Search results for " Design"
showing 10 items of 5050 documents
Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging
2020
Contains fulltext : 220838.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Lately, zirconium-89 has shown great promise as a radionuclide for PET applications of long circulating biomolecules. Here, the design and synthesis of protracted and long-lived GLP-1 receptor agonists conjugated to desferrioxamine and labelled with zirconium-89 is presented with the purpose of studying their in vivo distribution by PET imaging. The labelled conjugates were evaluated and compared to a non-labelled GLP-1 receptor agonist in both in vitro and in vivo assays to certify that the modification did not significantly alter the peptides' structure or function. Finally, the zirconium-89 labelled peptide…
Straining at work and its relationship with personality profiles and individual consequences in healthcare workers (HCWs)
2020
Straining is an attenuated form of mobbing, in which the continuity of vexatious actions is not driven by a discriminatory intent. With the objective of testing the possible moderating role of personality in the relationship between perceptions about straining at work and individual consequences, a correlational design research involved 374 healthcare workers (HCWs) from two Italian hospitals. The following questionnaires were administered: (1) Short Negative Acts Questionnaire (S-NAQ), to assess discriminative actions at work)
Guardare in due direzioni diverse
2017
Aiap Design Per, International Graphic Design Week è la grande manifestazione itinerante curata da Aiap, Associazione italiana design della comunicazione visiva*, che nella settima edizione, dopo essersi svolta a Napoli, Bologna, Cagliari, Treviso, Genova e Milano, approda a Roma dove continua a mostrare le sue peculiarità, che si affrontano come in un rinnovato ma pacato duello. Aiap Design Per, International Graphic Design Week – this year at the 7th edition – is the major travelling event organised by Aiap, Italian Association of Visual communication Design* which, after Naples, Bologna, Cagliari, Treviso, Genoa and Milan, finally reaches Rome with all its peculiarities, which confront o…
Can technical, functional and structural characteristics of dental units predict Legionella pneumophila and Pseudomonas aeruginosa contamination?
2011
Legionella pneumophila and Pseudomonas aeruginosa are common colonizers of water environments, particularly dental unit waterlines. The aim of this study was to assess whether the technical, functional and structural characteristics of dental units can influence the presence and the levels of opportunistic pathogens. Overall, 42 water samples were collected from dental units in a teaching hospital in Palermo, Italy, including 21 samples from the 21 taps supplied by the municipal water distribution system and 21 samples from oral rinsing cups at 21 dental units. L. pneumophila was present in 16 out of 21 water samples (76.2%) from dental units, and the median concentration was higher in samp…
Practical strategies for stable operation of HFF-QCM in continuous air flow
2013
Currently there are a few fields of application using quartz crystal microbalances (QCM). Because of environmental conditions and insufficient resolution of the microbalance, chemical sensing of volatile organic compounds in an open system was as yet not possible. In this study we present strategies on how to use 195 MHz fundamental quartz resonators for a mobile sensor platform to detect airborne analytes. Commonly the use of devices with a resonant frequency of about 10 MHz is standard. By increasing the frequency to 195 MHz the frequency shift increases by a factor of almost 400. Unfortunately, such kinds of quartz crystals tend to exhibit some challenges to obtain a reasonable signal-to…
Adaptive BEM for Low Noise Propeller Design
2009
A potential-based Boundary Element Method is presented for the aerodynamic and acoustic design of propel- lers at on- and off-design point conditions. Using an adaptive method, a family of airfoil sections is selected to produce the required performance (thrust, torque and efficiency versus advance ratio) at different cruise flight levels. Climb condi- tions are also considered in order to check the off-design point performance. Once the available airfoil data have been stored in a database, the code processes the families of airfoils to generate a complete geometry for a propeller of the specified performance with an optimized noise emission. The computational scheme adjusts the blade geom…
Shock control bump design optimization on natural laminar aerofoil
2011
The chapter investigates Shock Control Bumps (SCB) on a Natural Laminar Flow (NLF) aerofoil; RAE 5243 for Active Flow Control (AFC). A SCB approach is used to decelerate supersonic flow on the suction/pressure sides of transonic aerofoil that leads delaying shock occurrence or weakening of shock strength. Such an AFC technique reduces significantly the total drag at transonic speeds. This chapter considers the SCB shape design optimisation at two boundary layer transition positions (0 and 45%) using an Euler software coupled with viscous boundary layer effects and robust Evolutionary Algorithms (EAs). The optimisation method is based on a canonical Evolution Strategy (ES) algorithm and inco…
Alchimia e Memphis. I colori progettati del design
2012
Il design italiano, tra anni Settanta e Ottanta, viene marchiato a fuoco dalla definizione “Made in Italy” che ne riporta provenienza geografica, qualità progettuale e innovativa ed eccellenza assoluta. In tale scenario, all’interno di tante realtà legate al design e diffuse capillarmente sul territorio, si continua a sperimentare in modo ininterrotto, e in ogni settore legato alla progettazione, alla produzione, alla ricerca tecnologica e dei nuovi materiali. Scenario nel quale si muovono anche le realtà di Alchimia e Memphis che ripensano il progetto, attribuiscono nuovo valore a elementi come il colore e la decorazione, costruiscono nuovi lessici. In the 1970s and 1980s, the identity of …
Alessandro Costariol. 永远的视觉设计师 / Alessandro Costariol. Remote future visual designer
2010
永远的视觉设计师 如果用一个词来简洁鲜明的概括一个人的话，我认 为永恒一词是最佳选择。这个词是个近代词汇， 始创于20世纪，表达出一种时代特性。在逻辑学 和语言学领域重复出现。它标志着客体和时间连 续性的中断。并赋予客体以特权， 跨越时间的限 制，忽略时间发展的顺序和速度，使客体处于一种 独立的暂停状态。永恒所表达的含义如同一个现代 人穿了一件古时的衣服，这种古时和现代的不同风 格常常冲突不断，就像一道糖醋口味的菜肴中，一 个口味偏咸的人却意外的品尝到了甜味。 If you could define a person with only one term, to have a concise, sharp and lapidary picture of him, then I think the word I'd choose to refer to Alessandro Costariol, is timeless. This is a rather recent term, coined in the twentieth century, expression of contemporaneity, recurrent in the philosophical and linguistic fields, which marks a break in continuity between object and time, giving the first a privileged status that allows it to cross the second, ign…
Additivity of affine designs
2020
We show that any affine block design $$\mathcal{D}=(\mathcal{P},\mathcal{B})$$ is a subset of a suitable commutative group $${\mathfrak {G}}_\mathcal{D},$$ with the property that a k-subset of $$\mathcal{P}$$ is a block of $$\mathcal{D}$$ if and only if its k elements sum up to zero. As a consequence, the group of automorphisms of any affine design $$\mathcal{D}$$ is the group of automorphisms of $${\mathfrak {G}}_\mathcal{D}$$ that leave $$\mathcal P$$ invariant. Whenever k is a prime p, $${\mathfrak {G}}_\mathcal{D}$$ is an elementary abelian p-group.