Search results for "Anglia"

Nigral control of hippocampal epilepsy: a dopaminergic hypothesis

1988

The action of iontophoretically applied acetylcholine and dopamine on single claustrum neurones in the cat.

1981

Abstract The effects of iontophoretically applied acetyl-choline (ACh) and dopamine (DA) on spontaneously active claustral neurones, in chloralose-anaesthetised cats, have been investigated. Acetylcholine had both facilitatory and inhibitory effects in almost the same proportions. The action of DA was prevalently inhibitory. Two types of inhibitory response to ACh and DA are described: short-lasting inhibition and long-lasting inhibition. The excitatory response always outlasted the period of drug application.

Relations between basal ganglia and hippocampus: Action of substantia nigra and pallidum

1986

Several interrelationships exist between basal ganglia and hippocampus. The ventral striatum appears to be involved in the control of the dopaminergic nigro-striatal pathway. The caudate, in turn, seems to influence the hippocampal theta rhythm and to inhibit hippocampal spikes. In the present work the role played by globus pallidus pars interna and substantia nigra pars compacta on hippocampal bioelectrical activity is studied. Injection of sodium penicillin i.v. produces steady interictal spikes in the hippocampus. Substantia nigra stimulation induces regular theta rhythm and inhibits the spikes. Pallidal stimulation, on the contrary, appears to strongly enhance epileptiform activity, pro…

Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration.

2014

Injured peripheral neurons successfully activate intrinsic signaling pathways to enable axon regeneration. We have previously shown that dorsal root ganglia (DRG) neurons activate the mammalian target of rapamycin (mTOR) pathway following injury and that this activity enhances their axon growth capacity. mTOR plays a critical role in protein synthesis, but the mTOR-dependent proteins enhancing the regenerative capacity of DRG neurons remain unknown. To identify proteins whose expression is regulated by injury in an mTOR-dependent manner, we analyzed the protein composition of DRGs from mice in which we genetically activated mTOR and from mice with or without a prior nerve injury. Quantitati…

Imbalance between sympathetic and sensory innervation in peritoneal endometriosis

2011

To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n= 40) and healthy peritoneum (n= 12) were immunostained and analysed with anti-protein gene product 9.5 (PGP 9.5), anti-substance P (SP) and anti-tyrosine hydroxylase (TH), specific markers for intact nerve fibres, sensory nerve fibres and sympathetic nerve fibres, respectively, to identify the ratio of sympathetic and sensory nerve fibres. In addition, immune cell infiltrates in peritoneal endometriotic lesions were analysed and the nerve growth factor (NGF) and interleuki…

Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in M…

2020

The subthalamic nucleus (STN), a key component of the basal ganglia circuitry, receives inputs from broad cerebral cortical areas and relays cortical activity to subcortical structures. Recent human and animal studies have suggested that executive function, which is assumed to consist of a set of different cognitive processes for controlling behavior, depends on precise information processing between the cerebral cortex and subcortical structures, leading to the idea that the STN contains neurons that transmit the information required for cognitive processing through their activity, and is involved in such cognitive control directly and dynamically. On the other hand, the STN activity also …

ATTUALI ORIENTAMENTI NELLA DIAGNOSTICA DELLA MALATTIA DI HIRSCHSPRUNG

1979

Gli Autori analizzano l'ier diagnostico nella malattia di Hirschsprung sulla base del quadro clinico e dell'età del paziente

Stimulant-induced adaptations in neostriatal matrix and striosome systems: Transiting from instrumental responding to habitual behavior in drug addic…

2005

Abstract Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug. Such alterations, which correlate with persistent patterns of repetitive behavior, associate with distinct compartmental changes in the neostriatum. Striatal matrix system neurons undergo “silencing” following repeated drug challenges, allowing striosome system neurons to exhibit preferential activation. Matrix neurons are innervated by sensory and motor areas of neocortex and are activated in the course of on-going, adaptive behavior. Inactivation of m…

The zona incerta system: Involvement in attention and movement

2021

The zona incerta (ZI) is a large structure made of four neurochemically defined regions (at least, in rodents). It is globally involved in complex connections with telencephalic and brainstem centers. In this work, we focus on some of the anatomical links this structure develops with the cerebral cortex and the tectum. We also point to its integration within a larger basal ganglia network. The functions of this region are still mysterious, even if recent works suggest its participation in behavioral expression. Studies about the functional organization of the vibrissal system have provided the first integrated model, illustrating the ZI's role in sensory-motor programing. In addition, ZI co…

Normanowie w dziełach Geralda z Walii a świat bizantyński

2018

The main purpose of this paper is to analyze the selscted works of one of the twelfth century Normans historian living in the British Isles, Gerald de Barri of Wales (1146-1223) in terms of knowledge of the Byzantine world and its correlation with the Normans (from England and Southern Italy). The term Byzantine world has been evolving for several decades. Today it refers no longer just to the land of the former East European Empire, which later transformed itself into the Greek Byzantium, but it can be referred to the Balans or the Kingdom of Normandy, while scientists are constantly expanding its borders with the help of other sciences such as archeology. We will do this based on his work…