Search results for " transplantation."
showing 10 items of 1389 documents
Analysis of Immunomodulatory Properties of Spheroids from Adipose-derived Stem Cells
2020
Purpose: Adipose Stem Cells (ASCs) represent promising cell therapies for regenerative medicine and immunomodulation. The recently isolated spheroids from adipose-derived stem cells (S-ASCs) have shown being superior stemness and enhanced regenerative capability than the classical ASCs. The aims of this study were (1) to investigate the effects of adipose tissue donor-site, harvesting technique and patients’ characteristics on the yield of S-ASCs and (2) to investigate the immunomodulatory properties of S-ASCs comparing them with the adherent ASCs. Material and Methods: The study was divided into two phases. Phase I (prospective clinical study) between July 2016 and August 2019 was conducte…
Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.
2009
Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…
Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…
2006
BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…
Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs).
2019
Adipose tissue is now on the top one of stem cell sources regarding its accessibility, abundance, and less painful collection procedure when compared to other sources. The adipose derived stem cells (ADSCs) that it contains can be maintained and expanded in culture for long periods of time without losing their differentiation capacity, leading to large cell quantities being increasingly used in cell therapy purposes. Many reports showed that ADSCs-based cell therapy products demonstrated optimal efficacy and efficiency in some clinical indications for both autologous and allogeneic purposes, hence becoming considered as potential tools for replacing, repairing, and regenerating dead or dama…
Puente a trasplante cardiaco con oxigenación de membrana extracorpórea
2012
PUENTE A TRASPLANTE CARDIACO CON OXIGENACIÓN DE MEMBRANA EXTRACORPÓREA Objetivos: Los nuevos sistemas de Oxigenación de Membrana Extracorpórea (ECMO) han presentado un desarrollo tecnológico notable, fundamentalmente debido a la incorporación de oxigenadores y bombas centrífugas de larga duración, lo cual ha conducido a una importante mejoría en la supervivencia de los pacientes en shock cardiogénico refractario tratados con este tipo de asistencia mecánica circulatoria de corta duración. La implantación de este dispositivo por vía periférica de forma sencilla, rápida y poco agresiva en estos pacientes en shock cardiogénico con signos incipientes de fracaso multiorgánico puede mejorar su su…
Haematopoietic stem cell transplantation in the treatment of autoimmune diseases: current experience from an international data base.
2000
Thymic transplantation for relief of immunodeficiency diseases.
1979
Tremendous advances have been made in replacement therapy regimens for the correction of immunodeficiency in transplant patients. Recently, cultured thymic fragments were shown to be devoid of lethal graft-versus-host cells and research in this area indicates that thymic transplantation may have a sustained positive effect in immunosuppressed patients.
Reply to the Letter «A challenge for medium and small pancreatic transplant groups: How can the learning curve from the retrieval team affect the pan…
2021
Impact of DLI after In Vivo T-Cell-Depletion: Prophylactic CD8 Depleted or Preemptive CD3pos DLI?
2016
Abstract Introduction: The combination of reduced-intensity conditioning (RIC) with in vivo T-cell depletion by alemtuzumab prior to hematopoietic stem cell transplantation (HSCT) has demonstrated efficient engraftment and reduced graft-versus-host disease (GVHD). However, this regimen is associated with slow lymphocyte recovery leading to a delayed anti-infectious and anti-malignant immunity. DLI can be used to improve immune reconstitution. Here we investigate on the impact of different DLI: prophylactic CD8-depleted DLI vs preemptive non-depleted DLI. Methods: 256 patients with different hematologic malignancies were planned for treatment with DLI after allogeneic HSCT following reduced …
Imaging evaluation of cardiac stem cells transplantation
2012
Cardiovascular Disease is the number one cause of death in the World. Although advances in treatment and intervention have reduced the mortality rate in patients with coronary artery disease, the number of patients with refractory myocardial ischemia and congestive heart failure is rapidly increasing. “Cellular therapy” represents an important new approach in the treatment of cardiovascular disease and the scientific community needs to establish not only the appropriate type and timing of cellular administration but also the diagnostic gold standard to better enable the study of subjects before and after cellular therapy