Search results for " Moda"

Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selecte…

2021

BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (<1%, 1–49%, ≥50%). Pooled hazard ratios (HRs) and risk ratios (RRs) for progression-free survival (PFS), over…

Update endokrine Orbitopathie

2009

Lip repositioning technique. A simple surgical procedure to improve the smile harmony

2018

Excessive gingival display is an esthetic concern for patients. It is a condition in which an overexposure of the maxillary gingiva (>3mm) is present during smiling. There are different etiologies of a gummy smile, such as vertical maxillary excess, short and hyperactive upper lip, altered passive eruption, anterior dentoalveolar extrusion, or a combination of these causes. The correct diagnosis of all etiologic factors is imperative for its appropriate management. Many techniques have been used to restore the dentogingival relation for the management of gummy smile. Lip repositioning is a conservative surgical technique used to treat excess gingival display. It is a largely unknown treatme…

Neural networks engaged in milliseconds and seconds time processing: evidence from transcranial magnetic stimulation and patients with cortical or su…

2009

Here, we review recent transcranial magnetic stimulation studies and investigations in patients with neurological disease such as Parkinson's disease and stroke, showing that the neural processing of time requires the activity of wide range-distributed brain networks. The neural activity of the cerebellum seems most crucial when subjects are required to quickly estimate the passage of brief intervals, and when time is computed in relation to precise salient events. Conversely, the circuits involving the striatum and the substantia nigra projecting to the prefrontal cortex (PFC) are mostly implicated in supra-second time intervals and when time is processed in conjunction with other cognitiv…

Lack of Association Between Tumor Hypoxia, Glut-1 Expression and Glucose Uptake in Experimental Sarcomas

2003

Hypoxia is a common phenomenon in experimental and human tumors which not only limits the efficacy of non-surgical treatment modalities such as irradiation and 02-dependent chemotherapy but also affects the long-term prognosis of cancer patients. Numerous studies have clearly demonstrated that patients with more hypoxic tumors have a reduced probability for survival and disease-free survival’. For this reason it might be helpful to non-invasively identify patients with hypoxic malignancies.

Physiological properties of malignant tumours

1992

It is generally accepted that tumour microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status--factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumours to conventional irradiation, chemotherapy, other non-surgical treatment modalities, and the cell proliferation activity within the tumours. Currently available information on the parameters defining the metabolic micromilieu in human tumours is presented in this paper. According to these data, significant variations in these relevant factors are likely to occur between different …

Dermatofibrosarcoma protuberans: a comprehensive review and update on diagnosis and management

2013

Dermatofibrosarcoma protuberans (DFSP) is a rare superficial tumor characterized by high rates of local recurrence and low risk of metastasis. DFSP occurs most commonly on the trunk and proximal extremities, affects all races, and often develops between the second and fifth decade of life. The tumor grows slowly, typically over years. Histologically, several variants of DFSP have been described and should be well characterized to avoid misdiagnosis with other tumors. These include pigmented (Bednar tumor), myxoid, myoid, granular cell, sclerotic, atrophic DFSP, giant cell fibroblastoma, and DFSP with fibrosarcomatous areas. Of all these variants, only the DFSP with fibrosarcomatous areas is…

Endometrial stromal sarcomas: immunohistochemical, electron microscopical and cytogenetic findings in two cases.

1999

Uterine sarcomas are approximately 3% of all malignant uterine corpus tumours. Of these, the tumours that originate solely in the stromal elements of the uterine wall are infrequent and have not been well characterized cytogenetically. We report two cases of endometrial stromal sarcomas (ESS), one low grade and one high grade, diagnosed by conventional histology, immunocytochemistry, electron microscopy and cytogenetics. Morphologically clear-cut differential structures were seen at optical, immunohistochemical, and electron microscopic levels, permitting a clear differential diagnosis. The low-grade ESS expressed hormonal receptors and vimentin, whereas the high-grade ESS showed no hormone…

Human Mammary Carcinomas in Nude Rats — A New Approach for Investigating Oxygen Transport and Substrate Utilization in Tumor Tissues

1985

An understanding of tumor pathophysiology with respect to blood flow, oxygenation status, pH distribution and utilization of the relevant substrates which, all together, critically influence growth kinetics and the efficiency of nonsurgical therapeutic modalities in vivo requires information derived directly from human malignant tissues. At present, only inadequate knowledge of the relevant physiological factors in tumor tissues of patients are accessible. The little data available to date were obtained from clinical observations rather than from systematic studies, i.e., data were collected from various tumor types with differing staging and grading. For this reason generally valid stateme…

Revised recommendations of the Italian Society of Pediatrics about the general management of Kawasaki disease

2021

AbstractAim of these revised recommendations for the general management of Kawasaki disease is to encourage its prompter recognition and warrant the most appropriate therapy, based on ascertained scientific data, raising awareness of the complications related to misdiagnosis or delayed treatment. A set of 20 synthetic operative statements is herein provided, including the definition of Kawasaki disease, its protean presentations, clinical course and seminal treatment modalities of all disease phases. The application of these recommendations should improve prognosis of Kawasaki disease and prevent the progression to permanent vascular abnormalities, thereby diminishing morbidity and mortalit…