Search results for " PHI"
showing 10 items of 3225 documents
Ethics Literacy and "Ethics University": Two Intertwined Models for Public Involvement and Empowerment in Bioethics.
2016
Background Informing lay citizens about complex health-related issues and their related ethical, legal, and social aspects (ELSA) is one important component of democratic health care/research governance. Public information activities may be especially valuable when they are used in multi-staged processes that also include elements of information and deliberation. Objectives This paper presents a new model for a public involvement activity on ELSA (Ethics University) and evaluation data for a pilot event. Methods The Ethics University is structurally based on the “patient university,” an already established institution in some German medical schools, and the newly developed concept of “ethic…
Ovarian and Adrenal Hyperandrogenism
2007
Because in normal women androgens are secreted in almost equal quantities by both adrenals and ovaries, for many years many studies have tried to distinguish the source of androgen excess. However, in the last 10-15 years, the diagnoses of ovarian or adrenal hyperandrogenism have almost disappeared. This is due to the lack of specificity of dynamic tests as well as to the emphasis given on clinical information and ovarian sonography for the diagnosis of hyperandrogenic syndromes. However, determination of the source of increased androgens may still be useful for improving the classification and the understanding of androgen excess disorders. The aim of this review is to examine the source o…
Possible Pathogenetic Relevance of Interleukin-1beta in "Destructive" Organ-specific Autoimmune Disease (Hashimoto's Thyroiditis)
1999
Thyroid follicular cells (TFC) abundantly express a variety of immunologically relevant surface molecules in Hashimoto's thyroiditis (HT), for example, MHC antigens and adhesion molecules such as ICAM-1. Cytokines produced by infiltrating type 1 helper and cytotoxic T cells are importantly involved in de novo expression or up-regulation of such molecules. We recently demonstrated that TFC from HT patients almost invariably bear on their surface two additive functional molecules: Fas/Apo1/CD95, an important participant in apoptosis, and B7.1, a member of a family of "co-stimulatory" molecules that are crucial for efficient antigen presentation. To date, 12 out of 14 surgical HT thyroid speci…
Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis
2006
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.
Characterization of the Adjuvant Effect of IL-12 and Efficacy of IL-12 Inhibitors in Type II Collagen-Induced Arthritis
1996
A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil and either killed Mycobacterium tuberculosis or IL-12 as adjuvant. Cellular and humoral anti-collagen immune mechanisms appear to be involved in the pathogenesis of arthritis. We have characterized the adjuvant effect or IL-12 in more detail and addressed the question whether mycobacteria might act via the induction of endogenous IL-12. Injections of IL-12 into collagen-immunized DBA/1 mice promoted the development of IFN-gamma-producing CD4+ T cells and strongly upregulated the production of complement-fixing IgG2a and IgG2b antibodies resulting in severe arthritis…
Recensione a: Polipticum quod appellatur Perpendiculum
2021
Recensione alla prima vera e propria edizione critica del Polipticum quod appellatur Perpendiculum di Attone di Vercelli, curata da Giacomo Vignodelli e con un saggio di Luigi G.G. Ricci, apparsa a Firenze, presso la SISMEL – Edizioni del Galluzzo, nel 2019, all'interno dell'Edizione Nazionale dei Testi Mediolatini d’Italia. Review of the first real critical edition of the Polipticum quod appellatur Perpendiculum by Attone di Vercelli
Livelli di rappresentazione del testo nell’edizione del De nomine di Orso Beneventano
2018
Viene presentato l’impianto metodologico e tecnologico dell’edizione critica digitale del De nominedi Orso Beneventano (http://www.unipa.it/paolo.monella/ursus), una proof of concept delle innovazioni metodologiche proposte da Tito Orlandi. Il modello qui sperimentato intende superare la dicotomia tra edizione diplomatica e critica grazie ad un ripensamento profondo, semioticamente fondato, dei livelli di trascrizione e di edizione di un testo. I livelli scelti per questa edizione sono: (1) Livello grafematico, le cui unità minime sono i grafemi, inclusi i segni paragrafematici e le brachilogie sistematiche. Tutti i grafemi individuati dall’editore sono elencati nella Graphemic Table of Sig…
Kritiskā domāšana: izglītība, medijpratība, spriestspēja
2018
Šā pētījuma iniciatīva izriet no LU Ekspertu Padomes1 2017. gada 20. septembra apaļā galda diskusijas “Kritiskā domāšana — kā to mācīt, veicināt un sasaistīt ar mediju lietotprasmi Latvijā?”. Diskusijas gaitā šīs jomas ekspertu lokā skaidri izkristalizējās iepriekš izklāstītās problemātikas aktualitāte Latvijā, tostarp būtiskas nepilnības gan vispārējās, gan augstākās izglītības sistēmā attiecībā uz kritiskās domāšanas prasmju attīstības veicināšanu, trūkumi Latvijas mediju politikā, kā arī saistībā ar mediju lietotprasmi sabiedrībā. LU rektora Ekspertu padome sadarbībā ar LU Filozofijas un socioloģijas institūtu, kura pārziņā ir prioritārā joma “Kritiskā domāšana, inovācija, konkurētspēja …
The 4th international oral history conference «Generation, Migration and Memory: Narrative and its Transformations»: Conference programm and abstracts
2020
The 4th international oral history conference «Generation, Migration and Memory: Narrative and its Transformations», November 12-13, 2020. University of Latvia, Institute of Philosophy and Sociology. Conference programm and abstracts.
Ments alterades en el segle XIX: Els relats d'Edgar Allan Poe i Guy de Moupassant
2014
En el present article s’aborda la confl uencia entre l’autor nord-america Edgar Allan Poe (1809-1849) i l’autor frances Guy de Maupassant (1850-1893), que, a pesar d’estar adscrits a tendencies literaries divergents (romanticisme enfront de realisme/naturalisme), van compartir interessos tematics i formals inequivocs en l’ambit del relat. Partint de les primerenques infl uencies de la contistica de Poe sobre l’escriptura de Maupassant, aquest treball se centra en una seleccio dels relats de l’autor frances que el vinculen literariament a Poe (tant en el terreny tematic com en el narratologic), relacionats amb la fascinacio d’ambdos autors per estats mentals atipics i narradors alterats o «a…