Search results for "BCA"
showing 10 items of 110 documents
Multiple Zeta Values
2017
We study in some detail the very important class of periods called multiple zeta values (MZV). These are periods of mixed Tate motives, which we discussed in Sect. 6.4. Multiple zeta values are in fact periods of unramified mixed Tate motives, a full subcategory of all mixed Tate motives.
Phenotype and function of monocyte derived dendritic cells in chronic hepatitis B virus infection.
2004
The antiviral T cell failure of patients with chronic hepatitis B virus (HBV) infection was suggested to be caused by a T cell stimulation defect of dendritic cells (DC). To address this hypothesis, monocyte derived DC (MDDC) of patients with chronic or resolved acute HBV infection and healthy controls were studied phenotypically by FACS analyses and functionally by mixed lymphocyte reaction, ELISA, ELISpot and proliferation assays of MDDC cultures or co-cultures with an allogeneic HBc-specific Th cell clone. HBV infection of MDDC was studied by quantitative PCR. MDDC from HBV patients seemed to be infected by the HBV, showed a reduced surface expression of HLA DR and CD40 and exhibited a r…
G-Sica 10.1
2013
SOMMAIRE :-*- Introduction / Marc Veyrat ; -1- ©box : InterMade pour un dispositif de médiation ? / Marc Veyrat ; mise en forme graphique Floriane Roussel, Delphine Lorenzetti ; -2- U-RSS en point de fuite. Symposium Texte & Image : une mise en voyage, Université de Malte, 2012 / Franck Soudan, Marc Veyrat ; mise en forme graphique Clara Blanchet, Lise Haudebourg ; -3- Kiss & Fly [ est une oeuvre interactive qui interroge la notion de paysage comme une rencontre de tous les paramètres identitaires d'un lieu ] / Carole Brandon et Arnaud Burgniard ; mise en forme graphique Marie-Albéric Martin, Arnaud Burgniard ; -4- eMotion. Pour une mobilité multi-sensorielle / Ghislaine Chabert, Marc Veyra…
Modification of the immune response against hepatitis B virus by the human immunodeficiency virus.
1989
Hepatitis B virus and the human immunodeficiency virus are similarly transmitted. Individuals with preexisting HIV infection have a higher chance to become HBsAg carriers than do anti-HIV negative persons. Cytotoxic T cells with specificity for HBcAg, that are under the control of HBcAg-specific helper T cells, are responsible for liver injury. There is good evidence that HIV infection lowers inflammatory activity, is associated with milder liver histology, high levels of viral replication and low seroconversion rates. In addition interferon alpha therapy is less effective in anti-HIV positive subjects. The immune response against HBsAg is helper T-cell dependent and vaccination against hep…
Target 5G visible light positioning signal subcarrier extraction method using particle swarm optimization algorithm
2021
International audience; With the explosive growth of demand for Internet of Things (IoT) applications and the increasing dependence of users on wireless connections, indoor location based service(LBS) under 5G-Public-Private Partnership (5G-PPP) using cases have received more attention and get rapid development. Thanks to the safty, security and customization of 5G network pointed by 5G forum white paper, indoor positioning systems using unified 5G New Radio (NR) signals have become the focus of the next generation of visible light positioning (VLP) systems. In 5G New Radio(NR) frame, totally 192 subcarriers are used to carry positioning reference signal(PRS). In order to improve the positi…
Dysfunction of Torr causes a Harlequin-type ichthyosis-like phenotype in Drosophila melanogaster
2019
AbstractPrevention of desiccation is a constant challenge for terrestrial organisms. Land insects have an extracellular coat, the cuticle, that plays a major role in protection against exaggerated water loss. Here, we report that the ABC transporter Torr - a human ABCA12 paralog - contributes to the waterproof barrier function of the cuticle in the fruit fly Drosophila melanogaster. We show that the reduction or elimination of Torr function provokes rapid desiccation. Torr is also involved in defining the inward barrier against xenobiotics penetration. Consistently, the amounts of cuticular hydrocarbons that are involved in cuticle impermeability decrease markedly when Torr activity is redu…
Hepatīta B kora antigēna veidoto vīrusveidīgo daļiņu modificēšana vakcīnu prototipa izstrādei
2017
DENV vakcīnu izveide balstās galvenokārt, izmantojot dzīvus novājinātus vīrusus. 2015. gadā tika reģistrēta pirmā tetravalenta novājināta denges vīrusa vakcīna. Kā drošāks vakcīnas veids ir subvienību vakcīnas. Daudzsološākais DENV antigēns subvienību vakcīnas izveidē ir apvalka proteīna III domēns. Lai palielinātu antigēna subvienības imunogenitāti, tiek izmantotas vīrusveidīgās daļiņas (VLP) kā svešu antigēnu nesēji. Tā kā VLP ir pašnereplicējošas, tās tiek uzskatītas par drošākiem kandidātiem vakcīnu izveidē, salīdzinot ar dzīviem novājinātiem vīrusiem. Maģistra darba mērķis bija iegūt 2. serotipa denges vīrusa apvalka III domēnu (DV2-III) prezentējošas mutantās HBc VLP. Pētījumā tika pā…
Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents
2015
A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.
Hepatīta B vīrusa G genotipa serdes antigēna veidoto vīrusveidīgo daļiņu raksturošana
2016
Šajā darbā tika salīdzinātas divas metodes HBV serdes antigēna veidoto vīrusveidīgo daļiņu (VVD) attīrīšanai no iepakotajām nukleīnskābēm – metode kapsīdu disociācijai ar GuHCl un sārmu hidrolīzes metode. Darbā aprakstīti un analizēti abu attīrīšanas metožu posmi un izdarīti secinājumi par attiecīgo attīrīšanas metožu efektivitāti. Tāpat tika raksturotas ar abām attīrīšanas metodēm iegūtās HBV G genotipa serdes antigēna VVD, nosakot to morfoloģiju (elektronu mikroskopija, dinamiskā gaismas izkliede) un spēju pakot raksturotas funkcionālas nukleīnskābes – CpG oligonukleotīdus, bakteriofāga dsRNS un DTxA mRNS. Eksperimentu rezultāti parāda, ka ar abām attīrīšanas metodēm iegūtās tukšās VVD sp…
Melua mittaavan langattoman anturiverkon klusterointi
2015
Langattomat anturiverkot soveltuvat moniin eri käyttötarkoituksiin, mutta anturisolmujen niukat resurssit asettavat kuitenkin omat haasteensa. Erityisesti anturisolmujen energiaa tulisi säästää, jotta verkon elinikä olisi mahdollisimman pitkä. Energiankulutusta voidaan vähentää jakamalla anturisolmut ryhmiin, klustereihin. Klusterointiprotokollan suoritus tapahtuu kierroksittain sisältäen yleensä seuraavat neljä vaihetta: pääsolmun valinta, klusterin muodostus, datan kokoaminen ja tiedonsiirto. Klusterointiprotokollan valinta voi olla haastavaa, sillä valintaan vaikuttaa monet tekijät. Klusterointiprotokollalle asetetut tavoitteet vaihtelevat ja ne määräytyvät usein sovelluksen vaatimusten …