showing 36 of ~574560 from 574555 documents
Increased migraine-free intervals with multifocal repetitive transcranial magnetic stimulation.
2021
Introduction: Episodic migraine is a debilitating condition associated with vast impairments of health, daily living, and life quality. Several prophylactic treatments exist, having a moderate ratio of action related to side effects and therapy costs. Repetitive transcranial magnetic stimulation (rTMS) is an evidence based therapy in several neuropsychiatric conditions, showing robust efficacy in alleviating specific symptoms. However, its efficacy in migraine disorders is unequivocal and might be tightly linked to the applied rTMS protocol. We hypothesized that multifocal rTMS paradigm could improve clinical outcomes in patients with episodic migraine by reducing the number of migraine day…
Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
2021
Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing ra…
Plasmonic Biosensors for the Detection of Lung Cancer Biomarkers: A Review
2021
Lung cancer is the most common and deadliest cancer type globally. Its early diagnosis can guarantee a five-year survival rate. Unfortunately, application of the available diagnosis methods such as computed tomography, chest radiograph, magnetic resonance imaging (MRI), ultrasound, low-dose CT scan, bone scans, positron emission tomography (PET), and biopsy is hindered due to one or more problems, such as phenotypic properties of tumours that prevent early detection, invasiveness, expensiveness, and time consumption. Detection of lung cancer biomarkers using a biosensor is reported to solve the problems. Among biosensors, optical biosensors attract greater attention due to being ultra-sensi…
Historical Landscape Ecology of the Favorita Park in Palermo (Sicily)
2021
Historical Landscape Ecology of the Favorita Park in Palermo
Structural Discrimination in Physical Education. The “Encounter” Between the (White) Norwegian Teaching Content in Physical Education Lessons and Fem…
2021
Background: Throughout society, including in the field of sports and physical education (PE), there are extensive debates on racism and structural racism. Researchers have found that students of color experience racial stereotyping and discrimination in PE. Studies also show that PE teaching practices reflect a masculine culture, emphasizing traditional (Western) competitive male sports and physical fitness practices, while marginalizing female students of color. Simultaneously these students also negotiate, resist, and operate as visible agents within these practices. While previous research has tended toward focusing on the experiences (of discrimination) from the perspective of students …
Developmental profiles of reading fluency and reading comprehension from grades 1 to 9 and their early identification.
2021
This study examined developmental profiles of reading fluency and reading comprehension in Grades 1 to 9 (ages 7 to 15) in a large Finnish sample (N = 2,518). In addition, early predictors of the profiles were analyzed with respect to kindergarten cognitive skills (phonological awareness, letter knowledge, rapid automized naming [RAN], number counting, word reading, vocabulary, and listening comprehension), parental factors (level of education, reading difficulties), and gender. Four different profiles of reading fluency and reading comprehension development were identified using latent profile analysis. These comprised one profile with persistent reading difficulties across the grades, one…
Vitom® 3D in arterio-venous fistulas: Single centre preliminary surgical experience
2021
Background: Arteriovenous fistula (AVF) is the vascular access of choice for hemodialysis patients. A correct microsurgical vascular anastomoses is essential to the optimal care of patients. Loupes can help surgeons perform such procedures, but often cause neck or back pain and fatigue. Aim: This study aimed to evaluate whether a video telescopic operating microscope (VITOM®; Karl Storz Endoscopy GmbH, Tuttlingen, Germany) could be used as a substitute for loupes to create microsurgical vascular anastomoses. Methods: We evaluated microsurgical anastomoses with VITOM® in 10 patients (6 male, 4 female) from January 2019 to December 2019. The created anastomoses were 7 side-to-side, 2 side-to-…
COVID-19 Confinement and Health Risk Behaviors in Spain
2021
The World Health Organization (WHO) has declared a world pandemic due to COVID-19. In response, most affected countries have enacted measures involving compulsory confinement and restrictions on free movement, which likely influence citizens' lifestyles. This study investigates changes in health risk behaviors (HRBs) with duration of confinement. An online cross-sectional survey served to collect data about the Spanish adult population regarding health behaviors during the first 3 weeks of confinement. A large sample of participants (
Stendi il lembo del tuo mantello sulla tua serva (Rut 3, 1-18)
2021
Contributo all'interno della Bibbia dell'Amicizia, commenti scritti da ebrei e cristiani. Partendo dai riferimenti all'originale ebraico di alcuni passi del libro di Rut si elabora una riflessione sul significato di elementi testuali ponendoli in relazione con esegesi filosofiche dell'ebraismo medievale.
A non-linear Ritz method for the analysis of low velocity impact induced dynamics in variable angle tow composite laminates
2021
Abstract Variable angle tow (VAT) laminates feature composite layers reinforced by fibres following continuous curved paths and offer a wide structural design space for the manufacturing of composite components. In this work, a formulation for the analysis of the impact-induced dynamics in VAT laminated plates is proposed, implemented and tested in this work. The method is based on the adoption of first order shear deformation kinematics and includes von Karman non-linear strains. The discrete system is obtained by employing a pb-2 Ritz series expansion into the Hamilton’s variational statement, while the impact loading is modelled through Hertzian contact law. The resulting non-linear gove…
Erwiderung auf den Leserbrief zum Beitrag „Neue Therapieoption für akute hepatische Porphyrien“
2021
Effects of a mobile disturbance pattern on dynamic patch networks and metapopulation persistence
2021
Abstract Motivation Certain early-succession habitats may emerge only at restricted locations following disturbance. Therefore, whether disturbances tend to occur at certain sites or not can significantly affect habitat availability and metapopulation persistence of early-successional habitat specialists. Available models that combine metapopulation and landscape processes do not address how to model mobile, spatially shifting disturbance intensities independent of factors of site suitability. We present a model that allows the study on how a mobile disturbance pattern, of either natural or anthropogenic origin, affects patch network and metapopulation dynamics in realistic, heterogeneous l…
Confirmation of gA quenching using the revised spectrum-shape method for the analysis of the 113Cd β-decay as measured with the COBRA demonstrator
2021
In this article we present an updated spectrum-shape analysis of the $^{113}$Cd fourfold forbidden non-unique $\beta$-decay transition in order to address the quenching of the weak axial-vector coupling $g_{\rm A}$ in low-momentum exchange nuclear processes. The experimental data were collected in a dedicated low-threshold run with the COBRA demonstrator at the LNGS and resulted in 44 individual $^{113}$Cd spectra. These data are evaluated in the context of three nuclear model frameworks based on a revised version of the spectrum-shape method and the conserved vector current hypothesis. The novel idea devised in the present work is to fit the value of the small relativistic nuclear matrix e…
Efficacy of Immune Checkpoint Inhibitors Alone or in Combination With Chemotherapy in NSCLC Harboring ERBB2 Mutations
2021
Abstract Introduction In contrast to other driver mutations, no targeted therapies have yet been approved in ERBB2-mutated NSCLC (HER2mu NSCLC). Nevertheless, several compounds have revealed promising early efficacy data, which need to be evaluated in the context of current standard approaches. Although data on the efficacy of immune checkpoint inhibitors (ICIs) in second or subsequent lines of treatment remain limited and conflicting, there are virtually no data on patient outcome under ICI/platinum-doublet combinations in the first-line setting. Methods We retrospectively evaluated outcomes of patients with HER2mu NSCLC treated with ICI alone or in combination with chemotherapy within the…
Effect of self-regulatory behaviour change techniques and predictors of physical activity maintenance in cancer survivors: a 12-month follow-up of th…
2021
Abstract Background Current knowledge about the promotion of long-term physical activity (PA) maintenance in cancer survivors is limited. The aims of this study were to 1) determine the effect of self-regulatory BCTs on long-term PA maintenance, and 2) identify predictors of long-term PA maintenance in cancer survivors 12 months after participating in a six-month exercise intervention during cancer treatment. Methods In a multicentre study with a 2 × 2 factorial design, the Phys-Can RCT, 577 participants with curable breast, colorectal or prostate cancer and starting their cancer treatment, were randomized to high intensity exercise with or without self-regulatory behaviour change technique…
#EEGManyLabs
2021
There is growing awareness across the neuroscience community that the replicability of findings about the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by recent efforts from the psychological sciences, and with the desire to examine some of the foundational findings using electroencephalog-raphy (EEG), we have launched #EEGManyLabs, a large-scale international collaborative replication effort. Since its discovery in the early 20th century, EEG has had a profound in-fluence on our understanding of human cognition, but there is limited evid…
Multistep Crystallization Pathways in the Ambient‐Temperature Synthesis of a New Alkali‐Activated Binder
2021
Wind gust estimation for precise quasi-hovering control of quadrotor aircraft
2021
Abstract This paper focuses on the control of quadrotor vehicles without wind sensors that are required to accurately track low-speed trajectories in the presence of moderate yet unknown wind gusts. By modeling the wind disturbance as exogenous inputs, and assuming that compensation of its effects can be achieved through quasi-static vehicle motions, this paper proposes an innovative estimation and control scheme comprising a linear dynamic filter for the estimation of such unknown inputs and requiring only position and attitude information. The filter is built upon results from Unknown Input Observer theory and allows estimation of wind and vehicle state without measurement of the wind its…
An Insight into the Role of Postmortem Immunohistochemistry in the Comprehension of the Inflammatory Pathophysiology of COVID-19 Disease and Vaccine-…
2021
On 11 March 2020, the World Health Organization (WHO) declared a pandemic due to the spread of COVID-19 from Wuhan, China, causing high mortality rates all over the world. The related disease, which mainly affects the lungs, is responsible for the onset of Diffuse Alveolar Damage (DAD) and a hypercoagulability state, frequently leading to Severe Acute Respiratory Syndrome (SARS) and multiorgan failure, particularly in old and severe-critically ill patients. In order to find effective therapeutic strategies, many efforts have been made aiming to shed light on the pathophysiology of COVID-19 disease. Moreover, following the late advent of vaccination campaigns, the need for the comprehension …
Les usages de l’ekphrasis. Introduction
2021
Le terme ekphrasis peut recouvrir des sens différents, dépendant en particulier du champ d’études au sein duquel ce procédé est envisagé. Dès lors, avant d’entrer dans le cœur de ce dossier, il nous a semblé opportun de préciser au lecteur notre propos et de définir ce que nous entendions ici par « ekphrasis ». Nous clôturerons cette exploration du terme par une brève présentation des différentes contributions regroupées dans ce volume. Comment définir l’ekphrasis ? Puisque nous parlions d’a...
Adaptation and Validation of the Spanish Version of the Instrument to Evaluate Nurses’ Attitudes Toward Communication With the Patient for Nursing St…
2021
Communication is essential to quality of care and patient satisfaction. It has been linked to positive patient outcomes, increased engagement, improved health outcomes and safe practices. Given these benefits and the association between attitudes and behaviours, as behaviours can be predicted by studying attitudes, assessing nursing students' attitudes toward patient communication is critical as future nursing professionals. For this purpose, the main aim of this study was to adapt and validate an instrument to measure nurses´ attitudes towards communication (ACO) for nursing students. The attitudes towards communication with patients were analyzed. Then, differences in the dimensions of th…
Stent oversizing or not-oversizing? An unresolved dilemma
2021
Primary PCI plus stent implantation is indicated for treatment of acute coronary syndrome. Technically, due to the difference in lumen diameter between vessel portions and stent size in some coronary arteries, post-expansion of the stent is usually necessary to match proximal reference diameter and optimize stent apposition. Incomplete stent apposition has been associated with increased risk of in stent restenosis (ISR) and stent thrombosis (1) despite new stent technologies have largely reduced this risk (2-3). Although new antiplatelet drugs showed a more rapid onset of action and a stronger effect (4-5), stent apposition remains an important risk factor for stent thrombosis. As stent pos…
Phenotype associated with TAF2 biallelic mutations: a clinical description of four individuals and review of the literature
2021
International audience; Transcription factor IID is a multimeric protein complex that is essential for the initiation of transcription by RNA polymerase II. One of its critical components, the TATA-binding protein-associated factor 2, is encoded by the gene TAF2. Pathogenic variants of this gene have been shown to be responsible for the Mental retardation, autosomal recessive 40 syndrome. This syndrome is characterized by severe intellectual disability, postnatal microcephaly, pyramidal signs and thin corpus callosum. Until now, only three families have been reported separately. Here we report four individuals, from two unrelated families, who present with severe intellectual disability and…
Design framework and principles for learning environment co-design: Synthesis from literature and three empirical studies
2021
Funding Information: The research was funded by the Finnish Funding Agency for Technology and Innovation through the Indoor Environment Program (2011?2014), the Finnish Cultural Foundation?s Central Finland Regional Fund (2013?2018), and the Finnish Foundation for Municipal Development (2020?22). Funding Information: Funding: The research was funded by the Finnish Funding Agency for Technology and Innovation through the Indoor Environment Program (2011–2014), the Finnish Cultural Foundation’s Central Finland Regional Fund (2013–2018), and the Finnish Foundation for Municipal Development (2020–22). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. The need for en…
Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine
2021
Abstract Collagen is one of the most important biomaterials for tissue engineering approaches. Despite its excellent biocompatibility, it shows the non-negligible disadvantage of poor mechanical stability. Photochemical crosslinking with rose bengal and green light (RGX) is an appropriate method to improve this property. The development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated substances. In this study, we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior and mechanical behavior in micro tensile tests to obtain information on its wearin…
Paleolimnological evidence of environmental changes in seven subtropical reservoirs based on metals, nutrients, and sedimentation rates
2021
Made available in DSpace on 2022-04-28T19:40:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01 Paleolimnological research can shed light on a broad range of environmental concerns; however, such studies are scarce in reservoirs. To address this lack of knowledge, a paleolimnological investigation was conducted to determine historical changes in sedimentation rates (SR), using 210Pb geochronology, and concentrations of nutrients and metals (Cr, Cu, Ni, Pb, Zn, Al, Mn, Fe) in seven subtropical reservoirs (São Paulo, Brazil). Sediment cores were collected in the dam areas. Increasing SR was observed in all reservoirs and was mainly attributed to eutrophication and changes in land…
Degree of conversion and microhardness of resin cements photoactivated through glass ceramic
2021
Background To assess whether glass-ceramic shade, thickness and translucency affect degree of conversion (DC) and Knoop microhardness (KHN) of resin cements photoactivated using light-emitting diode (LED) or quartz-tungsten-halogen (QTH) units. Material and Methods Glass-ceramic blocks were cut (2, 3 and 4mm) and sintered. For DC FT Raman spectroscopy (n=3), film specimens of cements (RelyX ARC, U200, Veneer, C&B) were obtained. For KHN test (n=3), cements were inserted in cylindrical matrix and covered by polyester strip. Specimens were photoactivated (30s) using LED or QTH according to each group: direct photoactivation (DP), interposing ceramic specimens or no photoactivation (NP). Data …
Hypofractionated Radiotherapy in Head and Neck Cancer Elderly Patients: A Feasibility and Safety Systematic Review for the Clinician
2021
ObjectiveRadiotherapy (RT) in the head and neck (H&N) site are undoubtedly the most challenging treatments for patients. Older and frail patients are not always able to tolerate it, and there are still no clear guidelines on the type of treatments to be preferred for them. The recommendations for Risk-Adapted H&N Cancer Radiation Therapy during the coronavirus disease 2019 (COVID-19) pandemic provided by the ASTRO-ESTRO consensus statement achieved a strong agreement about hypofractionated RT (HFRT). A systematic literature review was conducted in order to evaluate the feasibility and safety of HFRT for older patients affected by H&N malignancies.Materials and Method…
Jet propagation through inhomogeneous media and shock ionization
2021
In this contribution we present the first numerical simulations of a relativistic outflow propagating through the inner hundreds of parsecs of its host galaxy, including atomic and ionised hydrogen, and the cooling effects of ionisation. Our results are preliminary, but we observe efficient shock ionization of atomic hydrogen in interstellar clouds. The mean density of the interstellar medium in these initial simulations is lower than that expected in typical galaxies, which makes cooling times longer and thus no recombination is observed inside the shocked region. The velocities achieved by the shocked gas in the simulations are in agreement with observational results, although with a wide…
Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis
2021
Abstract Aims Cardiac resynchronization therapy (CRT) is highly effective in dilated cardiomyopathy (DCM) patients with impaired left ventricular ejection fraction (LVEF) and left bundle block branch. In cardiac amyloidosis (CA) patients, left ventricular dysfunction and conduction defects are common, but the potential of CRT to improve cardiac remodelling and survival in this particular setting remains undefined. We investigated cardiovascular outcomes in CA patients after CRT implantation in terms of CRT echocardiographic response and major cardiovascular events (MACEs). Methods and results Our retrospective study included 47 CA patients implanted with CRT devices from January 2012 to Feb…
Gastrointestinal tumors: Phytochemical and drug combinations targeting the hallmarks of cancer
2021
Cancer is a worldwide burden resulting in millions of deaths each year. In particular, gastrointestinal tumors are life-threatening malignancies and one of the leading reasons for death in developed countries. Phytochemicals can be found in grains, vegetables, fruits and several foods. Many phytochemicals, such as curcumin, genistein, luteolin, vitexin-2-O-xyloside, avenanthramides, quercetin, epigallocatechin-3-gallate (EGCG), resveratrol, sulforaphane, piperine and thymoquinone have been used in combination with different chemotherapeutic agents for their synergistic anticancer effects against various forms of cancer. In this review, we describe the antitumor properties and biological eff…
An Original Risk Score to Predict Early Major Bleeding in Acute Pulmonary Embolism
2021
Background Improved prediction of the risk of early major bleeding in pulmonary embolism (PE) is needed to optimize acute management. Research Question Does a simple scoring system predict early major bleeding in acute PE patients, identifying patients with either high or low probability of early major bleeding? Study Design and Methods From a multicenter prospective registry including 2,754 patients, we performed post hoc multivariable logistic regression analysis to build a risk score to predict early (up to hospital discharge) major bleeding events. We validated the endpoint model internally, using bootstrapping in the derivation dataset by sampling with replacement for 500 iterations. P…
Investigation of absorber and heterojunction in the pure sulphide kesterite
2021
This paper aims to study the properties of the absorber layer and the heterojunction in kesterite solar cells. The Cu2ZnSnS4 (CZTS) thin films were layered on a glass substrate from a colloidal solution of metal salts and thiourea dissolved in a mixture of water and ethanol and deposited by spin coating technique. The samples were then heat treated in a furnace, in the presence of sulphur powder and under a nitrogen gas flow. The results revealed the formation of homogeneous layers of a pure kesterite phase of CZTS crystallites after heat treatment with correct stoichiometry and oxidation states. The optical transmission measurements indicate an energy band-gap of 1.4 eV and an absorption c…
Exploratory study of the hoaxes spread via WhatsApp in Spain to prevent and/or cure COVID-19
2021
Objective: To review the hoaxes’ characteristics spread through WhatsApp in Spain during COVID-19 lockdown and identify what kind of substances were promoted for consumption or application. Method: A phone number was activated to receive hoaxes via WhatsApp. A total of 2353 messages were collected, and among those 584 different hoaxes were identified and validated, between March 18 and April 18, 2020. From these 584 hoaxes, a sub-sample of 126 was selected, exclusively related to the object of study, and a content analysis table with fourteen registration fields was applied. Besides, the averages and medians of the quantitative fields were extracted. Results: Most of the messages received w…
High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glyc…
2021
Upon infection withMycobacterium tuberculosis(Mtb) the host immune response might clear the bacteria, control its growth leading to latent tuberculosis (LTB), or fail to control its growth resulting in active TB (ATB). There is however no clear understanding of the features underlying a more or less effective response. Mtb glycolipids are abundant in the bacterial cell envelope and modulate the immune response to Mtb, but the patterns of response to glycolipids are still underexplored. To identify the CD45+leukocyte activation landscape induced by Mtb glycolipids in peripheral blood of ATB and LTB, we performed a detailed assessment of the immune response of PBMCs to the Mtb glycolipids lip…
Effective Management of Severe Asthma with Biologic Medications in Adult Patients: A Literature Review and International Expert Opinion
2021
International audience; Severe asthma often remains uncontrolled despite effective treatments and evidence-based guidelines. A group of global experts in asthma and biologic medications from nine countries considered the most relevant clinical variables to manage severe asthma in adult patients and guide treatment choice. The resulting recommendations address the investigation of biomarker levels (blood eosinophil count along with fractional concentration of exhaled nitric oxide [FeNO]), clinical features (oral corticosteroid [OCS] dependency, specific comorbid disease entities associated with severe type 2 asthma), and safety considerations. Current evidence suggests that biomarkers, inclu…