Search results for "Activation"

Brain responses to sound intensity changes dissociate depressed participants and healthy controls.

2017

Depression is associated with bias in emotional information processing, but less is known about the processing of neutral sensory stimuli. Of particular interest is processing of sound intensity which is suggested to indicate central serotonergic function. We tested weather event-related brain potentials (ERPs) to occasional changes in sound intensity can dissociate first-episode depressed, recurrent depressed and healthy control participants. The first-episode depressed showed larger N1 amplitude to deviant sounds compared to recurrent depression group and control participants. In addition, both depression groups, but not the control group, showed larger N1 amplitude to deviant than standa…

Noise phenomena and soliton dynamics in long Josephson junctions

2013

In this work we computationally explore the transient dynamics of a noisy Josephson junction (JJ). Principal purpose is to investigate the behavior of the lifetime of the superconductive state as a function of the system and noise source parameters. The relations between the emerging phenomena and the evolution of the JJ order parameter φ, that is the phase difference between the macroscopic wave functions describing the superconducting condensate in the two electrodes, is deeply investigated. We focus our interest on the switching events from the superconducting metastable state, and in particular on the mean escape time (MET). In the used model, a long JJ can be represented by a string co…

SPH modeling of blood flow in cerebral aneurysms

Gli aneurismi cerebrali sono dilatazioni patologiche di arterie cerebrali. Queste patologie hanno un intrinseco rischio di rottura con conseguenti emorragie intracraniche. Sebbene i meccanismi di formazione, crescita e rottura degli aneurismi cerebrali non sono ancora del tutto compresi, è comunemente riconosciuto che in questi processi i fattori emodinamici giocano un ruolo molto importante. Le simulazioni numeriche possono fornire utili informazioni sull'emodinamica e possono essere usate per applicazioni cliniche. Nei tradizionali metodi numerici basati su una griglia di calcolo il processo di discretizzazione dei vasi cerebrali sui quali insiste un aneurisma è molto complesso. D’altra p…

Inhibitory priming in auditory word recognition: Is it really the product of response biases ?

2007

Les études en amorçage phonologique ont révélé des temps de réponse plus lents lorsque des mots cibles sont précédés d’une amorce partageant avec eux les premiers phonèmes. Cependant, l’interprétation de l’effet d’amorçage inhibiteur est source de controverses. Alors que certains auteurs ont interprété l’effet comme reflétant des processus lexicaux, Pitt et Shoaf (2002) ont émis l’hypothèse que l’effet résulterait d’une surprise des participants lorsqu’ils rencontrent le premier essai relié. Pour éviter un tel biais de réponse, nous avons inclus des amorces et des cibles reliées dans la session d’entraînement, et nous avons comparé comme l’ont fait Pitt et  Shoaf, l’amplitude de l’effet sur…

Sustainable virtual teams: promoting well-being through affect management training and openness to experience configurations

2021

A disruptive digitalization recently occurred that led to the fast adoption of virtual teams. However, membership diversity and team virtuality threaten members’ well-being, especially if faultlines appear (i.e., subgroups). Considering the job demands–resources model and the role of group affect in shaping members’ perceptions of well-being, we test the effectiveness of a short-term affect management training for increasing members’ eudaimonic well-being. Moreover, based on the trait activation theory and the contingent configuration approach, we draw on the personality composition literature to test how different openness to experience configurations of team level and diversity together m…

Data from: Independent and interactive effects of immune activation and larval diet on adult immune function, growth and development in the greater w…

2018

Organisms in the wild are likely to face multiple immune challenges as well as additional ecological stressors, yet their interactive effects on immune function are poorly understood. Insects are found to respond to cues of increased infection risk by enhancing their immune capacity. However, such adaptive plasticity in immune function may be limited by physiological and environmental constraints. Here, we investigated the effects of two environmental stressors – poor larval diet and an artificial parasite-like immune challenge at the pupal stage – on adult immune function, growth and development in the greater wax moth (Galleria mellonella). Males whose immune system was activated with an …

Analysis of complement C3 activation products in human atherosclerotic lesions.

1991

Abstract Cleavage of the complement C3 protein is essential for complement activation. Saline extracts of human atherosclerotic lesions were examined by various techniques for the presence of C3 cleavage fragments. Crossed intermediate gel immunoelectrophoresis revealed that native C3 was the predominate C3 protein in extracts and that the C3dg fragment was also detected. SDS-PAGE/ Western blot analyses of lesion extracts employing monoclonal antibodies directed at C3c and C3dg fragment determinants demonstrated molecular weight bands corresponding to the known molecular weights of all the physiologic C3 cleavage fragments, except Cab which is known to have a short half-life. After C3, the …

Squaric Acid-Based Radiopharmaceuticals for Tumor Imaging and Therapy.

2021

Targeting vectors bound to a chelator represent a significant fraction of radiopharmaceuticals used nowadays for diagnostic and therapeutic purposes in nuclear medicine. The use of squaramides as coupling units for chelator and targeting vector helps to circumvent the disadvantages of several common coupling methods. This review gives an overview of the use of squaric acid diesters (SADE) as linking agents. It focuses on the conjugation of cyclic chelators, e.g., DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), as well as hybrid chelators like AAZTA5 (6-pentanoic acid-6-amino-1,4-diazepine tetracetic acid) or DATA5m (6-pentanoic acid-6-amino-1,4-diazapine-triacetate) to diff…

Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells.

2000

This paper studies the effects caused in human retinoblastoma Y79 cells by treatment with combinations of sodium butyrate, the inhibitor of topoisomerase I camptothecin and the inhibitor of 26S proteasome MG132. The combination of sodium butyrate and camptothecin resulted in a strong synergistic cytotoxicity, as revealed by combination indices of 0.77 and 0.52 calculated at IC(50) and IC(75). Synergistic interactions were also demonstrated for combinations of sodium butyrate and MG132, camptothecin and MG132 and for a combination of all three compounds. The cytotoxic effects observed after the combined treatments can be considered a consequence of apoptosis, as suggested by the appearance o…

Monoclonal antibodies against components of the classical pathway of complement.

1989

Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far which recognize either conserved epitopes or activation-dependent epitopes with particular emphasis on neoepitopes occurring during the activation cascade.