Search results for " Br"

Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety

2019

σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…

L'idéologie durable. Une analyse sémiotique du Rapport Brundtland

2017

Le rapport "Notre avenir à tous" (1989) exprime, en définissant le « développement durable », un souci d’harmonisation des rapports entre les nations qui était déjà présent dans la charte (1945) des nations unies prônant, de son côté, la paix internationale. Ce rapport marque pourtant un tournant stratégique: l’invitation à un mode de vie partagé passe cette fois par un « retour à la nature ». Il semble que la nature y acquière la valeur d’un impératif urgent, tout en faisant problème. En effet, en lisant le rapport, on s’aperçoit que cet appel à la nature est loin d’être univoque. Malgré ses apparences, la rien n’est plus instable que le concept de nature. L’analyse montre que le champ sém…

« L’Ecriture d’Art Brut : les innovations du mot et de l’image »

2009

International audience

L'Age du Bronze à Barbuise-Courtavant (Aube) du XIXe siècle... à demain

2004

International audience

Enclos fossoyés et sépultures de l'âge du Bronze à Saint-Vulbas : la fouille du PIPA, lot 7, secteur 4000 (Ain, Auvergne-Rhône-Alpes)

2017

Le fonctionnement des sépultures en position assise des confluences Seine-Yonne et Seine-Aube (France)

2001

International audience

Chapitre XIV. Du Néolithique final au Bronze ancien : les sépultures individuelles campaniformes dans le sud de la France

2011

Vibrational Perturbations and Ligand–Layer Coupling in a Single Crystal of Au144(SC2H4Ph)60 Nanocluster

2015

We have determined vibrational signatures and optical gap of the Au144(PET)60 (PET: phenylethylthiol, SC2H4Ph) nanocluster solvated in deuterated dichloromethane (DCM-D2, CD2Cl2) and in a single crystal. For crystals, solid-state (13)C NMR and X-ray diffraction were also measured. A revised value of 2200 cm(-1) (0.27 eV) was obtained for the optical gap in both phases. The vibrational spectra of solvated AU144(PET)60 closely resembles that of neat PET, while the crystalline-state spectrum exhibits significant inhomogeneous spectral broadening, frequency shifts, intensity transfer between vibrational modes, and an increase in the overtone and combination transition intensities. Spectral broa…

Symmetry breaking in ligand-protected gold clusters probed by nonlinear optics

2016

The first hyperpolarizabilities of [Au25(SR)18](-1/0) and Au38(SR)24 clusters were determined by Hyper-Rayleigh Scattering. A strong dependence on the molecular symmetry was observed, and we explore two strategies to destroy the center of inversion in [Au25(SR)18](-1/0), protection by chiral ligands and alloying of the cluster with silver. This may open new avenues to applications of Au : SR clusters in second-order nonlinear optics.

Visualising maritime vessel open data for better situational awareness in ice conditions

2018

Situational awareness of maritime vessels in ice conditions is important for the operation of supply chains. In the artic sea areas, the ice conditions pose a major challenge for maritime vessels getting stuck in the ice and being significantly delayed in arrival to harbor. Data science and open data provide new opportunities to overcome these challenges. This paper introduces available open data sources and data visualizations that can be used to develop applications, for example, for detecting maritime vessel collision, predicting estimated time of arrival to harbor, as well as maritime vessel route optimization in ice conditions. The paper begins by introducing available open data source…