Search results for " Anatomia Patologica"

showing 10 items of 239 documents

Successful treatment of a young patient with locally advanced clear cell adenocarcinoma of the uterine cervix undergoing chemoradiation followed by r…

2014

Clear cell adenocarcinoma (CCAC) of the uterine cervix is a rare variant of cervical adenocarcinoma accounting for approximately 4-9% of this disease. Given the rarity of this pathological entity, the optimal treatment management is far from being defined. Earlier evidence suggested that the prognosis of patients bearing cervical CCAC is worse than with other histotypes, thus making the investigation of multimodal treatment strategies clinically worthwhile. Herein, we report the first case of locally advanced, large size cervical CCAC in a young woman who was triaged to concomitant chemoradiotherapy followed by radical surgery and experienced a pathologically assessed optimal response to th…

Adultmedicine.medical_specialtyAdvanced clear cell adenocarcinomaUterine Cervical NeoplasmRadical surgeryUterine Cervical NeoplasmsDisease-Free SurvivalObstetrics and gynaecologyadenocarcinoma uterine cervixUterine cervixmedicineHumansCombined Modality TherapyClear-cell adenocarcinomaRadical surgeryPathologicalSettore MED/08 - ANATOMIA PATOLOGICAbusiness.industryObstetrics and GynecologyMultimodal therapyChemoradiotherapy Adjuvantmedicine.diseaseMultimodal approachCombined Modality TherapyImmunohistochemistryMagnetic Resonance ImagingSurgeryChemoradiationReproductive MedicineAdenocarcinomaFemalebusinessChemoradiotherapyAdenocarcinoma Clear CellHuman
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The accuracy of sentinel lymph node biopsy in the treatment of multicentric invasive breast cancer using a subareolar injection of tracer.

2008

BACKGROUND: The aim of this study was to evaluate the feasibility and the accuracy of sentinel lymph node biopsy in multicentric breast cancer (MBC) performed by means of a subareolar (SA) injection of both 99Tc-labeled human albumin colloid and lymphazurin. METHODS: Between January 2002 and October 2007, 34 patients with MBC with clinically negative axilla underwent sentinel lymph node biopsy (SLNB) followed by total axillary node dissection (AD). Overall successful identification rate of SLN was 100%; there were no false negatives and overall accuracy rate was 100%. RESULTS: The mean number of sentinel lymph nodes (SLNs) identified was 1.8 +/- 0.88 (range = 1-4); the mean number of axilla…

Adultmedicine.medical_specialtyAxillary lymph nodesInjections IntradermalSentinel lymph nodeBreast NeoplasmsIsosulfan BlueSettore MED/08 - Anatomia PatologicaCohort StudiesBreast cancerPredictive Value of TestsBiopsymedicineRosaniline DyesHumansRadioactive TracersColoring AgentsTechnetium Tc 99m Aggregated AlbuminAgedRetrospective Studiesmedicine.diagnostic_testbusiness.industrySentinel Lymph Node BiopsyCarcinoma Ductal BreastReproducibility of ResultsSentinel Lymph Node Biopsy Multicentric Invasive Breast CancerMiddle Agedmedicine.diseaseSurgeryAxillaCarcinoma LobularSettore MED/18 - Chirurgia Generalemedicine.anatomical_structureSurgeryFemaleBreast diseaseRadiologyLymphRadiopharmaceuticalsbusiness
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Double Endocrine Neoplasia in a Renal Transplant Recipient: Case Report and Review of the Literature

2011

Abstract Introduction The incidence of cancer compared for age groups is 3–4 times higher in transplant recipients than the general population. The increased risk is related to immunosuppressive therapy as well as the use of increasingly older donors and recipients. Although cardiovascular disease with a functioning transplant is the leading cause of death (47%), cancer mortality is significant especially among older patients. However, the most frequent posttransplantation cancers relate to hemolymphopoietic organs and skin, whereas the occurrence of solid tumors elsewhere is rare. Herein we have described a rare case of synchronous double malignancy of endocrine organs (thyroid-adrenal) in…

Adultmedicine.medical_specialtyBiopsymedicine.medical_treatmentAdrenal neoplasmSettore MED/08 - Anatomia PatologicaNephrectomyEndocrine neoplasia renal transplant recipientAdrenocortical CarcinomamedicineAdjuvant therapyHumansAdrenocortical carcinomaThyroid NeoplasmsMultiple endocrine neoplasiaThyroid cancerNeoplasm StagingTransplantationOxyphil Cellsbusiness.industryCarcinomaGraft SurvivalMultiple Endocrine NeoplasiaThyroidectomyAdrenalectomyMycophenolic Acidmedicine.diseaseKidney TransplantationAdrenal Cortex NeoplasmsCarcinoma PapillaryNephrectomySurgeryTransplantationSettore MED/18 - Chirurgia GeneraleTreatment OutcomeThyroid Cancer PapillaryCyclosporineThyroidectomyKidney Failure ChronicLymph Node ExcisionDrug Therapy CombinationFemaleSteroidsSurgeryTomography X-Ray ComputedbusinessImmunosuppressive AgentsTransplantation Proceedings
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The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma.

2009

PURPOSE: In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients with positive SLN. METHODS: A retrospective review of 364 breast cancer patients undergoing SLN biopsy with intraoperative FS evaluation of SLN was performed. RESULTS: Sensitivity and accuracy of FS examination of SLN were 76.4% and 94.2%, respectively. The sensitivity was significantly higher in larger tumors (p < 0.01). No significant correlation was found between FS and histologic type. A …

Adultmedicine.medical_specialtyBreast surgerymedicine.medical_treatmentSentinel lymph nodeBreast NeoplasmsSettore MED/08 - Anatomia PatologicaSensitivity and SpecificityIntraoperative PeriodBreast cancermedicineFrozen SectionsHumansBreastSentinel lymph node - Frozen section - Intraoperative - Breast carcinomaLymph nodeMastectomyAgedNeoplasm StagingRetrospective StudiesAged 80 and overbusiness.industrySentinel Lymph Node BiopsyGeneral surgeryCarcinoma Ductal BreastAxillary Lymph Node DissectionReproducibility of ResultsMiddle Agedmedicine.diseaseCarcinoma LobularSettore MED/18 - Chirurgia Generalemedicine.anatomical_structureLymphatic MetastasisAxillaLymph Node ExcisionSurgeryFemaleIntraoperative PeriodRadiologyLymph NodesbusinessBreast carcinomaMastectomy
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Unexpected high frequency of genital involvement in women with clinical and hostological features of oral lichen planus

2006

The main aims of this cross-sectional study were: (i) to assess the frequency of genital (vulval) lichen planus (VLP) and vulval lichen sclerosus (VLS) in women affected with oral lichen planus (OLP), regardless of the genital symptoms reported; and (ii) to verify whether any demographic, clinical, or histological features of OLP are associated with a higher risk of vulvo-vaginal involvement. Fifty-five women, presenting OLP, consecutively underwent gynaecological examination and, if they demonstrated positive clinical signs of VLP, underwent biopsy. After a drop-out of 14 subjects, 31/41 (75.6%) were found to have signs of genital involvement, of which 13/31 (44.0%) were asymptomatic. Foll…

Adultmedicine.medical_specialtyDermatologyLichen sclerosusSettore MED/08 - Anatomia PatologicaAsymptomaticVulvar Lichen Sclerosusoral lichen planuTherapeutic approachstomatognathic systemSettore MED/28 - Malattie OdontostomatologicheBiopsyoral lichen planus; genital lichen planusgenital lichen planusMedicineHumansSex organAgedAged 80 and overmedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseDermatologySettore MED/40 - Ginecologia E Ostetriciastomatognathic diseasesGynaecological examinationCross-Sectional StudiesOral lichen planusFemaleVulvar DiseasesMultivariate statisticalmedicine.symptombusinessLichen Planus Oral
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YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING

2022

Ageing is intimately connected to the induction of cell senescence(1,2), but why this is so remains poorly understood. A key challenge isthe identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing(3). Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing. Conversely, sustaining YAP function rejuvenates old cells and opposes the e…

AgingMechanotransductionActin-Related Protein 2; Cellular Senescence; Extracellular Matrix; Healthy Aging; Immunity Innate; Lamin Type B; Mechanotransduction Cellular; Nuclear Envelope; Signal Transduction; Aging; Membrane Proteins; Nucleotidyltransferases; Stromal Cells; Transcriptional Coactivator with PDZ-Binding Motif Proteins; YAP-Signaling ProteinsNuclear EnvelopeSettore MED/08 - Anatomia PatologicaYAP TAZ ageing C-GAS STINGMechanotransduction CellularArticleHealthy AgingInnateCellular SenescenceAdaptor Proteins Signal TransducingMultidisciplinaryLamin Type BImmunityMembrane ProteinsYAP-Signaling ProteinsPhosphoproteinsNucleotidyltransferasesImmunity InnateExtracellular MatrixTranscriptional Coactivator with PDZ-Binding Motif ProteinsActin-Related Protein 2CellularStromal CellsSignal Transduction
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I CARCINOMI TRIPLO-NEGATIVI DELLA MAMMELLA: caratterizzazione morfologica e immunoistochimica della stromatogenesi tumorale, del contesto immunologic…

2021

Androgen receptortriple-negativeCarcinoma della mammellaBreast carcinomaimmune-checkpointstromatogenesi neoplasticatumor stromatogenesisSettore MED/08 - Anatomia PatologicaTNBCtriplo-negativirecettore androgenicheckpoint immunologici
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CK2β-regulated signaling controls B cell differentiation and function

2023

Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first B-cell specific knockout (KO) mouse model of the β regulatory subunit of CK2. CK2βKO mice present an increase in marginal zone (MZ) and a reduction in follicular B cells, suggesting a role for CK2 in the regulation of the B cell receptor (BCR) and NOTCH2 signaling pathways. Biochemical analyses demonstrate an increased activation of the NOTCH2 pathway in CK2βKO animals, which sustains MZ B-cell development. Transcriptomic analyses indicate alterations in biological processes involved in immune response and B-cell activation. Upo…

B lymphocytegerminal centerB cell developmentprotein kinase CK2B cell development B cell receptor signaling B lymphocyte Diffuse large B cell lymphoma germinal center marginal zone protein kinase CK2ImmunologyB cell receptor signalingmarginal zoneSettore MED/05 - Patologia ClinicaImmunology and AllergyDiffuse large B cell lymphomaSettore MED/08 - Anatomia PatologicaB cell development; B cell receptor signaling; B lymphocyte; Diffuse large B cell lymphoma; germinal center; marginal zone; protein kinase CK2Frontiers in Immunology
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Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection.

2011

BACKGROUND AND AIMS: Steatosis and insulin resistance (IR) are the major disease modifying in patients with chronic hepatitis C (CHC). Only few studies evaluated these features in patients with chronic hepatitis B (CHB). We aimed to assess the prevalence and the factors related to steatosis and IR in CHB patients, compared with CHC subjects, and to evaluate the potential association between these features and fibrosis severity. MATERIAL AND METHODS: One hundred and seventy consecutive patients with CHB (28 HBeAg positive, 142 HBeAg negative), were evaluated using liver biopsy and metabolic measurements and matched for sex, age and body mass index with 170 genotype 1 CHC patients. IR was def…

Blood GlucoseLiver CirrhosisMaleSettore MED/09 - Medicina InternaBiopsyEnzyme-Linked Immunosorbent AssaySettore MED/08 - Anatomia PatologicaSettore MED/13 - EndocrinologiaBody Mass IndexteatosisHBVPrevalenceHumansInsulinHepatitis B AntibodiesTriglyceridesImmunoassaySettore MED/12 - GastroenterologiaHBV;HCV;steatosisAlanine TransaminaseHepatitis BHepatitis CFatty LiverItalyHCVRegression AnalysisFemaleInsulin ResistanceLiver international : official journal of the International Association for the Study of the Liver
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Platelets accumulate in lung lesions of tuberculosis patients and inhibit T-cell responses and Mycobacterium tuberculosis replication in macrophages

2021

: Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here, we show that patients with active TB have a high number of platelets in peripheral blood and a low number of lymphocytes leading to a high platelets to lymphocytes ratio (PL ratio). Moreover, the serum concentration of different mediators promoting platelet differentiation or associated with platelet activation is increased in active TB. Immunohistochemistry analysis shows that platelets localise around the lung granuloma lesions in close contact with T lymphocytes and macrophages. Transcriptomic analysis of caseous tissue of human …

Blood PlateletsProteomicsPlateletsSettore MED/04 - Patologia GeneraleMacrophageMacrophagesT-LymphocytesImmunologyMycobacterium tuberculosisMycobacterium tuberculosiSettore MED/08 - Anatomia PatologicaHumansTuberculosisImmunology and AllergyLymphocyteLungCytokine
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