Search results for " Tremor"
showing 10 items of 47 documents
Terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica: studio retrospettivo sui parametri di trattamento
2019
SCOPO DEL LAVORO: La terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica (tcMRgFUS) è stata recentemente introdotta per il trattamento non invasivo di alcuni disordini del movimento quali il tremore essenziale (ET) ed il Parkinson idiopatico unilaterale prevalentemente tremorigeno (PD). Sebbene con tale tecnica sia possibile generare con successo talamotomie del nucleo Vim nella maggior parte dei pazienti, in alcuni casi si incontrano difficoltà nell’indurre un incremento di temperatura nel target pianificato sufficiente ad indurre e consolidare una lesione permanente. La causa di questi fenomeni è da ricercare nelle caratteristiche specifiche del tavolato cranico…
TERAPIA TRANS-CRANICA AD ULTRASUONI FOCALIZZATI GUIDATI DA RISONANZA MAGNETICA UTILIZZANDO UN SISTEMA INTEGRATO CON UNO SCANNER RM DA 1.5T
2019
Scopo Negli ultimi anni la terapia transcranica ad ultrasuoni focalizzati guidati da risonanza magnetica (tcMRgFUS) per il trattamento di disordini neurologici quali il tremore essenziale (ET) e il Parkinson tremorigeno (PD) è stata effettuata utilizzando esclusivamente scanner RM da 3T. Presentiamo i risultati ottenuti con il primo sistema tcMRgFUS mai integrato con uno scanner RM da 1.5T. Materiali e metodi 50 pazienti (39 ET; 11 PD) sono stati selezionati per essere sottoposti a tcMRgFUS (talamotomia monolaterale; target: nucleo ventrale intermedio, VIM). I pazienti arruolati sono stati valutati prima del trattamento e 2 giorni dopo. L'efficacia del trattamento è stata valutata utilizzan…
Terapia trans-cranica ad ultrasuoni focalizzati guidati da Risonanza Magnetica (tcMRgFUS): studio di parcellizzazione talamica per l'identificazione …
2018
Scopo La tcMRgFUS consente di effettuare una vera e propria esplorazione neurofunzionale per confermare ed ottimizzare il target lesionale prima di indurre una lesione cerebrale permanete. La scelta del target di trattamento si basa tuttavia su coordinate stereotassiche che non tengono conto delle diversità anatomiche di ciascun individuo. L'ottimizzazione del target viene effettuata sulla base del feedback del paziente durante la procedura stessa. Scopo di questo lavoro è valutare il possibile ruolo della parcellizzazione talamica per l'identificazione del nucleo ventrale intermedio (VIM) in pazienti sottoposti a tcMRgFUS. Materiali e metodi È’ stato utilizzato uno scanner RM da 1,5T per a…
The weak and superfast Cretan detachment, Greece: exhumation at subduction rates in extruding wedges
2002
Low-angle normal faults (detachments) are only efficient agents for bringing rocks from 40–>100 km depth back to the Earth’s surface if they operate with extreme slip rates exceeding 20 km Ma −1 . Here we propose a slip rate of ≧20–30 km Ma −1 for the Cretan detachment in the Aegean, Greece. The Cretan detachment and the subjacent subduction thrust bounded an extruding wedge above the Miocene Hellenic subduction zone. During exhumation the high-pressure rocks in the wedge were not significantly deformed. Very low shear coupling at the bounding faults (which are therefore weak) is needed to prevent significant deformation in the extruding wedge. The proposed slip rate of ≧20–30 km Ma −1 is s…
Even violins can cry: specifically vocal emotional behaviours also drive the perception of emotions in non-vocal music.
2021
A wealth of theoretical and empirical arguments have suggested that music triggers emotional responses by resembling the inflections of expressive vocalizations, but have done so using low-level acoustic parameters (pitch, loudness, speed) that, in fact, may not be processed by the listener in reference to human voice. Here, we take the opportunity of the recent availability of computational models that allow the simulation of three specifically vocal emotional behaviours: smiling, vocal tremor and vocal roughness. When applied to musical material, we find that these three acoustic manipulations trigger emotional perceptions that are remarkably similar to those observed on speech and scream…
Prevalence of essential tremor: A door-to-door survey in Terrasini, Sicily
1994
As part of a door-to-door neuroepidemiologic survey, we investigated the frequency and distribution of essential tremor (ET) in a Sicilian municipality. During phase 1, we administered a screening instrument for tremor to 7,653 persons residing in Terrasini (Palermo province). During phase 2, neurologists evaluated those subjects who had screened positive. The diagnoses, based on specified clinical criteria, were reviewed to increase reliability across neurologists. We found 31 subjects affected by ET (17 men, 14 women); 11 patients (35.5%) reported a familial aggregation. The prevalence of ET as of November 1, 1987, was 405.1 per 100,000 for the total population, and 1,074.9 per 100,000 fo…
Transcranial magnetic resonance-guided focused ultrasound thalamotomy as a safe treatment option in multiple sclerosis patients with essential tremor
2020
Transcranial magnetic resonance-guided focused ultrasound is a recently introduced incisionless treating option for essential tremor and tremor-dominant idiopathic Parkinson disease. There is preliminary evidence that it may result in a promising effective treatment option for other movement disorders too. Here, we report on two patients with multiple sclerosis with medication refractory debilitating essential tremor comorbidity who successfully underwent unilateral Vim tcMRgFUS thalamotomy for tremor control. Patients' clinical condition and expanded disability status scale scores showed no changes during the 1-year follow-up period with no evidence of multiple sclerosis activity or progre…
Restoring Neurological Physiology: The Innovative Role of High-Energy MR-Guided Focused Ultrasound (HIMRgFUS). Preliminary Data from a New Method of …
2017
Background Tremor is a disabling condition, common to several neurodegenerative diseases. Lesioning procedures and deep brain stimulation, respectively, of the ventralis intermedius nucleus for intentional tremor, and of the subthalamic nucleus for parkinsonian resting tremor, have been introduced in clinical practice for patients refractory to medical treatment. The combination of high-energy focused ultra-sound (HIFUS) with sophisticated magnetic resonance (MR) instrumentation, together with accurate knowledge of the stereotactic brain coordinates, represents a revolution in neuromodulation. Methods At the Neurosurgical Clinic and the Radiology Department of the University of Palermo,, tw…
Advanced technologies for detecting tremor in Parkinson's disease.
2019
Objective Accurate and reliable detection of tremor onset in Parkinson’s disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy. Here, we investigated the potential use of feature engineering and machine learning methods for more accurate detection of rest tremor in PD. Methods We analyzed the local field potential (LFP) recordings from the subthalamic nucleus region in 12 patients with PD (16 recordings). To explore the optimal biomarkers and the best performing classifier, the performance of state-of-the-art machine learning (ML) algorithms and various features of the subthalamic LFPs were compared. We further used a Kalman filtering technique in feature…