Search results for "Asian"

Tuntuuko, jos tästä painaa? Epäsuoruus, toimintaan kehottaminen ja asiantuntijuus terveydenhuollon ammattilaisten teksteissä

2014

Artikkelissa kasitellaan suomea toisena kielena kayttavien terveydenhuoltoalan ammattilaisten epasuoraa viittaamista henkiloon ja epasuoraa toimintaan kehottamista seka epasuoruuden kytkeytymista asiantuntijuuden muunlaiseen ilmenemiseen teksteissa. Epasuora ilmaustapa on tyypillinen erilaisissa terveydenhuollon tilanteissa, kuten potilaan ja terveydenhuollon ammatilaisen valisessa vuorovaikutuksessa ja kollegojen valisessa viestinnassa. Epasuoraa viittausta kaytetaan esimerkiksi kuvattaessa jonkin ilmion yleisia vaikutuksia keneen tahansa henkiloon tai toisaalta tiettyyn puhuteltavaan, joka jatetaan kuitenkin kielellisesti maarittelematta. Epasuoruus on tyypillista myos kehotettaessa toist…

The zoom-on-possessee construction in Kam (Dong): the anatomy of a new construction type

2005

Kam, a Kadai language spoken in Guizhou province (People's Republic of China), has a family of intransitive possessive constructions with the word order ‘Possessor–Verb–Possessee’. (The basic word order in Kam is SV and AVO.) While two recent papers have featured this unique construction type for an array of other Southeast Asian languages, they fail to acknowledge its distinct semantic value in contrast to the related construction type ‘Possessee–Possessor–Verb’. The former construction type displays a so-called ‘zoom-effect’: the possessor is predicated IN, AT or THROUGH his/her/its possessee; the predication zooms from the possessor on his/her/its possessee. The latter construction, in c…

Problems with primary vs. secondary grammaticalization: the case of East and mainland Southeast Asian languages

2015

Abstract The present paper aims at testing four criteria for the distinction between primary vs. secondary grammaticalization in East and mainland Southeast Asian languages. These languages are of special interest for research on grammaticalization because they show limitations in the coevolution of meaning and form and because pragmatic inference is very prominent (lack of obligatory grammatical markers, multifunctionality). If the four criteria work in these languages, this can be taken as a good indicator for their cross-linguistic, maybe universal relevance. The criteria are tested with three markers that stand for three different types of multifunctionality: (i) the Khmer verb baːn ‘co…

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations.

2005

Cytochrome P450 3A enzymes (CYP3A) play a major role in the metabolism of steroid hormones, drugs and other chemicals, including many carcinogens. The individually variable CYP3A expression, which remains mostly unexplained, has been suggested to affect clinical phenotypes. We investigated the CYP3A locus in five ethnic groups. The degree of linkage disequilibrium (LD) differed among ethnic groups, but the most common alleles of the conserved LD regions were remarkably similar. Non-African haplotypes are few; for example, only four haplotypes account for 80% of common European Caucasian alleles. Large LD blocks of high frequencies were suggestive of selection. Accordingly, European Caucasia…

An Indian Tartuffe: P. K. Atre's comedy ‘Buvā teth bāyā’ and its literary models

1984

qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Ste…

2020

[Background and Aims] Nonalcoholic steatohepatitis (NASH) is a common cause of chronic liver disease. Clinical trials use the NASH Clinical Research Network (CRN) system for semiquantitative histological assessment of disease severity. Interobserver variability may hamper histological assessment, and diagnostic consensus is not always achieved. We evaluate a second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) imaging‐based tool to provide an automated quantitative assessment of histological features pertinent to NASH.

Has 1997 Asian crisis increased information flows between international markets

2003

Abstract The Asian crisis started on July 2, 1997 and caused turmoil in developed as well as emerging international stock markets. The objective of this paper is to analyse the effects of the crisis on the relationships of the Southeast Asian stock markets with the stock markets of three geographical areas (Europe, North America, and Latin America). We use the Morgan Stanley national and international indexes (MSCI) for two homogeneous and nonoverlapping time intervals. The econometric techniques used in this paper include the cointegration test, vector autoregression analysis, forecast error variance decomposition (FEVD), and impulse–response relationships. Our results show that: (i) there…

New insights from GWAS for the cleft palate among han Chinese population

2016

Background Genome wide association studies (GWAS) already have identified tens of susceptible loci for nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, whether these loci associated with nonsyndromic cleft palate only (NSCPO) remains unknown. Material and Methods In this study, we replicated 38 SNPs (Single nucleotide polymorphisms) which has the most significant p values in published GWASs, genotyping by using SNPscan among 144 NSCPO trios from Western Han Chinese. We performed the transmission disequilibrium test (TDT) on individual SNPs and gene-gene (GxG) interaction analyses on the family data; Parent-of-Origin effects were assessed by separately considering trans…

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consorti…

2018

Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with i…

BMP7 Gene involved in nonsyndromic orofacial clefts in western han Chinese

2015

Background: Nonsyndromic orofacial clefts (NSOCs) are the most common craniofacial birth defects with complex etiology in which multiple genes and environmental exposures are involved. Bone morphogenetic protein 7 (BMP7), as a member of the transforming growth factor-beta (TGF-beta) superfamily, has been shown to play crucial roles in palate and other orofacial ectodermal appendages development in animal models. Material and Methods: This study was designed to investigate the possible associations between BMP7 gene and the NSOCs (221 case-parent trios) in Western Han Chinese. Five tagSNPs at BMP7, rs12438, rs6099486, rs6127973, rs230188 and rs6025469 were picked and tried to cover the entir…