Search results for "Azide"

3'-Arylazido-beta-alanyl-2-azido ATP, a cross-linking photoaffinity label for F1ATPases.

1989

Abstract The synthesis of the 3′-arylazido-2-azido ATP derivative 3′-O-{3-[N-(4-azido-2-nitrophenyl)-amino]propionyl}2-azido-adenosine 5′-triphosphate (2,3′-DiN3ATP) is described. The bifunc­ tional photoreactive ATP analog is characterized spectroscopically. Photoaffinity labeling of F, ATPase from Micrococcus luteus by this analog results in the inactivation of the enzyme and in the formation of higher molecular weight cross-links,

Synthesis and biological evaluation of antimalarial and antileukemic activity of new C-10 modified artemisinin derivatives

2021

Abstract Several non-acetal artemisinin derivatives were synthesized and their antimalarial activity against chloroquine-resistant parasites as well as their antileukemic activity were investigated. The azide 10 was proved to have slightly better activity than the current antimalarial drugs such as artesunate and chloroquine. In addition, the azide 10 and the aldehyde 7 were found to be effective in decreasing cell proliferation in leukemia cells.

Influence of functionalization on interaction and drug release from α,β-polyaspartylhydrazide derivatives to a biomembrane model: evaluation by diffe…

2004

Abstract A comparative study on the ability of various polymers to interact with a biomembrane model was carried out by differential scanning calorimetry (DSC). The investigated samples were a water soluble polymer, the α,β-polyaspartylhydrazide (PAHy) and its derivatives containing polyethylene glycol (PEG2000) (sample PAHy–PEG2000), or hexadecylamine (C16) (sample PAHy–C16) or both compounds (sample PAHy–PEG2000–C16). Some samples are able to arrange themselves as micellar structures and to interact potentially with the membrane surface so as to favor the release of the drug near the target membrane and consequently to improve drug adsorption processes. First, the interaction of all polym…

Copper(I)‐chitin biopolymer based: An efficient and recyclable catalyst for click azide–alkyne cycloaddition reactions in water

2021

Synthesis, Structures and DFT Calculations on Alkaline-Earth Metal Azide-Crown Ether Complexes

2008

The first examples of azide complexes of calcium, strontium or barium with crown ethers have been prepared and fully characterised, notably [Ba([18]crown-6)(N3)2(MeOH)], [Sr([15]crown-5)(N3)2(H2O)], [Ca([15]crown-5)(N3)2(H2O)] and [Sr([15]crown-5)(N3(NO3)]. Crystal structures reveal the presence of a variety of coordination modes for the azide groups including kappa 1-, mu-1,3- and linkages via H-bonded water molecules, in addition to azide ions. The [Ba([18]crown-6)(N3)2(MeOH)].1/3 MeOH contains dinuclear cations with three mu-1,3-NNN bridges, the first example of this type in main group chemistry. The structures obtained have been compared with molecular structures computed by density fun…

Synthesis of Highly Functionalized Cyclopentanes as Precursors of Hydroxylated Azidocarbonucleosides

2009

Regio- and stereoisomers of functionalized azido amino alcohols with a cyclopentane skeleton were synthesized in enantiomerically pure forms. Enzymatic ring cleavage of racemic 2-azabicyclo[2.2.1]hept-5-en-3-one gave the corresponding amino acid and one enantiomer of the lactam stereospecifically. These were protected by esterification and carbamoylation, and then epoxidized. The resulting oxiranes underwent cleavage by sodium azide with complementary stereoselectivities. The regioisomeric products were easily separated by crystallization or column chromatography.

Multidentate Polysarcosine-Based Ligands for Water-Soluble Quantum Dots

2016

We describe the synthesis of heterotelechelic polysarcosine polymers and their use as multidentate ligands in the preparation of stable water-soluble quantum dots (QDs). Orthogonally functionalized polysarcosine with amine and dibenzocyclooctyl (DBCO) end groups is obtained by ring-opening polymerization of N-methylglycine N-carboxyanhydride with DBCO amine as initiator. In a first postpolymerization modification step, the future biological activity of the polymeric ligands is adjusted by modification of the amine terminus. Then, in a second postpolymerization modification step, azide functionalized di- and tridentate anchor compounds are introduced to the DBCO terminus of the polysarcosine…

Synthese und Reaktionen der 3-O-Phosphoniogluco-und -allofuranosen

1982

Aus den bicyclischen Gluco- (3, 5, 7 und 9) und Allofuranosen 11 werden mit Triphenylphosphan (1), Azodicarbonsaure-diethylester (2) und Alkylierungs- oder Acylierungsmitteln isolierbare 3-O-Phosphoniokohlenhydrate (4, 6, 8, 10 und 12) hergestellt. Durch Erwarmen der allo-konfigurierten Salze 12 konnen an C-3 epimere gluco-konfigurierte Substitutionsprodukte in groser Vielfalt gewonnen werden. Die Reaktionen der gluco-konfigurierten Salze werden stark vom Charakter des einzufuhrenden Nucleophils und von Nachbargruppen im Kohlenhydratgerust beeinflust. Wahrend das Iodid 4a und das Azid 4g unter Substitution zum allo-Derivat 15 reagieren, tritt in den Fallen mit Bromid, Chlorid oder Sulfonat …

Cu(ii)-alginate-based superporous hydrogel catalyst for click chemistry azide-alkyne cycloaddition type reactions in water.

2020

A novel sustainable hydrogel catalyst based on the reaction of sodium alginate naturally extracted from brown algae Laminaria digitata residue with copper(II) was prepared as spherical beads, namely Cu(II)-alginate hydrogel (Cu(II)-AHG). The morphology and structural characteristics of these beads were elucidated by different techniques such as SEM, EDX, BET, FTIR and TGA analysis. Cu(II)-AHG and its dried form, namely Cu(II)-alginate (Cu(II)-AD), are relatively uniform with an average pore ranging from 200 nm to more than 20 μm. These superporous structure beads were employed for the copper catalyzed [3 + 2] cycloaddition reaction of aryl azides and terminal aryl alkynes (CuAAC) via click …

Synthesis and biological evaluation of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine and its cycloalkane and cycloa…

2021

Derivatives of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepinone and its cycloalkane and cycloalkene condensed analogues have been conveniently synthesized through a three-step reaction sequence. An atom-economical, one-pot, three-step cascade process engaging five reactive centers (amide, amine, carbonyl, azide, and alkyne) has been performed for the synthesis of alicyclic derivatives of quinazolinotriazolobenzodiazepine using cyclohexane, cyclohexene, and norbornene β-amino amides. The stereochemistry and relative configurations of the synthesized compounds were determined by 1D and 2D NMR spectroscopy and X-ray crystallography. The reaction was also perfor…