showing 36 of ~574560 from 574555 documents
Inverse problems for semilinear elliptic PDE with measurements at a single point
2023
We consider the inverse problem of determining a potential in a semilinear elliptic equation from the knowledge of the Dirichlet-to-Neumann map. For bounded Euclidean domains we prove that the potential is uniquely determined by the Dirichlet-to-Neumann map measured at a single boundary point, or integrated against a fixed measure. This result is valid even when the Dirichlet data is only given on a small subset of the boundary. We also give related uniqueness results on Riemannian manifolds.
Right to Food and Geoengineering
2023
AbstractClimate change poses grave risks to food security, and mitigation and adaptation actions have so far been insufficient to lessen the risk of climate-induced violations of the right to food. Could safeguarding the right to food, then, justify some forms of geoengineering? This article examines geoengineering through the analytical lens of the right to food. We look at the components of food security and consider how the acceptability of geoengineering relates to the right to food via its impacts on these components. Our examination shows that results vary greatly between different forms of geoengineering: while some forms of geoengineering fail to respect the right to food, certain o…
Cosmic primordial density fluctuations and Bell inequalities
2023
The temperature measurements, $T$, of the perturbed cosmic microwave background, performed by the cosmic background explorer satellite (COBE), are considered. A dichotomist function, $f = \pm 1$, is defined such that $f =+1$ if $\delta T > 0$ and $f =-1$ if $\delta T < 0$, where $\delta T$ stands for the fluctuation of $T$. Then, it is assumed that behind the appearance of these fluctuations there is local realism. Under this assumption, some specific Clauser-Horne-Shimony-Holt (CHSH) inequalities are proved for these fluctuation temperatures measured by COBE in the different sky directions. The calculation of these inequalities from the actual temperature measurements shows that these ineq…
Hemp Flour Particle Size Affects the Quality and Nutritional Profile of the Enriched Functional Pasta
2023
The rheological and chemical quality of pasta samples, which were obtained using the durum wheat semolina fortified with the hemp seed solid residue, after oil extraction, sieved at 530 μm (Hemp 1) or 236 μm (Hemp 2) at different percentages of substitution (5%, 7.5%, and 10%, were evaluated. The total polyphenolic content in hemp flour was quantified in the range of 6.38–6.35 mg GAE/g, and free radical scavenging was included in the range from 3.94–3.75 mmol TEAC/100 g in Hemp 1 and Hemp 2, respectively. The phenolic profiles determined by UHPLC-ESI/QTOF-MS showed that cannabisin C, hydroxycinnamic and protocatechuic acids were the most abundant phenolic compounds in both…
Improving the Aromatic Profiles of Catarratto Wines: Impact of Metschnikowia pulcherrima and Glutathione-Rich Inactivated Yeasts
2023
Catarratto is one of the most widely cultivated grape varieties in Sicily. It is an indigenous non-aromatic white grape variety. Despite its widespread use in winemaking, knowledge of the aroma and chemical and microbiological properties of Catarratto wines is quite limited. The influence of Metschnikowia pulcherrima combined with Saccharomyces cerevisiae on the aromatic expression of Catarratto wines was investigated with and without the addition of glutathione-rich inactivated yeast. The substance is a natural specific inactivated yeast with a guaranteed glutathione level used to limit oxidative processes. The aromatic profiles of the final wines were determined through analysis of the vo…
Humic Substances: From Supramolecular Aggregation to Fractal Conformation—Is There Time for a New Paradigm?
2023
Natural organic matter, including humic substances (HS), comprises complex secondary structures with no defined covalent chemical bonds and stabilized by inter- and intra-molecular interactions, such as hydrogen bonding, Van der Waal’s forces, and pi-pi interactions. The latest view describes HS aggregates as a hydrogel-like structure comprised by a hydrophobic core of aromatic residues surrounded by polar and amphiphilic molecules akin a self-assembled soft material. A different view is based on the classification of this material as either mass or surface fractals. The former is intended as made by the clustering of macromolecules generating dendritic networks, while the latter have been …
Cyclic Sulfoximine and Sulfonimidamide Derivatives by Copper‐Catalyzed Cross‐Coupling Reactions with Elemental Sulfur
2023
Copper-catalyzed cross-coupling reactions of α-bromoaryl NH-sulfoximines with elemental sulfur lead to benzo[d][1,3,2]dithiazole-1-oxides, which represent a new class of three-dimensional heterocycles. The reactions proceed under mild conditions showing good functional group and heterocycle tolerance. By imination/oxidation, the initial cross-coupling products can be converted to unprecedented cyclic sulfonimidamides derivatives. Furthermore, a seven-membered heterocycle was obtained by a ruthenium-catalyzed ring-expansion with ethyl propiolate. peerReviewed
New insights on partial trisomy 3q syndrome: de novo 3q27.1-q29 duplication in a newborn with pre and postnatal overgrowth and assisted reproductive …
2023
Abstract Background Duplications of the long arm of chromosome 3 are rare, and associated to a well-defined contiguous gene syndrome known as partial trisomy 3q syndrome. It has been first described in 1966 by Falek et al., and since then around 100 patients have been reported. Clinical manifestations include characteristic facial dysmorphic features, microcephaly, hirsutism, congenital heart disease, genitourinary anomalies, hand and feet abnormalities, growth disturbances and intellectual disability. Most of cases are due to unbalanced translocations, inherited from a parent carrying a balanced aberration (reciprocal translocation or inversion), and rarely the genomic anomaly arises de no…
Welded section defence by LRPD devices
2023
The present paper concerns a special application of some recently proposed structural devices, called LRPD, able to protect the welded sections of frame steel structures from undesired brittle collapse ensuring the good expected ductile behaviour. Standard I-shaped cross-sections are treated, and the proposed devices are suitably considered as moment resisting connections between beams and columns. At first the domain representing the brittle safe conditions is defined in the N,V,M space; then a sample plane frame subjected to seismic load conditions is studied and it is proved that, equipping the structure with the proposed devices suitably designed, the generalized stresses at the welded …
Aperiodicity in Quantum Wang Tilings
2023
By reformulating the Wang tiles formalism with tensors, we propose a natural generalization to the probabilistic and quantum setting. In this new framework, we introduce notions of tilings and periodicity directly extending their classical counterparts. In the one dimensional case, we recover the decidability of the generalized domino problem by linking it to the trace characterization of nilpotent matrices. In the two-dimensional case, we provide extension of weak and strong aperiodicity respectively and show the equivalence of those generalized notions, extending the well known equivalence in the classical case. We also exhibit a quantum tile set being aperiodic while its underlying class…
paisaje sonoro y visual como recurso educativo para la formación del profesorado
2023
The results of research on the didactic usefulness of the visual and sound landscape developed at the Teacher Training Faculty of the University of Valencia are shown. Following a mixed methodology with qualitative and quantitative questionnaires, the concept that future teachers have of agricultural landscapes and their possibilities as an educational resource is analysed. The sample consisted of 146 teachers in training for the Primary School Teacher Degree. The results show that sound and visual landscapes improve the understanding of natural phenomena from an interdisciplinary approach and promote the teachers' competence development. Se muestran los resultados de una investigación sobr…
Vicarious Social Defeat Increases Conditioned Rewarding Effects of Cocaine and Ethanol Intake in Female Mice
2023
Stress is a critical factor in the development of mood and drug use disorders. The social defeat model is not appropriate for female rodents due to their low level of aggression. Therefore, a robust female model of social stress needs to be developed and validated. The aim of the present study was to unravel the long-lasting effects of vicarious social defeat (VSD) on the conditioned rewarding effects of cocaine and ethanol intake in female mice. Although VSD seems to be a good model for inducing behavioral and physiologic endophenotypes induced by stress, there are no studies to date that characterize the effect of VSD on cocaine or alcohol use. The results confirm that VSD females showed …
Longitudinal Changes in Suicide Bereavement Experiences : A Qualitative Study of Family Members over 18 Months after Loss
2023
Family members bereaved by their loved ones’ suicidal death normally undergo a complicated and lengthy bereavement process. In this qualitative case study, we explored longitudinal changes in the suicide bereavement process by applying assimilation analysis, based on the Assimilation Model (AM) and the Assimilation of Problematic Experiences Scale (APES), to longitudinal interview data collected from two Chinese suicide-bereaved individuals within the first 18 months after their loss. The results showed that over time the participants both progressed in adapting to their traumatic losses. Assimilation analysis both effectively elaborated the difference in the inner world of the bereaved and…
Caracterización fónica de la (des)cortesía en el español hablado de Valencia. Aproximación cualitativo-cuantitativa
2023
En este artículo se presentan los resultados de un estudio de doble naturaleza cualitativo-cuantitativa basado en la exploración y el análisis de los datos pertenecientes a la base de datos Fonocortesía (www.fonocortesia.es), que recoge 278 secuencias de habla espontánea (des)corteses derivadas del proyecto Fonocortesía (FFI2009-07034-FILO), desarrollado entre 2009-2013. Tales secuencias (des)corteses, analizadas y sometidas a revisión conjunta por el equipo investigador del mencionado proyecto, han sido procesadas con la herramienta Oralstats (https://github.com/acabedo/oralstats) capaz de desarrollar el análisis estadístico inferencial y la visualización exploratoria de bases de datos. Lo…
Crowdfunding performance, market performance, and the moderating roles of product innovativeness and experts' judgment: Evidence from the movie indus…
2023
Reward-based crowdfunding (CF) has emerged as a method to solicit funds for innovative projects. Yet, little is still known about the ability of reward-based CF to act as a signal in the eyes of future consumers, and thus boost the future market performance of new products that innovators intend to commercialize using the campaign funds. In addition, scant research has clarified the boundary conditions that can magnify or weaken the efficacy of this CF signal. Given the relevance of reward-based CF for supporting innovation, understanding when the CF campaign performance works as an effective signal is of great interest, especially in business settings characterized by high product quality …
Heart rate variability is associated with disease severity and portal hypertension in cirrhosis
2023
Introduction: Autonomic nervous system activity in cirrhotic portal hypertension is linked to hyperdynamic circulation. Heart rate variability (HRV) is a validated noninvasive method to assess the sympathovagal balance. To investigate the correlation between HRV parameters and degree of portal hypertension, we studied a cohort of patients with cirrhosis accounting for etiology and treatments. Patients and Methods: In this cross-sectional, observational cohort study, 157 outpatients of both sex with nonalcoholic cirrhosis were assessed by upper gastrointestinal endoscopy to search for esophagogastric varices. Twenty-four-hour electrocardiogram Holter monitoring with 3 HRV parameters measurem…
Observation of the decay $D^+_s\to \omega\pi^+\eta$
2023
Using 7.33 fb$^{-1}$ of $e^+e^-$ collision data collected by the BESIII detector at center-of-mass energies between 4.128 and 4.226~GeV, we observe for the first time the decay $D^{\pm}_s\to \omega\pi^{\pm}\eta$ with a statistical significance of 7.6$\sigma$. The measured branching fraction of this decay is $(0.54\pm0.12\pm0.04)\%$, where the first uncertainty is statistical and the second is systematic.
Carotid Artery Disease in the Era of Biomarkers: A Pilot Study
2023
The intima-media thickness (IMT) and its irregularities or ulcerations in the common carotid artery (CCA) are useful tools as sentinel biomarkers for the integrity of the cardiovascular system. Total homocysteine and lipoprotein levels are the most commonly used elements in cardiovascular risk stratification. Duplex ultrasound (DUS), associated with serum biomarkers, can be used simply to assess the degree of atherosclerotic disease and cardiovascular risk. This study highlights the role of different kinds of biomarkers, showing their usefulness and potentiality in multi-district atherosclerotic patients, especially for early diagnosis and therapy effectiveness monitoring. A retrospective a…
Vibronic Relaxation Pathways in Molecular Spin Qubit Na9[Ho(W5O18)2]·35H2O under Pressure
2023
In order to explore how spectral sparsity and vibronic decoherence pathways can be controlled in a model qubit system with atomic clock transitions, we combined diamond anvil cell techniques with synchrotron-based far infrared spectroscopy and first-principles calculations to reveal the vibrational response of Na9[Ho(W5O18)2]·35H2O under compression. Because the hole in the phonon density of states acts to reduce the overlap between the phonons and f manifold excitations in this system, we postulated that pressure might move the HoO4 rocking, bending, and asymmetric stretching modes that couple with the MJ = ±5, ±2, and ±7 levels out of resonance, reducing their …
#selberdenken.
2023
Soziale Medien stellen wichtige Bühnen für zeitgenössische Konflikte um Wissen und Wahrheit dar. Der Artikel widmet sich vor diesem Hintergrund dem Gebrauch des Hashtags #selberdenken auf Twitter. Mittels einer quantitativen Datenanalyse wird zunächst die Konjunktur der Verwendung des Hashtags nachgezeichnet. Eine anschließende hermeneutische Sequenzanalyse zeigt, wie in seinem Gebrauch ein Anspruch auf epistemische Autonomie zum Ausdruck gebracht wird: Allein die eigenen Erfahrungen, Interpretationen und Quellen gelten als vertrauenswürdig. Dies korrespondiert mit einem grundlegenden Misstrauen in die von den Massenmedien konstruierten Realitäten und einer Trivialisierung von Erkenntnispro…
Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps
2023
(1) Background: Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients’ QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: Th…
El archivo de la "Antigua Real Fábrica de la seda de Vinalesa"
2023
NOTICIAS SOBRE ARCHIVOS News on historical archives Amparo Ruiz Llopis: El archivo de la "Antigua Real Fábrica de la seda de Vinalesa" The archive of the "Antigua Real Fábrica de la seda de Vinalesa")
Correcting Exoplanet Transmission Spectra for Stellar Activity with an Optimised Retrieval Framework
2023
Stellar activity in the form of photospheric heterogeneities such as spots and faculae may present a significant noise source for exoplanetary observations by introducing a chromatic contamination effect to the observed transmission spectrum. If this contamination is not identified and corrected for, it can introduce substantial bias in our analysis of the planetary atmosphere. In this work we aim to determine how physically realistic and complex our stellar models must be in order to accurately extract the planetary parameters from transmission spectra. We explore which simplifying assumptions about the host star are valid at first order and examine if these assumptions break down in cases…
Safety and efficacy outcomes after intranasal administration of neural stem cells in cerebral palsy : a randomized phase 1/2 controlled trial
2023
Abstract Background Neural stem cells (NSCs) are believed to have the most therapeutic potential for neurological disorders because they can differentiate into various neurons and glial cells. This research evaluated the safety and efficacy of intranasal administration of NSCs in children with cerebral palsy (CP). The functional brain network (FBN) analysis based on electroencephalogram (EEG) and voxel-based morphometry (VBM) analysis based on T1-weighted images were performed to evaluate functional and structural changes in the brain. Methods A total of 25 CP patients aged 3–12 years were randomly assigned to the treatment group (n = 15), which received an intranasal infusion of NSCs loade…
X(3960) seen in Ds+Ds− as the X(3930) state seen in D+D−
2023
Digitalización del sector agroproductor: intercooperación y tecnologías disruptivas
2023
La digitalización del sector agroproductor es un hecho, aunque todavía sigue siendo lenta y necesita de herramientas que le resulten de fácil implementación en sus organizaciones y además les permitan interactuar con otros agroproductores sin alterar las reglas de la libre competencia. En este trabajo ofrecemos las claves para la aplicación de las tecnologías disruptivas en el sector de las cooperativas agroalimentarias, formulando propuestas concretas de implantación de las tecnologías de la información y comunicación en sus respectivas organizaciones. Las TICs han llegado para mejorar las funciones de las organizaciones y de sus actividades, pero además, para proveer a las entidades de la…
Impact of treatment with dimethyl fumarate on sleep quality in patients with relapsing-remitting multiple sclerosis: A multicentre Italian wearable t…
2023
Background Sleep disorders are common in patients with multiple sclerosis and have a bidirectional interplay with fatigue and depression. Objective To evaluate the effect of treatment with oral dimethyl fumarate on the quality of sleep in relapsing-remitting multiple sclerosis. Methods This was a multicentre observational study with 223 relapsing-remitting multiple sclerosis subjects starting treatment with dimethyl fumarate ( n=177) or beta interferon ( n=46). All patients underwent subjective (Pittsburgh Sleep Quality Index) and objective (wearable tracker) measurements of quality of sleep. Fatigue, depression, and quality of life were also investigated and physical activity was monitored…
Down-Sampled Epsilon-Lexicase Selection for Real-World Symbolic Regression Problems
2023
Epsilon-lexicase selection is a parent selection method in genetic programming that has been successfully applied to symbolic regression problems. Recently, the combination of random subsampling with lexicase selection significantly improved performance in other genetic programming domains such as program synthesis. However, the influence of subsampling on the solution quality of real-world symbolic regression problems has not yet been studied. In this paper, we propose down-sampled epsilon-lexicase selection which combines epsilon-lexicase selection with random subsampling to improve the performance in the domain of symbolic regression. Therefore, we compare down-sampled epsilon-lexicase w…
A diffeomorphism invariant family of metric-affine actions for loop cosmologies
2023
In loop quantum cosmology (LQC) the big bang singularity is generically resolved by a big bounce. This feature holds even when modified quantization prescriptions of the Hamiltonian constraint are used such as in mLQC-I and mLQC-II. While the later describes an effective description qualitatively similar to that of standard LQC, the former describes an asymmetric evolution with an emergent Planckian de-Sitter pre-bounce phase even in the absence of a potential. We consider the potential relation of these canonically quantized non-singular models with effective actions based on a geometric description. We find a 3-parameter family of metric-affine $f(\mathcal{R})$ theories which accurately a…
Effect of TiO2 and Al2O3 Addition on the Performance of Chitosan/Phosphotungstic Composite Membranes for Direct Methanol Fuel Cells
2023
Composite chitosan/phosphotungstic acid (CS/PTA) with the addition of TiO2 and Al2O3 particles were synthesized to be used as proton exchange membranes in direct methanol fuel cells (DMFCs). The influence of fillers was assessed through X-ray diffraction, scanning electron microscopy, thermogravimetric analysis, liquid uptake, ion exchange capacity and methanol permeability measurements. The addition of TiO2 particles into proton exchange membranes led to an increase in crystallinity and a decrease in liquid uptake and methanol permeability with respect to pristine CS/PTA membranes, whilst the effect of the introduction of Al2O3 particles on the characteristics of membranes is almost the op…
Impact of formulations of the homogeneous nucleation rate on ice nucleation events in cirrus
2023
Abstract. Homogeneous freezing of solution droplets is an important pathway of ice formation in the tropopause region. The nucleation rate can be parameterized as a function of water activity, based on empirical fits and some assumptions on the underlying properties of super-cooled water, although a general theory is missing. It is not clear how nucleation events are influenced by the exact formulation of the nucleation rate or even their inherent uncertainty. In this study we investigate the formulation of the nucleation rate of homogeneous freezing of solution droplets (1) to link the formulation to the nucleation rate of pure water droplets, (2) to derive a robust and simple formulation …
Promoting emotional skills in early adolescents with mental health conditions in music therapy : a content analysis of focus group interviews
2023
Introduction: Music therapy is actively used with early adolescents in relation to their emotional skill development. Yet, the conceptualization of emotional skills is typically not systematically addressed in therapeutic practice. This study examined music therapists’ views on the progress of emotional skills when working with early adoles-cents with mental health conditions. The study also explored what kind of methods the therapists use with the target group, and the applicability of a previously pub-lished conceptual model. Method: We conducted a deductive-inductive content analysis of transcripts from four focus group interviews among 13 professional music therapists. Results: The ther…
Intention affects fairness processing : Evidence from behavior and representational similarity analysis of event‐related potential signals
2023
In an ultimatum game, the responder must decide between pursuing self-interest and insisting on fairness, and these choices are affected by the intentions of the proposer. However, the time course of this social decision-making process is unclear. Representational similarity analysis (RSA) is a useful technique for linking brain activity with rich behavioral data sets. In this study, electroencephalography (EEG) was used to measure the time course of neural responses to proposed allocation schemes with different intentions. Twenty-eight participants played an ultimatum game as responders. They had to choose between accepting and rejecting the fair or unfair money allocation schemes of propo…
Case report: Novel compound heterozygosity for pathogenic variants in MED23 in a syndromic patient with postnatal microcephaly
2023
Biallelic loss-of-function variants in MED23 cause a recessive syndromic intellectual disability condition with or without epilepsy (MRT18). Due to the small number of reported individuals, the clinical phenotype of the disorder has not been fully delineated yet, and the spectrum and frequency of neurologic features have not been fully characterized. Here, we report a 5-year-old girl with compound heterozygous for two additional MED23 variants. Besides global developmental delay, axial hypotonia and peripheral increased muscular tone, absent speech, and generalized tonic seizures, which fit well MRT18, the occurrence of postnatal progressive microcephaly has been here documented. A retrospe…
The “nitrogen effect” : Complexation with macrocycles potentiates fused heterocycles to form halogen bonds in competitive solvents
2023
Weak intermolecular forces are typically very difficult to observe in highly competitive polar protic solvents as they are overwhelmed by the quantity of competing solvent. This is even more challenging for three-component ternary assemblies of pure organic compounds. In this work, we overcome these complications by leveraging the binding of fused aromatic N-heterocycles in an open resorcinarene cavity to template the formation of a three-component halogen-bonded ternary assembly in a protic polar solvent system. peerReviewed
Russia’s cultural policy abroad as a projection of the “Russian World”
2023
The policy review discusses the recent developments in Russian cultural policy. These developments incorporate Russian culture into its geo-political ambitions. Obviously, the war in Ukraine makes these developments relevant. However, this review piece also seeks to explain the place of cultural policy in the Russian political system and the scope of its geopolitical ambitions. nonPeerReviewed