showing 36 of ~574560 from 574555 documents
Higher glucose availability augments the metabolic responses of the C2C12 myotubes to exercise-like electrical pulse stimulation
2021
The application of exercise-like electrical pulse simulation (EL-EPS) has become a widely used exercise mimetic in vitro. EL-EPS produces similar physiological responses as in vivo exercise, while less is known about the detailed metabolic effects. Routinely, the C2C12 myotubes are cultured in high-glucose medium (4.5 g/L), which may alter EL-EPS responses. In this study, we evaluate the metabolic effects of EL-EPS under the high- and low-glucose (1.0 g/L) conditions to understand how substrate availability affects the myotube response to EL-EPS. The C2C12 myotube, media, and cell-free media metabolites were analyzed using untargeted nuclear magnetic resonance (NMR)-based metabolomics. Furt…
Fungal Biofilms as a Valuable Target for the Discovery of Natural Products That Cope with the Resistance of Medically Important Fungi—Latest Findings
2021
The development of new antifungal agents that target biofilms is an urgent need. Natural products, mainly from the plant kingdom, represent an invaluable source of these entities. The present review provides an update (2017–May 2021) on the available information on essential oils, propolis, extracts from plants, algae, lichens and microorganisms, compounds from different natural sources and nanosystems containing natural products with the capacity to in vitro or in vivo modulate fungal biofilms. The search yielded 42 articles; seven involved essential oils, two Brazilian propolis, six plant extracts and one of each, extracts from lichens and algae/cyanobacteria. Twenty articles deal with th…
Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer’s Dis…
2021
Oxidative stress is an early occurrence in the development of Alzheimer’s disease (AD) and one of its proposed etiologic hypotheses. There is sufficient experimental evidence supporting the theory that impaired antioxidant enzymatic activity and increased formation of reactive oxygen species (ROS) take place in this disease. However, the antioxidant treatments fail to stop its advancement. Its multifactorial condition and the diverse toxicological cascades that can be initiated by ROS could possibly explain this failure. Recently, it has been suggested that cerebral small vessel disease (CSVD) contributes to the onset of AD. Oxidative stress is a central hallmark of CSVD and is depicted as …
Magnetic Resonance Imaging of Nonhepatocellular Malignancies in Chronic Liver Disease.
2021
Hepatocellular carcinoma (HCC) is the most common liver malignancy associated with chronic liver disease. Nonhepatocellular malignancies may also arise in the setting of chronic liver disease. The imaging diagnosis of non-HCC malignancies may be challenging. Non-HCC malignancies in patients with chronic liver disease most commonly include intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma, and less commonly hepatic lymphomas and metastases. On MR imaging, non-HCC malignancies often demonstrate a targetoid appearance, manifesting as rim arterial phase hyperenhancement, peripheral washout, central delayed enhancement, and peripheral restricted diffusion. When apply…
Jerzy Kostorz, Zdzisław Pytka, Piotr Bechta (red.). Katechizm dla średnio zaawansowanych. Opole: Wydawnictwo Świętego Krzyża, 2021
2021
.
Who’s afraid of Mihai Iovănel? Regimes of Relevance and New Literary Historiography
2021
The present article addresses Mihai Iovănel’s recently published History of Contemporary Romanian Literature: 1990-2020 while pursuing a series of similarities with other contributions to postcommunist national literatures in the Central and Eastern European cultural space, on the one hand, and with previous ways of understanding the concept of literary history, on the other. The article argues that Iovănel’s History is one of the first to assess the importance of the social in the production, study, and national, as well as transnational dissemination of Romanian literature, an emphasis without which the study of literary phenomena risks falling into the blindness of aesthetic autonomy, wh…
The frequent stressor and mental health monitoring-paradigm: a proposal for the operationalization and measurement of resilience and the identificati…
2021
Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. How to operationalize resilience and to determine the factors and processes that lead to good long-term mental health outcomes in stressor-exposed individuals is a matter of ongoing debate and of critical importance for the advancement of the field. One of the biggest challenges for implementing an outcome-based definition of resilience in longitudinal observational study designs lies in the fact that real-life adversity is usually unpredictable and that its substantial qualitative as well as temporal variability between subjects often precludes defining circumscribed time …
Niko Huttunen, Early Christians Adapting to the Roman Empire. Mutual Recognition, Supplements to Novum Testamentum 179, Leiden-Boston, Brill 2020, 28…
2021
Evidence of quasifission in the 180Hg composite system formed in the 68Zn + 112Sn reaction
2021
Abstract For the 68Zn + 112Sn reaction the Coulomb parameter Z 1 Z 2 is equal to 1500 that is close to the threshold value for the appearance of quasifission process. It was found that mass-energy distributions of the reaction fragments differ significantly from those obtained in the 36Ar + 144Sm reaction leading to the formation of the same composite system of 180Hg at similar excitation energies of about 50 MeV. In the case of the reaction with 68Zn ions, the mass distribution of fissionlike fragments has a wide two-humped shape with maximum yields at 70 and 110 u for the light and heavy fragments, respectively, instead of 80 and 100 u observed in the fission of 180Hg formed in the 36Ar +…
Metagenomic Survey of the Highly Polyphagous Anastrepha ludens Developing in Ancestral and Exotic Hosts Reveals the Lack of a Stable Microbiota in La…
2021
We studied the microbiota of a highly polyphagous insect, Anastrepha ludens (Diptera: Tephritidae), developing in six of its hosts, including two ancestral (Casimiroa edulis and C. greggii), three exotic (Mangifera indica cv. Ataulfo, Prunus persica cv. Criollo, and Citrus x aurantium) and one occasional host (Capsicum pubescens cv. Manzano), that is only used when extreme drought conditions limit fruiting by the common hosts. One of the exotic hosts (“criollo” peach) is rife with polyphenols and the occasional host with capsaicinoids exerting high fitness costs on the larvae. We pursued the following questions: (1) How is the microbial composition of the larval food related to the composit…
Gingivitis
2021
Gingival inflammation is caused by bacterial plaque (dental biofilm) that accumulates daily on the teeth. Results in redness, slight swelling, or "puffiness" of the gums and bleeding on tooth brushing. Treatment involves thorough professional tooth cleaning and effective daily removal of dental plaque by tooth brushing and cleaning between the teeth. Necrotizing gingivitis is a more serious condition that is mainly found in developing countries and is associated with people with severe malnutrition or people living with HIV with low CD4 counts.
Coping strategies in life stories of young adults with foster care backgrounds
2021
Tutkimuksessa tarkasteltiin sijoitettuna olleiden nuorten aikuisten selviytymiskeinoja 18 yksilöhaastattelun avulla. Fenomenologisella analyysilla (IPA; Smith & Osborn, 2003. Interpretative phenomenological analysis. Teoksessa J. A. Smith (toim.), Qualitative Psychology (s. 51–80). Sage) tunnistettiin kolme pääteemaa liittyen selviytymiskeinoihin vastoinkäymisissä ja haasteissa: sisäänpäin suuntautuminen, ulospäin suuntautuminen sekä omiin elinolosuhteisiin vaikuttaminen. Lisäksi tunnistettiin keino, joka oli käytössä vain varhaisaikuisuudessa, hyväksyminen. Tulosten perusteella on tärkeää kuulla sijoitettuna olleita nuoria aikuisia koskien heidän selviytymiskeinojaan sekä lisätä sijaisperh…
Comparing technology acceptance of K‐12 teachers with and without prior experience of learning management systems : A Covid‐19 pandemic study
2021
Covid-19 pandemic has caused a massive transformation in K-12 settings towards online education. It is important to explore the factors that facilitate online teaching technology adoption of teachers during the pandemic. The aim of this study was to compare Learning Management System (LMS) acceptance of Finnish K-12 teachers who have been using a specific LMS as part of their regular teaching before the Covid-19 pandemic (experienced group) and teachers who started using it for emergency remote teaching during the pandemic (inexperienced group). Based on the Unified Theory of Acceptance and Use of Technology framework, a self-report questionnaire was administered to 196 teachers (nexperienc…
Improving the onset potential and Tafel slope determination of earth-abundant water oxidation electrocatalysts
2021
To date, a plethora of electrocatalysts for the Oxygen Evolution Reaction (OER) have been proposed. For evaluating their electrocatalytic behavior the determination of the onset potential in each studied electrolyte is a key parameter. Nevertheless, this evaluation becomes particularly problematic for first- transition metal catalysts as well as by the use of electroactive collectors ( e.g. Ni foams) whose redox peaks overlap the onset potential. A usual solution to detect the onset potential requires the availabil- ity of in-situ mass spectrometric determination of the generated oxygen. In this work, we present fast and easier available cyclic voltammetry and coulovoltammetric responses to…
Predicting the outcome of patients with hepatocellular carcinoma treated with immunotherapy - the CRAFITY score
2021
BEFORE THE EARTHQUAKE: RECONSTRUCTION AND PRESENTATION OF LOST SITES AND BUILDINGS
2021
Abstract. The paper presents the results of a research aiming at proving the efficacy of perspective restitution from photos for the reconstruction of buildings and sites that disappeared in the past century. The case study is the town of Messina, sited at the north-eastern corner of Sicily (Italy), facing the homonymous strait that divides Sicily from the Italian peninsula; in 1908 Messina and Reggio Calabria, at the opposite side of the strait, were levelled to the ground by a powerful earthquake, followed by a tsunami.No building or monument survived the destruction: a new town with the same name took the site of Messina. Except for few strongly reshaped buildings, the memory of the stre…
Loneliness: A Social Problem by Keming Yang (2019)
2021
Sull’importanza di essere estremi : esercizi di utopie praticabili
2021
"Per Fare un Tavolo. Arte e territorio" è un evento ideato da Bianco-Valente e Pasquale Campanella nell'ambito del Padiglione Italia alla 17ª Mostra Internazionale di Architettura della Biennale di Venezia e parte integrante del progetto A Cielo Aperto, le cui attività sono sostenute dall'Associazione Culturale Vincenzo De Luca, nel Comune di Latronico. I contributi presenti nella pubblicazione provengono da personalità afferenti a diversi ambiti disciplinari, sono un approfondimento sulle tematiche delle aree interne e degli sviluppi delle pratiche artistiche legate al territorio, per definire il ruolo "pubblico" dell'arte, degli artisti e delle comunità.
Landscape and fuel management in the context of prehistoric and historical occupations of Cova des Moro (Manacor, Mallorca, Spain)
2021
Abstract In this paper, the first results of charcoal analyses carried out at Cova des Moro (Manacor, Mallorca, Spain) are presented. This cave is an archaeological but also palaeontological site that provides information on endemic fauna (the extinct caprine Myotragus balearicus) before the arrival of humans and, later, the relationship between the first farmers and the landscape. Several human occupations in the cave have been documented, from the Chalcolithic (end of the 3rd millennium cal BC), the Bronze Age (2nd millennium cal BC) and, finally, the Almohad period (13th century AD), during which the cave was used for different purposes. The first results of charcoal analyses at Cova des…
¿El sexismo y la autoestima sexual guardan relación? Análisis de las diferencias de género
2021
Las creencias sexistas se originan ante la percepción de diferencias entre hombres y mujeres respecto a características biológicas y sociales. Se trata de un constructo bidimensional compuesto por el sexismo hostil, que implica actitudes abiertamente negativas hacia las mujeres, y el sexismo benévolo, que se caracteriza por un tono afectivo positivo que idealiza a las mujeres al tiempo que enfatiza su debilidad. Ambos tipos de sexismo son perjudiciales y contribuyen a mantener las desigualdades sociales, por lo que es necesario conocer aquellas variables que pueden estar relacionadas con este tipo de actitudes. En este sentido, la autoestima sexual parece actuar como una variable predictora…
A Multi-Criteria Decision Support System for Strategic Planning at the Swiss Forest Enterprise Level: Coping With Climate Change and Shifting Demands…
2021
Sustainable forest management plays a key role for forest biodiversity and the provisioning of ecosystem services (BES), including the important service of carbon sequestration for climate change mitigation. Forest managers, however, find themselves in the increasingly complex planning situation to balance the often conflicting demands in BES. To cope with this situation, a prototype of a decision support system (DSS) for strategic (long-term) planning at the forest enterprise level was developed in the present project. The DSS was applied at three case study enterprises (CSEs) in Northern Switzerland, two lowland and one higher-elevation enterprise, for a 50-year time horizon (2010 to 2060…
Authentication of berries and berry-based food products.
2021
Abstract Berries represent one of the most important and high-valued group of modern-day health-beneficial “superfoods” whose dietary consumption has been recognized to be beneficial for human health for a long time. In addition to being delicious, berries are rich in nutrients, vitamins, and several bioactive compounds, including carotenoids, flavonoids, phenolic acids, and hydrolysable tannins. However, due to their high value, berries and berry-based products are often subject to fraudulent adulteration, commonly for economical gain, but also unintentionally due to misidentification of species. Deliberate adulteration often comprises the substitution of high-value berries with lower valu…
Control of Power Converters with Hybrid Affine Models and Pulse-Width Modulated Inputs
2021
In this paper, hybrid dynamical systems theory is applied to the analysis and control of switched converters with Pulse-Width Modulated (PWM) inputs. The system is described by a state-space model with continuous flows and discrete jumps, without averaged equations. The modulation effects are captured in full without using time-dependent signals, by enlarging the state vector to include the PWM waveform generation process. Furthermore, the sample-and-hold mechanism associated with the sampling frequency is also taken into account with this approach. A control law is proposed based on a Lyapunov function candidate. Furthermore, convergence sets and the steady state jitter, inherent to PWM-ba…
Shear Capacity Model with Variable Orientation of Concrete Stress Field for RC Beams Strengthened by FRP with Different Inclinations
2021
A design-oriented analytical model able to evaluate the shear capacity of reinforced concrete (RC) beams strengthened with fiber-reinforced polymer (FRP) sheets or strips oriented in any direction is proposed. The formulation of the model is based on the variable-inclination stress-field approach, aiming to extend the provisions of current European standards to beams strengthened in shear using FRP. The main novelty of the model lies in taking into account the possible different inclination of steel stirrup and FRP reinforcement in determining the orientation of a compressed concrete stress field, and in shear strength evaluation, overcoming the approximation of the known models with variab…
Moisture ingress in photovoltaic modules: A review
2021
Abstract Moisture ingress in photovoltaic (PV) modules is the core of most degradation mechanisms that lead to PV module power degradation. Moisture in EVA encapsulant can lead to metal grids corrosion, delamination and discolouration of encapsulants, potential induced degradation, optical and adhesion losses. The present work is a review of literature on the causes, effects, detection, and mitigation techniques of moisture ingress in PV modules. Literature highlights on determining the diffusivity, solubility, and permeability of polymeric components of PV modules via water vapour transmission rate tests, gravimetric, and immersion methods, have been presented. Electroluminescence, photolu…
The Social Exclusion Bench Tool (SEBT): A visual way of assessing interpersonal social exclusion
2021
People usually prefer to appear with an inclusive and positive attitude to others’ eyes. For this reason, the self-report scales assessing social exclusion intentions are often biased by social desirability. In this work, we present an innovative graphical tool, named Social Exclusion Bench Tool (SEBT), for assessing social exclusion not influenced by social desirability. The tool is based on the consistency between social distance and physical distance evaluation. The results showed that in two samples of adults from Italy (N = 252) and the UK (N = 254), the SEBT positively correlated with self-report measures of social exclusion, but not with the social desirability measure. The tool has …
Dizziness: Prevalence, risk factors and management
2021
Vertigo and dizziness are two conditions whose prevalence throughout an individual's lifespan is estimated to range from 20% to 50% with a marked incidence regarding women. Starting from the frequency of these symptoms, the book explores different aspects of the otoneurology field and the vestibular diseases, from the anatomy of vestibular organs to the pharmacological, surgical and rehabilitative treatment of posterior labyrinth disorders. In particular, the benign paroxysmal positional vertigo (VPPB), Meniere's disease and dizziness in patients suffering from temporomandibular joint disorders and vertebral fractures are described. A focus on specific techniques to evaluate vestibular diso…
Corticokinematic coherence is stronger to regular than irregular proprioceptive stimulation of the hand
2021
Funding Information: This study was supported by the Academy of Finland “Brain changes across the life-span” profiling funding to University of Jyva€skyla€. H. Piitulainen was supported by Academy of Finland (Grants 296240, 326988, 307250, and 327288) and Jane and Aatos Erkko Foundation. Publisher Copyright: © 2021 the American Physiological Society. Proprioceptive afference can be investigated using corticokinematic coherence (CKC), which indicates coupling between limb kinematics and cortical activity. CKC has been quantified using proprioceptive stimulation (movement actuators) with fixed interstimulus interval (ISI). However, it is unclear how regularity of the stimulus sequence (jitter…
Profiles of Volatile Biomarkers Detect Tuberculosis from Skin
2021
Abstract Tuberculosis (TB) is an infectious disease that threatens >10 million people annually. Despite advances in TB diagnostics, patients continue to receive an insufficient diagnosis as TB symptoms are not specific. Many existing biodiagnostic tests are slow, have low clinical performance, and can be unsuitable for resource‐limited settings. According to the World Health Organization (WHO), a rapid, sputum‐free, and cost‐effective triage test for real‐time detection of TB is urgently needed. This article reports on a new diagnostic pathway enabling a noninvasive, fast, and highly accurate way of detecting TB. The approach relies on TB‐specific volatile organic compounds (VOCs) that are …
Influence of rigid taping on the acromiohumeral distance in healthy recreational weightlifters
2021
BackgroundSubacromial pain syndrome is one of the most frequent injuries in overhead athletes, and it takes place when the acromiohumeral distance (AHD) is narrowed. Conservative treatment is the first approach to this syndrome, being shoulder taping one of the most used techniques. Although there are quite a few studies that analyse the effect of taping on the AHD, most of them do not include sham tapings. This study aimed to examine if the Relocation of the humeral head (RHH) taping produced an increase in the AHD in healthy recreationally weightlifter males, quantifying the change that may be due to a placebo effect.MethodsThe design of this study was a two-group pretest-posttest, in whi…
The Importance of Lipidomic Approach for Mapping and Exploring the Molecular Networks Underlying Physical Exercise: A Systematic Review
2021
Maintaining appropriate levels of physical exercise is an optimal way for keeping a good state of health. At the same time, optimal exercise performance necessitates an integrated organ system response. In this respect, physical exercise has numerous repercussions on metabolism and function of different organs and tissues by enhancing whole-body metabolic homeostasis in response to different exercise-related adaptations. Specifically, both prolonged and intensive physical exercise produce vast changes in multiple and different lipid-related metabolites. Lipidomic technologies allow these changes and adaptations to be clarified, by using a biological system approach they provide scientific u…
Recent advances on development of portable biosensors for monitoring of biological contaminants in foods
2021
Abstract Background There is a demand for easy, rapid and affordable analysis of biological contaminants in foods to guarantee their safety and quality. Most analysis of food contaminants is commonly performed in a limited number of samples in centralized laboratories by an expert technician. Therefore, developing of alternative techniques such as portable biosensors is of great significance. Scope and approach This review aims to discuss the recent advances in designing and applying of portable biosensors for the detection of biological food contaminants including bacteria, fungi and the related toxins. Also, the review deals briefly the basic knowledge of various portable biosensors which…
Carbon and nitrogen isotopic values in Lithops aucampiae during leaf development.
2021
Abstract Lithops (Aizoaceae) are succulent plants consisting of a pair of opposite succulent leaves inserted on an extremely short stem. The apical meristem produces a new leaf pair that develops between the older pair, recycling water and metabolites. This peculiar anatomy and growth form make ecophysiological studies quite challenging. Lithops are considered to have CAM metabolism, though experimental evidence is scarce. We followed the changes in carbon and nitrogen isotopic values in mature leaves, young leaves and roots, with the aim of investigating how the use of resources is optimized to achieve survival in extremely arid environments. Two-year-old plants of Lithops aucampiae were g…
Translational readthrough of ciliopathy genes BBS2 and ALMS1 restores protein, ciliogenesis and function in patient fibroblasts
2021
Abstract Background Ciliary dysfunction underlies a range of genetic disorders collectively termed ciliopathies, for which there are no treatments available. Bardet-Biedl syndrome (BBS) is characterised by multisystemic involvement, including rod-cone dystrophy and renal abnormalities. Together with Alstrom syndrome (AS), they are known as the ‘obesity ciliopathies’ due to their common phenotype. Nonsense mutations are responsible for approximately 11% and 40% of BBS and AS cases, respectively. Translational readthrough inducing drugs (TRIDs) can restore full-length protein bypassing in-frame premature termination codons, and are a potential therapeutic approach for nonsense-mediated ciliop…
Do Individual Effects Reflect Quantitative or Qualitative Differences in Cognition?
2021
Rouder and Haaf (2020) posed the important question if there are some individuals whose behavior is not in accordance with well-established experimental effects and whether these individual differences are quantitative or qualitative in nature. In our commentary, we discuss the distinction between quantitative and qualitative individual differences and between individual and average causal effects and come to the conclusion that this is not a new question, but in fact one that has already been discussed by Gordon W. Allport (1937) and Donald B. Rubin (1974, 1978). Moreover, we critically examine their proposed rule of thumb to collect about 100 trials per experimental condition to reliably …
In Vitro Evaluation of Poly(lactide-co-glycolide) In Situ Forming Gels for Bedaquiline Fumarate Salt and Pharmacokinetics Following Subcutaneous Inje…
2021
This study evaluated in vitro and in vivo drug release of bedaquiline from in situ forming gels (ISGs) containing 200 mg eq./g bedaquiline fumarate salt prepared with four different grades of poly(d,l-lactide) (PDLLA) or poly(d,l-lactide-co-glycolide) (PLGA) with a lactide/glycolide ratio of 50/50 or 75/25 and acid (A) or ester (E) end-capping in N-methyl-2-pyrrolidone at a polymer/solvent ratio of 20/80% (w/w). Mean in vitro drug release in 0.05 M phosphate buffer pH 7.4 with 1% (w/v) sodium lauryl sulphate was 37.3, 47.1, 53.3, and 62.3% within 28 days for ISGs containing PLGA5050A, PDLLA, PLGA7525A, and PLGA7525E, respectively. The data suggested that drug release was primarily controlle…