Search results for " DOM"
showing 10 items of 2750 documents
Damping Provision by Different Virtual Synchronous Machine Schemes
2020
The adoption of virtual synchronous machine (VSM) schemes for the control of power converters is gaining more and more attention both in academia and industry. The VSM control strategies fall into the category of grid-forming converter controls, and they are intended for a range of different applications, providing specific services and different kinds of support to the grid. The paper investigates the possibility of damping provision to the system by VSM power converters. Different schemes are considered and compared, showing the opportunity of the investigated solutions through combined modal and time domain analyses. A specific modification of the power synchronization loop is recognized…
Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.
2021
The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …
Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry
2012
ABSTRACT Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the virus capsid, leading to the exposure of infection-relevant protein domains. These protein domains, which are located on the N-terminal portion of the structural proteins VP1 and VP2, include a catalytic phospholipase A 2 domain and three clusters of basic amino acids. We have identified additional protein sequence motifs located on the VP1/2 N terminus that also proved to be obligatory for virus infectivity. These motifs include signals that are known to be involved in protein interaction, endosomal sort…
Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix
2019
Abstract Coat protein (COP) I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin C18:0 molecule. Furthermore, a potential cholesterol-binding sequence has also been predicted in the p24 transmembrane domain. Thus, sphingomyelin and/or cholestero…
A Perturbed Cauchy Viscoelastic Problem in an Exterior Domain
2023
A Cauchy viscoelastic problem perturbed by an inverse-square potential, and posed in an exterior domain of RN, is considered under a Dirichlet boundary condition. Using nonlinear capacity estimates specifically adapted to the non-local nature of the problem, the potential function and the boundary condition, we establish sufficient conditions for the nonexistence of weak solutions.
4-5 gadu vecu bērnu radošās darbības veicināšana vizuālās mākslas nodarbībās
2018
Kvalifikācijas tēmas nosaukums ir “4-5 gadu vecu bērnu radošās darbības veicināšana vizuālās mākslas nodarbībās”, darbs sastāv no ievada, 3 nodaļām, 8 apakšnodaļām, kas apkopotas 55 lpp. Darbā ievietoti 13 attēli, 8 tabulas, 7 pielikumi , 56 literatūras avoti. Darba autore: Revita Vildava Pētījuma mērķis: Pētīt skolotāja iespējas sekmēt bērnu radošo darbību vizuālās mākslas nodarbībās. Pētījuma objekts: Vizuālās mākslas nodarbības pirmsskolā Pētījuma priekšmets: 4-5 gadu vecu bērnu radošā darbība Pētījuma hipotēze: Vizuālās mākslas nodarbībās ir iespējams sekmēt bērna radošo darbību, izmantojot dažādas mākslas veidus, tehnikas, palīglīdzekļus. Pētījuma teorētiskajā daļā tiek aprakstīts, kas…
Skolēnu radošās domāšanas veicināšana vizuālajā mākslā sākumskolas 4.klasē
2022
Bakalaura darbā “Skolēnu radošās domāšanas veicināšana vizuālajā mākslā sākumskolas 4. klasē” ietvaros tiek teorētiski un praktiski izpētīts kā radošums palīdz mācību procesā, un kā šīs prasmes attīstību var mobilizēt caur vizuālās mākslas priekšmetu ar dažādiem uzdevumiem, kas tiek veikti mācību stundās. Darba mērķis ir izpētīt radošumu, tā attīstību skolēnos un skolotāja ietekmi uz visu mācīšanas un mācīšanās procesu. Pētījumā tika izvirzīta hipotēze: skolēnu radošā domāšana vizuālajā mākslā sākumskolas 4.klasē tiks veicināta, ja skolotājs: 1)Uzdodot stundās veikt dizaina uzdevumus, veicinās skolēniem radošo domāšanu. 2)Mācību saturu sasaistīs ar ikdienu un veidos uzdevumus, kas pielīdzin…
Kritiskās domāšanas veidošanās vēstures mācīšanas procesā pamatskolā
2021
Diplomdarbs ir veltīts kritiskās domāšanas veicināšanas procesam vēstures mācību stundās. Darba aktualitāti nosaka Latvijas izglītības reformas „Skola 2030” pamatnostādnes, kur kritiskā domāšana ir atzīta par vienu no caurviju prasmēm. Darba mērķis ir izpētīt kritiskās domāšanas veicināšanas iespējas vēstures stundās pamatskolā. Diplomdarbu veido divas nodaļas. Pirmā nodaļa ir veltīta teorētiskajam pētījumam, kur analizētas atziņas un pētījumu rezultāti par kritiskās domāšanas jēdzienu un tā interpretēšanu, nozīmīgākajām komponentēm un novērtēšanas kritērijiem. Darba otrajā nodaļā aprakstīta un analizēta pedagoģiskā izmēģinājumdarbība, kur, balstoties uz pirmajā nodaļā izstrādātajiem kritēr…
Levels and Potential Health Hazards of Chlorinated Pesticidesin Surface Water Samples of Charsadda Area of Pakistan Using SPME-GC-ECD Technique
2021
In the present study, we determined the levels of chlorinated pesticide residues in surface water samples collected from the Charsadda district (KPK, Pakistan). SPME-GC-ECD with COMBI PAL CTC autosampler was used for extraction and analysis of 20 organochlorine pesticides in the collected water samples. For maximum efficiency of the SPME procedure, several parameters were studied, including the extraction and desorption time of the fiber, solution pH, agitation of samples, and stirring speed, etc. This method showed good liner response, with R2 values in the range of 0.9887 to 0.9999 for all pesticides. This method also provided good percent recoveries at 1 µg L−1 (87.5 to 106.0%) and at 2 …
Welded section defence by LRPD devices
2023
The present paper concerns a special application of some recently proposed structural devices, called LRPD, able to protect the welded sections of frame steel structures from undesired brittle collapse ensuring the good expected ductile behaviour. Standard I-shaped cross-sections are treated, and the proposed devices are suitably considered as moment resisting connections between beams and columns. At first the domain representing the brittle safe conditions is defined in the N,V,M space; then a sample plane frame subjected to seismic load conditions is studied and it is proved that, equipping the structure with the proposed devices suitably designed, the generalized stresses at the welded …