Search results for " Magne"
showing 10 items of 8203 documents
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors
2016
Novel rhodesain inhibitors were developed by combining an enantiomerically pure 3-bromoisoxazoline warhead with a 1,4-benzodiazepine scaffold as specific recognition moiety. All compounds were proven to inhibit rhodesain with Ki values in the low-micromolar range. Their activity towards rhodesain was found to be coupled to an in vitro antitrypanosomal activity, with IC50 values ranging from the mid-micromolar to a low-micromolar value for the most active rhodesain inhibitor (R,S,S)-3. All compounds showed a good selectivity against the target enzyme since all of them were proven to be poor inhibitors of human cathepsin L. Novel rhodesain inhibitors were developed by combining an enantiomeri…
L'ERNIAZIONE DELLE GHIANDOLE LACRIMALI IN PAZIENTI CON OFTALMOPATIA DI GRAVES: UN POSSIBILE MARKER DI ATTIVITÀ DELLA MALATTIA.
2018
Scopo Il coinvolgimento delle ghiandole lacrimali (GL) in pazienti affetti da Oftalmopatia di Graves (OG) è stato considerato come una potenziale causa dei sintomi tipicamente associati a questa malattia. Diversi studi hanno rilevato che le dimensioni delle GL nei pazienti OG sono aumentate, ma non ci sono studi che prendono in considerazione pazienti con diversa attività della malattia. Abbiamo valutato l'erniazione delle GL rilevata sulle immagini di risonanza magnetica (RM), in pazienti con diversa attività OG. Materiale e metodi Trentadue pazienti (10M, 22F, età media 49,5 anni, range 30-68) con OG sono stati arruolati e raggruppati in base all'attività della malattia (A: n = 16 co…
Valutazione delle lesioni focali del tendine del sovraspinato con elastosonografia: confronto con ecografia B-mode e risonanza magnetica: esperienza …
2012
Obiettivo. Scopo dello studio era valutare l’elasticità del tendine del sovraspinato nella spalla sintomatica di pazienti con sospetto clinico di rottura unilaterale della cuffia dei rotatori, e comparare i reperti riscontrati con quelli dell’ecografia convenzionale (ultrasound, US) e della risonanza magnetica (RM). Metodi. Nel periodo compreso tra gennaio e dicembre 2009 sono state esaminate da un radiologo entrambe le spalle di 58 pazienti (età media: 46 anni; range 32-58 anni) sia con modulo elastosonografico in real-time che in B-mode tramite uno stesso ecografo (EUB - Hitachi 7500), usando una sonda lineare a elevata frequenza (13 MHz). L’elasticità delle fibre tendinee del sovraspinat…
Room temperature synthesis of lanthanum phosphates with controlled nanotexture as host for Ln(III) through the Epoxide Route
2022
AbstractHerein, the Epoxide Route, a one-pot room temperature alkalinization method based on the reaction between a nucleophile and an epoxide, has been employed to synthesize LaPO4 in the form of a Rhabdophane phase. The intrinsic features of this synthetic approach allow the reaction to be followed by pH monitoring, making possible the identification of the different precipitation steps involved in the formation of the solid. Once demonstrated the effectiveness of this chemical methodology, the size and shape of the LaPO4 particles were controlled by varying the identity and proportion of the organic co-solvents employed to perform the reaction. By these means, crystalline particles with …
Age and Muscle Function Are More Closely Associated With Intracellular Magnesium, as Assessed by
2019
Total serum magnesium is a common clinical measurement for assessing magnesium status; however, magnesium in blood represents less than 1% of the body’s total magnesium content. We measured intramuscular ionized magnesium by phosphorus magnetic resonance spectroscopy (31P-MRS) and tested the hypothesis that this measure better correlates with skeletal muscle function and captures more closely the effect of aging than the traditional measure of total serum magnesium. Data were collected from 441 participants (age 24–98 years) in the Baltimore Longitudinal Study of Aging (BLSA), a study of normative aging that encompasses a broad age range. Results showed that intramuscular ionized magnesium …
EMI Worsening in a SMPS with Non-linear Inductor
2022
This paper is focused on the input current in a Switched Mode Power Supply (SMPS) in which the power inductor is exploited up to the saturation showing a non-linear behaviour. The input current exhibits a distortion due to the non-linearity. The electromagnetic interference (EMI) caused by the ripple at switching frequency, superimposed to the DC value of the input current, requires a suitable design of the input differential mode (DM) filter. The input current is analyzed both in the time and frequency domain for different operating conditions, and it is compared to a SMPS equipped with a traditional linear inductor.
Improved High-Fidelity IPMSM mathematical model Including Saturation, Cross-Coupling, Torque Ripple and Iron Loss effects
2022
For enhanced control algorithm design purposes, accurate and high-fidelity electrical machine mathematical models are fundamentals. Usually, accurate evaluation of electrical machine behaviour requires finite element analysis (FEA) with consequent high-computational times. This paper presents an improved high-fidelity Interior Permanent Magnet Synchronous Machine (IPMSM) mathematical model including saturation, cross-coupling, torque ripple and iron loss effects. This model has been implemented in Matlab®/Simulink environment and its parameters are implemented by the use of lookup tables. To validate the modelling approach proposed, a comparative analysis between the proposed Matlab®/Simuli…
Impact Evaluation of Innovative Selective Harmonic Mitigation Algorithm for Cascaded H-Bridge Inverter on IPMSM Drive Application
2021
This paper presents a detailed analysis of the use of a novel Harmonic Mitigation algorithm for Cascaded H-Bridge Multilevel Inverter in electrical drives for the transportation field. For this purpose, an enhanced mathematical model of Interior Permanent Magnet Synchronous Motor (IPMSM), that takes into account simultaneously saturation, cross-coupling, spatial harmonics, and iron loss effects, has been used. In detail, this model allows estimating accurately the efficiency and the torque ripple of the IPMSM, crucial parameters for transportation applications. Moreover, two traditional pulse width modulation strategies, Sinusoidal Phase-Shifted and Switching Frequency Optimal Phase-Shifted…
Formation, Structural Characterization, and Calculated NMR Chemical Shifts of Selenium-Nitrogen Compounds from SeCl4 and ArNHLi (Ar = supermesityl, m…
2004
Supermesityl selenium diimide [Se{N(C6H2tBu3-2, 4, 6)}2; Se{N(mes*)}2] can be prepared in a good yield from the reaction of SeCl4 and (mes*)NHLi. The molecule adopts an unprecedented anti, anti-conformation, as deduced by DFT calculations at PBE0/TZVP level of theory and supported by 77Se NMR spectroscopy and a crystal structure determination. An analogous reaction involving (C6H2Me3-2, 4, 6)NHLi [(mes)NHLi] unexpectedly lead to the reduction of selenium and afforded the selenium diamide Se{NH(mes)}2 that was characterized by X-ray crystallography and 77Se NMR spectroscopy. The Se-N bonds of 1.847(3) and 1.852(3) A show normal single bond lengths. The <NSeN bond angle of 109.9(1)° also indi…
Charge Transport Mechanisms in Heavy-Ion Driven Leakage Current in Silicon Carbide Schottky Power Diodes
2016
Under heavy-ion exposure at sufficiently high reverse bias voltages silicon carbide (SiC) Schottky diodes are observed to exhibit gradual increases in leakage current with increasing ion fluence. Heavy-ion exposure alters the overall reverse current-voltage characteristics of these diodes, leaving the forward characteristics practically unchanged. This paper discusses the charge transport mechanisms in the heavy-ion damaged SiC Schottky diodes. A macro model, describing the reverse current-voltage characteristics in the degraded SiC Schottky diodes is proposed. peerReviewed