Search results for "AGENT"

Simuler la mobilité urbaine quotidienne : le projet MIRO

2010

Modélisation et simulation multi-agents de la dynamique urbaine : application à la mobilité résidentielle

2007

From a conceptual and methodological reflection about an effective association of system based cellular automata and multi-agents models, the simulation model VisualSimores was conceived in order to give even partially, a response concerning the impact of residential mobility in urban areas. According to the goal to develop a support system for urban planning, the major interest of this approach is to focus on the relationship between two separately observable phenomena: the residential mobility of household on one hand and the urban dynamics on the other hand. Then it becomes particularly important to identify the reasoning that helps to establish a correspondence between the demands of di…

Effets de la distance et dépendance d’échelles dans les modèles géographiques de villes et de territoires

2020

International audience

L’apport de la simulation multi-agent du trafic routier pour l’estimation des pollutions atmosphériques automobiles

2015

National audience; La pollution atmosphérique est aujourd’hui considérée comme cancérigène pour la santé humaine (OMS, 2013). Avec le bruit, elle est l’une des premières nuisances directement ressenties par les populations en milieu urbain. Son évaluation présente un véritable enjeu pour les pouvoirs publics afin de mieux en identifier ses sources, ses impacts en vue de définir des politiques territoriales (PDU, cadastre d’émission). A l’échelle locale, la pollution atmosphérique est à relier directement à l’intensité des sources d’émissions qui vont accentuer, ou non, la qualité de l’air extérieure (Elichegaray, 2010) . En milieu urbain, le premier contributeur en émission de NOx, CO, ou P…

Web Directories as a Knowledge Base to Build a Multi-Agent System for Information Sharing

2004

. A neural based multi-agent system, exploiting the Web Directories as a Knowledge Base for information sharing and documents retrieval, is presented. The system is based on the E?Net architecture, a neural network capable of learning the activation function of its hidden units and having good generalization capabilities. System goal is to retrieve, among documents shared by a networked community, documents satisfying a query and dealing with a specific topic. The system is composed by four agents: the Trainer Agent, the Neural Classifier Agent, the Interface Agent, and the Librarian Agent. The sub-symbolic knowledge of the Neural Classifier Agent is automatically updated each time a new, n…

Rational Chemical Multifunctionalization of Graphene Interface Enhances Targeted Cancer Therapy

2020

The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.

Application of Molecular Topology for the Prediction of Reaction Yields and Anti-Inflammatory Activity of Heterocyclic Amidine Derivatives

2011

Topological-mathematical models based on multiple linear regression analyses have been built to predict the reaction yields and the anti-inflammatory activity of a set of heterocylic amidine derivatives, synthesized under environmental friendly conditions, using microwave irradiation. Two models with three variables each were selected. The models were validated by cross-validation and randomization tests. The final outcome demonstrates a good agreement between the predicted and experimental results, confirming the robustness of the method. These models also enabled the screening of virtual libraries for new amidine derivatives predicted to show higher values of reaction yields and anti-infl…

Comparison of the acute effects of anti-TNF-alpha drugs on a uveitis experimental model.

2010

To compare histopathological and biochemical effects of the anti-TNF-alpha drugs adalimumab and infliximab in a uveitis experimental model.Histopathological evaluation was performed 24 h after endotoxin (200 microg into the footpad) and drug administration, as well as biochemical analysis of oxidative stress-related markers in the aqueous humor.Severe inflammation was found in rat anterior chamber of the eye 24 h after endotoxin. Only infliximab administration partially prevented the endotoxin-induced disruption of the blood-aqueous barrier, as well as the increase in Rantes and MCP-1 concentration in aqueous humor. Both drugs ameliorated the histopathological score after endotoxin. Biochem…

Adalimumab in active ulcerative colitis: A “real-life” observational study

2013

Abstract Background and aims The effectiveness of adalimumab in the treatment of ulcerative colitis is under debate. Although controlled trials have shown that adalimumab is significantly better than placebo, the absolute clinical benefit is modest. We report data on the effectiveness of adalimumab in a cohort of ulcerative colitis patients treated in 22 Italian centres. Methods All patients with active disease treated with adalimumab were retrospectively reviewed. Co-primary endpoints were clinical remission at weeks 4, 12, 24 and 54. Secondary endpoints were sustained clinical remission, steroid discontinuation, endoscopic remission and need for colectomy. Results Eighty-eight patients we…

Transdermal nitroglycerine treatment of shoulder tendinopathies in patients with spinal cord injuries.

2011

A clinical blind study was conducted to determine the efficacy of transdermal nitroglycerine treatment on the awareness of shoulder pain. This study aims to determine the effects of transdermal nitroglycerine on shoulder pain and on functional shoulder movement in patients with spinal cord injuries and shoulder tendinopathies. A second aim is to establish the side effects of the treatment. Hospital “La Fe” in Valencia, Spain. A total of 45 spinal cord injury patients, all of whom are wheelchair users with shoulder tendinopathy, were randomly divided into two groups: placebo (n=12) and experimental (n=33). The experimental group (EG) received transdermal treatment for 6 months in the form of…