Search results for " Skin"
showing 10 items of 1220 documents
Anti-Aging Effects of GDF11 on Skin
2020
International audience; Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial process that affects every phase of its biology and function. The expression profiles of inflammation-related genes analyzed in resident immune cells demonstrated that these cells have a strong ability to regenerate adult skin stem cells and to produce endogenous substances such as growth differentiation factor 11 (GDF11). GDF11 appears to be the key to progenitor proliferation and/or differentiation. The preservation of youthful phenot…
GLP-2: What do we know? What are we going to discover?
2014
Glucagon-like peptide 2 [GLP-2] is a 33-amino acid peptide released from the mucosal enteroendocrine L-cells of the intestine. The actions of GLP-2 are transduced by the GLP-2 receptor [GLP-2R], which is localized in the neurons of the enteric nervous system but not in the intestinal epithelium, indicating an indirect mechanism of action. GLP-2 is well known for its trophic role within the intestine and interest in GLP-2 is now reviving based on the approval of the GLP-2R agonist for treatment of short bowel syndrome [SBS]. Recently it also seems to be involved in glucose homeostasis. The aim of this review is to outline the importance of neuroendocrine peptides, specifically of GLP-2 in th…
Meaning in life in Eating Disorders patients with Non-suicidal self Injuries.
2020
Low meaning in life it is associated to psychopathology in a large amount of research in clinical sample. However, the studies on meaning in life in people with eating disorders is scarce. Moreover, important NSSI rates have been reported in patients with eating disorders. The aims of the study are: (1) to analyze whether the participants diagnosed with eating disorders have lower meaning in life than the general population; (2) to analyze possible differences in meaning in life among participants based on the eating disorder diagnosis (anorexia nervosa, bulimia nervosa and EDNOS) or subtype (restrictive vs. purgative); (3) to study which psychopathological variables (hopelessness, meaning …
Analysis of a database to predict the result of allergy testing in vivo in patients with chronic nasal symptoms and the development of the software A…
2014
Background. This thesis consist of parts(i)Introduction in wich we present the clinical problem of rhinitis;(ii)the methods to evaluate the diagnostic choises;(iii)the rational errors in Allergy,(iv)the experimental part of thesis with wich we developed the software ARTSTAT,wich is the application of the analysis reported.Objective: We studied the ability of the logistic regression model obtained by the evaluaqtion of a database, to detect patients with positive allergy skin prick test(SPT)and patients with negative SPT. The model developed was valitated using the data set obtained from another medical institution. Methods: The analysis was carried out using a database obtained from a quest…
Nasal IgE in subjects with allergic and non-allergic rhinitis
2020
Abstract Purpose The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students. Methods 131 students (age 25.0 ± 5.1 years) with a possible allergic rhinitis and 25 non-allergic controls without rhinitis symptoms (age 22.0 ± 2.0 years) were recruited by public postings. 97 of 131 students with rhinitis were tested positive (≥3 mm) to prick testing with 17 frequent allergens at visit 1. Twenty-fo…
The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update
2014
This guideline is the result of a systematic literature review using the 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2)LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies. Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioe…
Nasal Cellularity in 183 Unselected Schoolchildren Aged 9 to 11 Years
2002
Objective. Although rhinitis is extremely frequent in children, methods for assessing the severity of nasal inflammation produce results with wide variability and hence weak clinical significance. We designed this epidemiologic investigation to define the clinical usefulness of assessing nasal cellularity in children. Methods. We studied 183 of 203 eligible unselected schoolchildren who were aged 9 to 11 years and whose parents gave informed consent and completed a questionnaire on the history of atopic and respiratory symptoms. In all children, nasal swabs were obtained from both nostrils and eluted in saline and slides were prepared from cytospin preparations for staining and white cell c…
Cat Allergy as a Source Intensification of Atopic Dermatitis in Adult Patients
2020
Atopic dermatitis (AD) is characterized by exacerbations and remissions of eczematous skin, underlain by impaired skin barrier and aberrant Th2-type and Th-22 cytokine production. A number of allergens, in particular contact with fur animals, may aggravate the disease. This study seeks to define the influence of having a regular contact with a pet cat at home on the severity of symptoms and signs of AD. We addressed the issue using the SCORing Atopic Dermatitis (SCORAD) and visual analog (VAS) scores to assess the intensity of pruritus and by measuring the blood content of specific IgE and IL-4, IL-13, and IL-22 cytokines. The study group consisted of 47 adult patients suffering from AD sin…
Oval fiber posts do not improve adaptation to oval-shaped canal walls.
2011
Abstract Introduction Oval fiber posts attempt to provide better adaptation to root canals. The hypothesis of this study was that there are no differences in adaptation of oval and circular fiber posts to canal walls. Methods Posts were inserted in 20 canals; 10 were oval, and 10 were circular. The posts were cemented with composite cement. Coronal, middle, and apical sections were observed through a microscope. The space occupied by the post and the maximum distance between it and the canal wall were calculated. The 2 groups were compared with analysis of variance. In all the analyses the level of significance was set at P Results The proportion of space occupied by the post showed no sign…
Flow-injection spectrofluorimetric determination of paracetamol
1990
Abstract A flow-injection spectrofluorimetric determination of paracetamol is reported, based on the oxidation of the analyte with potassium hexacyanoferrate(III) immobilized on an anion-exchange resin, the fluorescence being enhanced with N,N′-dimethylformamide. Concentrations of paracetamol in the range 0.04–17.60 mg l−1 are determined with a relative standard deviation of 1.5%. The injection rate is 25 samples h−1. The influence of foreign species and the determination of paracetamol in several pharamaceutical formulations are also reported.