showing 36 of ~574560 from 574555 documents
Chemotherapy-Induced Neuropathy and Diabetes: A Scoping Review
2021
Although cancer and diabetes are common diseases, the relationship between diabetes, neuropathy and the risk of developing peripheral sensory neuropathy while or after receiving chemotherapy is uncertain. In this review, we highlight the effects of chemotherapy on the onset or progression of neuropathy in diabetic patients. We searched the literature in Medline and Scopus, covering all entries until 31 January 2021. The inclusion and exclusion criteria were: (1) original article (2) full text published in English or Spanish; (3) neuropathy was specifically assessed (4) the authors separately analyzed the outcomes in diabetic patients. A total of 259 papers were retrieved. Finally, eight art…
Immune-Mediated Desquamative Gingivitis and Optical Coherence Tomography Diagnostic Patterns: Clinical Implication from a Systematic Review
2021
Desquamative Gingivitis (DG) comprises heterogeneous clinical manifestations of numerous immune-mediated muco-cutaneous diseases. Optical Coherence Tomography (OCT) has been proposed as a valuable diagnostic support even if, to date, there are no standardized OCT-diagnostic patterns applicable to DGs. A systematic review was performed to detect existing data on in vivo OCT diagnostic patterns of the most common immune-mediated DGs (i.e., pemphigus vulgaris, mucous membrane pemphigoid and oral lichen planus). It has been found that OCT exhibits specific patterns that address the diagnosis of DG by pemphigus vulgaris (i.e., intraepithelial unilocular blister, reduced epithelial thickness, pre…
La declaración del estado de emergencia frente a las epidemias en la República romana
2021
espanolResumen El articulo tiene por objeto el estudio a traves de la historiografia clasica de las medidas extraordinarias adoptadas en la Republica romana en situaciones de epidemia, con especial referencia a dos instrumentos juridico-religiosos ordenados a aplacar la colera divina: el lectisternium y la dictadura clavi figendi causa. EnglishAbstract The paper aims at the study through the classical sources the extraordinary measures taken in the roman republic in the case of epidemic, paying special attention to some legal-religious actions in order to soften the divine rage: the lectisternium and the dictatura clavi figendi causa.
An interaction orientation approach to SME-Intermediaries relationships
2021
Abstract Small and medium-sized enterprises (SMEs) engaging in foreign operations have drawn significant research attention in recent years. One of the aspects linked to such operations is SMEs’ expansion to foreign markets, often relying on local intermediaries. These intermediaries provide the firms with valuable resources such as market knowledge and recognition and reduce foreign operations’ costs. Hence, they are often considered as strategic partners. The current study aims to expand the existing knowledge regarding the relationships between business to business SMEs and their intermediaries by exploring interaction orientation as an organizational cultural aspect and its linkage to t…
Romania’s SMEs on the Way to EU’s Twin Transition to Digitalization and Sustainability
2021
Abstract European Commission’s six priorities for 2019-2024 are all in line with and leverage each other to support Europe’s twin transition to digitalization and sustainability; aiming to address the challenges posed by the COVID-19 pandemic, The Recovery Plan for Europe adds resilience as key dimension of EU’s progress, while reinforcing its commitment to the green and digital transformation. Counting for more than 99% of the enterprises, employing about two of three people, and generating more than a half of the value added - with similar weights as concerns Romania - EU’s SMEs are the engine of Europe's economy, therefore essential contributors to these transformative processes - as emp…
Follow‐up of patients subjected to direct and indirect pulp capping of young permanent teeth. A retrospective study
2021
Abstract Objective A retrospective study of the success rate of direct pulp capping (DPC) and indirect pulp capping (IPC) was carried out in children between 6–14 years‐old, considering separately primary caries or caries affecting teeth with molar incisor hypomineralization (MIH). Material and methods Data were collected in a dental public health service. Following the inclusion criteria, 232 treatments were analyzed. Success was defined by the presence of a functional tooth without clinical signs or symptoms of pulpal or periapical disease. The success rate was correlated to patient gender, the affected tooth and the indication of therapy using the chi‐squared and Fisher exact test. The s…
false
2021
Abstract The use of the internet and social media have changed consumer behavior and the ways in which companies conduct their business. Social and digital marketing offers significant opportunities to organizations through lower costs, improved brand awareness and increased sales. However, significant challenges exist from negative electronic word-of-mouth as well as intrusive and irritating online brand presence. This article brings together the collective insight from several leading experts on issues relating to digital and social media marketing. The experts’ perspectives offer a detailed narrative on key aspects of this important topic as well as perspectives on more specific issues i…
Who’s afraid of Mihai Iovănel? Regimes of Relevance and New Literary Historiography
2021
The present article addresses Mihai Iovănel’s recently published History of Contemporary Romanian Literature: 1990-2020 while pursuing a series of similarities with other contributions to postcommunist national literatures in the Central and Eastern European cultural space, on the one hand, and with previous ways of understanding the concept of literary history, on the other. The article argues that Iovănel’s History is one of the first to assess the importance of the social in the production, study, and national, as well as transnational dissemination of Romanian literature, an emphasis without which the study of literary phenomena risks falling into the blindness of aesthetic autonomy, wh…
SMART CONTRACTS E TECNOLOGIE BASATE SU REGISTRI DISTRIBUITI NELLA L. 12/2019
2021
The essay addresses the issue of the regulation of smart contracts and technologies based on distributed ledgers, as regulated by the national law 12/2019. It highlights some critical issues related to the formulation and understanding of these concepts, definitely relevant for scholars but, at the same time, very complex in their understanding, giving the multidisciplinary implications they are related to. Finally, the essay addresses the two different approaches in the matter, the European and the national one, and underlines the necessity of a more uniform perspective, also in consideration of the missing guidelines by the Agenzia per l’Italia digitale (AgID).
The Ninevite 5 pottery assemblage of Phase A25 from the extra-mural dwellings and the kiln. In P. Pfaelzner and A. H. Hasim "From Akkadian Maridaban …
2021
The focus of the 2018 and 2019 excavations at Bassetki was on investigating the beginning of the city in the Ninevite 5 period, its importance in the Akkadian and Old Babylonian periods, and its function as a governor’s seat in Middle Assyrian times. Thus, the main stages of the urban development of Maridaban/Mardaman/Mardama can be traced, which are also documented textually. Der Fokus der Ausgrabungen 2018 und 2019 in Bassetki lag auf der Untersuchung des Beginns der Stadtanlage in der Ninive 5-Periode, ihrer Bedeutung in der Akkad- und der Altbabylonischen Zeit sowie ihrer Funktion als Statthaltersitz in Mittelassyrischer Zeit. Damit können die wesentlichen Etappen der Stadtentwicklung v…
Core-shell PLA/Kef hybrid scaffolds for skin tissue engineering applications prepared by direct kefiran coating on PLA electrospun fibers optimized v…
2021
Abstract Over the recent years, there is a growing interest in electrospun hybrid scaffolds composed of synthetic and natural polymers that can support cell attachment and proliferation. In this work, the physical and biological properties of polylactic acid (PLA) electrospun mats coated with kefiran (Kef) were evaluated. Gravimetric, spectroscopic (FTIR-ATR) and morphological investigations via scanning electron microscopy confirmed the effective formation of a thin kefiran layer wrapped on the PLA fibers with an easy-tunable thickness. Air plasma pre-treatment carried out on PLA (P-PLA) affected both the morphology and the crystallinity of Kef coating as confirmed by differential scanning…
Salud sexual de los menores y jóvenes del sistema de protección y en conflicto con la ley
2021
La literatura existente centrada en el estudio de la salud sexual de los/as niños/as y adolescentes, ha reportado resultados heterogéneos que varían en función de las experiencias vitales y de la historia sexual. Los/as niños/as y adolescentes del sistema de protección, a diferencia de los/as jóvenes en conflicto con la ley o de la población general, han sido retirados de sus hogares por sufrir abusos físicos o sexuales, entre otras razones. La vivencia de este tipo de sucesos en la infancia se ha vinculado con una serie de conductas disruptivas, entre las que destacan las conductas sexuales problemáticas. A pesar de ello, tanto los/as niños/as y adolescentes del sistema de protección como …
Enuresis. Miremos al futuro. ¿Qué conceptos son útiles?
2021
Gut-microbiota-derived extracellular vesicles: Overlooked mediators in host–helminth interactions?
2021
Helminth infections impact the composition of the mammalian gut microbiota; however, the mechanisms underpinning these interactions are, thus far, unknown. In this article, we propose that microbiota-derived extracellular vesicles might represent key players in host-helminth-microbiome crosstalk, and outline future directions to elucidate their role(s) in host-parasite relationships.
Archaeometric analysis of building ceramics and ‘dolia defossa’ from the Roman Imperial estate of Vagnari (Gravina in Puglia, Italy)
2021
Abstract This paper concerns the archaeometric analysis of ceramic finds dating to the Roman Imperial period, brought to light during the excavation campaigns conducted at Vagnari (Puglia) in south-east Italy. On the site of the central village (vicus) of this imperial estate, established by the Roman Emperor in the early 1st century CE, large dolia (wine vats) sunk into the floor of a winery of the 2nd century CE recently were brought to light. Other discoveries include kilns for the production of ceramic roof tiles and also kiln wasters such as misfired tiles. The purpose of the analytical approach was therefore twofold: 1) to establish the composition of local ceramic products and of raw…
Second language comprehensibility and accentedness across oral proficiency levels : A comparison of two L1s
2021
Second language comprehensibility and accentedness are highly complex phenomena, and numerous studies have been conducted to better understand these constructs. However, research has seldom addressed L2 comprehensibility and accentedness in relation to speakers' proficiency in the target language. This study explores L2 English comprehensibility and accentedness across three proficiency levels. The speakers were 60 teenaged Finns, half of them speaking Finnish as their L1 and half speaking Finland-Swedish as their L1. Using 20-s speech samples, the comprehensibility and accentedness of the speakers were rated by 34 English-speaking teenagers on a 9-point scale. Comparisons were made regardi…
Preemptive analgesia in dental implant surgery: A systematic review and meta-analysis of randomized controlled trials
2021
Background To assess the effectiveness of preemptive analgesia in dental implant surgery in randomized controlled trials (RCTs). Material and Methods The present study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and registered in PROSPERO database CRD42020168757. A search without restrictions regarding language or date of publication was conducted in six databases and gray literature. A random effect meta-analysis compared the efficacy of preemptive analgesia compared to placebo through pooled OR and 95%CI. The interpretation of results followed the certainty of evidence using the Grading of Rec…
Corona-Komposita und ‚Corona‘-Konzepte in der Medienberichterstattung in Standardsprache und in Leichter Sprache
2021
Abstract First linguistic studies have paid attention to the influence of the current corona pandemic on language use in the German media coverage. They have revealed, amongst other things, that compounds beginning with corona are very productive and frequent. Against this background, the questions arise how frequent these compounds de facto are, what their morphological and graphematic characteristics look like, which second constituents can be observed, which semantic relations between the constituents exist and what their referents are. However, not only people being able to read texts in standard language need information concerning the pandemic; individuals lacking this capacity also n…
Operaționalizarea experimentului în critica literară românească
2021
This study has a two-fold structure, in its first part exploring various models of experimental literature, proposed by researchers such as Gerald Prince and Warren Motte, as well as theoretical attempts to define and analyze experimental literature in Romania. The second part focuses on the quantitative analysis of keywords related to “the experimental” found in literary histories of Romanian literature authored by E. Lovinescu, G. Călinescu, Nicolae Manolescu, and Mihai Iovănel, as well as The General Dictionary of Romanian Literature and The Chronological Dictionary of the Romanian Novel. By simply searching several pointedly chosen terms in the corpus, a cartography of what is considere…
Ni-Fe alloy nanostructured electrodes for water splitting in alkaline electrolyser
2021
Abstract In this work, nickel-iron alloy nanostructured electrodes obtained by template electrosynthesis method are investigated for both hydrogen and oxygen evolution reactions. Electrodes consist of nanowire arrays with high surface area that are able to ensures a high electrolytic activity. To obtain different alloy compositions, the concentration of the elements in the deposition baths is appropriately tuned. Results show that the composition of nanowires does not change linearly with the composition of deposition bath but are richer in Fe. Nanostructured electrodes are tested as both cathodes and anodes in 30 wt% KOH aqueous solution, at room temperature to determine the best alloy com…
Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea…
2021
Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (n = 4,853, mean age +/- SD 54.8 +/- 11.8 years, 26.1% females), at baseline and at the first visit (median follow-up: 5 months, interquartile range 3-13). An ESS > 10 occurred in 56% of patients at baseline and in 28.2% of patients at follow-up. Residual EDS was analyzed in 2,190 patients (age: 55.1 +/- 12…
Heterogeneity of traditional and digital media use among older adults: A six-country comparison
2021
Abstract The concept of aged heterogeneity has been associated with older adults' ability to adapt to the digital age without a systematic empirical analysis. We analyse retired adults' (aged 62 or more) use of traditional media and their digital equivalents in six countries. First, we ask whether heterogeneity in traditional and digital media use increases with age. Second, we study to what extent gender is related to this heterogeneity, and third, the country differences in the heterogeneity of media use in later life. We analyse the 2018 data (N = 5865) of the ‘Older audiences in the digital media environment’ survey using zero-inflated negative binomial models. The results provide parti…
Neue Therapieoption für akute hepatische Porphyrien
2021
Was ist neu? Therapie mit Givosiran Givosiran ist ein kleines synthetisches doppelsträngiges siRNA-Fragment mit 20 Basenpaaren Länge. Eine prospektive, randomisierte multizentrische Studie (Envision) zeigte erstmalig die klinische Wirksamkeit von monatlich subkutan applizierten synthetischen RNA-Molekülen („small interfering“ RNA, siRNA) zur Prävention von Attacken bei akuten hepatischen Porphyrien (AHP) 2. Die Koppelung von siRNA-Molekülen an N-Acetyl-Galaktosamin (GalNAc) und die hierdurch leberspezifische Aufnahme durch den Asialoglykoprotein-Rezeptor auf Hepatozyten sind ein Meilenstein in der Hepatologie. Dies führt zu einer hochselektiven Inhibition der Translation der bei AHP überexp…
Single crystal-like thin films of blue bronze
2021
Abstract Pulsed laser deposition technique was employed to grow thin films of K 0.3 M o O 3 on A l 2 O 3 (1-102) and S r T i O 3 (510) substrates. Structural and imaging characterization revealed good quality films with well oriented grains of few microns in length. Both non-selective (transport) and order-selective (femtosecond pump-probe spectroscopy) probes revealed charge density wave properties that are very close to those of the single crystals. The films exhibit metal-semiconductor phase transition in resistivity, pump-probe data show phase transition at the same temperature as the single crystal and the threshold for the photo-induced phase transition is approximately the same as in…
The Pion Single-Event Latch-Up Cross Section Enhancement: Mechanisms and Consequences for Accelerator Hardness Assurance
2021
Pions make up a large part of the hadronic environment typical of accelerator mixed fields. Characterizing device cross sections against pions is usually disregarded in favor of tests with protons, whose single-event latch-up (SEL) cross section is, nonetheless, experimentally found to be lower than that of pions for all energies below 250 MeV. While Monte Carlo simulations are capable of reproducing such behavior, the reason for the observed pion cross-section enhancement can only be explained by a deeper analysis of the underlying mechanisms dominating proton–silicon and pion–silicon reactions. The mechanisms dominating the SEL response are found to vary with the energy under consideratio…
Impact of Oral Microbiota on Flavor Perception: From Food Processing to In-Mouth Metabolization.
2021
International audience; Flavor perception during food intake is one of the main drivers of food acceptability and consumption. Recent studies have pointed to the oral microbiota as an important factor modulating flavor perception. This review introduces general characteristics of the oral microbiota, factors potentially influencing its composition, as well as known relationships between oral microbiota and chemosensory perception. We also review diverse evidenced mechanisms enabling the modulation of chemosensory perception by the microbiota. They include modulation of the chemosensory receptors activation by microbial metabolites but also modification of receptors expression. Specific enzy…
false
2021
Abstract Background As virtual reality (VR) has become more accessible, it has increasingly come into focus for clinical application. Therapy with VR shows potential as an engaging, effective, and economic way to improve cognitive abilities following a stroke. Objectives While application of VR in clinical settings appears promising, its widespread use will crucially depend on acceptance of immersive head mounted display virtual reality (HMD-VR) systems when used in different patient groups. This study aimed to investigate acceptance of HMD-VR in stroke patients compared to a control group of healthy age-matched adults. Methods The attitude towards HMD-VR, as one of the most important predi…
Unveiling the Intramolecular Ionic Diels–Alder Reactions within Molecular Electron Density Theory
2021
The intramolecular ionic Diels–Alder (IIDA) reactions of two dieniminiums were studied within the Molecular Electron Density Theory (MEDT) at the ωB97XD/6-311G(d,p) computational level. Topological analysis of the electron localization function (ELF) of dieniminiums showed that their electronic structures can been seen as the sum of those of butadiene and ethaniminium. The superelectrophilic character of dieniminiums accounts for the high intramolecular global electron density transfer taking place from the diene framework to the iminium one at the transition state structures (TSs) of these IIDA reactions, which are classified as the forward electro density flux. The activation enthalpy ass…
Impact of anionic system modification on the desired properties for CuGa(S1−Se )2 solid solutions
2021
Abstract One of promising directions of the modern solar cells’ development is related to the use of the ternary chalcopyrite crystals (CuInS2, CuGaS2 etc.) and their solid solutions as efficient light absorbing layers. Unfortunately, so far there is no systematic research linking chemical composition to useful properties allowing their optimization to increase the efficiency of solar cells. Therefore, we report the results of the detailed theoretical studies of the structural, electronic, and optical properties for the series of CuGa(S1−xSex)2 solid solutions (x = 0, 0.25, 0.5, 0.75, 1) in the framework of the density functional theory. For this purpose, crystal structures are analyzed wit…
Setting the future of digital and social media marketing research: Perspectives and research propositions
2021
in press The use of the internet and social media have changed consumer behavior and the ways in which companies conduct their business. Social and digital marketing offers significant opportunities to organizations through lower costs, improved brand awareness and increased sales. However, significant challenges exist from negative electronic word-of-mouth as well as intrusive and irritating online brand presence. This article brings together the collective insight from several leading experts on issues relating to digital and social media marketing. The experts' perspectives offer a detailed narrative on key aspects of this important topic as well as perspectives on more specific issues i…
Rodent host population dynamics drive zoonotic Lyme Borreliosis and Orthohantavirus infections in humans in Northern Europe
2021
Zoonotic diseases, caused by pathogens transmitted between other vertebrate animals and humans, pose a major risk to human health. Rodents are important reservoir hosts for many zoonotic pathogens, and rodent population dynamics affect the infection dynamics of rodent-borne diseases, such as diseases caused by hantaviruses. However, the role of rodent population dynamics in determining the infection dynamics of rodent-associated tick-borne diseases, such as Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato bacteria, have gained limited attention in Northern Europe, despite the multiannual abundance fluctuations, the so-called vole cycles, that characterise rodent population d…
Somatic symptoms in the Eastern and Western states of Germany 30 years after unification: Population-based survey analyses.
2021
Background Following German reunification, physical health indicators in the formerly separated states (German Democratic Republic- East/ Federal Republic of Germany-West) have converged. However, it remains unclear how these societal changes have impacted somatic complaints, a major indicator of physical and mental health. Therefore, we investigated how somatic symptom reporting in men and women evolved regarding residency. Methods We administered cross-sectional surveys representative of the German population with comparable sample size in 1994 (N = 3047), 2001 (N = 2050), 2013 (N = 2508) and 2019 (N = 2531) following random route procedure. Men and women aged 14-99 reported demographics …
Performative Control and Rhetoric in Aotearoa New Zealand’s Response to COVID-19
2021
This article analyses how specific nodal points of performative control developed and consequently structured the discourse on Aotearoa New Zealand’s response to the COVID-19 pandemic. It identifies these points by adopting a rhetorical-performative approach to uncover three particular performances of control that articulated the pandemic in Aotearoa New Zealand, from the diagnosis of the first COVID-19 case in the country in February 2020 through to October 2020. This period of analysis covers the emergence, subsequent nationwide lockdown, elimination, and re-emergence of the virus. There are three distinct nodal points that unfold as key to the nation’s ability to control COVID-19: the he…
PROBLEMS OF DIFFERENTIAL DIAGNOSIS IN PALEOPATHOLOGY
2021
This work discusses on the problems of the differential diagnosis in paleopathology, describing one case of intense modification observed in a skeletal sample from the archaelogical site of Baucina (Sicily, VI century BCE). Difficulties in this setting originate mainly from the aspecificity or absence of pathological markers on ancient bones and confounding features arising from clinical phenocopies or taphonomic artifacts. On the base of an in-depth morphological analysis of the find, with aid of CT scan imaging and wide revision of the medical and paleopathological literature, we arrived to a convincing diagnosis.
Polarization properties of a fiber optic loop mirror
2021
Abstract In this work, we present the spectral polarization properties of a fiber optic loop mirror (FOLM) which includes a 50/50 coupler and 25-cm long highly birefringent (hi-bi) fiber. The modulation depth of the reflection/transmission spectra can be adjusted by twisting the hi-bi fiber at the splices by means of two azimuth rotators (AR). The results show that the polarization properties of the reflection strongly depends on the angle rotation. We found that it is possible to obtain reflection spectral polarization independence for any modulation depth with the proper parameters. The experimental behavior was confirmed by numerical simulations based on the Jones matrix formulation.
Supported iridium catalysts for the total oxidation of short chain alkanes and their mixtures: Influence of the support
2021
13 figures, 3 tables.-- Supplementary information available.-- © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/