Search results for " multiple"

The Fluorescence Detector of the Pierre Auger Observatory

2010

The Pierre Auger Observatory is a hybrid detector for ultra-high energy cosmic rays. It combines a surface array to measure secondary particles at ground level together with a fluorescence detector to measure the development of air showers in the atmosphere above the array. The fluorescence detector comprises 24 large telescopes specialized for measuring the nitrogen fluorescence caused by charged particles of cosmic ray air showers. In this paper we describe the components of the fluorescence detector including its optical system, the design of the camera, the electronics, and the systems for relative and absolute calibration. We also discuss the operation and the monitoring of the detecto…

Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.

2018

Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3-6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1-2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicit…

All-optical regeneration of polarization of a 40 Gbit/s return-to-zero telecommunication signal

2013

International audience; We report all-optical regeneration of the state of polarization of a 40 Gbit/s return-to-zero telecommunication signal. The device discussed here consists of a 6.2-km-long nonzero dispersion-shifted fiber, with low polarization mode dispersion, pumped from the output end by a backward propagating wave coming from either an external continuous source or a reflection of the signal. An initially scrambled signal acquires a degree of polarization close to 100% toward the polarization generator output. All-optical regeneration is confirmed by means of polarization and bit-error-rate measurements as well as real-time observation of the eye diagrams. We show that the physic…

Assessing anthropogenic pressures on coastal marine ecosystems using stable CNS isotopes: State of the art, knowledge gaps, and community-scale persp…

2015

Abstract In recent decades, the analysis of carbon, nitrogen and sulfur stable isotopes (SIA) has emerged as a powerful, viable methodology for examining food web structure and dynamics, as well as addressing a number of applied issues. Here, we provide a state-of-the-art review of the use of SIA for assessing anthropogenic pressures on natural ecosystems, in order to establish current knowledge gaps and identify promising applications for evaluating the ecological status of marine coastal waters. Specifically, the potential of SIA to provide food web-scale indicators for estimating cumulative anthropogenic pressures is addressed. The review indicates that the methodology has been used for …

Weyers acrodental dysostosis in a family.

1984

A four generation family with postaxial polydactyly of hands and feet and dental anomalies is reported. Lower and upper incisors were abnormal in shape and number. Additional findings were prominent ear anthelices, hypoplastic and dysplastic nails and mild shortness of stature. Inheritance was dominant with variable expression. It is proposed that the family presents the syndrome of acrofacial dysostosis described by Weyers in 1952. To differentiate it from other acrofacial dysostoses, we suggest naming the condition acrodental dysostosis.

Clinical cardiac assessment in newborns with prenatally diagnosed intrathoracic masses

2018

Abstract Background Congenital space-occupying thoracic malformations and diaphragmatic hernia have in common pulmonary hypoplasia. Our study aims to assess cardiac involvement during post-natal adaptation. Methods A retrospective study was carried out on newborns with prenatally diagnosed intrathoracic mass. Gathering for respiratory distress syndrome (RDS), 35 neonates were compared for clinical course, cardiovascular enzymes, ECG, and ultrasound. Results The analysis revealed a high left heart defect rate in patients with severe RDS, without being influenced by the laterality. Ultrasound or laboratory assessment did not detect altered cardiac dimension or cardiomyopathy. Solely ECG signs…

Clinical and Instrumental Findings and Disability Progression in Primary Progressive and Progressive Relapsing Multiple Sclerosis: A Comparison Study…

2013

Conditions et enjeux pédagogiques de la constitution de classes à cours multiples dans les écoles primaires

2006

06022; La problématique de cette recherche s'inscrit dans le schéma global suivant, qui se donne pour objectif d'analyser successivement les pratiques de constitution des classes (nombre et nature des classes au sein des écoles), les modalités d'affectation des élèves et des enseignants dans ces classes et enfin l'efficacité pédagogique des différents types de groupement réalisés.

Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells

2015

Abstract Ethnopharmacological relevance Rosmarinic acid (RA), a major hydrosoluble bioactive compound found in the Chinese medicinal herb, Salvia miltiorrhiza Bunge, which has been used in traditional Chinese medicine to treat various diseases, including cancer. However, the mechanisms have not been fully elucidated. Aim of the study Guided by microarray hybridization and Ingenuity Pathway Analysis, we identified modes of action of rosmarinic acid (RA) isolated from S. miltiorrhiza on acute lymphoblastic leukemia cells. Materials and methods Microarray data were verified by independent methods: Real-time RT-PCR (mRNA expression), resazurin assay (cytotoxicity of RA towards parental CCRF-CEM…

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

2019

Abstract Background The multidrug resistance (MDR) phenotype encounters a major challenge to the success of established chemotherapy in cancer patients. We hypothesized that cytotoxic medicinal plants with novel phytochemicals can overcome MDR and kill MDR-cells with similar efficacy as drug sensitive cells. Purpose We evaluated plant extracts from an unexplored ecosystem in Egypt with unusual climate and nutrient conditions for their activity against sensitive and multidrug-resistant cancer cell lines. Material and methods/study design Methylene chloride: methanol (1:1) and methanol: H2O (7:3) extracts of 40 plants were prepared resulting in a sum of 76 fraction containing compounds with v…