Search results for " Farm"
showing 10 items of 2009 documents
Saslimstība ar kuņģa un kolorektālo vēzi Latvijā un vēža slimnieku uzskaites sistēmas ticamības un kvalitātes analīze
2013
Promocijas darba anotācija Saslimstība ar kuņģa un kolorektālo vēzi Latvijā un vēža slimnieku uzskaites sistēmas ticamības un kvalitātes analīze Promocijas darbā ir veikta saslimstības ar kuņģa un kolorektālo vēzi Latvijā analīze un vēža slimnieku uzskaites sistēmas kvalitātes noteikšana. Pētījumā tika analizēta 1980.-2010.gadā reģistrā iesniegtā informācija par pacientiem, kuri slimo ar onkoloģiskām slimībām, iesniegto datu apjoms un to kvalitāte, datu atbilstība statistisko aprēķinu un epidemioloģisko pētījumu veikšanai, un notikušo pārmaiņu ietekme uz pacientu uzskaiti. Iegūtie epidemioloģiskie rādītāji tika salīdzināti ar starptautiskās publikācijās un datubāzēs pieejamo informāciju. Pa…
Biomarķieru metode kuņģa gļotādas atrofijas noteikšanai
2014
Promocijas darba „Biomarķieru metode kuņģa gļotādas atrofijas noteikšanai” anotācija latviešu valodā Pētījumā tika veikta kuņģa biomarķieru metodes validācija, salīdzinot metodes rezultātus ar standartizēti veiktiem morfoloģijas izmeklējumu rezultātiem. Iegūtie dati parāda labu korelāciju starp PGI/II attiecību un kuņģa korpusa daļas atrofiju (p<0.0001) ar jutību (83.3%), kopējo precizitāti (86.7%). Biomarķieru samazinājums PGI un PGI/II tika noteikts atbilstoši paaugstinoties OLGA gastrīta stadijām. Mazāk pieņemama bija samazinātās sG-17 vērtības uzrādīja labu korelāciju ar kuņģa vārtnieka daļas atrofiju (p=0.007), neskatoties uz jutību, kas bija ievērojami zema (36.8%). Samazinātām G-17 u…
«Was not the labour problem the same everywhere». «Homo ad laborem nascitur et avis ad volatum»! (Prolegomena per uno studio del diritto del lavoro t…
2019
The purpose of this research is to catalogue the biblical texts - notably in a first phase those which are in the first (or old) testament of the Christian Bible - which contain both prescriptive structures and pathways designed to protect the position of social weakness of the "worker", understood in its broadest sense and in its various and diverse facets: worker, salaried employee, servant, even slave, and so on. The starting point and most immediate objective of this work is therefore to find the biblical sources - and to get ready one first critical apparatus - which refer, directly or indirectly, to work in a broad sense, that is a personal relationship in which one of the two subject…
Effects of extra virgin olive oil phenols on HL60 cell lines sensitive and resistant to anthracyclines
2009
The aim of our study was to evaluate the capability of a crude extract of phenols from extra virgin olive oil of Moraiolo cultivar to induce apoptosis and/or differentiation in sensitive and resistant HL60 cell lines to anticancer drugs (Typical Multidrug Resistance). Our data highlight that the crude extract is able to induce apoptosis on both sensitive and resistant cells, whereas the exposure to a number of anticancer drugs does not induce apoptosis in resistant cells. In differentiation experiments we investigated the capability of crude extract of phenols to induce the expression of CD11 granulocytic or CD14 monocytic cell surface antigen in sensitive and resistant HL60 cell lines. At …
Sorafenib in Mice – A Pharmacokinetic Study
2015
Pharmacokinetic models are applied to determine the drug distribution in the organism with respect to a given administration. Models based on body anatomy and physiology can provide an accurate description of drug concentrations reached in specific organs and tissues of mammals. This article proposes a model based on mammalian anatomy and physiology to predict the biodistribution in mice of sorafenib, an anti-cancer drug, with specific attention to the concentration reached in the liver, as that is the action site in case of hepatocellular carcinoma treatment. The model reveals a close correspondence respect to experimental concentration data in the organism and also assesses with good fide…
Tillage Versus No-Tillage. Soil Properties and Hydrology in an Organic Persimmon Farm in Eastern Iberian Peninsula
2020
There is an urgent need to implement environmentally friendly agriculture management practices to achieve the Sustainable Goals for Development (SDGs) of the United Nations by 2030. Mediterranean agriculture is characterized by intense and millennia-old tillage management and as a consequence degraded soil. No-Tillage has been widely examined as a solution for soil degradation but No-Tillage relies more on the application of herbicides that reduce plant cover, which in turn enhances soil erosion. However, No-Tillage with weed cover should be researched to promote organic farming and sustainable agriculture. Therefore, we compare Tillage against No-Tillage using weed cover as an alternative …
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R
2021
Euphorbia species have a large spectrum of traditional medicinal uses. We tested the biological activities of the essential oil (EO) of Euphorbia intisy Drake in an acquired multidrug resistance leukemia model to assess whether the EO obtained by hydrodistillation of stems was able to reverse the resistant phenotype. HL-60R cell lines are characterized by the overexpression of P-glycoprotein (P-gp), inhibitors of apoptosis proteins (IAPs) and constitutive expression of NF-κB. EO chemical composition was determined by GC/MS analysis
Synthesis of pyrazolo[4,3-c][1,2,6]benzothiadiazocine, a new ring system as potential COX inhibitor
2012
Derivatives of the new ring system 1,4-dihydropyrazolo[4,3-c][1,2,6] benzothiadiazocin-11(10H)one 5,5-dioxide were synthesized in five or six steps in 57-66% overall yields and tested as COX inhibitors.
Pre-conceptional and Peri-Gestational Maternal Binge Alcohol Drinking Produces Inheritance of Mood Disturbances and Alcohol Vulnerability in the Adol…
2018
Although binge drinking is on the rise in women of reproductive age and during pregnancy, the consequences in the offspring, in particular the inheritance of alcohol-related mood disturbances and alcohol abuse vulnerability, are still poorly investigated. In this study, we modeled both Habitual- and Binge Alcohol Drinking (HAD and BAD) in female rats by employing a two-bottle choice paradigm, with 20% alcohol and water. The exposure started 12 weeks before pregnancy and continued during gestation and lactation. The consequences induced by the two alcohol drinking patterns in female rats were assessed before conception in terms of behavioral reactivity, anxiety- and depressive-like behavior.…
Anti-tumor activity of the methanolic extracts of Salvia menthifolia
2012
In the present research we investigated the anti-proliferative activity of Salvia menthifolia Ten. (formerly Salvia menthaefolia), Lamiaceae, on a glioblastoma cell line, since up to date poor therapeutic results have been reported for treatment of malignant glioblastoma. Methanol extracts from different anatomical parts of S. menthifolia were tested on DBTRG-05MG cell line by MTT assay. The most active primary stems extract was also evaluated for apoptosis induction. Results confirmed the anti-tumor property of all the organs and demonstrated that the primary stems extract induced apoptosis after 4 h with the highest values of DNA fragmentation after 6 to 24 h. Some extracts were also HPLC…