Search results for "47"

A basic analysis toolkit for biological sequences

2007

This paper presents a software library, nicknamed BATS, for some basic sequence analysis tasks. Namely, local alignments, via approximate string matching, and global alignments, via longest common subsequence and alignments with affine and concave gap cost functions. Moreover, it also supports filtering operations to select strings from a set and establish their statistical significance, via z-score computation. None of the algorithms is new, but although they are generally regarded as fundamental for sequence analysis, they have not been implemented in a single and consistent software package, as we do here. Therefore, our main contribution is to fill this gap between algorithmic theory an…

Interface Amorphization of Two‐Dimensional Black Phosphorus upon Treatment with Diazonium Salts

2021

Abstract Two‐dimensional (2D) black phosphorus (BP) represents one of the most appealing 2D materials due to its electronic, optical, and chemical properties. Many strategies have been pursued to face its environmental instability, covalent functionalization being one of the most promising. However, the extremely low functionalization degrees and the limitations in proving the nature of the covalent functionalization still represent challenges in many of these sheet architectures reported to date. Here we shine light on the structural evolution of 2D‐BP upon the addition of electrophilic diazonium salts. We demonstrated the absence of covalent functionalization in both the neutral and the r…

Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging

2014

Dietary restriction extends longevity in organisms ranging from bacteria to mice and protects primates from a variety of diseases, but the contribution of each dietary component to aging is poorly understood. Here we demonstrate that glucose and specific amino acids promote stress sensitization and aging through the differential activation of the Ras/cAMP/PKA, PKH1/2 and Tor/S6K pathways. Whereas glucose sensitized cells through a Ras-dependent mechanism, threonine and valine promoted cellular sensitization and aging primarily by activating the Tor/S6K pathway and serine promoted sensitization via PDK1 orthologs Pkh1/2. Serine, threonine and valine activated a signaling network in which Sch…

Second-line administration of thrombopoietin receptor agonists in immune thrombocytopenia: Italian Delphi-based consensus recommendations

2021

Introduction: In patients with primary immune thrombocytopenia (ITP), a short course of steroids is routinely given as first-line therapy. However, the response is often transient and additional therapy is usually needed. Thrombopoietin receptor agonists (TPO-RAs) are frequently used as second-line therapy, although there is little clinical guidance on the timing of their administration and on tapering/discontinuation of the drug. To provide clinical recommendations, we used the Delphi technique to obtain consensus for statements regarding administration and on tapering/discontinuation of second-line TPO-RAs among a group of Italian clinicians with expertise in management of ITP. Methods: T…

The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors

2020

Essential thrombocythemia is a rare hematological malignancy with good overall survival, but moderate to high risk of developing arterial or venous thrombosis lifelong. Different thrombotic risk scores for patients with essential thrombocythemia have been proposed, but only one of them (the IPSET-t scoring system) takes into account the classical cardiovascular risk factors as one of the scoring items. Currently, in clinical practice, the presence of cardiovascular risk factors in patients with diagnosis of ET rarely determines the decision to initiate cytoreductive therapies. In our study, we compared different risk models to estimate the thrombotic risk of 233 ET patients and the role of …

Investigation of Tinnitus Patients in Italy: Clinical and Audiological Characteristics

2010

Objective. 312 tinnitus sufferers were studied in order to analyze: the clinical characteristics of tinnitus; the presence of tinnitus-age correlation and tinnitus-hearing loss correlation; the impact of tinnitus on subjects' life and where possible the etiological/predisposing factors of tinnitus.Results. There is a slight predominance of males. The highest percentage of tinnitus results in the decades 61–70. Of the tinnitus sufferers, 197 (63.14%) have a hearing deficit (light hearing loss in 37.18% of cases). The hearing impairment results of sensorineural type in 74.62% and limited to the high frequencies in 58.50%. The tinnitus is referred as unilateral in 59.93%, a pure tone in 66.99%…

Colònia alvernesa a Cocentaina als segles XVII y XVIII

2021

Local maximal operators on fractional Sobolev spaces

2016

In this note we establish the boundedness properties of local maximal operators MG on the fractional Sobolev spaces Ws;p(G) whenever G is an open set in Rn, 0 < s < 1 and 1 < p < 1. As an application, we characterize the fractional (s;p)-Hardy inequality on a bounded open set by a Maz'ya-type testing condition localized to Whitney cubes. pq(G) whenever G is an open set in R n , 0 < s < 1 and 1 < p;q <1. Our main focus lies in the mapping properties of MG on a fractional Sobolev space W s;p (G) with 0 < s < 1 and 1 < p < 1, see Section 2 for the denition or (3) for a survey of this space. The intrinsically dened function space W s;p (G) on a given domain G coincides with the trace space F s …

Da poeta a poeta, da traduttore a traduttore: il carteggio tra Umberto Saba e Tomàs Garcés

2015

Riassunto: Il rapporto personale tra Umberto Saba e Tomàs Garcés cominciò agli inizi degli anni  Trenta e si interruppe poco prima della guerra civile spagnola. Quest’articolo analizza  ed edita per la prima volta tutte le lettere scritte da Saba al poeta catalano che sono  state conservate presso l’archivio della famiglia Garcés.   Parole chiave: poesia, traduzione, Umberto Saba, Tomàs Garcés   Abstract: The personal relationship between Umberto Saba and Tomàs Garcés began in the early  thirties and stopped just before the Spanish Civil War. This article analyses and edits for  the first time all the letters written by Saba to the Catalan poet that have been preserved  in the archives of f…

Habilidades matemáticas tempranas en niños chilenos con Trastorno del Desarrollo del Lenguaje: Un estudio comparativo

2021

En las últimas décadas se ha incrementado el interés de las investigaciones respecto a las dificultades académicas que presentan los niños con Trastorno del Desarrollo del Lenguaje (TDL). No obstante, su relación con las habilidades matemáticas es una de las menos estudiadas. El objetivo de este estudio consistió en determinar si existen diferencias relevantes entre las habilidades matemáticas tempranas de niños con TDL y con desarrollo típico (DT). Participaron 78 niños de 4 a 7 años 11 meses de edad, pertenecientes a colegios con programas de integración escolar de Santiago de Chile. Se conformó un grupo de 44 niños con TDL y un grupo de 34 con DT. Se establecieron comparaciones del rendi…