Search results for "129"

L-selectin regulates human neutrophil transendothelial migration

2021

ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and rolling – the initial stages of the multi-step adhesion cascade. Here, we provide direct evidence for L-selectin contributing to neutrophil transendothelial migration (TEM). We show that L-selectin co-clusters with PECAM-1 – a well-characterised cell adhesion molecule involved in regulating neutrophil TEM. This co-clustering behaviour occurs specifically during …

Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease

2014

Abstract Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. In this study, I have reviewed observed associations between folate intake, as well as its blood levels, and BC. The purpose of this review is to analyse the role of folate and the two SNPs associated with reduced enzyme activity in B…

X-Ray Eclipse Time Delays in 4U2129+47

2007

4U 2129+47 was discovered in the early 80's and classified as an accretion disk corona source due to its broad and partial X-ray eclipses. The 5.24 hr binary orbital period was inferred from the X-ray and optical light curve modulation, implying a late K or M spectral type companion star. The source entered a low state in 1983, during which the optical modulation disappeared and an F8 IV star was revealed, suggesting that 4U 2129+47 might be part of a triple system. The nature of 4U 2129+47 has since been investigated, but no definitive conclusion has been reached. Here, we present timing and spectral analyses of two XMM-Newton observations of this source, carried out in May and June, 2005.…

Pathogens and host immunity in the ancient human oral cavity.

2014

Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize: (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) the first evidence of ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing co…

Application of the SKYRAD Improved Langley plot method for the in situ calibration of CIMEL Sun-sky photometers

2007

The in situ procedure for determining the solar calibration constants, originally developed for the PREDE Sun-sky radiometers and based on a modified version of the Langley plot, was applied to a CIMEL instrument located in Valencia, Spain, not integrated into AERONET. Taking into account the different mechanical and electronic characteristics of the two radiometers, the method was adapted to the characteristics of the CIMEL instrument. The iterative procedure for the determination of the solar calibration constants was applied to a 3-year data set. The results were compared with the two sets of experimental calibration constants determined during this period using the standard Langley plot…

En los inicios de la experimentación de la albañilería moderna: Las escaleras de yeso en la arquitectura valenciana de los siglos XIV al XVI

2017

El Museo del Hombre entre 1938 y 1949: un museo bajo presión

2018

Arendt y Heidegger ante el 'diluvio de Auschwitz'

2019

Tras las Conferencias de Bremen de Martin Heidegger y, más aún, tras los escritos de Hannah Arendt, el nacionalsocialismo ha sido reinterpretado como revelador de la modernidad técnica hasta el punto de que la institución nazi de los campos de concentración y exterminio se ha visto erigida en paradigma de esta modernidad. Esta visión, que podría llamarse posmoderna, de la historia del siglo xx merece ser cuestionada.1 ¿Cómo es posible que la obra de Heidegger, ese profesor y rector nacionalsocialista a quien se le prohíbe enseñar en 1945, haya tardado tanto tiempo en ser reconocida como un caso ejemplar, dentro del campo filosófico, de la visión del mundo o Weltanschauung nacionalsocialista…

Trombosi portale mesenterica idiopatica in paziente con doppia mutazione eterozigote del gene C677T e del gene A1298C della MTHFR

2002

Evolutionary processes in the emergence and recent spread of the syphilis agent, Treponema pallidum

2022

Abstract The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum (TPA), very closely related to subsp. pertenue (TPE) and endemicum (TEN), responsible for the human treponematoses yaws and bejel, respectively. Although much focus has been placed on the question of the spatial and temporary origins of TPA, the processes driving the evolution and epidemiological spread of TPA since its divergence from TPE and TEN are not well understood. Here, we investigate the effects of recombination and selection as forces of genetic diver…