Search results for "Autoimmune"

Statin-induced autoimmune myositis: a proposal of an “experience-based” diagnostic algorithm from the analysis of 69 patients

2023

AbstractStatin-induced autoimmune myositis (SIAM) represents a rare clinical entity that can be triggered by prolonged statin treatment. Its pathogenetic substrate consists of an autoimmune-mediated mechanism, evidenced by the detection of antibodies directed against the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR Ab), the target enzyme of statin therapies. To facilitate the diagnosis of nuanced SIAM clinical cases, the present study proposes an “experience-based” diagnostic algorithm for SIAM. We have analyzed the clinical data of 69 patients diagnosed with SIAM. Sixty-seven patients have been collected from the 55 available and complete case records regarding SIAM in the l…

p Natural polyphenols as anti-inflammatory agents p

2009

Celiac Disease is a worldwide spread condition affecting 1:100-1:200 individuals. It is a permanent food intolerance to ingested gluten in genetically predisposed subjects. In this review we analyze the biochemical markers of the disease going from laboratory findings to histology passing through genetics. Gluten intolerance is a unique model of autoimmune disease in which we can recognize the main environmental factor (gluten) and the more complex genetic background. In additional way, serological markers for monitoring the disease and a safe and effective therapy (gluten free diet) are also available. In deed the environmental factor such as gluten intake is necessary to trigger the disea…

Antivielas pret parietālajām šūnām un iekšējo faktoru kuņģa vēža pacientiem

2022

Ievads. Saistība starp H. pylori infekciju un kuņģa adenokarcinomas attīstību ir plaši pētīta, bet autoimūnā gastrīta nozīmei nav pievērsta tik liela uzmanība. Mērķis. Noteikt kuņģa adenokarcinomas pacientu īpatsvaru ar pozitīvām pret partikulāro šūnu (APCA) un anti intrīna faktora (IF) antivielām, izpētīt saistību starp kuņģa atrofijas marķieriem, H. pylori un auto antivielu pozitīvismu, kā arī novērtēt vairākas adenokarcinomas pazīmes saistībā ar autoimūno gastrītu. Materiāli un metodes. Pacientiem ar morfoloģiski apstiprinātu kuņģa adenokarcinomu tika izmērīts APCA un anti-IF antivielu līmenis un novērtēta to saistība ar PGI/PGII attiecību, kā arī H. pylori IgG līmeni. APCA un anti-IF an…

Missense mutations in the fas gene resulting in autoimmune lymphoproliferative syndrome: A molecular and immunological analysis

1997

AbstractProgrammed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system. The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene. We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis. The children share common clinical features including splenomegaly and lymphadenopathy, b…

Anti-parietal cell antibodies – diagnostic significance

2015

Anti-parietal cell antibodies (APCA) are an advantageous tool for screening for autoimmune atrophic gastritis (AAG) and pernicious anemia (PA). The target for APCA is the H+/K+ ATP-ase. It has been demonstrated, that APCA target both, the alpha, and beta subunits of the proton pump, although the major antigen is the alpha subunit. Circulating serum APCA can be detected by means of immunofluorescence, enzyme-linked immunosorbent assay – currently the most commonly used method, and radioimmunoprecipitation assay (RIA) – the 4A subunit has been optimized as a molecularspecific antigen probe. RIA is the most accurate method of antibody assessment, characterized by highest sensitivity. APCA can …

Ruolo della terapia medica nel Morbo di Basedow.

2004

Hepatitis C virus (HCV) and autoimmune liver diseases

1992

Anti-HCV tests were positive in 18–45% of sera from patients with autoimmune chronic active hepatitis. High gammaglobulin levels may result in false positive results, however, some sera show true positivity. PCR testing of such sera is necessary in order to determine whether HCV is directly involved in specific forms of the disease.

Platelet-neutrophil aggregates promote skin pathology in psoriasis

2019

AbstractPsoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes but frequently also presents with cardiovascular comorbidities. Especially polymorphonuclear neutrophils (PMNs) abundantly infiltrate psoriatic skin but the cues that prompt PMNs to home to the skin are not well defined. To identify PMN surface receptors that may explain PMN skin homing in psoriasis patients, we screened 332 surface antigens on primary human blood PMNs from healthy donors and psoriasis patients. We identified platelet surface antigens as a defining feature of psoriasis PMNs, due to a significantly increased aggregation of n…

Mechanisms of resistance to autoimmune disease induced by T-cell vaccination.

1991

Many human autoimmune diseases tend to progress slowly. Phases of rapid progression may come to a halt and may be followed by transient or even permanent remissions. Autoimmune diseases in animals either arise spontaneously or are induced. The former tend to be slowly progressive, the latter mostly acute to subacute, and usually followed by spontaneous remissions. The mechanisms at work that prevent rapid disease progression and can effect remissions are poorly understood, but they may provide us with a clue both to natural self-tolerance and to the therapeutic induction of self-tolerance.

HEp-2 intensity classification based on deep fine-tuning

2020

The classification of HEp-2 images, conducted through Indirect ImmunoFluorescence (IIF) gold standard method, in the positive / negative classes, is the first step in the diagnosis of autoimmune diseases. Since the test is often difficult to interpret, the research world has been looking for technological features for this problem. In recent years the methods of deep learning have overcome the other machine learning techniques in their effectiveness and robustness, and now they prevail in artificial intelligence studies. In this context, CNNs have played a significant role especially in the biomedical field. In this work we analysed the capabilities of CNN for fluorescence classification of…