Search results for " Mapping"

Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance.

2000

The present report describes the participation of nicotinic receptors (nAChRs) in controlling the excitability of local neuronal circuitries in the rat hippocampus and in the human cerebral cortex. The patch-clamp technique was used to record responses triggered by the non-selective agonist ACh and the alpha7-nAChR-selective agonist choline in interneurons of human cerebral cortical and rat hippocampal slices. Evidence is provided that functional alpha7- and alpha4beta2-like nAChRs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the CA1 field of the rat hippocampus and in the human cerebral cortex and that activation of the different nAChR subtypes pres…

A coincidence-point problem of Perov type on rectangular cone metric spaces

2017

We consider a coincidence-point problem in the setting of rectangular cone metric spaces. Using alpha-admissible mappings and following Perov's approach, we establish some existence and uniqueness results for two self-mappings. Under a compatibility assumption, we also solve a common fixed-point problem.

Fixed point theorems for fuzzy mappings and applications to ordinary fuzzy differential equations

2014

Abstract Ran and Reurings (Proc. Am. Math. Soc. 132(5):1435-1443, 2004) proved an analog of the Banach contraction principle in metric spaces endowed with a partial order and discussed some applications to matrix equations. The main novelty in the paper of Ran and Reurings involved combining the ideas in the contraction principle with those in the monotone iterative technique. Motivated by this, we present some common fixed point results for a pair of fuzzy mappings satisfying an almost generalized contractive condition in partially ordered complete metric spaces. Also we give some examples and an application to illustrate our results. MSC:46S40, 47H10, 34A70, 54E50.

A spectral mapping theorem for perturbed strongly continuous semigroups

1991

Karyotype Abnormalities in a Variant Chinese Hamster Cell Line Resistant to Methyl Methanesulphonate

2004

A variant cell population, isolated from V79-CI 3 Chinese hamster cells after two consecutive treatments with methyl methanesulphonate (MMS), was found to be highly resistant to killing by this alkylating agent. The resistant cell line was cytogenetically characterized both by the presence of a stable translocation involving metacentric chromosome 2 and acrocentric chromosome 6 and by a supernumerary chromosome originated by the duplication of a small telocentric chromosome. This cell population also showed a transient transformed phenotype, seen as formation of transformed foci containing cells with high chromosomes counts and multiple chromosomal aberrations. As MMS-resistance and karyoty…

The ‘recent’ forests of Mount Venda (Padua, Italy): when historical cartography and archaeobotany tell quite a different story

2018

Forests, like agricultural systems and housing, are an integral part of the human landscapes. They evolve over time, not only in response to environmental factors (e.g. climate change) but also in response to developments in human society. This work on the analysis of forest dynamics in Euganean hills is the result of research carried out as part of the research programmes THISTLE (MSCA Fellowship, grant agreement: 656397) and MEMOLA (EU FP7 Project , grant agreement: 613265). The work is focused on two mountains in particular: Monte Venda and Monte della Madonna. The archaeobotanical investigations reveal the presence of ancient forests (since the 14th century) in these areas , although th…

Generation of monoclonal antibodies against human regulatory T cells.

2009

Abstract Natural CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) control the activation of the immune system and therefore have become a major area of research in immunology. The generation of monoclonal antibodies against human Tregs offers the possibility to discover novel Treg-specific or Treg-associated surface markers and to identify targets for a therapeutic modulation of Tregs. Here we present a methodology optimized to efficiently induce and select mAb against human Tregs by repeated immunization of mice with Tregs from a single donor and a differential two-step flow cytometry-based hybridoma screening procedure.

The Fumarate/Succinate Antiporter DcuB of Escherichia coli Is a Bifunctional Protein with Sites for Regulation of DcuS-dependent Gene Expression

2008

DcuB of Escherichia coli catalyzes C4-dicarboxylate/succinate antiport during growth by fumarate respiration. The expression of genes of fumarate respiration, including the genes for DcuB (dcuB) and fumarate reductase (frdABCD) is transcriptionally activated by C4-dicarboxylates via the DcuS-DcuR two-component system, comprising the sensor kinase DcuS, which contains a periplasmic sensing domain for C4-dicarboxylates. Deletion or inactivation of dcuB caused constitutive expression of DcuS-regulated genes in the absence of C4-dicarboxylates. The effect was specific for DcuB and not observed after inactivation of the homologous DcuA or the more distantly related DcuC transporter. Random and s…

Best approximation and variational inequality problems involving a simulation function

2016

We prove the existence of a g-best proximity point for a pair of mappings, by using suitable hypotheses on a metric space. Moreover, we establish some convergence results for a variational inequality problem, by using the variational characterization of metric projections in a real Hilbert space. Our results are applicable to classical problems of optimization theory.

The Nitsche phenomenon for weighted Dirichlet energy

2018

Abstract The present paper arose from recent studies of energy-minimal deformations of planar domains. We are concerned with the Dirichlet energy. In general the minimal mappings need not be homeomorphisms. In fact, a part of the domain near its boundary may collapse into the boundary of the target domain. In mathematical models of nonlinear elasticity this is interpreted as interpenetration of matter. We call such occurrence the Nitsche phenomenon, after Nitsche’s remarkable conjecture (now a theorem) about existence of harmonic homeomorphisms between annuli. Indeed the round annuli proved to be perfect choices to grasp the nuances of the problem. Several papers are devoted to a study of d…