Search results for "030204 cardiovascular system & hematology"

Exosomes as delivery vehicles: a commentary on "Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cells".

2017

Exosomes are lipoproteic nanosize vesicles of endocytic origin that are released in the extracellular space by several cell types when a multivesicular body fuses with the plasma membrane (1). To date, accumulating evidences highlight the potential of exosomes as messenger in intercellular communication. Indeed, several studies reported the presence of lipids, proteins, metabolites and nucleic acid (DNA, mRNA, microRNA, lncRNA) in exosomes and highlight their functional role in physiological and pathological processes (2).

Jillian Russyll (AKA Jill) Tate

2018

Utilización del ácido tranexámico tópico en la artroplastia total primaria de cadera. Eficacia y seguridad. Nuestra experiencia

2020

Resumen Antecedentes y objetivo El acido tranexamico por via intravenosa ha demostrado que disminuye el sangrado y la necesidad de transfusiones en la artroplastia total de cadera, aunque tiene un riesgo teorico de producir fenomenos tromboembolicos. Recientemente, se han publicado algunos trabajos con la aplicacion del acido tranexamico topico, sin haberse definido todavia cual es el protocolo de administracion ideal. El objetivo de este trabajo fue demostrar que nuestro protocolo de administracion topica de acido tranexamico es eficaz y seguro. Materiales y metodos Recogida de datos de una serie prospectiva de 80 artroplastias primarias de cadera, en las que se utilizo un protocolo de aci…

Die Fettsäurezusammensetzung von Gewebslipiden beim Rotbarsch (Sebastus viviparus)

1972

Beim kleinen Rotbarsch (Sebastus viviparus) wurden Lipidgehalt und Fettsaurezusammensetzung von 11 Geweben untersucht. Den grosten Fettgehalt haben Fettgewebe, Zentralnervensystem und Leber. Die Leber wies den hochsten Polyenfettsaurengehalt auf. Sie enthalt 23,7 % Docosahexaensaure und 18,8 % Docosapentaensaure. In Herz, Niere, ZNS und Testes sind zwischen 9,0 und 5,7 % Docosahexaensaure enthalten. Den hochsten Gehalt an Eicosapentaensaure besasen ZNS, Myokard, Testes, Milz, Niere und rote Muskulatur (16,7-11,2%). Weise Muskulatur, Fettgewebe und Leber enthielten nur 9,2-7,5 % Eicosapentaensaure. C20- und C22-Tetraensauren konnten vor allem im Fettgewebe, in der Muskulatur und in der Leber…

Small, dense HDL display potent vasorelaxing activity, reflecting their elevated content of S1P

2016

IF 3.942; International audience

Lysed Erythrocyte Membranes Promote Vascular Calcification

2019

Background: Intraplaque hemorrhage promotes atherosclerosis progression, and erythrocytes may contribute to this process. In this study we examined the effects of red blood cells on smooth muscle cell mineralization and vascular calcification and the possible mechanisms involved. Methods: Erythrocytes were isolated from human and murine whole blood. Intact and lysed erythrocytes and their membrane fraction or specific erythrocyte components were examined in vitro using diverse calcification assays, ex vivo by using the murine aortic ring calcification model, and in vivo after murine erythrocyte membrane injection into neointimal lesions of hypercholesterolemic apolipoprotein E–deficient mi…

Multisite field potential recordings and analysis of the impulse propagation pattern in cardiac cells culture

2007

To provide further insights into the impulse propagation between cardiac myocytes, we performed multiparametric studies of excitation spread with cellular resolution in confluent monolayers of cultured cardiomyocytes (CM). Simultaneous paired intracellular recordings of action potentials in two individual CM revealed slight periodic spontaneous advances/delays in the interspike time lag. Multisite field potential recordings performed with microelectrode arrays (MEA) confirmed random and iterative cycle-to-cycle changes in the direction of excitation spread. These local spontaneous variations in the cardiac impulse propagation pathways may be a safety process protecting against microscopical…

Abstract of the 68th Meeting (Spring Meeting) 6–9 March 1990, Heidelberg

1990

Leisure-time physical activity and artery lumen diameters: A monozygotic co-twin control study

2010

Exercise is thought to increase the diameter of the conduit arteries supplying the muscles involved. We studied the effects of a physically active vs inactive lifestyle on artery diameters in monozygotic (MZ) twin pairs discordant over 30 years for leisure-time physical activity habits. In a population-based co-twin control study design, six middle-aged (50-65 years) same-sex MZ twin pairs with long-term discordance for physical activity were comprehensively identified from the Finnish Twin Cohort (TWINACTIVE study). Discordance was initially defined in 1975 and the same co-twin remained significantly more active during the 32-year follow-up. The main outcomes were arterial lumen diameters …

Stimulation of the ADRB3 Adrenergic Receptor Induces Relaxation of Human Placental Arteries: Influence of Preeclampsia1

2006

Preeclampsia, which complicates 3-8% of pregnancies, is one of the leading causes of neonatal morbidity and mortality. Its pathophysiology remains unclear. The aim of the present study was to investigate the presence and the role of beta2- and beta2-adrenergic receptors (ADRB2 and ADRB3, respectively) in human placental arteries and to assess the influence of preeclampsia on ADRB responsiveness. SR 59119A, salbutamol, and isoproterenol (ADRB3, ADRB2, and nonselective ADRB agonists, respectively) induced a concentration-dependent relaxation of placental artery rings obtained from women with uncomplicated or preeclamptic pregnancies. SR 59119A-induced relaxation was unaffected by the blockade…