Search results for "41"
showing 10 items of 3365 documents
Understanding the Solution Behavior of Epinephrine in the Presence of Toxic Cations: A Thermodynamic Investigation in Different Experimental Conditio…
2020
The interactions of epinephrine ((R)-(&minus
Comparing soil inventory with modelling: Carbon balance in central European forest soils varies among forest types
2018
Abstract Forest soils represent a large carbon pool and already small changes in this pool may have an important effect on the global carbon cycle. To predict the future development of the soil organic carbon (SOC) pool, well-validated models are needed. We applied the litter and soil carbon model Yasso15 to 1838 plots of the German national forest soil inventory (NFSI) for the period between 1985 and 2014 to enables a direct comparison to the NFSI measurements. In addition, to provide data for the German Greenhouse Gas Inventory, we simulated the development of SOC with Yasso15 applying a climate projection based on the RCP8.5 scenario. The initial model-calculated SOC stocks were adjusted…
Synthesis and Structure-Activity Relationships of Amino Acid Conjugates of Cholanic Acid as Antagonists of the EphA2 Receptor
2013
The Eph–ephrin system plays a critical role in tumor growth and vascular functions during carcinogenesis. We had previously identified cholanic acid as a competitive and reversible EphA2 antagonist able to disrupt EphA2-ephrinA1 interaction and to inhibit EphA2 activation in prostate cancer cells. Herein, we report the synthesis and biological evaluation of a set of cholanic acid derivatives obtained by conjugation of its carboxyl group with a panel of naturally occurring amino acids with the aim to improve EphA2 receptor inhibition. Structure-activity relationships indicate that conjugation of cholanic acid with linear amino acids of small size leads to effective EphA2 antagonists whereas …
Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet
2020
The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the …
Obesity and Cardiometabolic Risk Factors : from Childhood to Adulthood
2021
Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also …
Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis.
2014
Background/Aims: Oxysterol activity on the erythrocyte (RBC) programmed cell death (eryptosis) had not been studied yet. Effects of an oxysterol mixture in hyper-cholesterolemic-relevant proportion, and of individual compounds, were investigated on RBCs from healthy humans. Methods: Membrane phosphatidylserine (PS) externalization, calcium entry, ROS production, amino-phospholipid translocase (APLT) activity were evaluated by cytofluorimetric assays, cell volume from forward scatter. Prostaglandin PGE2 was measured by ELISA; GSH-adducts and lipoperoxides by spectrophotometry. Involvement of protein kinase C and caspase was investigated by inhibitors staurosporin, calphostin C, and Z-DEVD-FM…
La sociedad y el espacio público
2019
El espacio público y los actos de la propia sociedad, ¿hasta dónde llega el límite de unos para que comience el derecho de los otros? Son muchas las actuaciones que se suceden en la vía pública y que tienen una repercusión, en la mayoría de los casos, negativa para el paisaje urbano. En esta fina línea, entre la preservación del paisaje urbano y los derechos que la ley confiere a los ciudadanos, se enmarcan las ordenanzas de convivencia ciudadana como el mecanismo adecuado que normativice las conductas que inciden en el espacio público. Se juzga imprescindible analizar las normas de convivencia que presiden nuestro país, a fin de dar con soluciones ecuánimes que garanticen la viabilidad de …
Percepción de los residentes sobre el impacto del Mundobasket 2014 en Gran Canaria y apoyo a la celebración de eventos deportivos
2016
[ES] El objetivo de este trabajo es analizar la percepción de los residentes en Gran Canaria sobre el impacto del Mundobasket (2014) y su predisposición apoyar la celebración de eventos deportivos en la isla. Se recogió una muestra de 342 residentes que contestaron una encuesta de 41 ítems. Los resultados ermitieron agrupar en cuatro factores los beneficios percibidos y en tres los costes. Los beneficios en la imagen y el reconocimiento de la ciudad fueron los más destacados, mientras que señalaron los costes en la vida diaria como principal impacto negativo. Asimismo, se constató que los residentes apoyan la celebración de futu…
Missing Value Estimation for Microarray Data by Bayesian Principal Component Analysis and Iterative Local Least Squares
2013
Published version of an article from the journal: Mathematical Problems in Engineering. Also available from Hindawi: http://dx.doi.org/10.1155/2013/162938 Missing values are prevalent in microarray data, they course negative influence on downstream microarray analyses, and thus they should be estimated from known values. We propose a BPCA-iLLS method, which is an integration of two commonly used missing value estimation methods-Bayesian principal component analysis (BPCA) and local least squares (LLS). The inferior row-average procedure in LLS is replaced with BPCA, and the least squares method is put into an iterative framework. Comparative result shows that the proposed method has obtaine…
Mathematical modeling and parameters estimation of a car crash using data-based regressive model approach
2011
Author's version of an article in the journal: Applied Mathematical Modelling. Also available from the publisher at: http://dx.doi.org/10.1016/j.apm.2011.04.024 n this paper we present the application of regressive models to simulation of car-to-pole impacts. Three models were investigated: RARMAX, ARMAX and AR. Their suitability to estimate physical system parameters as well as to reproduce car kinematics was examined. It was found out that they not only estimate the one quantity which was used for their creation (car acceleration) but also describe the car's acceleration, velocity and crush. A virtual experiment was performed to obtain another set of data for use in further research. An A…