Search results for " SAHA"

CHEMICAL COMPOSITION OF ATMOSPHERIC BULK DEPOSITION AT THE INDUSTRIAL AREA OF GELA (SICILY, ITALY)

2014

Bulk deposition has been collected at six sampling sites in area of Gela plain (Italy) in the period from February 2008 to May 2009. Samples collected each two weeks were analysed for the major ion and trace elements content. Preliminary results allow identifying three different sources that control the abundance of the elements in atmospheric deposition: (1) sea spray, (2)geogenic dust, and (3) anthropogenic pollution. Due to the closeness of the coast, clear evidence of sea spray input is detectable for most of the samples. The high excess of non sea-salt sulphate(50 - 90% of the total) is prevailingly ascribable to the abundant SO2 emissions of the refinery.The pH values of the collected…

EFFETTI CITOTOSSICI SINERGICI INDOTTI DALLA COMBINAZIONE SAHA/PARTENOLIDE IN CELLULE DI CARCINOMA MAMMARIO UMANO MDA-MB231

Il Partenolide (PN) è un sesquiterpene lattone, estratto dalla pianta medicinale Tanacetum Parthenium, noto per le sue proprietà antiinfiammatorie, antimicrobiche e antitumorali. A tal proposito, recentemente è stato dimostrato che il PN è in grado di esercitare un potente effetto citotossico in cellule di “carcinoma mammario umano triplo negativo” (TNBC) MDA-MB231. Tuttavia quando il composto è impiegato a basse dosi determina effetti citotossici molto limitati, anche dopo lunghi periodi di trattamento. Questi risultati suggeriscono che il PN nelle cellule MDA-MB231 è in grado di indurre effetti citoprotettivi che si evidenziano quando impiegato a basse dosi. Poiché tale caratteristica pot…

Jay Amin Hydroxamic Acid (JAHA), a histone deacetylase inhibitor with cytotoxic activity and the property to increase DNA repair of triple-negative M…

2017

Jay Amin Hydroxamic Acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA). JAHA’s cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with an IC50 of 8.45 M. JAHA’s lethal effect was found linked to perturbations of cell cycle, mitochondrial activity, signal transduction and autophagy mechanisms. In order to glean novel insights on how MDA-MB231 breast cancer cells respond to the cytotoxic effect induced by JAHA, and to compare the biological effect with the related compound SAHA, we have employed a combination o…

Identidad transterritorial en la literatura saharaui: La luz de cuatro velas en el Sáhara de Ali Salem Iselmu

2022

The study focuses on the analysis of Ali Salem Iselmu's collection of short stories, La luz de cuatro velas en el Sáhara, as an expression, within Saharawi Literature, of a peculiar identity paradigm, which is based on the transterritorial experience of the author and its characters. The book is made up of four parts, four 'chronotopes', according to a journey from the past to the vision of the future. It is about the four candles that are lit to the beat of the stories that the grandfather/teacher Sidati, one night inside the tent in the camp, decides to start narrating to his granddaughter Marta, to clarify his constant doubts about his name and the two languages she speaks. The constitut…

Factors Affecting E-Business Adoption by SMEs in Sub-Saharan Africa

2009

The use of information communication technologies (ICT) especially the Internet by small- and medium-sized enterprises (SMEs) is on the increase in many regions of the world, including Africa. Nevertheless, empirical evidence from Sub-Saharan Africa (SSA) regarding the factors that affect the adoption of e-business is scarce. In that regard, the main objective of this chapter is to fill the research gap with an exploratory study that is aimed at eliciting views from SMEs in Nigeria. This article made use of a theoretical framework encompassing organizational, external and technological contexts to deliberate the issue. A survey is conducted in three Nigerian cities and the findings of the s…

First morphogenetic analysis of parasite eggs from Schistosomiasis haematobium infected sub-Saharan migrants in Spain and proposal for a new standard…

2021

International audience; Schistosomiasis is a Neglected Tropical Disease caused by trematode species of the genus Schistosoma. Both, autochthonous and imported cases of urogenital schistosomiasis have been described in Europe. The present study focuses on eggs, considered pure S. haematobium by genetic characterisation (intergenic ITS region of the rDNA and cox1 mtDNA). A phenotypic characterisation of S. haematobium eggs was made by morphometric comparison with experimental populations of S. bovis and S. mansoni, to help in the diagnosis of S. haematobium populations infecting sub-Saharan migrants in Spain. Analyses were made by Computer Image Analysis System (CIAS) applied on the basis of …

Social Disparities in Education in Sub-Saharan African Countries

2007

In this paper we have two complementary objectives: the first is to describe the magnitude of social disparities that exist in the systems of education of sub-Saharan African countries; we focus on recent data but we also put these data in a time perspective. The second objective is to identify some of the factors that may explain these disparities and the impact of policies aimed at their reduction.

Du verbe instrumental dans la musique subsaharienne

2021

Sub-Saharan music results from the spoken language/instrumental language relation, directed by an oral culture. In this culture, these languages transmit ? beyond their singularities ? messages thanks to either a coded signal known by the linguistic community or previously defined among a group of individuals, or is used as a true meta-language copied on the articulated and usual language used every day. Here, an instrumental musical speech can then imitate and reproduce the tonal inflexions of the language to make its matter understandable. This fact is the natural result of a strong interaction and interrelation between the spoken language and the music as well as the conception that the …

Conflict management in the international context : analyzing the role of the United Nations in the Western Sahara conflict

2017

The United Nations is the most productive international organization in resolving international world conflicts. The UN uses different techniques and approaches to resolve international conflicts, including mediation. This study analyzes the process of mediation and international conflict management from the point of view of UN efforts in the Western Sahara conflict, which has been ongoing since 1975. This study specifically focuses on the UN’s role in resolving intercultural conflict in Western Sahara and the concrete steps it has taken, such as implementation of the cease-fire, the Settlement Plan and establishing the Mission for an independence referendum in Western Sahara (MINURSO). It …

Challenges Associated with Reading Acquisition in Sub-Saharan Africa : Promotion of Literacy in Multilingual Contexts

2019

Heikki Lyytinen and his co-authors note the problems of poorly trained teachers and large class sizes in Africa. Drawing on experience in Zambia, they present a case study of a digital game that can help overcome these problems and lead to more effective literacy instruction, particularly for students facing barriers to learning how to read. peerReviewed