Search results for " modifica"

NEW GRAFT COPOLYMERS OF HYALURONIC ACID AND POLYLACTIC ACID: SYNTHESIS AND CHARACTERIZATION

2006

Abstract New graft copolymers have been synthesized, using hyaluronic acid (HA) as a hydrophilic backbone and polylactic acid (PLA) as an aliphatic polyester in order to obtain new polymeric derivatives of HA able to hydrophobically associate in an aqueous medium. Hyaluronic acid with low molecular weight was made soluble in organic solvent by transformation to its tetrabutylammonium (TBA) salt. Using the HA–TBA derivative, the reaction was performed in dimethylsulfoxide adding as a reagent the N -hydroxysuccinimide derivative of PLA. Two HA–PLA graft copolymers have been synthesized and characterized by FT-IR, 1 H NMR spectroscopy and gel permeation chromatography. The interaction between …

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

2020

The effect of the polyanionic polymer of inorganic polyphosphate (polyP) involved in innate immunity on the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to the cellular ACE2 receptor was studied. The RBD surface comprises a basic amino acid stretch of four arginine residues which interact with the physiological polyP (polyP40) and polyP3. Subsequently, the interaction of RBD with ACE2 is sensitively inhibited. After the chemical modification of arginine, an increased inhibition by polyP, at a 1 : 1 molar ratio (polyP : RBP), is measured already at 0.1 μg mL−1. Heparin was ineffective. The results suggest a potential therapeutic benefit of polyP against SARS-C…

Study of Inductive Coupled Hydrogen and Argon Plasma Interaction with SiO2 Glass

2009

This work is devoted to the diagnostics of interaction between hydrogen and argon with the surface of SiO2 glass walls. For diagnostics of the interaction, special high-frequency electrodeless light sources were prepared, filled with pure argon of 1 Torr or argon-hydrogen of total pressure of 1 Torr (Ar/H2 mixing ratio is 9:1). Besides the mostly used spherical and cylindrical lamps, dumbbell type lamps have also been investigated. The spectroscopic and AFM measurements showed that in comparison with pure argon plasma, the argon-hydrogen plasma causes non-uniform changes of the SiO2 surface. For these modifications active OH are primarily responsible molecules, created in the reactions of h…

Speech Emotion Recognition method using time-stretching in the Preprocessing Phase and Artificial Neural Network Classifiers

2020

Human emotions are playing a significant role in the understanding of human behaviour. There are multiple ways of recognizing human emotions, and one of them is through human speech. This paper aims to present an approach for designing a Speech Emotion Recognition (SER) system for an industrial training station. While assembling a product, the end user emotions can be monitored and used as a parameter for adapting the training station. The proposed method is using a phase vocoder for time-stretching and an Artificial Neural Network (ANN) for classification of five typical different emotions. As input for the ANN classifier, features like Mel Frequency Cepstral Coefficients (MFCCs), short-te…

2011

Abstract. The ability of coated mineral dust particles to act as ice nuclei (IN) was investigated at LACIS (Leipzig Aerosol Cloud Interaction Simulator) during the FROST1- and FROST2-campaigns (Freezing of dust). Sulphuric acid was condensed on the particles which afterwards were optionally humidified, treated with ammonia vapour and/or heat. By means of aerosol mass spectrometry we found evidence that processing of mineral dust particles with sulphuric acid leads to surface modifications of the particles. These surface modifications are most likely responsible for the observed reduction of the IN activation of the particles. The observed particle mass spectra suggest that different treatme…

Cytotoxic activity of several ent-kaurane derivatives of atractyligenin. Synthesis of unreported diterpenic skeleton by chemical rearrangement

2022

Atractyloside, carboxyatractyloside, their aglycon atractyligenin, and several synthetic derivatives were tested and found to be active against a panel of human tumor cell lines. Atractyligenin was subjected to oxidation, bromination, and elimination reactions, obtaining several compounds. A singular skeleton was synthesized by chemical rearrangement starting from 3 beta-bromo-2,15-diketoatractyligenin methyl ester. The synthesized compounds resulted active against all cell lines tested. In particular, 15-ketoatractyligenin methyl ester and 3 beta bromo-2,15-diketoatractyligenin methyl ester resulted the most active with IC50 values of 0.427 and 0.723 mu M against A375 melanoma cell line. E…

Functionalization using biocompatible carboxylated cyclodextrins of iron-based nanoMIL-100

2021

9 pags., 7 figs., 1 tab.

Generic Method for Modular Surface Modification of Cellulosic Materials in Aqueous Medium by Sequential Click-Reaction and Adsorption

2012

A generic approach for heterogeneous surface modification of cellulosic materials in aqueous medium, applicable for a wide range of functionalizations, is presented. In the first step, carboxymethyl cellulose (CMC) modified with azide or alkyne functionality, was adsorbed on a cellulosic substrate, thus, providing reactive sites for azide–alkyne cycloaddition click reactions. In the second step, functional units with complementary click units were reacted on the cellulose surface, coated by the click-modified CMC. Selected model functionalizations on diverse cellulosic substrates are shown to demonstrate the generality of the approach. The concept by sequentially combining the robust physic…

The selective synthesis of metallanucleosides and metallanucleotides: a new tool for the functionalization of nucleic acids.

2012

Nucleobases team up: the efficient and selective preparation of purine-derived metallanucleosides, metallanucleotides, and metalladinucleotides having M-C bonds (M=Ir(III), Rh(III)) is reported for the first time. The results presented may be applied to the synthesis of functionalized nucleic acids, or DNA/RNA-modified segments.

Kinetics of the Strain-Promoted Oxidation-Controlled Cycloalkyne-1,2-quinone Cycloaddition: Experimental and Theoretical Studies

2018

Stimulated by its success in both bioconjugation and surface modification, we studied the strain-promoted oxidation-controlled cycloalkyne–1,2-quinone cycloaddition (SPOCQ) in three ways. First, the second-order rate constants and activation parameters (ΔH⧧) were determined of various cyclooctynes reacting with 4-tert-butyl-1,2-quinone in a SPOCQ reaction, yielding values for ΔH⧧ of 4.5, 7.3, and 12.1 kcal/mol, for bicyclo[6.1.0]non-4-yne (BCN), cyclooctyne (OCT), and dibenzoazacyclooctyne (DIBAC), respectively. Second, their reaction paths were investigated in detail by a range of quantum mechanical calculations. Single-configuration theoretical methods, like various DFT and a range of MP2…