Search results for " Design"
showing 10 items of 5050 documents
Architecture of dissonance : a study on the strategic management process of higher education internationalization
2018
In this study I analyze the neglected notion of organizational architecture in the strategic process of internationalization in the context of higher education. I examine the internationalization process through the development and management of international master’s degree programmes and their relation to the broader strategy of one particular Finnish university. I interviewed acting coordinators and directors of the programmes regarding their view on the administrative work, as well as the structures and resources, related to the programmes. Strategy documents, internal evaluations, and statistics were also analyzed. The omission of an explicit strategy and strategic program for internat…
Conception de documents numériques : Parcours méthodologique
2009
There is a strong social demand for studies of digital document. Yet our models of society and education are struggling to integrate issues related to these types of documents. However, the subject is less than half a century old, and so it is hardly surprising that the writing and training practices are just being developed. Like the book, the digital document involves many different skills and techniques in its development. The list of jobs tends to grow steadily: ergonomists, referencing specialists, information architects, programmers, designers, integrators ... It is therefore difficult to have a global view on all this know-how and the related methodologies. This special edition seeks…
Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…
2009
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…
Towards a Guidance System to Aid in the Dosimetry Calculation of Intraoperative Electron Radiation Therapy
2015
In Intraoperative Electron Radiation Therapy (IOERT), the lack of specific planning tools limits its applicability, the need for accurate dosimetry estimation and application during the therapy being the most critical. Recently, some works have been presented that try to overcome some of the limitations for establishing planning tools, though still an accurate guidance system that tracks, in real-time, the applicator and the patient is needed. In these surgical environments, the acquisition of an accurate 3D shape of the patient’s tumor bed in real-time is of high interest, as current systems make use of a 3D model acquired before the treatment. In this paper, an optical-based system is pre…
Sulfonamide moiety as "molecular chimera" in the design of new drugs.
2021
Background: The -SO2NH- group is of great significance in modern pharmaceutical use since, in sulfa-drugs, it is possible to introduce easily chemical modifications, and even small changes may lead to an improved version of an already existing drug. Objective: This paper aims to describe updated information in the sulfonamide field with a particular focus on new mechanisms of action, especially if discovered by employing computational approaches. Methods: Research articles that focused on the use of the sulfonamide moiety for the design, synthesis, and in vitro/in vivo tests of various diseases were collected from various search engines like PubMed, Science Direct, Google Scholar, and Scop…
il volto della morte: le maschere funerarie della sepoltura dei preti morti di Gangi
2014
riassunto — Le mummie moderne e il signifcato recondito della doppia sepoltura nelle culture mediterranee moderne sono da tempo ampiamente dibattuti. In questo lavoro si discute di una particolare “collezione” di corpi di ecclesiastici, mummifcati ed esposti in un comune montano madonita della Sicilia, Gangi. I corpi, principalmente risalenti al XIX secolo, mummifcati per colatura come nella tradizione del tempo e vestiti degli abiti talari, sono esposti nel piano sottostante della Chiesa Madre, in quella che nella tradizione è detta la “fossa dei parrini” (fossa dei preti). Le mummie, a differenza di altri siti siciliani e mediterranei, sono altresì corredate di sonetto commemorativo e di …
Joint Subcarrier and Phase Shifts Optimization for RIS-aided Localization-Communication System
2022
Joint localization and communication systems have drawn significant attention due to their high resource utilization. In this paper, we consider a reconfigurable intelligent surface (RIS)-aided simultaneously localization and communication system. We first determine the sum squared position error bound (SPEB) as the localization accuracy metric for the presented localization-communication system. Then, a joint RIS discrete phase shifts design and subcarrier assignment problem is formulated to minimize the SPEB while guaranteeing each user’s achievable data rate requirement. For the presented non-convex mixed-integer problem, we propose an iterative algorithm to obtain a suboptimal solution …
’Green’ strategies and approaches. A contribution from the off-site and upcycling of discarded shipping containers
2021
La Terra versa oggi in una condizione di vulnerabilità che gran parte degli studiosi attribuisce a un modello di crescita infinita inseguita su un pianeta con risorse limitate. In relazione a questo contesto ambientale critico il contributo si propone di stimolare nuove prassi per il settore delle costruzioni suggerendo una visione sistemica che faccia ricorso contemporaneamente a più approcci sostenibili e circolari e che, combinando tecniche e tecnologie tradizionali e innovative, consenta l’eliminazione di scarti e rifiuti. In particolare, l’articolo illustra le potenzialità della prefabbricazione nel contenimento degli impatti ambientali diretti e indiretti rispetto a un’equivalente cos…
Sustainable Hospital Architecture: Quality Principles for a Responsable Design
2006
The theme of sustainability in the hospital design is today a subject widely discussed in the architectural field. The functioning of the health facility, also under the point of view of physical and organizational consistency is one of the primary objectives of the national government. There is the urgency to answer adequately and responsibly for the needs of society, assuring physical and psychological comfort and putting the center of the design process the individual sanitary needs. The social transformations and the technological progress in sanitary field have considerably modified the hospital conception. The hospital becomes space in which the individual is revalued for him itself a…
Stormwater Source Control as a Strategy for Sustainable Development: State of the Practice and Perceived Trends
2005
The primary objective of the paper is to draw upon the experiences acquired in many parts of the world to provide an up-to-date summary of the state of the practice for source control techniques and approaches, in a sustainable development context. After a discussion of the prevailing context for urban drainage approaches, three main themes covering techniques and design criteria, institutional aspects and performance issues are discussed relative to source control implementation. The discussion is based on findings from the compilation and analysis of available literature, recently developed databases, the experience of the different members of the SOCOMA group and recent research on desig…