Search results for " X-Ray"
showing 10 items of 2156 documents
First discovery of orichalcum ingots from the remains of a 6th century BC shipwreck near Gela (Sicily) seabed
2017
Ingots recently recovered from the seabed near Gela, a major harbour of Sicily, reveal an unexpected side of ancient metallurgy. The ingots were found near remains of a ship and earthenware dated around the end of the VI century BC and probably coming from the eastern Mediterranean and the Aegean sea. The ingots were analysed by means of X-Ray Fluorescence spectroscopy via a portable spectrometer. Results indicate that they are mostly consist of copper and zinc although many of them have a significant amount of lead. This alloy is nowday called brass, but in ancient time it was know as orichalcum, one of the rarest and most precious alloy along with gold and silver. Only small items of oric…
Chemical and mineralogical analyses on stones from Sagunto Castle (Spain)
2019
Abstract For the first time, an archaeometric study was carried out on the carbonate rock ashlars of the Sagunto Castle. The studied site is one of the most important and best preserved Spanish archaeological and architectural monuments, characterized by different construction phases from the Roman period to Modern Ages. Forty samples collected from thirteen different structures of Sagunto Castle and two quarries, located in the Sagunto's hill were used for comparative purposes. The samples were analyzed by X-ray diffraction, X-ray fluorescence and inductively coupled plasma mass spectrometry to determine their mineralogical and elemental composition. The obtained data show similar chemical…
Low-Power, Subthreshold Reference Circuits for the Space Environment : Evaluated with -rays, X-rays, Protons and Heavy Ions
2019
The radiation tolerance of subthreshold reference circuits for space microelectronics is presented. The assessment is supported by measured results of total ionization dose and single event transient radiation-induced effects under &gamma
Residual stress measurement in innovative friction stir welding processes
2017
In recent years, important innovations have been introduced in Friction Stir Welding (FSW) technology such as, for example, the Laser assisted Friction Stir Welding (LFSW) and in-process Cooled Friction Stir Welding (CFSW). Residual stresses have a fundamental role in welded structures because they affect the way to design the structures, fatigue life, corrosion resistance and many other material properties. Consequently, it is important to investigate the residual stress distribution in FSW where, though the heat input is lower compared to traditional welding techniques, the constraints applied to the parts to weld are more severe. The aim of the present work is to verify the capabilities …
Direct laser welding of pure titanium to austenitic stainless steel
2018
Abstract Direct butt joining of pure titanium to 316L stainless steel with continuous Yb:YAG laser was performed with variation of the beam offset from joint line. Mechanical properties of samples were evaluated by tensile tests and three-point flexural tests. The fractured surfaces and cross sections of welds were examined by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). Tensile properties of welds were strongly determined by the beam offset from joint line and are well described by Weibull statistics. Ultimate tensile strength of 174 ± 69 MPa and ultimate flexural strength of 297 ± 48 MPa were obtained. Brittle fracture took place in…
Investigation of Isoindolo[2,1-a] quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods
2017
Background: Isoindolo[2,1-alpha] quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell lines and topoisomerase I inhibitors. In particular, their water soluble imine or iminium salts recently synthesized showed potent growth inhibitory effect on NCI-60 tumor cell line panel and biological studies performed on the most active compounds demonstrated that they cause DNA damage via topoisomerase I poisoning. Objective: Herein, we investigate with molecular modeling methods, the common features responsible for topoisomerase I inhibition of the water-soluble isoindolo[2,1-alpha] quinoxalin-6-imines, by compa…
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
2020
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced…
2019
Abstract Purpose: IDO1 induces immune suppression in T cells through l-tryptophan (Trp) depletion and kynurenine (Kyn) accumulation in the local tumor microenvironment, suppressing effector T cells and hyperactivating regulatory T cells (Treg). Navoximod is an investigational small-molecule inhibitor of IDO1. This phase I study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of navoximod in combination with atezolizumab, a PD-L1 inhibitor, in patients with advanced cancer. Patients and Methods: The study consisted of a 3+3 dose-escalation stage (n = 66) and a tumor-specific expansion stage (n = 92). Navoximod was given orally every 12 hours continuously for 21 consecu…
The torso integration hypothesis revisited in Homo sapiens: Contributions to the understanding of hominin body shape evolution.
2018
Objectives: Lower thoracic widths and curvatures track upper pelvic widths and iliac blades curvatures in hominins and other primates (torso integration hypothesis). However, recent studies suggest that sexual dimorphism could challenge this assumption in Homo sapiens. We test the torso integration hypothesis in two modern human populations, both considering and excluding the effect of sexual dimorphism. We further assess covariation patterns between different thoracic and pelvic levels, and we explore the allometric effects on torso shape variation. Material and Methods: A sex-balanced sample of 50 anatomically connected torsos (25 Mediterraneans, 25 Sub-Saharan Africans) was segmented fro…
Prediction of unfavorable outcomes in West Nile virus neuroinvasive infection - Result of a multinational ID-IRI study
2019
Background: WNV causes 1.4% of all central nervous system infections and is the most common cause of epidemic neuro-invasive disease in humans. Objectives: Our main objective was to investigate retrospectively West Nile virus neuroinvasive disease (WNND) cases hospitalized during 2010–2017 and identified factors that can influence prognosis. Study design: We documented the demographic, epidemiologic, clinical and laboratory data of WNND and identified factors that can influence prognosis. The data were recruited through Infectious Diseases International Research Initiative (ID-IRI), which serves as a network for clinical researches. Results: We investigated 165 patients with WNND in 10 coun…