'inscrit dans un dossier consacré aux prix littéraires attribués en 2021 à des auteurs africains (Gurnah, Galgut, Diop, Sarr).

Eckhaus instability of stationary patterns in hyperbolic reaction–diffusion models on large finite domains

2022

AbstractWe have theoretically investigated the phenomenon of Eckhaus instability of stationary patterns arising in hyperbolic reaction–diffusion models on large finite domains, in both supercritical and subcritical regime. Adopting multiple-scale weakly-nonlinear analysis, we have deduced the cubic and cubic–quintic real Ginzburg–Landau equations ruling the evolution of pattern amplitude close to criticality. Starting from these envelope equations, we have provided the explicit expressions of the most relevant dynamical features characterizing primary and secondary quantized branches of any order: stationary amplitude, existence and stability thresholds and linear growth rate. Particular em…

The Effect of Bariatric Surgery on Circulating Levels of Lipoprotein (a): A Meta-analysis.

2022

Background. Obesity, especially severe obesity, is associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) morbidity and mortality. Bariatric surgery is a durable and effective weight loss therapy for patients with severe obesity and weight-related comorbidities. Elevated plasma levels of lipoprotein (a) (Lp(a)) are causally associated with ASCVD. The aim of this meta-analysis was to analyze whether bariatric surgery is associated with Lp(a) concentrations. Methods. A literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to May 1st, 2021. A random-effects model and the generic inverse variance weighting method were used to compe…

Network Analysis of Well-Being Dimensions in Vaccinated and Unvaccinated Samples of University Students from Poland during the Fourth Wave of the COV…

2022

Although numerous studies investigated the predictors of vaccination intention and decision, little is known about the relationship between vaccination and well-being. This study compares the physical and mental health dimensions among vaccinated and unvaccinated people. In a cross-sectional online survey, 706 university students from Poland (mean age of 23 years, 76% of women) participated in this study during the fourth pandemic wave (November–December 2021). Standardized questionnaires with a Likert response scale were included in the survey to measure spirituality, exposure to the COVID-19 pandemic, perceived physical health, stress, coronavirus-related PTSD, fear of COVID-19, anxiety, …

Kielitietoinen kielikasvatus

2022

Supporting data of: Hydrography and food distribution during a tidal cycle above a cold-water coral mound

2022

This file contains the raw data and data analyses scripts to: Hydrography and food distribution during a tidal cycle above a cold-water coral mound Evert de Froe, Sandra R. Maier, Henriette G. Horn, George A. Wolff, Sabena Blackbird, Christian Mohn, Mads Schultz, Anna-Selma van der Kaaden, Chiu H. Cheng, Evi Wubben, Britt van Haastregt, Eva Friis Moller, Marc Lavaleye, Karline Soetaert, Gert-Jan Reichart, Dick van Oevelen. Deep Sea Research Part I: Oceanographic Research Papers, 2022, ISSN 0967-0637, https://doi.org/10.1016/j.dsr.2022.103854. Abstract: Cold-water corals (CWCs) are important ecosystem engineers in the deep sea that provide habitat for numerous species and can form large cora…

Koulujen kirjavalikoimat osana kielitietoista kirjallisuuskasvatusta

2022

Tässä tutkimuksessa selvitettiin suomalaisten koulujen kirjavalikoimien monikielisyyttä sekä opettajien kokemuksia koulujensa luokka- ja koulukirjastojen laadusta. Kyselyyn vastasi ala- ja yläkoulujen opettajia ympäri Suomea (N = 83). Opettajat olivat koulukirjastoihin enemmän tyytyväisiä kuin luokkakirjastoihin: puolet alakoulun opettajista ja yli puolet yläkoulun opettajista oli tyytyväisiä koulukirjastoonsa. Opettajat, jotka pitivät koulu- tai luokkakirjastoaan hyvinä, kokivat, että heidän koulussaan arvostettiin kirjallisuutta ja lukemista. Ero oli tilastollisesti merkittävä opettajiin, jotka olivat tyytymättömiä koulunsa kirjavalikoimiin. Opettajat mainitsivat luokka- ja koulukirjastoj…

Meaningful work, pleasure in working, and the moderating effects of deep acting and COVID-19 on nurses' work

2022

This study aims to verify the association between nurses' perception of the meaningfulness of their work and their pleasure in working, and whether this relationship may change based on the level of deep acting performed to cope with emotional regulation demands and the influence of the COVID-19 pandemic on the healthcare work.Nurses from both private and public Italian institutions (N = 239) completed an online questionnaire between June 2021 and January 2022. A moderated moderation model was tested through SPSS Process macro. The design is cross-sectional.The results show that the perception of meaningfulness of work is positively associated with pleasure in working, especially in conditi…

Drivers for SMEs participation in entrepreneurial ecosystems: evidence from health tech ecosystem in Northern Finland

2022

PurposeThe entrepreneurial ecosystem (EE) literature is dominated by conceptual studies with insufficient theoretical foundations and empirical evidence on the micro-level. This study aims to explore the largely overlooked question of what the drivers that motivate small and medium-sized enterprises (SMEs) to participate in an ecosystem are.Design/methodology/approachThe study adopts a qualitative exploratory approach. The empirical data consists of 19 semi-structured interviews with top management of SMEs in the health tech ecosystem in Finland. The data were analyzed using a thematic content analysis.FindingsThis study reveals a typology of drivers that motivate SMEs to participate in an …

Opettajaopiskelijoiden kielitoinen toimijuus monikielisten oppijoiden etäohjauksessa

2022

Artikkelissa tarkastellaan opettajaopiskelijoiden kielitietoista toimijuutta ohjaustilanteessa, jossa he tukevat etäyhteyksin eri-ikäisiä monikielisiä oppijoita. Ennestään tuntemattomien monikielisten oppijoiden ohjaaminen etäyhteyksin oli opettajaopiskelijoille uusi ja haastava tilanne pandemiakriisissä vuonna 2020. Tutkimuksen aineistona on yhdentoista opettajaopiskelijan ohjaustehtävästä kirjoittamat raportit, jotka on analysoitu aineistolähtöisen temaattisen analyysin keinoin. Analyysissa tarkasteltiin seikkoja, jotka mahdollistavat ja rajoittavat varhaiskasvatuksen, luokanopettajakoulutuksen ja kielten aineenopettajakoulutuksen opiskelijoiden kielitietoista toimijuutta monikielisten op…

Optimization of Polyphenols' Recovery from Purple Corn Cobs Assisted by Infrared Technology and Use of Extracted Anthocyanins as a Natural Colorant i…

2022

An ecofriendly extraction technology using infrared (IR) irradiation Ired-Irrad® was applied to purple corn cobs to enhance polyphenol recovery for the first time. The IR extraction efficiency was compared to that of the water bath (WB) method. Response surface methodology (RSM) using a central composite design was conducted to determine the effect of the experimental conditions (extraction time and treatment temperature) and their interactions on the total polyphenol and anthocyanin yields. Optimal extraction of total phenolic compounds (37 mg GAE/g DM) and total monomeric anthocyanins (14 mg C3G/g DM) were obtained at 63 °C for 77 min using IR as an extraction technique and water as a sol…

Tetrazine Linkers as Plug-and-Play Tags for General Framework Functionalization and C60 Conjugation

2022

The value of covalent post-synthetic modification in expanding the chemistry and pore versatility of reticular solids is well documented. Here we use mesoporous crystals of UiO-68-TZDC to demonstrate the value of tetrazine connectors for all-purpose inverse electron-demand Diels-Alder ligation chemistry. Our results suggest a positive effect of tetrazine reticulation over its reactivity for quantitative one-step functionalization with a broad scope of alkene or alkyne dienophiles into pyridazine and dihydropyridazine frameworks. This permits generating multiple pore environments with diverse chemical functionalities and the expected accessible porosities, that is also extended to the synthe…