Search results for " phosphorylation"
showing 10 items of 381 documents
ChemInform Abstract: Oxidative (Cross-)Coupling Reactions Mediated by C-H Activation of Thiophene Derivatives by Using Molybdenum(V) Reagents.
2015
The use of MoCl5 renders possible the preparation of various synthetically important polycyclic thienoacenes.
Peroxisomes and Hepatotoxicity
1995
Peroxisomes are ubiquitous organelles of eukaryotic cells and are present in significant amounts in hepatic liver cells. Peroxisomal enzymes contribute to several metabolic pathways including fatty acid, purine and amino acid catabolism or bile acid synthesis. The peroxisomal oxidative reactions produce hydrogen peroxide, mostly degraded by catalase which prevents oxidative stress. Moreover, peroxisomes are involved in arylderivative drug detoxification through its epoxide hydrolase activity.
Phosphorylation of cytochrome P450 isoenzymes in intact hepatocytes and its importance for their function in metabolic processes.
1990
Recent data show that besides the well-known long-term regulation of cytochrome P450-dependent monooxygenase activity by induction there also exists a fast regulation by phosphorylation. This phosphorylation occurs when purified cytochromes P450 are combined with purified protein kinases, and also in intact cells. This process is donor- and acceptor-selective leading to phosphorylation of defined isoenzymes by defined protein kinases. This in turn leads to fast and marked changes in metabolism which are selective for given substrates and regio- and stereo-selective for given positions. This in turn is selectively and differentially influenced by the individual control of the protein kinase …
Synthesis of novel functionalized cispentacins through C–C oxidative cleavage of diendo-norbornene β-amino acid
2013
Difunctionalized cispentacin derivatives with two new stereogenic centres have been synthesized from a diendo-norbornene β-amino acid in a stereocontrolled route, involving C–C double bond functionalization by dihydroxylation, followed by oxidative ring cleavage and transformation of the dialdehyde intermediates through a Wittig reaction.
Regulatory features of glycogen phosphorylase from frog brain (Rana temporaria)
1985
1. Glycogen content and the activity of glycogen phosphorylase (GPase) are much higher in brain tissue of the Common frog (Rana temporaria) than in brain tissue of mammals and birds (Table 1). 2. In phosphate buffer GPase is extracted from frog orain in a form completely active without addition of AMP and has therefore to be regarded as phosphorylase a. Several procedures to extract the b-form of the enzyme from the tissue have been unsuccessful. In resting skeletal muscle predominantly the AMP dependent b-form is present (Table 1). 3. In vitro, however, the existence of the complete interconverting system can be demonstrated. If NaF (a phosphatase inhibitor) was omitted from the homogeniza…
Oxidative halogenation of substituted pyrroles with Cu(II). PartIII. Bromination and chlorination of 2-benzoylpyrrole
1992
The bromination of 2-benzoylpyrrole with copper(II) bromide in the homogeneous and the heterogeneous phase is described, giving 4- and 5-monobromo derivatives whose ratio decreases as the temperature is increased. The same reaction with copper(II) chloride in acetonitrile at 60° produces 5-chloro-2-benzoylpyrrole as the major product. 4,5-Dihalopyrroles in good yields are obtained with an excess of halogenating agent.
The Distribution of Carcinogen Metabolizing Enzymes in the Mouse Liver: Comparison of Parenchymal and Non-Parenchymal Cell Populations
1987
The distribution of aminopyrine N-demethylase (APND), ethoxy- resorufin O-deethylase (ERRD), epoxide hydrolase (EH) and glutathione transferase (GST) activities in parenchymal (PC) and non-parenchymal (NPC) cell populations of control and Aroclor 1254-treated C57BL/6N and DBA/2N mice was determined. Furthermore, the metabolism of benzo(a)- pyrene (BP) in PC and NPC of both Aroclor 1254-treated mice strains was examined. Measurable activities of all enzymes investigated were detected in control PC as well as NPC of both mice strains; in all instances the PC possessed greater enzyme activities than did the NPC. The PC and NPC of DBA/ 2N mice had significantly lower ERRD and EH activities than…
Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors - analysis of LIPIDOGRAM2015 and LIPIDOGEN201…
2021
IntroductionOxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA.Material and methodsWe examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in i…
Antioxidation and the Hypoxic Ventilatory Response
2012
Reactive oxygen species favor the reductive state of iron. Antioxidation, by depleting biologically active ferrous iron, could then have a stabilizing effect, akin to hypoxia, on HIF-1α; the process which controls the genetic responses to hypoxia. However, the influence of antioxidation on the hypoxic ventilatory responses (HVR) is unclear. In this study we set out to determine the influence of mangiferin, a natural polyphenolic compound present in mango trees, with strong antioxidant and iron chelating properties, on the HVR. The study was performed in awake Wistar rats. Acute HVR to 12% and 8% FiO2 before and 40 min after mangiferin (300 mg/kg, i.p.) pretreatment were recorded plethysmogr…
The Role of Mitochondrial Reactive Oxygen Species Formation for Age-Induced Vascular Dysfunction
2010
Aging is an important risk factor for the development of cardiovascular diseases, which can be accelerated by atherosclerosis, diabetes, hypercholesterolemia, or obesity. Vascular aging is mainly characterized by endothelial dysfunction, an alteration of endothelium-dependent signaling processes, and vascular remodeling. The underlying mechanisms include increased production of reactive oxygen species (ROS), inactivation of nitric oxide (•NO), and subsequent formation of reactive nitrogen and oxygen species (RNOS). Elevated RNOS may exhibit new messenger functions by posttranslational oxidative modification of intracellular regulatory proteins or lead to irreversible alterations of biologic…