Search results for "AIV"
showing 10 items of 375 documents
Decoding Musical Training from Dynamic Processing of Musical Features in the Brain
2018
AbstractPattern recognition on neural activations from naturalistic music listening has been successful at predicting neural responses of listeners from musical features, and vice versa. Inter-subject differences in the decoding accuracies have arisen partly from musical training that has widely recognized structural and functional effects on the brain. We propose and evaluate a decoding approach aimed at predicting the musicianship class of an individual listener from dynamic neural processing of musical features. Whole brain functional magnetic resonance imaging (fMRI) data was acquired from musicians and nonmusicians during listening of three musical pieces from different genres. Six mus…
Tracking the corticospinal responses to strength training
2020
Purpose\ud The motor cortex (M1) appears to be a primary site of adaptation following both a single session, and repeated strength-training sessions across multiple weeks. Given that a single session of strength-training is sufficient to induce modification at the level of the M1 and corticospinal tract, this study sought to determine how these acute changes in M1 and corticospinal tract might accumulate across the course of a 2-week heavy-load strength-training program.\ud \ud Methods\ud Transcranial magnetic stimulation (TMS) was used to infer corticospinal excitability (CSE), intracortical facilitation (ICF), short and long-interval intracortical inhibition (SICI and LICI) and silent per…
Temporally stable beta sensorimotor oscillations and cortico–muscular coupling underlie force steadiness
2022
Funding Information: Data and code are available on the Open Science Framework (OSF) at the following link: https://osf.io/4rmex/?view_only=7d17c2334ace4a0d83087bddf2a64a68. Scott Mongold, Thomas Legrand, and Mathieu Bourguignon were supported by the Fonds de la Recherche Scientifique (F.R.S.-FNRS, Brussels, Belgium; grant MIS F.4504.21). Harri Piitulainen was supported by the Academy of Finland (grants 266133, 296240, 326988, 327288 and 311877) including “Brain changes across the life-span” profiling funding to University of Jyväskylä. We thank Helge Kainulainen and Ronny Schreiber at Aalto NeuroImaging for providing technical help and the force sensor system for the study. We thank Riitta…
Double Negative (CD19+IgG+IgD-CD27-) B Lymphocytes: A New Insight from Telomerase in Healthy Elderly, in Centenarian Offspring, and in Alzheimer’s Di…
2014
Background: We have previously reported the increase of IgD-CD27- (Double Negative, DN) B cell population in the aged. These memory B cells have short telomeres and poor abilities to proliferate in vitro. Here, we investigated whether the low ability of DN B cells to proliferate depends on the expression levels of the CD307d and CD22 inhibitory receptors or whether DN B cells can proliferate and reactivate telomerase by the engagement of both innate and adaptive immune receptors. Methods: Phenotypic analyses were made by using flow cytometry. Quantitative analysis of telomerase activity was made by using a TRAP and a photometric enzyme immunoassay in young, healthy elderly, centenarian offs…
Neural specialization to human faces at the age of 7 months.
2021
AbstractSensitivity to human faces has been suggested to be an early emerging capacity that promotes social interaction. However, the developmental processes that lead to cortical specialization to faces has remained unclear. The current study investigated both cortical sensitivity and categorical specificity through event-related potentials (ERPs) previously implicated in face processing in 7-month-old infants (N290) and adults (N170). Using a category-specific repetition/adaptation paradigm, cortical specificity to human faces, or control stimuli (cat faces), was operationalized as changes in ERP amplitude between conditions where a face probe was alternated with categorically similar or …
B cells in the aged: CD27, CD5, and CD40 expression.
2003
Ageing is characterized by numerous changes in lymphocyte subpopulations. In the present paper we have focused on B cells carrying the surface markers CD27, CD5 and CD40. CD27 is considered a marker of primed (memory) cells and its engagement promotes the differentiation of memory B cells into plasma cells. CD5 is expressed on B1 cells, which are considered to be responsible for T cell-independent antibody production other than autoantibodies. The CD40 molecule binds CD40L (CD154) and is necessary for T-dependent antibody responses. Here we show that the absolute number of CD5+ and CD40+ B cells is decreased in the elderly, while CD27+ B lymphocytes only marginally decrease in centenarians.…
B Cells Compartment in Centenarian Offspring and Old People
2010
Immunosenescence is considered a major contributory factor to the increased frequency of morbidity and mortality among elderly. On the other hand centenarians are considered the best example of successful ageing. To gain insight into mechanisms of immunosenescence and its clinical relevance, a possible model is represented by centenarians and/or their offspring. Nowadays centenarians are not more a curiosity, but in Europe are 1/8000 inhabitants and it has been demonstrated that the centenarian offspring, who are typically in their 70s and 80s, have a survival advantage when compared with age-matched controls whose parents died at an average life expectancy. Then again, studies on immunosen…
Cortical Proprioceptive Processing Is Altered by Aging
2018
Proprioceptive perception is impaired with aging, but little is known about aging-related deterioration of proprioception at the cortical level. Corticokinematic coherence (CKC) between limb kinematic and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. We, thus, compared CKC strength to ankle movements between younger and older subjects, and examined whether CKC predicts postural stability. Fifteen younger (range 18-31 years) and eight older (66-73 years) sedentary volunteers were seated in MEG, while their right and left ankle joints were moved separately at 2 Hz (for 4 min each) using a novel MEG-compatible ankle-movement actuator. Coherence…
Faldaprevir (BI 201335), BI 207127 and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
2013
Background Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib SOUND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods Patients were randomized to receive deleobuvir 400 mg ( n=15) or 600 mg ( n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results…
Machine learning for rapid mapping of archaeological structures made of dry stones – Example of burial monuments from the Khirgisuur culture, Mongoli…
2020
11 pages; International audience; The present study proposes a workflow to extract from orthomosaics the enormous amount of dry stones used by past societies to construct funeral complexes in the Mongolian steppes. Several different machine learning algorithms for binary pixel classification (i.e. stone vs non-stone) were evaluated. Input features were extracted from high-resolution orthomosaics and digital elevation models (both derived from aerial imaging). Comparative analysis used two colour spaces (RGB and HSV), texture features (contrast, homogeneity and entropy raster maps), and the topographic position index, combined with nine supervised learning algorithms (nearest centroid, naive…