Search results for " 2"
showing 10 items of 10825 documents
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)
2008
BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contra…
Learning across contexts: How can vocational teachers facilitate boundary learning for students in work-based placements?
2022
A well-known challenge in vocational education and training (VET) programmes is the lack of coherence between school-based and workplace learning. The Norwegian VET model consists of two years of upper secondary education followed by two years of apprenticeship at work. This small-scale study of vocational teacher’s vocational didactics aims to investigate boundary learning at the VET Programme for Sales and Service at the Norwegian upper secondary level. The research question explored is: How can vocational teachers improve boundary learning for students in work-based placements in the subject vocational in-depth study (YFF)? The methodological approach is qualitative interviews with vocat…
R. Ghezzi - Volume measures in non equiregular sub-Riemannian manifolds
2017
In this talk we study the Hausdorff volume in a non equiregular sub-Riemannian manifold and we compare it to a smooth volume. First we give the Lebesgue decomposition of the Hausdorff volume. Then we focus on the regular part, show that it is not commensurable with a smooth volume and give conditions under which it is a Radon measure. Finally we give a complete characterization of the singular part. This is a joint work with F. Jean (ENSTA).
Wybory niekonkurencyjne w Polsce na poziomie lokalnym – wstępne oceny
2020
Artykuł podejmuje problem obsadzania mandatów bez głosowania w wyborach do rad gmin w gminach liczących do 20 tys. mieszkańców. W stosunku do wyborów z 2014 r. liczba takich przypadków wzrosła w 2018 r. o 77%. Wydaje się, że obowiązujące prawo wyborcze, w szczególności art. 418 § 1 (podział gmin na jednomandatowe okręgi wyborcze), art. 434 § 1 i 2 (zasady organizacji wyborów w przypadku zgłoszenia liczby kandydatów równej liczbie mandatów do obsadzenia) i art. 478 § 2 (tryb zgłaszania kandydatów na wójta lub burmistrza) Kodeksu wyborczego, w połączeniu z uwarunkowaniami lokalnej rywalizacji wyborczej, może sprzyjać powstawaniu zjawiska niekonkurencyjnych wyborów, które skutkują m.in. spadki…
Logoritmikas izmantošana vārdu krājuma paplašināšanā bērniem no 2 līdz 3 gadiem vecumā
2016
Bakalaura darba tēma: Logoritmikas izmantošana vārda krājuma paplašināšanā bērniem vecumā no 2 līdz 3 gadiem. Bakalaura darba autore: Ļubova Voronka. Zinātniskais vadītājs: Mg. paed. Egija Laganovska. Darbā apkopota teorija par bērnu attīstības fiziskajām, kognitīvajām, emocionālajām īpatnībām un vārdu krājuma veidošanos vecumā no diviem līdz trīs gadiem, kā arī par iespējām vārdu krājuma palielināšanā izmantot logoritmiku. Apkopotā un analizētā teorija tika izmantota, lai atrastu interesantu pieeju bērnu vārdu krājuma paplašināšanā, pedagoģiskā procesā izmantojot logoritmiku. Lai pārbaudītu bakalaura darba hipotēzi „2 – 3 gadīgu bērnu vārdu krājuma bagātināšana ir veiksmīgāka, ja tiek ievē…
Spēles vārdu krājuma veidošanai 2.klases skolēniem angļu valodas stundās
2021
Bakalaura darbā „Spēles vārdu krājuma veidošanai 2.klases skolēniem angļu valodas stundās” tiek pētīta spēles kā mācību metodes nozīme un izmantošanas iespējas angļu valodas stundās, lai bagātinātu skolēnu vārdu krājumu. Pētījuma mērķis ir teorētiski pamatot un pārbaudīt praksē spēļu izmantošanas iespējas angļu valodas stundās vārdu krājuma veidošanai 2.klasē. Darbs sastāv no divām nodaļām un vairākām apakšnodaļām. Pirmajā nodaļā tiek apkopota un analizēta pedagoģiskā literatūra un dokumenti par vārdu krājumu, tā veidošanos nosacījumiem un prasībām, kā arī jaunākā skolas vecuma, kurā iekļaujas 2.klases skolēni, vecumposma iezīmēm. Bakalaura darba empīriskajā daļā ir veikts novērojums un sit…
Una más de la familia. Au pairs atrapadas entre el capital humano y la economía moral
2018
In contemporary societies we are witnessing an expansion of the messages of human capital. These messages have as their central dimension idea of the self-entrepreneur, which implies a deepening in the logic of activation, while blurring the wage relations. In this scenario, young people with university degrees are becoming a favourite target in the offensive of human capital. The penetration of these human capital messages can be seen in the discourses of young university students who have been forced to leave the country during the crisis. In the present text we approach the discourses of young women who came out as au pairs. The characteristics of this figure place it in a space halfway …
Le Crowdsourcing : problématisation sensible autour d'une mise en forme du lien communautaire
2014
International audience; Alors que l’utilisation des plateformes sociales (réseaux sociaux, blogs, wikis) est désormais généralisée (du côté des internautes comme des organisations), on observe un investissement et un intérêt croissant pour les plateformes de création collaborative, issues du paradigme de l’open-innovation (H.Chesbrough). On insistera plus exactement sur les dispositifs de crowdsourcing et de co-création en ligne ayant pour point commun la mise en relation de communautés (de professionnels, d’ingénieurs, de designers, d’experts, de fans…) avec les enjeux communicationnels des organisations. La recherche à propos de ces nouveaux espaces de collaboration en ligne a été jusqu’i…
Sbateyl.org: A Virtual Space for Effective Language Training
2016
AbstractThe paper presents an ongoing European cross-institutional project on teaching young language learners whose aim is to develop a web-based in-service teacher education programme with a school-based follow-up component. The main focus of the project is to bring researchers and teachers together to establish an innovative professional procedure blending theory and practice. Based on the strategic partnership between one local university and one primary school from each participant country, the project aims to foster the professional advancement and teaching practices of primary school teachers. The article initially outlines the main theoretical and methodological issues in the field …