Search results for " libraries"
showing 10 items of 239 documents
Managing Knowledge in Academic Libraries Are we? Should we?
2016
This article gives an overview of the field of knowledge management and suggests how this can be applied to academic libraries. A literature review has been conducted and has been subject to a critical analysis of comparison to IFLAs standard for “Continuing Professional Development: Principles and Best Practices” (IFLA, 2015). Here IFLA has identified 10 points of best practice. These 10 points will be measured against the literature in the field of knowledge management to ascertain if academic libraries would benefit from a stronger relation to knowledge management.
Accessing the gluonic structure of light nuclei at a future electron-ion collider
2020
We show how exclusive vector meson production off light ions can be used to probe the spatial distribution of small-$x$ gluons in the deuteron and $^3$He wave functions. In particular, we demonstrate how short range repulsive nucleon-nucleon interactions affect the predicted coherent $J/\Psi$ production spectra. Fluctuations of the nucleon substructure are shown to have a significant effect on the incoherent cross section above $|t|\gtrsim 0.2\,\mathrm{GeV}^2$. By explicitly performing the JIMWLK evolution, we predict the $x$-dependence of coherent and incoherent cross sections in the EIC energy range. Besides the increase of the average size of the nucleus with decreasing $x$, both the gro…
Getting out of the closet: Scientific authorship of literary fiction and knowledge transfer
2020
Trabajo presentado a la DRUID Society Conference, celebrada en New York (US) del 12 al 14 de junio de 2017.
Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules.
2012
While prognostic factors can help to classify the standard risk of subpopulations of patients with the same tumor entity, it is still not possible to predict the response of individual patients to specific therapies. The reason for such wide variation in cancer therapy responses remains largely unknown. The field of chemotherapy is currently undergoing a paradigm shift from classical cytotoxic chemotherapy to targeted therapy in order to kill tumor cells more efficiently with fewer side effects on normal tissue. In the present review, we focus on colorectal carcinoma, which is one of the most frequent tumor types worldwide and represents a leading cause of cancer-related deaths. The signali…
Contribution of phase-mixing of Alfvén waves to coronal heating in multi-harmonic loop oscillations
2018
This research has received funding from the Science and Technology Facilities Council (UK) through the consolidated grant ST/N000609/1 and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program ( grant agreement No. 647214). This work is supported by the European Research Council under the SeismoSun Research Project No. 321141 (DJP). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 724326). This work used the DiRAC Data Centric system at Durham University, operated by the Institute for Computational Cosmology on behalf o…
Conformal equivalence of visual metrics in pseudoconvex domains
2017
We refine estimates introduced by Balogh and Bonk, to show that the boundary extensions of isometries between smooth strongly pseudoconvex domains in $\C^n$ are conformal with respect to the sub-Riemannian metric induced by the Levi form. As a corollary we obtain an alternative proof of a result of Fefferman on smooth extensions of biholomorphic mappings between pseudoconvex domains. The proofs are inspired by Mostow's proof of his rigidity theorem and are based on the asymptotic hyperbolic character of the Kobayashi or Bergman metrics and on the Bonk-Schramm hyperbolic fillings.
Mapping properties for the Bargmann transform on modulation spaces
2010
We investigate mapping properties for the Bargmann transform and prove that this transform is isometric and bijective from modulation spaces to convenient Banach spaces of analytic functions.
A Model of Smart G-Quadruplex Ligand
2012
An unprecedented strategy to control the quadruplex- vs duplex-DNA selectivity of a ligand is reported. We designed a compound whose structure can rearrange when it interacts with a G-quadruplex, thereby controlling its affinity. Thus, the first "smart G-quadruplex ligand" is reported, since this ligand experiences a structural change in the presence of quadruplexes but not in the presence of duplexes, ensuring a high level of quadruplex selectivity.
Assessing the Differential Affinity of Small Molecules for Noncanonical DNA Structures
2012
The targeting of higher-order DNA structures has been thoroughly developed with G-quadruplex DNA but not with other structures like branched DNA (also known as DNA junctions). Because these alternative higher-order DNA architectures might be of high biological relevance, we implemented a high-throughput version of the FRET melting assay that enabled us to map the interactions of a candidate with four different DNA structures (duplex- and quadruplex DNA, three- and four-way junctions) in a rapid and reliable manner. We also introduce a novel index, the BONDS (branched and other noncanonical DNA selectivity) index, to conveniently quantify this differential affinity.
DesMol2, an Effective Tool for the Construction of Molecular Libraries and Its Application to QSAR Using Molecular Topology
2019
A web application, DesMol2, which offers two main functionalities, is presented: the construction of molecular libraries and the calculation of topological indices. These functionalities are explained through a practical example of research of active molecules to the formylpeptide receptor (FPR), a receptor associated with chronic inflammation in systemic amyloidosis and Alzheimer&rsquo