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showing 10 items of 31 documents
Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+TÂ cells
2018
HLA-E presented antigens are interesting targets for vaccination given HLA-Esâ essentially monomorphic nature. We have shown previously that Mycobacterium tuberculosis (Mtb) peptides are presented by HLA-E to CD8+effector TÂ cells, but the precise phenotype and functional capacity of these cells remains poorly characterized. We have developed and utilized in this study a new protocol combining HLA-E tetramer with intracellular staining for cytokines, transcription factors and cytotoxic molecules to characterize these cells in depth. We confirm in this study the significantly increased ex vivo frequency of Mtb-peptide/HLA-E-TM+CD8+TÂ cells in the circulation of patients with active tubercu…
Past, ongoing, and future debate on the interplay between internationalization and digitalization
2020
AbstractThe interplay between internationalization and digitalization (IDI) is a relatively young research domain that is finding its way into numerous academic journals, which motivates us to systematically portray the proceedings and evolutions of this interplay over time, analyze its methodological and theoretical background and, more importantly, provide insights to guide future research on these phenomena. Combining qualitative and quantitative approaches, we analyze 68 peer-reviewed international business and management papers to explore the structure of knowledge production and identify the emerging trends. Our research reveals four key stages of the debate: (a) how IDI influencesint…
Determinants affecting consumers' attention to fish eco-labels in purchase decisions: a cross-country study
2022
PurposeThe purpose of this study was to investigate the role of consumer altruism and other socio-cultural factors in predicting how much attention consumers pay to seafood eco-labels.Design/methodology/approachThe empirical investigation was carried out by administering an online questionnaire to a sample of Italian and Spanish people from December 2019 to April 2020. After carrying out the principal component analysis procedure, the work made use of an ordinal logistic regression.FindingsBoth Italian and Spanish consumers with an altruistic attitude, who feel that food produced in a sustainable way can protect the environment and workers, appear more likely to take an eco-label into accou…
Sub specie æternitatis: the role of the ruin and the ancient in the process of architectural renewal between metamorphosis and resurgence
2022
Composing new works of architecture inspired by vestiges from antiquity or archaeology. The reflections and the case study which will be proposed, pertaining to a recent design experiment for the archaeological area and Antiquarium of Tyndaris, are dedicated to this theme. Over and above any charm exerted by such places, by landscapes in which the ruins appear identical in substance and which sometimes manifest themselves as “sub specie æternitatis”, there are reasons linked to the very profession of architect and to the gashes in the crucible of controversies around the role of history in its contentious relationship with architectural design. That apart, the aporias revealed by Michel Fou…
New records and observations to the Characean flora (Charales, Charophyceae) of Sicily (Italy)
2019
New records to the Characean flora of Sicily are presented. Five species (Chara baltica, C. conimbrigensis, C. oedophylla, Nitella gracilis, Tolypella salina) are new to Sicily, two of them being also new to Italy (Chara conimbrigensis, C. oedophylla). Two species are confirmed for Sicily (Chara aspera, Nitella opaca), three (Chara braunii, C. canescens, Nitella capillaris) are rare taxa. The Characean flora of Sicily, updated with these records, currently includes 25 species, distributed in four genera: Chara (13 species), Nitella (eight species), Tolypella (three species) and Lamprothamnium (one species).
Linearized Calderón problem and exponentially accurate quasimodes for analytic manifolds
2022
In this article we study the linearized anisotropic Calderon problem on a compact Riemannian manifold with boundary. This problem amounts to showing that products of pairs of harmonic functions of the manifold form a complete set. We assume that the manifold is transversally anisotropic and that the transversal manifold is real analytic and satisfies a geometric condition related to the geometry of pairs of intersecting geodesics. In this case, we solve the linearized anisotropic Calderon problem. The geometric condition does not involve the injectivity of the geodesic X-ray transform. Crucial ingredients in the proof of our result are the construction of Gaussian beam quasimodes on the tra…
Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort…
2021
Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for…
Structural Behavior of Telescopic Steel Pipe for a Full-Scale 60 kW Wind Turbine Tower
2020
A simple analytical model, including local effects due to buckling and shear to moment interaction, was developed to pre-dict the load-carrying capacity of CHS tubes under flexure and shear. A finite-element analysis with ABAQUS Code was also conducted for validation of the proposed model. By properly modeling the imperfection effects due to the ovalization of steel tube, a good correlation of the structural response and failure mode was also achieved, and a good correlation with the analytical model was also achieved. Numerical and analytical results were compared with experimental results recently obtained by the author with good agreement. Experimental tests refer to full-scale static te…
Advances in pediatrics in 2017: current practices and challenges in allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseas…
2018
Abstract This review provides an overview of a remarkable number of significant studies in pediatrics that have been published over the past year in the Italian Journal of Pediatrics. We have selected information from papers presented in the Journal that deal with allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology. The relevant epidemiologic findings, and developments in prevention, diagnosis and treatment of the last year have been discussed and placed in context. We think that advances achieved in 2017 will help readers to make the future of patients better.
Bad News and Quality Reputation among Users of Public Services
2018
This manuexamines whether the effect of anchoring bias is greater when citizens evaluate the quality of a public service after receiving negative initial information about service performance than after receiving positive information. It also tests whether there are differences in this anchoring bias by comparing formal (report) vs. informal (rumor) communication. Two field experiments were conducted with the participation of passengers of a commuter public train transportation organization (Experiment 1, N = 105) and users of a public university administrative service (Experiment 2, N = 172). The first experiment confirmed the bias produced by the negative initial information, whereas this…