Search results for " Natural products"
showing 10 items of 32 documents
Marine Pyrrole Alkaloids
2021
Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.
Risk of classic Kaposi sarcoma with exposures to plants and soils in Sicily
2010
Abstract Background Ecologic and in vitro studies suggest that exposures to plants or soil may influence risk of Kaposi sarcoma (KS). Methods In a population-based study of Sicily, we analyzed data on contact with 20 plants and residential exposure to 17 soils reported by 122 classic KS cases and 840 sex- and age-matched controls. With 88 KS-associated herpesvirus (KSHV) seropositive controls as the referent group, novel correlates of KS risk were sought, along with factors distinguishing seronegatives, in multinomial logistic regression models that included matching variables and known KS cofactors - smoking, cortisone use, and diabetes history. All plants were summed for cumulative exposu…
Marine Isonitriles and Their Related Compounds.
2016
Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isoni…
Acid-induced rearrangement of epoxygermacra-8,12-olides: synthesis and absolute configuration of guaiane and eudesmane derivatives from artemisiifolin
2010
A study on the acid-induced rearrangement of 4,5-epoxy- and 1,10-epoxygermacra-8,12-olides was carried out. From a 4,5-epoxy derivative, guaianes were obtained, whereas 1,10-epoxy derivatives furnished, depending on the stereochemistry of the C-1/C-10 epoxy ring, trans-5β,10α- or trans-5α,10β-eudesmanolides.
Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
2020
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve di erent pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year.Marine-based pharmaceuticals have started to impactmodern pharmacology and diff…
Lemon post-harvest decay control by natural products
2008
Postharvest diseases of lemon fruits represent one of the most severe sources of loss production. They are controlled by imazalil (IMZ), thiabendazole (TBZ) and sodium ortho-phenil-phenate (SOPP) registered fungicides for postharvest treatments. Nowadays, the chemical use is becoming more restricted for environmental concerns and development of fungicide-tolerance strains of fungal pathogens. In the last few years a renewed interest in alternative methods of postharvest decay control has been increasing and the research for natural products has provided encouraging results. The aim of this research has been the in vitro and in vivo effectiveness evaluation of six essences (garlic, cloves, o…
Marine molecular biology : An emerging field of biological sciences
2007
An appreciation of the potential applications of molecular biology is of growing importance in many areas of life sciences, including marine biology. During the past two decades, the development of sophisticated molecular technologies and instruments for biomedical research has resulted in significant advances in the biological sciences. However, the value of molecular techniques for addressing problems in marine biology has only recently begun to be cherished. It has been proven that the exploitation of molecular biological techniques will allow difficult research questions about marine organisms and ocean processes to be addressed. Marine molecular biology is a discipline, which strives t…
MAPs in Sicily: cultivation, uses, and potentiality
2013
In Sicily, MAPs have been used and cultivated for centuries, with many uses ranging from the preparation of fresh or stored food items, flavoring of foods and beverages, home-made human or animal therapy or even aesthetical purposes. Many of them grow spontaneously into such areas, and are claimed to play a significant role inside land biodiversity. The widespread belief that only under “natural” conditions MAPs find their optimum quality features has driven in many cases to their uncontrolled collection from the wild, and as a result many of them are nowadays at a risk of extinction. The field cropping of such spontaneous species could play an important role in safeguarding biodiversity, a…
USE OF NATURAL PRODUCTS FOR THE CONTROL OF POWDERY MILDEW OF ROSE PLANTS
2007
PowDery mildew caused by Podosphaera pannosa (Wallr. Fr.) De Bary on roses in greenhouse cultivation is usually controlled by chemical products. Aiming to lower the use of chemical treatments, in vitro and in planta assays were carried out using some natural products. The inhibitory effect of essential oils extracted from oregano inflorescences (Origanum heracleoticum L.) and cloves (Syzygium aromaticum L. Merril et L.M. Perry), was evaluated by in vitro tests. Essential oil at 0.5, and 0.125 ml/L concentration was added to conidia suspension (8 x 105 conidia/ml). After 2, 4, 8, 12, 24 and 48 hours, 400 conidia for each treatment and control were evaluated and the germination percentage cal…