Search results for " Modeling"
showing 10 items of 2411 documents
Domain specific simulation language for IT risk assessment
2011
Information technology systems represent the backbone of a company's operational infrastructure. A company's top management typically ensures that computer software and hardware mechanisms are adequate, functional and in adherence with regulatory guidelines and industry practices. Nowadays, due to depressed economic and increased intensity of performed operations, business highly recognizes the influence of effective Information Technology risk management on profitability. Design of Unified Modelling Language (UML) based Domain Specific language (DSL) described in this paper achieves synergy from in IT industry widely used UML modelling technique and the domain specific risk management exte…
Exploring Neighborhood Influences on Small-Area Variations in Intimate Partner Violence Risk: A Bayesian Random-Effects Modeling Approach
2014
This paper uses spatial data of cases of intimate partner violence against women (IPVAW) to examine neighborhood-level influences on small-area variations in IPVAW risk in a police district of the city of Valencia (Spain). To analyze area variations in IPVAW risk and its association with neighborhood-level explanatory variables we use a Bayesian spatial random-effects modeling approach, as well as disease mapping methods to represent risk probabilities in each area. Analyses show that IPVAW cases are more likely in areas of high immigrant concentration, high public disorder and crime, and high physical disorder. Results also show a spatial component indicating remaining variability attribut…
Graphic readings and digital configurations: Akragas, Girgenti and Agrigento
2018
The study deals with a graphic analysis of the city of Agrigento through the identification of the territorial, urban and architectural peculiarities that have designed its evolution. Starting from the landscape representations realized since the sixteenth century, the views from the sea by Spannocchi, the glances on the apric territory by Pancrazi, the Hellenic ruins inside the medieval Girgenti by Martorana and the Grand Tour travelers’ productions, the urban transformations of Agrigento are reconstructed starting from the points of view adopted by the draftsmen. The aim is to provide a description through images of the multiple points of view with respect to which the territory has been …
How Many Clocks, How Many Times? On the Sensory Basis and Computational Challenges of Circadian Systems
2018
A vital task for every organism is not only to decide what to do but also when to do it. For this reason, “circadian clocks” have evolved in virtually all forms of life. Conceptually, circadian clocks can be divided into two functional domains; an autonomous oscillator creates a ~24 h self-sustained rhythm and sensory machinery interprets external information to alter the phase of the autonomous oscillation. It is through this simple design that variations in external stimuli (for example, daylight) can alter our sense of time. However, the clock’s simplicity ends with its basic concept. In metazoan animals, multiple external and internal stimuli, from light to temperature and even metaboli…
A high-quality homology model for the human dopamine transporter validated for drug design purposes.
2018
The human dopamine transporter (hDAT) plays many vital functions within the central nervous system and is thus targeted by many pharmaceutical agents. Dopamine-related therapies are in current development for individuals with dopamine-related disorders including depression, Parkinson's disease, and psychostimulant addictions such as cocaine abuse. Yet, most efforts to develop new dopamine therapies are within costly structure-activity relationship studies. Through structure-based drug design techniques, the binding site of hDAT can be utilized to develop novel selective and potent dopamine therapies at reduced costs. However, no structural models of hDAT specifically validated for rational …
Design and development of hyaluronan-functionalized polybenzofulvene nanoparticles as CD44 receptor mediated drug delivery system
2017
A tri-component polymer brush (TCPB), composed of a polybenzofulvene copolymer bearing low molecular weight hyaluronic acid (HA) on the surface of its cylindrical brush-like backbone and oligo-PEG fractions, was employed in the preparation of 350Â nm nanostructured drug delivery systems capable of delivering the anticancer drug doxorubicin. The obtained drug delivery systems were characterized on the basis of drug loading and release, dimensions and zeta potential, morphology and in vitro cell activity, and uptake on three different human cell lines, namely the bronchial epithelial 16HBE, the breast adenocarcinoma MCF-7, and the colon cancer HCT116 cells. Finally, the ability of doxorubicin…
Modeling Drug Effects on Personalized 3D Models of the Heart: A Simulation Study
2010
[EN] The use of anti-arrhythmic drugs is common to treat heart rhythm disorders. Computational modeling and simulation are powerful tools that can be used to investigate the effects of specific drugs on cardiac electrophysiology. In this work a patient-specific anatomical heart model is built to study the effects of dofetilide, a drug that affects IKr current in cardiac cells. We study the multi-scale effects of the drug, from cellular to organ level, by simulating electrical propagation on tissue coupled cellular ion kinetics for several heart beats. Different cell populations configurations namely endocardial, midmyocardial and epicardial are used to test the effect of tissue heterogeneit…
Modèle dynamique multiniveau et holonique pour la simulation d'un système complexe à grande échelle avec environnement spatial : Application à la sim…
2020
Nowadays, with the emergence of connected objects and cars, road traffic systems become more and more complex and exhibit hierarchical behaviours at several levels of detail. The multilevel modeling approach is an appropriate approach to represent traffic from several perspectives. Multilevel models are also an appropriate approach to model large-scale complex systems such as road traffic. However, most of the multilevel models of traffic proposed in the literature are static because they use a set of predefined levels of detail and these representations cannot change during simulation. Moreover, these multilevel models generally consider only two levels of detail. Few works have been inter…
The Psychobiosocial States (PBS-S) Scale
2019
Abstract. This study examined the factor structure and reliability of the Psychobiosocial States (PBS-S) scale in the assessment of situational performance-related experiences. We administered the scale to 483 Finnish athletes before a practice session to assess the intensity and perceived impact of their performance-related feeling states. The hypothesized two-factor structure indicating functional effects (10 items) and dysfunctional effects (10 items) toward performance was examined via exploratory structural equation modeling (ESEM) and confirmatory factor analysis (CFA). Regarding the intensity and perceived impact dimensions of reported states, ESEM and CFA showed a good fit for a tw…
Un'occasione perduta: l'Eden Teatro Biondo di Ernesto Basile. Dai disegni di archivio alla ricostruzione digitale
2016
Il lavoro si pone come obiettivo la ricostruzione congetturale del progetto dell’Eden Teatro Biondo (1912) a Palermo di Ernesto Basile (Palermo 1857–1932) a partire dai disegni originari. L’edifico propone una tipologia che fonde cinematografo (al piano terra) e teatro (al piano superiore). Pensato su un fronte di Piazza Verdi, non sarà realizzato per i costi ritenuti troppo elevati dai committenti. Le scansioni dei disegni originari (conservati presso il Fondo Basile del Dipartimento di Architettura dell’Università di Palermo) hanno consentito la vettorializzazione piana utilizzata per l’analisi e per la modellazione 3D. Gli apparati decorativi sono stati realizzati integrando la modellazi…