Search results for " pathology"
showing 10 items of 2852 documents
The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review
2019
Background Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The ability of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a pivotal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. Material and Methods Systematic searches were conducted on three databases: Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory stu…
Advances in surfaces and osseointegration in implantology. Biomimetic surfaces
2015
The present work is a revision of the processes occurring in osseointegration of titanium dental implants according to different types of surfaces -namely, polished surfaces, rough surfaces obtained from subtraction methods, as well as the new hydroxyapatite biomimetic surfaces obtained from thermochemical processes. Hydroxyapatite’s high plasma-projection temperatures have proven to prevent the formation of crystalline apatite on the titanium dental implant, but lead to the formation of amorphous calcium phosphate (i.e., with no crystal structure) instead. This layer produce some osseointegration yet the calcium phosphate layer will eventually dissolve and leave a gap between the bone and …
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
Approximators and mitigators in Chilean Spanish: the case of 'como' and 'como que'
2019
espanolEn el presente trabajo se realiza un analisis del uso de los aproximadores como y como que en el espanol de Chile y la vinculacion de su valor semantico aproximador con la atenuacion pragmatica. Diversos son los trabajos que han otorgado al marcador como un valor aproximativo (Mihatsch, 2009, 2010; Jorgensen y Stenstrom 2009; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013; Kern, 2014; Jimenez y Flores-Ferran, 2018) y tambien un valor atenuador (Briz, 1998; Jorgensen, 2011; Holmvik, 2011; Kornfeld, 2013, Panussis, 2016; Mondaca, 2017; Panussis y San Martin, 2017). Asi, el objetivo es analizar la relacion que existe entre la aproximacion semantica y la atenuacion pragmatica por medio d…
Impact du climat sur la santé : modélisation régionale des poussières pour les épidémies de méningites au Sahel.
2014
6 pages; International audience; Les épidémies des méningites bactériennes constituent encore à l’heure actuelle un problème de santé publiquemajeur en Afrique de l’Ouest. Chaque année, au coeur de la saison sèche (de janvier à mars), 25 000 à 250 000 cas sontenregistrés par l’Organisation Mondiale de la Santé (OMS) dans la zone latitudinale 10-15°N, plus communément appelée« ceinture de la méningite ». L’importance des facteurs sociétaux dans l’expansion des épidémies est indéniable. Cependant,une série d’études récentes a permis de mettre en lumière le rôle important du climat. Ainsi, l’intensité des épidémies sembleliée à des conditions de circulation atmosphérique spécifiques quelques m…
A genomic reappraisal of symbiotic function in the aphid/Buchnera symbiosis: reduced transporter sets and variable membrane organisations.
2011
International audience; Buchnera aphidicola is an obligate symbiotic bacterium that sustains the physiology of aphids by complementing their exclusive phloem sap diet. In this study, we reappraised the transport function of different Buchnera strains, from the aphids Acyrthosiphon pisum, Schizaphis graminum, Baizongia pistaciae and Cinara cedri, using the re-annotation of their transmembrane proteins coupled with an exploration of their metabolic networks. Although metabolic analyses revealed high interdependencies between the host and the bacteria, we demonstrate here that transport in Buchnera is assured by low transporter diversity, when compared to free-living bacteria, being mostly bas…
The patterned ways of interlinking linguistic and multimodal elements in visually oriented communities
2019
This paper attends to languaging in the context of visually oriented communities of sign language users through the concept of chaining. I define chaining as the patterned, routine ways of interlin...
Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle
2020
Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity.
The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases
2018
International audience; Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes. The relationship between bone regulatory proteins and vascular biology has attracted attention, and it has been suggested that OPG may medi…
miR-7 Restores Phenotypes in Myotonic Dystrophy Muscle Cells by Repressing Hyperactivated Autophagy
2019
International audience; Unstable CTG expansions in the 3' UTR of the DMPK gene are responsible for myotonic dystrophy type 1 (DM1) condition. Muscle dysfunction is one of the main contributors to DM1 mortality and morbidity. Pathways by which mutant DMPK trigger muscle defects, however, are not fully understood. We previously reported that miR-7 was downregulated in a DM1 Drosophila model and in biopsies from patients. Here, using DM1 and normal muscle cells, we investigated whether miR-7 contributes to the muscle phenotype by studying the consequences of replenishing or blocking miR-7, respectively. Restoration of miR-7 with agomiR-7 was sufficient to rescue DM1 myoblast fusion defects and…