Search results for " Formation"

Purkinje cell loss and motor coordination defects in profilin1 mutant mice.

2012

Profilin1 is an actin monomer-binding protein, essential for cytoskeletal dynamics. Based on its broad expression in the brain and the localization at excitatory synapses (hippocampal CA3-CA1 synapse, cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse), an important role for profilin1 in brain development and synapse physiology has been postulated. We recently showed normal physiology of hippocampal CA3-CA1 synapses in the absence of profilin1, but impaired glial cell binding and radial migration of cerebellar granule neurons (CGNs). Consequently, brain-specific inactivation of profilin1 by exploiting conditional mutants and Nestin-mediated cre expression resulted in a cerebellar hyp…

The GABAergic system of the dorsal cortex of lizards: a combined HRP-GABA immunohistochemistry study.

1990

Abstract γ-Aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neurons were found throughout the mediolateral and rostrocaudal axis of the dorsal cortex. They were horizontal, vertical and multipolar cells, mainly distributed in layers 1 and 3. GABA-LI boutons were diffusely distributed in layers 1 and 3, as well as forming basket-like images around layer 2 pyramidal perikarya. Double labelling experiments indicate that GABA-LI cells are an origin of and a target for rostrocaudal intrinsic projections within the dorsal cortex.

Enseignement artistique et marché, quelles relations ? Pour une conception élargie de la qualification

2022

International audience; L'objet de l'analyse est de relier l'enseignement (ses méthodes et ses contenus) au fonctionnement du marché du travail, en se concentrant spécifiquement sur les formations artistiques. L'auteur part des caractéristiques de l’œuvre d'art et montre comment ce bien hors du commun est, de façon a priori paradoxale et avec d'éventuelles tensions, enseigné. Il pose la question de la médiation du maître, de la place de la certification. Il en pointe les conséquences sur la relation - difficile - entre la formation et l'emploi et, en réponse, la tendance à la professionnalisation vers laquelle semblent s'orienter les écoles d'art.

Sequestration of organomettalic compounds by synthetic and naturally occuring polycarboxylate ligands. Binding of monomethylmercury(II) by polyacryli…

2007

The sequestering capacity of synthetic and naturally occurring polycarboxylate ligands towards mono- methylmercury(II) was evaluated by stability quantitative data on the interaction of CH3Hgþ with different molecular weight synthetic polyacrylates (2 and 20 kDa average M.wt) and alginate (70– 100 kDa) extracted from brown algae Macrocystis pyrifera. The influence of ionic medium was evaluated by measurements on the CH3Hgþ-polyacrylate systems in NaNO3 medium at different ionic strengths (0.10, 0.25, 0.50 and 0.75mol Lÿ1), and a Debye–Hu¨ ckel type equation was used for the dependence of complex formation constants on ionic strength. Measurements on the CH3Hgþ - alginate system were carried…

Nachweis der Faktoren Gm (1,2,4,5,21) und In V(1) in menschlichen Sekreten: Speichel, Schwei�, Nasensekret und Sperma

1977

Im Sperma sind bei genugend Substrat Gm- und InV-Faktoren nachweisbar. An Uberlagerungen durch Nasen- oder Scheidensekret mus gedacht werden. Dagegen wirkt sich Schweis als Verunreinigung nicht storend aus. Im Speichel konnen keine Gm-, wohl aber InV-Merkmale festgestellt werden. Die Gummierung der Briefmarken reagiert unspezifisch mit InV-Antiseren und kommt daher als Fehlerquelle in Betracht. Der Beweiswert von Gm- und InV-Befunden bei Spurenuntersuchungen ergibt sich aus den Phanotyp-Frequenzen, die im Serum von 400 nichtverwandten Personen festgestellt wurden.

Neural inflammation alters synaptic plasticity probed by 10 Hz repetitive magnetic stimulation

2020

ABSTRACTSystemic inflammation is associated with alterations in complex brain functions such as learning and memory. However, diagnostic approaches to functionally assess and quantify inflammation-associated alterations in synaptic plasticity are not well-established. In previous work, we demonstrated that bacterial lipopolysaccharide (LPS)-induced systemic inflammation alters the ability of hippocampal neurons to express synaptic plasticity, i.e., the long-term potentiation (LTP) of excitatory neurotransmission. Here, we tested whether synaptic plasticity induced by repetitive magnetic stimulation (rMS), a non-invasive brain stimulation technique used in clinical practice, is affected by L…

1981

Some fundamentals of the vapor and solution growth of ZnSe and ZnO

1999

Abstract Some fundamentals of ZnSe and ZnO vapor and solution growth are investigated. Residual water present in gases or gaseous mixtures such as H 2 , Ar or H 2 +H 2 O is shown to act as a sublimation activator in the vapor-phase transport of both compounds. The processes involved in the growth by chemically activated sublimation with such gases and gas mixtures have been studied by close-spaced vapor transport (CSVT). The ZnSe growth rate is found to be constant, while in the ZnO case a high initial growth rate is followed by slower growth subsequently. Using a theoretical model, the thermodynamic constants of the transport – energies of activation, sublimation and condensation and entha…

Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism

2010

Abstract 99mTc-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different 68Ga-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using μ-PET. Seven macrocyclic phosphorus-containing ligands and EDTMP were labelled in nanomolar scale with n.c.a. 68Ga in Na-HEPES buffer at pH∼4. Except for DOTP, all ligands were labelled with >92% yield. Binding of the 68Ga-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of 68Ga-EDTMP and 68Ga-DOTP was >83%. For the 68Ga-NOTA-phosphonates …

Die radikalausbeute beim thermischen zerfall von azoisobuttersäuredinitril in gegenwart von sauerstoff und in methylmethacrylat als lösungsmittel

1969

Die Radikalausbeute, gekennzeichnet durch den Radikalausbeutefaktor e (efficiency), beim thermischen Zerfall von Azoisobuttersauredinitril (AIBN) in sauerstoffhaltigen Losungen wurde mit Hilfe zweier direkter chemisch-analytischer Methoden bestimmt, die sich gegenseitig erganzen. Die 1. Methode beruht auf der gaschromatographischen Bestimmung des durch Kombination der primaren 2-Cyanoisopropylradikale entstehenden Tetramethylbernsteinsauredinitrils; sie liefert einen Wert fur (1-e). Die 2. Methode beruht auf der jodometrischen Bestimmung von 2-Cyanoisopropylhydroperoxid und p-Benzochinon, die letztlich durch eine Abfangreaktion mit Hydrochinon aus den der primaren Kombination entgangenen Ra…