Search results for " 16"
showing 10 items of 871 documents
WWOX, a Chromosomal Fragile Site Gene and its Role in Cancer
2006
Allelic imbalances affecting the long arm of chromosome 16 have been extensively reported in the literature as common abnormalities observed in various carcinoma types, As a result of loss of heterozygosity (LOH) studies in breast cancer, we delimited a genomic area within chromosome 16 that demonstrated the highest frequency of abnormalities. This led us to the identification and cloning of WWOX, a candidate tumor suppressor gene (TSG) that spans a fragile region of DNA located at 16q23.3-24.1 (FRA16D: the second most active common chromosomal fragile site in the human genome). This gene encodes a protein that contains two WW domains responsible of protein-protein interactions and a short-…
The singular fate of Genetics in the History of French Biology, 1900-1940
1988
In this study we have examined the reception of Mendelism in France from 1900 to 1940, and the place of some of the extra-Mendelian traditions of research that contributed to the development of genetics in France after World War II. Our major findings are: (1) Mendelism was widely disseminated in France and thoroughly understood by many French biologists from 1900 on. With the notable exception of Lucien Cuenot, however, there were few fundamental contributions to the Mendelian tradition, and virtually none from about 1915 to the midthirties. Prior to 1900, Cuenot's work was already marked by a striking interest in physiological mechanisms; his physiological preoccupations played a consider…
Identification of subdominant sourdough lactic acid bacteria and their evolution during laboratory-scale fermentations
2007
Abstract Presumptive lactic acid bacterial cocci were found in six sourdoughs (out of 20) from the Abruzzo region (central Italy) and subjected to phenotypic and genotypic characterization. A total of 21 isolates, recognized as seven strains by randomly amplified polymorphic DNA (RAPD)–polymerase chain reaction (PCR) typing, were identified by a polyphasic approach, consisting of 16S rRNA gene sequencing, multiplex PCR assays and physiological features, as Enterococcus faecium and Pediococcus pentosaceus. Four strains belonging to those species and previously isolated from wheat kernels were inoculated in sterile flour to verify their capacity to grow in sourdough environment. Doughs with s…
Lactobacillus rennini sp. nov., isolated from rennin and associated with cheese spoilage.
2006
Two bacterial strains, DSM 20253T and DSM 20254, isolated from rennin and regarded as causing cheese spoilage, were deposited in the DSMZ as Lactobacillus sp. by J. Stadhouders. The strains show 99·9 % 16S rRNA gene sequence similarity and have less than 94·3 % similarity with any other species of the genus. Lactobacillus coryniformis is their closest phylogenetic neighbour. DNA–DNA hybridization experiments confirmed that the two strains are members of the same species with separate status within the genus Lactobacillus. The strains are homofermentative lactic acid bacteria and can be phenotypically and genotypically distinguished from their closest relatives. 16S rRNA gene-targeted specif…
Lactobacillus rossii sp. nov. isolated from wheat sourdough
2005
Screening of sourdough lactic acid bacteria for bacteriocin production resulted in the isolation of a Gram-positive, catalase-negative, non-spore-forming, non-motile rod bacterium (strain CS1T) that could not be associated with any previously described species. Comparative 16S rRNA gene sequence analysis recognized strain CS1T as a distinct member of the genus Lactobacillus. By a species-specific PCR strategy, five additional strains previously isolated from sourdoughs were found to belong to the same species as strain CS1T, as confirmed by 16S rRNA gene sequence analysis. The closest related species were Lactobacillus durianis, Lactobacillus malefermentans and Lactobacillus suebicus, with …
Vertical stratification of bacteria and archaea in sediments of a small boreal humic lake
2019
ABSTRACT Although sediments of small boreal humic lakes are important carbon stores and greenhouse gas sources, the composition and structuring mechanisms of their microbial communities have remained understudied. We analyzed the vertical profiles of microbial biomass indicators (PLFAs, DNA and RNA) and the bacterial and archaeal community composition (sequencing of 16S rRNA gene amplicons and qPCR of mcrA) in sediment cores collected from a typical small boreal lake. While microbial biomass decreased with sediment depth, viable microbes (RNA and PLFA) were present all through the profiles. The vertical stratification patterns of the bacterial and archaeal communities resembled those in mar…
Obesity in Aging and Art
2009
THIS issue of Journal of Gerontology: Medical Sciences highlights new findings on obesity in older persons and its consequences for health and function (1,2,3). The obesity epidemic is spreading rapidly in both developed and developing countries, and perspectives on the negative effects of overweight and obesity abound in recent medical literature. What do we know so far about obesity over the lifetime? Obesity does not spare older persons (4). Obese older persons experience a wide range of negative consequences, including metabolic abnormalities, arthritis, pulmonary diseases, cataracts, cancer, impaired mobility, disability, and mortality. Given the already extensive knowledge base, why a…
Le città costiere di Sicilia e le loro architetture nella “memoria” di viaggio di Giovan Battista Pacichelli (1685)
2014
Il resoconto del viaggio che l’abate toscano Giovan Battista Pacichelli (1640-1702) compie in Sicilia nel 1684, Moderno stato della Sicilia, compreso dalla sua navigatione e passeggio, è parte integrante di una più ampia opera in cinque volumi intitolata Memorie de’ viaggi per l’Europa christiana …., edita a Napoli nel 1685. Il testo restituisce l’immagine urbana di alcune delle principali città costiere dell’isola, oggetto della sua visita, nonché una descrizione, in alcuni casi puntuale e resa con dovizia di particolari, delle architetture da lui selezionate. Il testo fornisce il punto di vista di un autentico viaggiatore, come si evince dalla grande quantità di luoghi da lui visitati, e …
Tristano, Giovanni
2019
Biographical profile of the Ferrarese Jesuit architect Giovanni Tristano.
Modulation of lipid metabolism and colonic microbial diversity of high-fat-diet C57BL/6 mice by inulin with different chain lengths
2019
Abstract The physicochemical properties, biological functions and microbial degradation of inulins differ according to their degree of polymerization. However, the relationship between inulin activities and its effect on gut microbiota remains unknown. In this study, high fat diet with inulin (1 or 5 g/kg·bw), either with short or long chains groups were administered to different groups of mice (n = 10) for 10 weeks in order to investigate the effect of inulin on the microbial diversity of the animals. Litchi pericarp procyanidins (LPPC) were used for comparison purposes. Furthermore, the lipid metabolism and key regulator genes in mice were determined. The results indicated that natural in…