Search results for " secretion"

Assessment of human cytomegalovirus specific T cell immunity in human immunodeficiency virus infected patients in different disease stages following …

2004

T cell immunity to human cytomegalovirus (HCMV) was assessed in HAART-treated HIV-1 infected patients (9 asymptomatic, CDC group A; and 22 symptomatic, CDC group B), and in eight HIV-1 long term non-progressors. Patients were either prospectively or cross-sectionally examined for CD4(+) T cell counts, HIV RNA load, HCMV leukoDNAemia, HCMV DNA in urine, lymphoproliferative response (LPR) to HCMV and phytohemagglutinin (PHA), and cytokine secretion (IFN-gamma and IL-4) by HCMV-stimulated peripheral blood mononuclear cell (PBMC) cultures. No patient either progressed to clinical AIDS or developed HCMV active infection during the study period. Twenty-nine patients responded to HAART, though 12 …

Experimental Preemptive Immunotherapy of Murine Cytomegalovirus Disease with CD8 T-Cell Lines Specific for ppM83 and pM84, the Two Homologs of Human …

2001

ABSTRACTCD8 T cells are the principal antiviral effectors controlling cytomegalovirus (CMV) infection. For human CMV, the virion tegument protein ppUL83 (pp65) has been identified as a source of immunodominant peptides and is regarded as a candidate for cytoimmunotherapy and vaccination. Two sequence homologs of ppUL83 are known for murine CMV, namely the virion protein ppM83 (pp105) expressed late in the viral replication cycle and the nonstructural protein pM84 (p65) expressed in the early phase. Here we show that ppM83, unlike ppUL83, is not delivered into the antigen presentation pathway after virus penetration before or in absence of viral gene expression, while other virion proteins o…

Benevolent and corrective humor, life satisfaction, and broad humor dimensions : extending the nomological network of the BenCor across 25 countries

2020

Indexación: Scopus. Benevolent and corrective humor are two comic styles that have been related to virtue, morality, and character strengths. A previous study also supported the viability of measuring these two styles with the BenCor in 22 countries. The present study extends the previous one by including further countries (a total of 25 countries in 29 samples with N = 7813), by testing the revised BenCor (BenCor-R), and by adding two criterion measures to assess life satisfaction and four broad humor dimensions (social fun/entertaining humor, mockery, humor ineptness, and cognitive/reflective humor). As expected, the BenCor-R showed mostly promising psychometric properties (internal consi…

Benevolent and corrective humor, life satisfaction, and broad humor dimensions: Extending the nomological network of the BenCor across 25 countries

2019

Benevolent and corrective humor are two comic styles that have been related to virtue, morality, and character strengths. A previous study also supported the viability of measuring these two styles with the BenCor in 22 countries. The present study extends the previous one by including further countries (a total of 25 countries in 29 samples with N = 7813), by testing the revised BenCor (BenCor-R), and by adding two criterion measures to assess life satisfaction and four broad humor dimensions (social fun/entertaining humor, mockery, humor ineptness, and cognitive/reflective humor). As expected, the BenCor-R showed mostly promising psychometric properties (internal consistency and factorial…

Modulatory role of glucagon-like peptidi-1 on neurally-evoked mucosal chloride secretion in the guinea-pig ileum.

2011

TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae.

2006

Toll-like receptors (TLRs) function as sensors for infection that induce the activation of the immune responses. Recent studies have demonstrated a crucial involvement of TLRs in the recognition of fungal pathogens such as Candida albicans. Although both TLR2 and TLR4 have been implicated in the host interaction with C. albicans, their specific role during infection has not been unequivocally established, as conflicting results have been reported. In this review, we summarize and discuss our own and others' key findings about the specific role of TLR2 and TLR4 in murine resistance to candidiasis, and in triggering cytokine secretion by murine cells in response to C. albicans yeasts and hyph…

Failure to Sustain Recovery of Na,K ATPase Function Is a Possible Mechanism for Striatal Neuron Necrosis in Hypoxic-Ischemic Newborn Piglets

1999

Failure to Sustain Recovery of Na,K ATPase Function Is a Possible Mechanism for Striatal Neuron Necrosis in Hypoxic-Ischemic Newborn Piglets

2004

Autoimmune inflammation, such as in rheumatoid arthritis, is characterized by activated Th1 cells without sufficient Th2 differentiation that might downmodulate the chronic immune response. Delineation of the mechanisms that control T-cell differentiation is therefore of major importance for the understanding of the pathogenesis of autoimmune diseases. The transcription factor GATA-3 has been implicated in regulating Th2 cell differentiation in murine T cells in vitro, but its role in vivo and, in particular, in human T-cell differentiation is currently unknown. To dissect the role of GATA-3 in human T-cell differentiation and T-cell-mediated effector functions, we used the unique opportuni…

Toll-like receptors – sentries in the B-cell response

2009

Summary Toll-like receptors (TLR) play a central role in the initiation of the innate immune response to pathogens. Upon recognition of molecular motifs specific for microbial molecules TLR mediate pro-inflammatory cytokine secretion and enhance antigen presentation; in B cells they further promote expansion, class switch recombination and immunoglobulin secretion. As a result of their adjuvant properties, TLR ligands have become an integral component of antimicrobial vaccines. In spite of this, little is known of the direct effects of TLR engagement on B-lymphocyte function. The scope of this review is to outline the differences in TLR expression and reactivity in murine and human B-cell s…

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations

2005

Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D ce…