showing 36 of ~574560 from 574555 documents
Design and development of safety and control systems in ATLAS
2021
El gran colisionador de hadrones, o LHC, es el acelerador de partículas más grande y potente del mundo. Ha sido construido por el CERN, la Organización Europea para la Investigación Nuclear, entre 1998 y 2008 en Ginebra, Suiza. Sucesivas mejoras en el LHC supondrán a partir de mediados del 2027 un incremento de la luminosidad, cuando pasará a llamarse High Luminosity LHC (HL-LHC). Esta tesis se divide en dos partes, por una parte la seguridad y operación de la infraestructura y por otra los sistemas de control y toma de datos. La primera parte de la tesis se dedica a la seguridad y operación de la infraestructura. Después de más de 10 años de funcionamiento, el riesgo de posibles fallos en …
The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds.
2021
ABSTRACT With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughput drug screening campaigns is a major obstacle in drug discovery. Moreover, in vivo testing using conventional animal TB models, such as mice, is time consuming and costly, and represents a major bottleneck in lead compound discovery and development. Here, we report the use of the zebrafish embryo TB model for evaluating the in vivo toxicity and efficacy of five poorly water-soluble nitronaphthofuran derivatives, which were recently id…
Graph Embedding via High Dimensional Model Representation for Hyperspectral Images
2021
Learning the manifold structure of remote sensing images is of paramount relevance for modeling and understanding processes, as well as to encapsulate the high dimensionality in a reduced set of informative features for subsequent classification, regression, or unmixing. Manifold learning methods have shown excellent performance to deal with hyperspectral image (HSI) analysis but, unless specifically designed, they cannot provide an explicit embedding map readily applicable to out-of-sample data. A common assumption to deal with the problem is that the transformation between the high-dimensional input space and the (typically low) latent space is linear. This is a particularly strong assump…
Incendiary Humor: Climate Change, Biodiversity, and Politics in Wildfire Cartoons
2021
Organic Compounds Evaluation from Fumes Generated in Laboratory by Bio-recycled Asphalt Mixtures
2021
Using bio-binder and bio-additives as recycling agents for asphalt mixtures with high-content of reclaimed asphalt (RA) is proving to be feasible. It is still not clear whether this combination might provide new hazardous emissions from airborne binder fumes. The health hazard related to airborne bitumen fume generation is primarily relevant for paving crews while there is little opportunity for exposure related to asphalt plant workers. In this study, measurements of gaseous organic compounds from airborne binder fumes of selected bio-asphalt mixtures have been measured during the laboratory mixing process, by using a thermo-mixer equipped with a chimney at University Gustave Eiffel. Param…
Cover Feature: Synthesis of Polycyclic Indolines by Utilizing a Reduction/Cyclization Cascade Reaction (Eur. J. Org. Chem. 45/2021)
2021
Detection of collinear high energetic di-photon signatures with Micromegas Detectors
2021
The search for weakly interacting, light particles that couple to photons received significant attention in recent years. When those particles are produced at high energies, they lead to two, nearly collinear photons after their decay and hence can be detected by an electromagnetic calorimeter system. The typical dominant background in searches for those high energetic weakly particles are single, high energetic photons, which leave similar signatures in a standard calorimeter system. One promising approach to separate signal from background events is to employ a dedicated pre-shower detector in front of the calorimeter that can distinguish one- and two-photon signatures. In this work we pr…
Museari, Educar en Arte LGTB para Superar la Homofobia y la Transfobia
2021
La presente investigación parte de un proceso de intervención en las aulas de formación del profesorado que pretende generar un acercamiento a las posibilidades educativas del arte LGTB, cuyo objetivo consiste en reflexionar sobre la oportunidad de utilizar piezas ar-tísticas, incorporando cuestiones como la diversidad sexual y de género, fomentando así la superación del odio, la homofobia y la transfobia. Como metodología se plantea un estu-dio de caso en el que se analiza un taller impartido a dos grupos de la Facultat de Magisteri de la Universitat de València, incorporando la Investigación Educativa Basada en Artes. La recogida de datos se lleva a cabo durante la práctica docente, usand…
Combining Academic Education With Soft Skills Development: Some Common Aspects of Educational Preparation of IT Professionals and Schoolteachers
2021
In the modern educational process aimed on preparing professionals in the applied areas, it’s crucial, along with purely professional training, to provide students both with solid theoretical background and help them to develop “soft skills” that will facilitate their smooth and efficient adaptation to the industry realities when they start their professional careers. In this paper we consider practical cases of acquiring soft skills through intensive field experience in two areas related to mathematical education.
Campodeidae (Hexapoda: Diplura) from Kyrgyzstan, Central Asia, with the description of a remarkable new genus and species
2021
Samples collected in Central Asia, Kyrgyzstan, have revealed a hitherto unknown diversity of Campodeidae (Diplura) in soil and cave habitats, including a new genus and species, Kyrgyzstancampa sanare Sendra & Ferreira gen. et sp. nov., Turkmenocampa edaphica Sendra & Sánchez-García sp. nov. and a previously recognized soil-dwelling species, Campodea (Dicampa) catalana Denis, 1930. Kyrgyzstancampa sanare Sendra & Ferreira gen. et sp. nov. was collected in the deep zone of an interesting geological and cultural cave, Ak-Turpak Cave, located near the western margin of Kadamjay District, Batken Province. This genus belongs to the subfamily Campodeinae, sharing the morphology of the …
Screen media and non-screen media habits among preschool children in Singapore, South Korea, Japan, and Finland: Insights from an unsupervised cluste…
2021
The main purpose of the research was to describe the daily screen media habits and non-screen media habits like indoor and outdoor play, and sleep of preschool children aged 2 to 6 years from Singapore, South Korea, Japan, and Finland using a content-validated online questionnaire (SMALLQ®) and unsupervised cluster analysis. Unsupervised cluster analysis on 5809 parent-reported weekday and weekend screen and non-screen media habits of preschool children from the four countries resulted in seven emergent clusters. Cluster 2 ( n = 1288) or the Early-screen media, screen media-lite and moderate-to-vigorous physical activity-lite family made up 22.2% and Cluster 1 ( n = 261) or the High-all-ro…
REP2
2021
REP2 is a web server to detect common tandem repeats in protein sequences.
Evaluation de l’impact de l’intervention d’un travailleur social sur la qualité de vie des aidants informels de personnes âgées atteintes d’un cancer
2021
International audience
Una aproximación jurídico-filosófica a la memoria y al olvido desde la teoría de los derechos fundamentales
2021
Nuestro mundo digital, basado en el recuerdo como principio categórico y el olvido como defecto anómalo, pone en tela de juicio el principio de que la dignidad humana es el fundamento y el valor superior de todo orden democrático y constitucional, garantizando el derecho de toda persona a definir libremente su identidad y proyecto de vida. En tiempos digitales, los derechos más personalísimos, dispuestos bajo el paraguas de la dignidad y la libertad, requieren un cierto poder de control, una autodeterminación y autonomía informativas. La postura europea ha sido regular el conocido derecho al olvido ante la elaboraciónautomática de perfiles, la compilación y la presentación descontextualizad…
Sofie's World : Resistance toward the Thin Ideal in Sofie Hagen's Fat Activist Online Content
2021
Disney y Ghibli: Educación sin migraciones en la cultura visual. El cine de animación como recurso didáctico en las aulas
2021
Se parte de Disney y Studio Ghibli como referentes del cine de animación en occidente y oriente respectivamente y se presenta el tratamiento que ambas toman sobre el concepto de migración. Siendo conscientes de la influencia de la cultura visual en quienes la consumen se pretende conocer el posicionamiento que un grupo de estudiantes del Grado en Maestro en Educación Primaria de la Universitat de València tiene sobre el concepto de migración en la cultura visual (Disney y Studio Ghibli) y las potencialidades que en esta perciben como recurso didáctico en las aulas. Para ello se recurre a la metodología cualitativa, concretamente al estudio de caso. Los resultados reafirman el potencial del …
Machine‐Learning Based Reconstructions of Past Regional Sea Level Variability From Proxy Data
2021
A Classification System for Decision-Making in the Management of Patients with Chronic Conditions
2021
Patients with chronic diseases are frequent users of healthcare services. The systematic use of stratification tools and predictive models for this group of patients can be useful for health professionals in decision-making processes. The aim of this study was to design two new classifier systems for detecting the risk of hospital admission for elderly patients with chronic conditions. In this retrospective cohort study, a set of variables related to hospital admission for patients with chronic conditions was obtained through focus groups, a health database analysis and statistical processing. To predict the probability of admission from the set of predictor variables, a logistic regression…
Modelling of an innovative membrane crystallizer for the production of magnesium hydroxide from waste brine
2021
Background The discharge of industrial waste brines into natural water bodies has gained large interest in recent years, both for its possible environmental impact, but also for the high potential of raw materials recovery contained in brines, pushing towards a circular economy approach. Among such raw materials, magnesium is often abundant and has been defined as aCritical Raw Material by EU [1]. Within this framework, a Crystallizer with Ion Exchange Membrane (CrIEM) has been proposed as an innovative process to recover magnesium from waste brines exploiting low-cost alkaline reactants. In the present work, a novel mathematical model of the CrIEM process is proposed providing a useful too…
Pioneers as Peers : How Entrepreneurial Journalists Imagine the Futures of Journalism
2021
The article investigates the futures of journalism that pioneering entrepreneurial journalists anticipate. This comprises the different imaginaries that journalists employ to make sense of journalism’s present potentials, anticipate its possible futures, and inform their decision-making. By analysing semi-structured interviews with Finnish entrepreneurial journalists, the article identifies a peer-to-peer imaginary on which the interviewees draw and construct to anticipate the potential futures of journalism. In this peer-to-peer imaginary, journalism is produced in journalists’ and audiences’ peer networks of affinity and shared interests. The imaginary promises elevated audience engagemen…
Determinisms of plant and microbiome interactions : a multidisciplinary approach involving high-throughput phenotyping
2021
International audience
Recent Advances on the Halo- and Cyano-Trifluoromethylation of Alkenes and Alkynes
2021
Incorporation of fluorine into organic molecules is a well-established strategy in the design of advanced materials, agrochemicals, and pharmaceuticals. Among numerous modern synthetic approaches, functionalization of unsaturated bonds with simultaneous addition of trifluoromethyl group along with other substituents is currently one of the most attractive methods undergoing wide-ranging development. In this review article, we discuss the most significant contributions made in this area during the last decade (2012−2021). The reactions reviewed in this work include chloro-, bromo-, iodo-, fluoro- and cyano-trifluoromethylation of alkenes and alkynes.
Geometric characterizations of the strict Hadamard differentiability of sets
2021
Let $S$ be a closed subset of a Banach space $X$. Assuming that $S$ is epi-Lipschitzian at $\bar{x}$ in the boundary $ \bd S$ of $S$, we show that $S$ is strictly Hadamard differentiable at $\bar{x}$ IFF the Clarke tangent cone $T(S, \bar{x})$ to $S$ at $\bar{x}$ contains a closed hyperplane IFF the Clarke tangent cone $T(\bd S, \bar{x})$ to $\bd S$ at $\bar{x}$ is a closed hyperplane. Moreover when $X$ is of finite dimension, $Y$ is a Banach space and $g: X \mapsto Y$ is a locally Lipschitz mapping around $\bar{x}$, we show that $g$ is strictly Hadamard differentiable at $\bar{x}$ IFF $T(\mathrm{graph}\,g, (\bar{x}, g(\bar{x})))$ is isomorphic to $X$ IFF the set-valued mapping $x\rightrigh…
Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach
2021
Physical activity could play a key role in improving the quality of life, particularly in patients with nervous system diseases such as multiple sclerosis (MS). Through lactacid anaerobic training, this study aims to investigate the effects at a bio-psycho-physical level to counteract the chronic fatigue associated with the pathology, and to improve mental health at a psychological and neurotrophic level. Eight subjects (age: 34.88 ± 4.45 years) affected by multiple sclerosis were involved. A lactate threshold training program was administered biweekly for 12 weeks at the beginning of the study (T0), at the end of the study (T1) and at 9 months after the end of the study (T2), with physical…
El municipalismo frente a la crisis de la covid-19: el caso de los ayuntamientos de la provincia de Valencia
2021
La crisis del coronavirus ha resaltado el poder de lo local y de la proximidad en la construcción de respuestas a la mitigación y expansión del virus. Las entidades locales han desarrollado respuestas tanto individuales como colectivas para hacer frente a la pluralidad de necesidades ciudadanas originadas tras la aparición del virus y la declaración del estado de alarma por el gobierno de España.
 En este sentido, es objeto del presente artículo analizar las iniciativas solidarias implementadas desde las entidades locales de la provincia de Valencia en aras de ejemplificar el papel protagónico de dichas entidades locales durante la crisis del COVID-19. Ante las recomendaciones y restri…
Structural Performances of Composite Pultruded GFRP Emergency Structures
2021
The use of composite FRP pultruded elements in civil constructions is nowadays widely accepted as a valid alternative to classic materials. In the case of emergency applications (as for temporary shelter after earthquakes, floods and all disastrous), the lightness, ease of transport, assembly, safety of use, possibility of disassembly and reuse are key aspects that composite FRP structures can provide easily.
The Influence of Industrial Waste on the Magnetic Properties of Salt-Affected Soils from Two Soda Ash Manufacturing Sites
2021
The aim of this study was to characterize the impact of soda ash manufacturing on the magnetic properties of soils located in the agricultural landscape in north-central Poland. Two study sites were chosen: Mątwy (SM) and Janikowo (SJ). Highly saline soils with halophyte communities were selected in order to develop an understanding of the relationship between salinization of water–soil interface and the potential contamination risk of the environment. Basic chemical and physicochemical properties of topsoil (0–25 cm) and water (surface and groundwater) samples from five locations were characterized. The characteristics of soil contamination were based on the content of sel…
Systematics of European coastal anchovies (genus Engraulis Cuvier).
2021
Reports of morphological differences between European anchovy (Engraulis cf. encrasicolus) from coastal and marine habitats have long existed in the ichthyologic literature, and have given rise to a long-standing debate on their taxonomic status. More recently, molecular studies have confirmed the existence of genetic differentiation between the two anchovy ecotypes. Using ancestry-informative markers, we show that coastal anchovies throughout the Mediterranean share a common ancestry, and that substantial genetic differentiation persists in different pairs of coastal/marine populations despite the presence of limited gene flow. On the basis of genetic and ecological arguments, we propose t…
Mechanical Characterization of a Basalt Fabric for TRM Composites: Role of the Test Variables
2021
Textile reinforced mortar (TRM) materials are currently receiving great attention for the strengthening of reinforced concrete and masonry structural elements. Mortars with different strength classes have been coupled with different kind of synthetic fabrics, such as carbon, glass, steel, PBO. Recently natural fibres and, in particular, basalt fibres are receiving increasing interest since they proved to be a promising alternative to the most common synthetic fabrics, thanks to the reduced production costs and the consequent benefits in terms of environmental impact. This paper presents an experimental investigation comprising forty-one monotonic tensile tests on textile strips made with a …
Interdisciplinarité et interculturalité à partir de deux romans : Les Nuits de Strasbourg d’Assia Djebar et Le Village de l’Allemand ou le journal de…
2021
My presentation focuses on interdisciplinarity and interculturality on the basis of two novels, "Les Nuits de Strasbourg" by Assia Djebar and "Le Village de l'Allemand ou le journal des frères Schiller" by Boualem Sansal. Firstly, I reflect in a general way on interdisciplinarity and its affinity with interculturality before addressing these issues in my corpus and in my work. Secondly, I look at some theories, interdisciplinary and sometimes intercultural, that help me to study my corpus in a harmonious way, which I illustrate with concrete analyses referring to the thought of Édouard Glissant. Finally, I propose interdisciplinary developments of an intercultural approach, that of Michael …
Click synthesis, anticancer activity, and molecular docking investigation of some functional 1,2,3-triazole derivatives
2021
1,2,3-triazole skeleton is a privileged building block for the discovery of new promising anticancer agents. In this report, new 1,4-disubstituted 1,2,3-triazoles with the bioisoster triazole moiety were straightforwardly prepared under copper-catalyzed azide-alkyne [3+2] cycloaddition reactions (CuAAC) regime using a variety of both functional organic azides and terminal alkynes. The resulting functional 1,4-disubstituted 1,2,3-triazole compounds were fully characterized and subsequently tested for their antiproliferative activity against four different cancer cell lines. The cytotoxicity tests carried out with these 1,2,3-triazole derivatives show average IC50 values ranging from 15 to 50…
Predictive Score of Nodal Involvement in Endometrial Cancer Patients: A Large Multicentre Series
2021
Background: Sentinel lymph node (SLN) biopsy is considered the standard of care in early-stage endometrial cancer (EC). For SLN failure, a side-specific lymphadenectomy is recommended. Nevertheless, most hemipelvises show no nodal involvement. The authors previously published a predictive score of lymphovascular involvement in EC. In case of a negative score (value 3–4), the risk of nodal metastases was extremely low. This multicenter study aimed to analyze a predictive score of nodal involvement in EC patients. Methods: The study enrolled patients with EC who had received comprehensive surgical staging with nodal assessment. A preoperative predictive score of nodal involvement was calculat…
Aging effects and feasibility of statistical learning tasks across modalities
2021
Knowledge on statistical learning (SL) in healthy elderly is scarce. Theoretically, it is not clear whether aging affects modality-specific and/or domain-general learning mechanisms. Practically, there is a lack of research on simplified SL tasks, which would ease the burden of testing in clinical populations. Against this background, we conducted two experiments across three modalities (auditory, visual and visuomotor) in a total of 93 younger and older adults. In Experiment 1, SL was induced in all modalities. Aging effects appeared in the tasks relying on an explicit posttest to assess SL. We hypothesize that declines in domain-general processes that predominantly modulate explicit learn…
Valutazione partecipata e continuità nei servizi educativi zero-sei: una ricerca-intervento in un quartiere della città di Palermo
2021
RIASSUNTO In questo articolo verrà condotta inizialmente una riflessione sulla funzione della valutazione di contesto sia in termini formativi individuali e di gruppo, sia in termini di cambiamento organizzativo, adottando una prospettiva ecologica e sistemica. Successivamente, attraverso la narrazione di un percorso di ricerca sulla costruzione di un possibile curricolo zero-sei, condotta per tre anni con un gruppo di insegnanti di scuola dell’infanzia statale ed un gruppo di educatrici di un nido comunale operanti nello stesso territorio (un quartiere del centro storico di Palermo), verranno messi in luce e problematizzati ambiti di continuità e di discontinuità tra i due servizi educativ…
¡No son las criaturas, es la Academia! Brechas salariales de género y carrera investigadora en la Universidad
2021
El objetivo del presente texto es presentar a la maternidad como argumento que naturaliza las dificultades de las mujeres en sus carreras académicas y que desplaza a los actuales criterios de evaluación científica. A partir de un estudio sobre la brecha salarial en la Universitat de València se identifican y se confrontan situaciones salariales como la penalización por maternidad y el plus salarial por paternidad para tratar de reconocer cómo opera una institución meritocrática. Se analiza el complemento salarial por sexenios que reconoce salarialmente la productividad de hombres y mujeres que ocupan posiciones estables en launiversidad y sus repercusiones en las distintas áreas de conocimi…
Research note: The COVID-19 pandemic and its effects on scientific work in German sociology
2021
Since the beginning of the COVID-19 pandemic, scientific work is highly affected by the governments’ measures taken to reduce the spread of the virus. With closing colleges, universities, and kindergartens, scientists had to adapt to new forms of working procedures. Immediately after the peak of the first COVID-19 wave in Germany, we surveyed in professors and postdoctoral researchers in the field of German sociology in May 2020 to investigate how their work is constrained by these measures. In this research note, we present the results of this survey. They show that the position in the sociological field as well as demographic factors affect the degree to which sociologists feel constraine…