Search results for "Adaptive"

On personalized adaptation of learning environments

2017

This work is devoted to the development of personalized training systems. A major problem in learning environments is applying the same approach to all students: i.e., teaching materials, time for their mastering, and a training program that is designed in the same way for everyone. Although, each student is individual, has his own skills, ability to assimilate the material, his preferences and other. Recently, recommendation systems, of which the system of personalized learning is a part, have become widespread in the learning environments. On the one hand, this shift is due to mathematical approaches, such as machine learning and data mining, that are used in such systems while, on the ot…

Divergent parasite infections in sympatric cichlid species in Lake Victoria

2018

Parasitism has been proposed as a factor in host speciation, as an agent affecting coexistence of host species in species‐rich communities and as a driver of post‐speciation diversification. Young adaptive radiations of closely related host species of varying ecological and genomic differentiation provide interesting opportunities to explore interactions between patterns of parasitism, divergence and coexistence of sympatric host species. Here, we explored patterns in ectoparasitism in a community of 16 fully sympatric cichlid species at Makobe Island in Lake Victoria, a model system of vertebrate adaptive radiation. We asked whether host niche, host abundance or host genetic differentiatio…

The role of maternal effects in host-parasite interactions: examination of the development of the immune defense in a colonial seabird, the black-leg…

2004

One of the main aims of evolutionary biology is to understand the mechanisms responsible for the phenotypic variation on which natural selection can act. Maternal effects occur when a mother's phenotype or her environment influence her offspring's phenotype. Despite the importance of such effects for the ecology of host-parasite interactions, their role has been relatively neglected to date. In this thesis, we examined how mothers influence the immune defense of their young in an environment that varies in space and time. This work has primarily focused on a colonial seabird, the black-legged kittiwake (Rissa tridactyla). Using this model, we have first shown that specific maternal antibodi…

A new subjective adaptive comfort model based on intelligent agents

2008

Koneoppiminen

2015

Koneoppiminen on monipuolinen ja tehokas työkalu erilaisiin tehtäviin. Tässä tutkielmassa on tarkoituksena tutustua sekä ohjatun että ohjaamattoman oppimisen yleisimpiin menetelmiin. Tarkoituksena on käsitellä nämä menetelmät yleisellä tasolla niin, että asiasta tietämätön ymmärtää perusperiaatteet miten eri menetelmät toimivat. Tarkempia yksityiskohtia ja matemaattisia algoritmejä ei tulla käsittelemään. Machine learning is powerfull and versatile tool for a multitude of tasks. The point of this study is to familiarize oneself with a couple of different methods of both supervised and unsupervised machine learning, so that anyone can understand the basic principles behind the different meth…

Adaptive forest governance to face land use change impacts in Italy: a review

2015

Il cambiamento dell’uso del suolo è uno dei driver principali della riduzione della resilienza ecosistemica, così come della perdita di biodiversità e approvvigionamento di servizi. Rappresenta una sfida peculiare, specialmente negli ambienti mediterranei, dove i fenomeni di abbandono e ricolonizzazione naturale stanno minacciando in modo sempre più crescente la capacità delle foreste di fornire benefici alle comunità locali. In queste condizioni, il sistema di governance forestale è chiamato a bilanciare gli impatti del cambiamento dell’uso del suolo con l’assicurazione della salute e della stabilità degli ecosistemi forestali, al fine di garantire la sostenibilità a lungo termine degli am…

Antigen-specific T cells and cytokines detection as useful tool for understanding immunity against zoonotic infections.

2012

Zoonoses include a broad range of diseases, that are becoming of great interest, due to the climate changing, that cause the adaptation of vectors to new niches and environments. Host immune responses play a crucial role in determining the outcome of infections, as documented by expansion of antigen-specific T cells during several zoonotic infections. Thus, understanding of the contribution of antigen-specific T-cell subsets in the host immune response is a powerful tool to evaluate the different immunological mechanisms involved in zoonotic infections and for the development of effective vaccines. In this paper we discuss the role of T cells in some eukaryotic and prokaryotic infectious mo…

New Insight into Immunity and Immunopathology of Rickettsial Diseases

2011

Human rickettsial diseases comprise a variety of clinical entities caused by microorganisms belonging to the generaRickettsia,Orientia,Ehrlichia, andAnaplasma. These microorganisms are characterized by a strictly intracellular location which has, for long, impaired their detailed study. In this paper, the critical steps taken by these microorganisms to play their pathogenic roles are discussed in detail on the basis of recent advances in our understanding of molecularRickettsia-host interactions, preferential target cells, virulence mechanisms, three-dimensional structures of bacteria effector proteins, upstream signalling pathways and signal transduction systems, and modulation of gene exp…

Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space

2019

Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different individuals remain poorly understood. To quantitatively describe epitope immunogenicity, here we propose a supervised machine learning framework generating probabilistic estimates of immunogenicity, termed "immunogenicity scores," based on the numerical features computed through sequence-based simulation approximating the molecular scanning process of peptides presented onto major histocompatibility complex (MHC) by the human T cell receptor (T…

γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection

2011

Protective immunity against mycobacterial infections such asMycobacterium tuberculosisis mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations onγδT lymphocytes and their role in tuberculosis immunity.