Search results for "36"

“ One Ring to Bind Them All ”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition

2010

International audience; Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the "standard" B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. Stimulated by the pioneering studies on the cationic porphyrin TMPyP4 and the natural product telomestatin, follow-up studies have developed, rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological activities. In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding …

Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound with a 1.5 Tesla Scanner: A Prospective Intraindividual Comparison Study of Intraop…

2021

Background: High-quality intraoperative imaging is needed for optimal monitoring of patients undergoing transcranial MR-guided Focused Ultrasound (tcMRgFUS) thalamotomy. In this paper, we compare the intraoperative imaging obtained with dedicated FUS-Head coil and standard body radiofrequency coil in tcMRgFUS thalamotomy using 1.5-T MR scanner. Methods: This prospective study included adult patients undergoing tcMRgFUS for treatment of essential tremor. Intraoperative T2-weighted FRFSE sequences were acquired after the last high-energy sonication using a dedicated two-channel FUS-Head (2ch-FUS) coil and body radiofrequency (body-RF) coil. Postoperative follow-ups were performed at 48 h usin…

Effects of school climate and teacher self-efficacy on job satisfaction of mostly STEM teachers: a structural multigroup invariance approach

2020

Abstract Background Identification and retention of effective teachers in STEM education play cardinal roles in teacher recruitment exercises worldwide. Studies on factors that characterize effective teachers have therefore gained popularity in recent times. Teacher self-efficacy, job satisfaction and school climate are among other factors that have attracted global attention. Thus, proper understanding of the relations between these factors is equally important. The purpose of this study is to validate and cross-validate a model of direct/indirect effects of school climate and teacher self-efficacy on job satisfaction. Results The data used for the current study are extracted from a public…

Aprendizaje basado en Proyectos en Educación Física en Primaria, un estudio de revisión

2019

espanolLa inclusion de las competencias en el sistema educativo espanol demanda la aplicacion de nuevas metodologias de aprendizaje, centradas en el alumnado; siendo las metodologias activas y concretamente el Aprendizaje basado en Proyectos (ABP), una oportunidad unica para responder a estos nuevos retos. El objetivo de este trabajo consiste en revisar, recopilar y analizar la bibliografia relacionada con el ABP en el area de Educacion Fisica (EF), en la etapa de Educacion Primaria (EP). Se realizo una revision documental en las siguientes bases de datos: Dialnet, ERIC, Google Academico, Redalyc, SciElo, Scopus, Sport Discus y Web of Science, seleccionando los documentos publicados entre 2…

Hydraulic kinetics of the graft union in different Olea europaea L. scion/rootstock combinations

2007

The hydraulic resistance of young olive trees grafted on rootstocks with contrasting size-controlling potential was measured 30, 90, 360 and 480 days after grafting. Olive (Olea europaea L.) clones inducing plant vigorous growth (Leccino ‘Minerva’, LM) or dwarfing (Leccino ‘Dwarf’, LD) were studied in different scion/rootstock combinations (LD/LD, LD/LM, LM/LD, LM/LM). Plants growing on LD root systems developed lower leaf surface areas (about 50% less) than plants grafted on LM rootstocks. Graft union represented the largest fraction (up to 85%) of whole-plant hydraulic resistance 30 days after grafting, and still represented an important fraction of it 2 months later (40–55%). Four-hundre…

Corso base di Imaging RM del Sistema Nervoso Centrale

2013

Eziopatogenesi, neuropatologia, semeiotica RM e terapia della Sclerosi Multipla.

Differential Effects of Fluvoxamine and Other Antidepressants on the Biotransformation of Melatonin

2001

Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is an inhibitor of several cytochrome P450 (CYP) enzymes, the authors studied the biotransformation of melatonin and the effects of fluvoxamine on the metabolism of melatonin in vitro using human liver microsomes and recombinant human CYP isoenzymes. Melatonin was found to be almost exclusively metabolized by CYP1A2 to 6-hydroxymelatonin and N-acetylserotonin with a minimal contribution of CYP2C19. Both reactions were potently in…

¡Hay que implantar el servicio militar obligatorio! dice el Partido Comunista.

El text està imprès sobre l'estrella vermella de cinc puntes amb la falç i el martell. La idea central és la necessitat d'implantar el servei militar obligatori, per a repartir equitativament entre la població les càrregues de la guerra

Appunti per una ricerca sui servizi di disposizione di ordini di pagamento

2021

This essay will explore issues related to the Payment Initiation Service, which are currently subject to Directive 2015/2366/EC (Payment Services Directive II) and, in Italy, to the Law Decree n. 11, 27th January 2010. The analysis will examine its key points, through the study of the nature of relations between payment service users and payment initiation service providers; as well as those between the latter and account servicing payment service providers. Moreover, this article will explore rights and obligations of all parties in payment transaction. Lastly, it will access criteria to allocate liability when a transaction initiated through a payment initiation service provider was unaut…

Effect of muscle type and animal category on fatty acid composition of bresaola made from meat of Cinisara cattle: preliminary investigation

2020

The bresaola could represent an alternative commercial opportunity for autochthonous dairy cattle farms. Therefore, a study was carried out to investigate the fatty acid (FA) composition of bresaola made using Semimembranosus (SMm), Semitendinosus (STm), and Biceps brachii (BBm) muscles from grazing young bulls (GB), housed young bulls (HB) or grazing adult cows (AC) of Cinisara breed. Animal category, fat content, feeding system, and type of muscle influenced the FA composition of bresaola. Fatter products, made from AC and HB meat, or with STm and BBm muscles showed lower polyunsaturated/saturated FA ratio. The bresaola from young bulls fed pasture-based diet showed an increased polyunsat…