Search results for "Amine gas treating"

1987

Drug carriers were prepared by combining oligopeptidic sequences with synthetic polymeric chains. Soluble copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) were synthesized containing oligopeptidic side chains terminating in a drug model (p-nitroaniline). The susceptibility of these oligopeptidic sequences to degradation on incubation with lysosomal enzymes and human serum was evaluated by monitoring the p-nitroaniline liberation. It was shown that the drug model can be attached to the polymer carrier by means of an oligopeptidic spacer stable in blood serum and degradable after the polymer has been in contact with intracellular lysosomal enzymes. The studied polymer carriers were used…

Antimykotische Wirkstoffe, 16. Mitt. Halogenierte Cyanaminomethylenpiperidine und -piperazine

1984

Die in Gegenwart der sekundaren Amine 5a-e mit Hilfe von s-Triazin (2) als Dreikomponentenreaktion durchgefuhrte Aminomethinylierung von Cyanamid (1) liefert die korrespondierenden als Dehydro-N-Mannich-Basen aufzufassenden Cyanaminomethylenheterocyclen 6a-e. Insbesondere 6a und 6e besitzen antimykotische Wirksamkeit. Antimycotic Agents, XVI: Halogenated (Cyanaminomethylene)piperidines and -piperazines The aminomethinylation of cyanamide (1) by means of s-triazine (2), carried out as three-component reaction in the presence of the secondary amines 5a–e, yields the cyanaminomethylene heterocycles 6a–e, which are to be classed as dehydro-N-Mannich bases. Compounds 6a and 6e in particular show…

1,3-Di(hetero)aryl-7-substituted Pyrenes—An Undiscovered Area of Important Pyrene Derivatives

2019

Despite the pyrene derivatives have been covered extensively by scientists during the last years, many interesting properties and applications of pyrene derivatives have been presented, nowadays there are still areas of pyrenes’ chemistry that need to be fulfilled. Most of the described in literature pyrenes are 1,3,6,8-tetrasubstituted followed by 4,5,9,10-tetrasubstituted, 2,7-, and 1,6-, and 1,8-disubstituted pyrene derivatives. In the case of 1,3-di(hetero)aryl-7-substituted, there are only a few examples of derivatives containing at position 7 - tert-butyl group. In this work, the necessity of synthesis of 1,3-di(hetero)aryl-7-substituted pyrenes is presented based on the results of th…

Antimykotische wirkstoffe. XXI. Aliphatisch und alicyclisch substituierte chlor-diallylamino-1l,3,5-triazine

1988

Aus der nucleophilen Substitution eines Chloratoms in 2,4-Dichlor-6-(diallylamino)-1,3,5-triazin (1) durch Amine (2a-g) gehen die Alkylamino- und Cycloalkylamino-chlor-(diallylamino)-1,3,5-triazine (3a-g) hervor. Von den zur Untermauerung des Strukturtyps 3 herangezogenen spektroskopischen Daten sind besonders charakteristisch die durch das 1,3,5-Triazinringsystem hervorgerufene IR-Bande bei 800 cm−1, die den Allylgruppen zuzuordnenden vier 1H-NMR-Signale zwischen 4,1–6,1 ppm und das beim massenspektroskopischen Abbau auftretende Rumpfkation m/e 158. Auffallend ausgepragt sind in Verbindungsklasse 3 antimykotische, trichomonazide und herbizide Wirksamkeit. By nucleophilic substitution of on…

Steady-state fluorescence emission studies on polyazacyclophane macrocyclic receptors and on their adducts with hexacyanocobaltate(III)

1995

The steady-state fluorescence emission spectra of the azacyclophanes 2,5,8,11-tetraaza[12] paracyclophane (L1), 2,6,9,13-tetraaza[14]paracyclophane (L2), 14,15,17,18-tetramethyl-2,5,8,11-tetraaza[12]paracyclophane (L3) and 16,17,19,20-tetramethyl-2,6,9,13-tetraaza[14]paracyclophane (L4) as a function of pH have been measured. The fully protonated species of each cyclophane gives the highest fluorescence-emission quantum yield. The shapes of the titration curves have been explained by the existence of an electron-transfer quenching effect from a non-protonated amine to the benzene chromophore. This effect is greater for macrocycles in which the first deprotonated amine group is closer to the…

1981

New nitrogen mustard analogues in which bis(2-chloroethyl)-amino groups are separated by oxyethylene groups, 1,14-dichloro-3,12-bis(2-chloroethyl)-3,12-diaza-6,9-dioxatetradecan (3c) and 1,17-dichloro-3,15-bis(2-chloroethyl)-3,15-diaza-6,9,12-trioxaheptadecane (3d), were synthesized by reaction of bis(2-hydroxyethyl)amine (2) with bis(2-chloroethyoxy)ethylene (1a) and with 1,11-dichloro-3,6,9-trioxaundecane (1b), respectively, followed by treatment with thionyl chloride. The analogues were then complexed with heparin. The resulting heparin-complexes show inhibiting activity against transplanted Sarcoma-180 A in mice.

Anion interaction with ferrocene-functionalised cyclic and open-chain polyaza and aza-oxa cycloalkanes

2016

A family of ferrocene-functionalised receptors of different topologies have been used as receptors for anions. The compounds have been designed to contain both amine nitrogen and ether oxygen atoms and comprises from monoaza to pentaaza derivatives both open-chain (L1, L2, L3) or cyclic (L4, L5) and having from one to five ferrocenyl groups. Solution studies directed to determine the protonation constants of L1, L2 and L3 have been carried out in water (0.1 mol dm3 KNO3, 25 °C) and those of L4 and L5 in 1,4-dioxane-water (70:30 v/v, 0.1 mol dm -3 KNO 3, 25 °C). The protonation behaviour of the receptors can be explained taking into account electrostatic considerations. Speciation studies in…

Die Beschleunigung der Polymerisation durch Hydroperoxyd und Aminsalz

1964

Di-n-butylaminhydrochlorid vergrosert die Geschwindigkeit der durch Tetralinhydroperoxyd initiierten Polymerisation von Styrol und von Methylmethacrylat. Im Bereich kleiner Konzentrationen von Hydroperoxyd und Aminsalz bis zu je etwa 5·10−4 Mol/l ist die Reaktionsgeschwindigkeit der Wurzel aus der Hydroperoxyd- und Aminsalzkonzentration jedoch der Monomerkonzentration direkt proportional. The polymerisation rate of styrene and methylmethacrylate initiated by tetraline hydroperoxide is accelerated by di-n-butylamine hydrochloride. In the range of low concentrations up to 5 · 10−4 mole/l. of each, hydroperoxide and amine salt, the rate of polymerisation is proportional to the square roote of …

Antidiabetische wirkstoffe. V Lang- und verzweigtkettig substituierte chlor-dihexylamino-1,3,5-triazine

1985

Die nucleophile Substitution eines Chloratoms in 2,4-Dichlor-6-dihexylamino-1,3,5-triazin (1) durch Amine (2a-c) fuhrt zu den Alkylamino-chlor-dihexylamino-1,3,5-triazinen 3a-c. Fur Strukturtyp 3 typische Signale in den 1H-NMR-Spektren sind das Triplett bei 0,9 ppm fur die endstandigen Methylgruppen und das Multiplett bei 3,3-3,65 ppm fur die den Stickstoffatomen benachbarten Methylengruppen. In Verbindungsklasse 3 finden sich Vertreter mit antidiabetischer, trichomonazider, antiviraler und anthelminthischer Wirksamkeit. The nucleophilic substitution of one chlorine atom in 2,4-dichloro-6-dihexylamino-1,3,5-triazine (1) by amines 2a-c leads to the alkylamino-chlorodihexylamino-1,3,5-triazin…

An Unexpected Three-Component Condensation Leading to Amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles.

2005

The reaction of 2-carboxybenzaldehyde with primary amines in the presence of cyanide leads to the formation of 2-substituted amino(3-oxo-2,3-dihydro-1H-isoindol-1-ylidene)acetonitriles. These compounds originate from the condensation of 2-carboxybenzaldehyde with the amine and two molecules of hydrogen cyanide and represent a novel class of isoindolinones.